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Themes and variations on ubiquitylation
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Alpha-synuclein and neurodegenerative diseases
NATURE REVIEWS NEUROSCIENCE
XIAP: Apoptotic brake and promising therapeutic target
APOPTOSIS
Baculoviruses and apoptosis: the good, the bad, and the ugly
CELL DEATH AND DIFFERENTIATION
Parkin and Parkinson's disease
CURRENT OPINION IN NEUROLOGY
ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal
MOLECULAR CELL
Importance of the regulation of nuclear receptor degradation
FRONTIERS IN BIOSCIENCE
Uptake of the ATP-binding cassette (ABC) transporter Ste6 into the yeast vacuole is blocked in the doa4 mutant
MOLECULAR BIOLOGY OF THE CELL
Apoptosis and the response to anticancer therapy
CURRENT OPINION IN ONCOLOGY
Functional production of mammalian concentrative nucleoside transporters in Saccharomyces cerevisiae
MOLECULAR MEMBRANE BIOLOGY
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
HUMAN MOLECULAR GENETICS
The importance of gene dosage studies: mutational analysis of the parkin gene in early-onset parkinsonism
HUMAN MOLECULAR GENETICS
Programmed cell death: alive and well in the new millennium
TRENDS IN CELL BIOLOGY
New complexities for BRCA1 and BRCA2
CURRENT BIOLOGY
Co-association of parkin and alpha-synuclein
NEUROREPORT
Regulation of the cell cycle and apoptosis by the oncogenes of adenovirus
ONCOGENE
The TNF-receptor-associated factor family - Scaffold molecules for cytokine receptors, kinases and their regulators
CELLULAR SIGNALLING
Parkin and the molecular pathways of Parkinson's disease
NEURON
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex
GENES & DEVELOPMENT
Parkin and Parkinson's: More than homonymy?
ANNALS OF NEUROLOGY
Genetics of Parkinson's disease
JOURNAL OF NEUROLOGY
Early-onset Parkinson's disease associated with a new parkin mutation in aSpanish family
NEUROSCIENCE LETTERS
Acute and chronic haloperidol treatments increase parkin mRNA levels in the rat brain
NEUROSCIENCE LETTERS
Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland
MOLECULAR AND CELLULAR BIOLOGY
Parkinson disease: etiology, pathogenesis and future of gene therapy
NEUROSCIENCE RESEARCH
Differential expression and tissue distribution of parkin isoforms during mouse development
DEVELOPMENTAL BRAIN RESEARCH
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin
CELL
Cell death inhibition: Keeping caspases in check
CELL
Liddle's syndrome: A novel mouse Nedd4 isoform regulates the activity of the epithelial Na+ channel
KIDNEY INTERNATIONAL
Mechanisms underlying ubiquitination
ANNUAL REVIEW OF BIOCHEMISTRY
Alpha synuclein aggregation: is it the toxic gain of function responsible for neurodegeneration in Parkinson's disease?
MECHANISMS OF AGEING AND DEVELOPMENT
Neuroscience - Parkin and its substrates
SCIENCE
Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Parkin is associated with cellular vesicles
JOURNAL OF NEUROCHEMISTRY
Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells
JOURNAL OF IMMUNOLOGY
The Npr1 kinase controls biosynthetic and endocytic sorting of the yeast Gap1 permease
JOURNAL OF BIOLOGICAL CHEMISTRY
N-end rule specificity within the ubiquitin/proteasome pathway is not an affinity effect
JOURNAL OF BIOLOGICAL CHEMISTRY
Processing of p105 is inhibited by docking of p50 active subunits to the ankyrin repeat domain, and inhibition is alleviated by signaling via the carboxyl-terminal phosphorylation/ubiquitin-ligase binding domain
JOURNAL OF BIOLOGICAL CHEMISTRY
A HECT domain E3 enzyme assembles novel polyubiquitin chains
JOURNAL OF BIOLOGICAL CHEMISTRY
c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment
JOURNAL OF BIOLOGICAL CHEMISTRY
WW domains of Rsp5p define different functions: Determination of roles in fluid phase and uracil permease endocytosis in Saccharomyces cerevisiae
GENETICS
Negative regulation of receptor tyrosine kinase signals
FEBS LETTERS
Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases
FEBS LETTERS
Identification of molecular determinants required for interaction of ubiquitin-conjugating enzymes and RING finger proteins
EUROPEAN JOURNAL OF BIOCHEMISTRY
The genomic structure and promoter region of the human Parkin gene
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Apoptotic death sensor: an organelle's alter ego?
TRENDS IN PHARMACOLOGICAL SCIENCES
Genomic imprinting: genetic mechanisms and phenotypic consequences in Prader-Willi and Angelman syndromes
GENETICS AND MOLECULAR BIOLOGY
The ubiquitin/proteasome pathway
M S-MEDECINE SCIENCES
Differential display and gene arrays to examine auditory plasticity
HEARING RESEARCH
The growth of mdp1/rsp5 mutants of Saccharomyces cerevisiae is affected bymutations in the ATP-binding domain of the plasma membrane H+-ATPase
GENE
Human papillomavirus oncogenesis
CLINICS IN LABORATORY MEDICINE
Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits
BIOCHEMICAL JOURNAL
Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing
CELL
Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination
KIDNEY INTERNATIONAL
Transcription-coupled repair in yeast is independent from ubiquitylation of RNA pol II: Implications for Cockayne's syndrome
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Ubiquitination and endocytosis of plasma membrane proteins: Role of Nedd4/Rsp5p family of ubiquitin-protein ligases
JOURNAL OF MEMBRANE BIOLOGY
Apical membrane targeting of Nedd4 is mediated by an association of its C2domain with annexin XIIIb
JOURNAL OF CELL BIOLOGY
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II
JOURNAL OF BIOLOGICAL CHEMISTRY
Rsp5 WW domains interact directly with the carboxyl-terminal domain of RNApolymerase II
JOURNAL OF BIOLOGICAL CHEMISTRY
Isolation and characterization of HRT1 using a genetic screen for mutants unable to degrade Gic2p in Saccharomyces cerevisiae
GENETICS
Human genetic diseases of proteolysis
HUMAN MUTATION
The interaction between p53 and papillomaviruses
SEMINARS IN CANCER BIOLOGY
The spectrum of mutations in UBE3A causing Angelman syndrome
HUMAN MOLECULAR GENETICS
SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
The role of the E6-p53 interaction in the molecular pathogenesis of HPV
ONCOGENE
DNA sequencing and analysis of a 40 kb region from the right arm of chromosome II from Schizosaccharomyces pombe
YEAST
Yeast tom1 mutant exhibits pleiotropic defects in nuclear division, maintenance of nuclear structure and nucleocytoplasmic transport at high temperatures
GENE
Screening for UBE3A gene mutations in a group of Angelman syndrome patients selected according to non-stringent clinical criteria
HUMAN GENETICS
Angelman syndrome resulting from UBE3A mutations in 14 patients from eightfamilies: clinical manifestations and genetic counselling
JOURNAL OF MEDICAL GENETICS
Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome
JOURNAL OF CLINICAL INVESTIGATION
Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast
JOURNAL OF CELL BIOLOGY
E2/E3-mediated assembly of lysine 29-linked polyubiquitin chains
JOURNAL OF BIOLOGICAL CHEMISTRY
Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex
JOURNAL OF BIOLOGICAL CHEMISTRY
Uracil-induced down-regulation of the yeast uracil permease
JOURNAL OF BACTERIOLOGY
MORPHOLOGY OF THE YEAST ENDOCYTIC PATHWAY
Molecular biology of the cell
Molecular cloning of Nedd4 from Xenopus laevis
DNA SEQUENCE
Inhibition of Bak-induced apoptosis by HPV-18 E6
ONCOGENE
THE MOUSE AND HUMAN GENES ENCODING THE RECOGNITION COMPONENT OF THE N-END RULE PATHWAY
Proceedings of the National Academy of Sciences of the United Statesof America
THE UBIQUITIN-PROTEIN LIGASE E6-ASSOCIATED PROTEIN (E6-AP) SERVES AS ITS OWN SUBSTRATE
European journal of biochemistry
LIDDLES-SYNDROME
The American journal of medicine
A C-TERMINAL DI-LEUCINE MOTIF AND NEARBY SEQUENCES ARE REQUIRED FOR NH4(-INDUCED INACTIVATION AND DEGRADATION OF THE GENERAL AMINO-ACID PERMEASE, GAP1P, OF SACCHAROMYCES-CEREVISIAE())
Molecular microbiology
CDNA CLONING, EXPRESSION ANALYSIS, AND MAPPING OF THE MOUSE NEDD4 GENE
Genomics
YEAST NUTRIENT TRANSPORTERS
Biochimica et biophysica acta, MR. Reviews on biomembranes
HUMAN PAPILLOMAVIRUS-ASSOCIATED TUMORS OF THE SKIN AND MUCOSA
Journal of the American Academy of Dermatology
MODERATE CONCENTRATIONS OF ETHANOL INHIBIT ENDOCYTOSIS OF THE YEAST MALTOSE TRANSPORTER
Applied and environmental microbiology
IDENTIFICATION OF AN UBIQUITIN-LIGATION SYSTEM FOR THE EPIDERMAL-GROWTH-FACTOR RECEPTOR - HERBIMYCIN-A INDUCES IN-VITRO UBIQUITINATION IN RABBIT-RETICULOCYTE LYSATE
European journal of biochemistry
MECHANISM OF HPV E6 PROTEINS IN CELLULAR-TRANSFORMATION
Seminars in cancer biology
UBIQUITIN AND THE ENIGMA OF INTRACELLULAR PROTEIN-DEGRADATION
European journal of biochemistry
METABOLISM OF THE POLYUBIQUITIN DEGRADATION SIGNAL - STRUCTURE, MECHANISM, AND ROLE OF ISOPEPTIDASE-T
Biochemistry
SELECTIVE UBIQUITINATION OF CALMODULIN BY UBC4 AND A PUTATIVE UBIQUITIN PROTEIN LIGASE (E3) FROM SACCHAROMYCES-CEREVISIAE
FEBS letters