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PPAR gamma agonists in type 2 diabetes: how far have we come in 'preventing the inevitable'? A review of the metabolic effects of rosiglitazone
DIABETES OBESITY & METABOLISM
Advances in the treatment of polycystic ovary syndrome
EXPERT OPINION ON INVESTIGATIONAL DRUGS
PPARs, insulin resistance and type 2 diabetes
JOURNAL OF CARDIOVASCULAR RISK
Thiazolidinediones and liver toxicity
DIABETES & METABOLISM
Insulin sensitivity and polycystic ovarian syndrome
DIABETES & METABOLISM
Insulin resistance: why is it important to treat?
DIABETES & METABOLISM
Thiazolidinediones: clinical data and perspectives
DIABETES & METABOLISM
Type 2 diabetes mellitus: Which place for thiazolidinediones in the therapeutic strategy?
DIABETES & METABOLISM
Using thiazolidinediones: Rosiglitazone and pioglitazone in clinical practice
AMERICAN JOURNAL OF MANAGED CARE
Oxidized LDL regulates vascular endothelial growth factor expression in human macrophages and endothelial cells through activation of peroxisome proliferator-activated receptor-gamma
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells
JOURNAL OF DIABETES AND ITS COMPLICATIONS
Metformin to restore normal menses in oligo-amenorrheic teenage girls withpolycystic ovary syndrome (PCOS)
JOURNAL OF ADOLESCENT HEALTH
Cyclopentenone prostaglandins inhibit cytokine-induced NF-kappa B activation and chemokine production by human mesangial cells
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Insulin resistance in the HIV-lipodystrophy syndrome
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Troglitazone stimulates basolateral rheogenic Na+/HCO3- cotransport activity in rabbit proximal straight tubules
EXPERIMENTAL NEPHROLOGY
Peroxisome proliferator-activated receptors in macrophage biology: friend or foe?
CURRENT OPINION IN LIPIDOLOGY
The impact of pioglitazone on glycemic control and atherogenic dyslipidemia in patients with type 2 diabetes mellitus
CORONARY ARTERY DISEASE
Insulinoma, type 2 diabetes and plasminogen activator inhibitor type-I
CORONARY ARTERY DISEASE
Troglitazone and rosiglitazone inhibit the low density lipoprotein-inducedvascular smooth muscle cell growth
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Comparison of the metabolic effects of metformin and troglitazone on fructose-induced insulin resistance in male Sprague-Dawley rats
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes
Hypertension research
Prevention of chemically induced diabetes mellitus in experimental animalsby polyunsaturated fatty acids
NUTRITION
A transcriptional inhibitor of TNF-alpha prevents diabetes induced by multiple low-dose streptozotocin injections in mice
JOURNAL OF AUTOIMMUNITY
Thiazolidinediones (PPAR gamma agonists) but not PPAR alpha agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes
FASEB JOURNAL
A comparison of the effects of troglitazone and vitamin E on the fatty acid composition of serum phospholipids in an experimental model of insulin resistance
PHYSIOLOGICAL RESEARCH
Peroxisome proliferator-activated receptors in human atherosclerosis
M S-MEDECINE SCIENCES
Type 2 diabetes mellitus: choosing the right therapeutic strategy
PRESSE MEDICALE
Metabolic effects of metformin in patients with impaired glucose tolerance
DIABETIC MEDICINE
Biorelevant dissolution testing to predict the plasma profile of lipophilic drugs after oral administration
PHARMACEUTICAL RESEARCH
Effects of high-dose troglitazone on insulin sensitivity and beta-cell function in watanabe heritable hyperlipidemic rabbits
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
Peroxisome proliferator-activated receptor-gamma activity is associated with renal microvasculature
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
Thiazolidinedione toxicity to isolated hepatocytes revealed by coherent multiprobe fluorescence microscopy and correlated with multiparameter flow cytometry of peripheral leukocytes
ARCHIVES OF TOXICOLOGY
Effect of a series of novel sulphonylthioureas on glucose tolerance in theobese fa/fa Zucker rat
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Combined treatment with specific ligands for PPAR gamma : RXR nuclear receptor system markedly inhibits the expression of cytochrome P450arom in human granulosa cancer cells
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Insulin resistance in nonobese patients with polycystic ovary syndrome
HORMONE RESEARCH
Combined effects of troglitazone and muscle contraction on insulin sensitization in Balb-c mouse muscle
BIOCHIMIE
Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate
TOXICOLOGY
Factors associated with the risk of liver enzyme elevation in patients with type 2 diabetes treated with a thiazolidinedione
PHARMACOTHERAPY
Drug-induced liver injury: Mechanisms and test systems
HEPATOLOGY
Effects of metformin on ovulation rate, hormonal and metabolic profiles inwomen with clomiphene-resistant polycystic ovaries: a randomized, double-blinded placebo-controlled trial
HUMAN REPRODUCTION
Drug-induced liver disease
CURRENT OPINION IN GASTROENTEROLOGY
Differential regulation of expression of genes encoding uncoupling proteins 2 and 3 in brown adipose tissue during lactation in mice
BIOCHEMICAL JOURNAL
Effects of troglitazone and temocapril in spontaneously hypertensive rats with chronic renal failure
JOURNAL OF HYPERTENSION
Oral agents for the treatment of type 2 diabetes mellitus: Pharmacology, toxicity, and treatment
ANNALS OF EMERGENCY MEDICINE
Expression and function of peroxisome proliferator-activated receptor-gamma in mesangial cells
HYPERTENSION
Oral antidiabetic drugs for cats
COMPENDIUM ON CONTINUING EDUCATION FOR THE PRACTICING VETERINARIAN
TZDs inhibit vascular smooth muscle cell growth independently of the cyclin kinase inhibitors p21 and p27
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Troglitazone treatment increases bone marrow adipose tissue volume but does not affect trabecular bone volume in mice
CALCIFIED TISSUE INTERNATIONAL
Diabetic KKA(y) mice exhibit increased hepatic PPAR gamma 1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones
JOURNAL OF HEPATOLOGY
Thiazolidinedione derivative improves fat distribution and multiple risk factors in subjects with visceral fat accumulation - double-blind placebo-controlled trial
DIABETES RESEARCH AND CLINICAL PRACTICE
Serum leptin level as an indicator to predict the clinical efficacy of troglitazone in patients with type 2 diabetes mellitus
DIABETES RESEARCH AND CLINICAL PRACTICE
Troglitazone, an antidiabetic drug, improves left ventricular mass and diastolic function in nonmotensive diabetic patients
INTERNATIONAL JOURNAL OF CARDIOLOGY
Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma
JOURNAL OF NEUROIMMUNOLOGY
Myositis, microvesicular hepatitis, and progression to cirrhosis from troglitazone added to simavastatin
DIGESTIVE DISEASES AND SCIENCES
Troglitazone improves whole-body insulin resistance and skeletal muscle glucose use in type II diabetic patients
JOURNAL OF NUCLEAR MEDICINE
Pioglitazone improves left ventricular diastolic function and decreases collagen accumulation in prediabetic stage of a type II diabetic rat
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
A randomized trial of rosiglitazone therapy in patients with inadequately controlled insulin-treated type 2 diabetes
DIABETES CARE
Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone
DIABETES CARE
Once- and twice-daily dosing with rosiglitazone improves glycemic control in patients with type 2 diabetes
DIABETES CARE
Homeostasis model assessment is a reliable indicator of insulin resistanceduring follow-up of patients with type 2 diabetes
DIABETES CARE
Control of vascular cell proliferation and migration by PPAR-gamma - A newapproach to the macrovascular complications of diabetes
DIABETES CARE
Lessons from the glitazones: a story of drug development
LANCET
Drug-induced liver disorders - Implications for drug development and regulation
DRUG SAFETY
Lack of effect of rosiglitazone on the pharmacokinetics of oral contraceptives in healthy female volunteers
JOURNAL OF CLINICAL PHARMACOLOGY
Insulin resistance and its treatment by thiazolidinediones
RECENT PROGRESS IN HORMONE RESEARCH, VOL 56
Beneficial effect of troglitazone, an insulin-sensitizing antidiabetic agent, on coronary circulation in patients with non-insulin-dependent diabetesmellitus
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
A transgenic model of visceral obesity and the metabolic syndrome
SCIENCE
Inhibitory effect of troglitazone on glucuronidation catalyzed by human uridine diphosphate-glucuronosyltransferase 1A6
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Pilot study of prescription-event monitoring in Japan comparing troglitazone with alternative oral hypoglycemics
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Troglitazone and rosiglitazone induce apoptosis of vascular smooth muscle cells through an extracellular signal-regulated kinase-independent pathway
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Characterization of an inhibitory effect of pioglitazone on balloon-injured vascular smooth muscle cell growth
METABOLISM-CLINICAL AND EXPERIMENTAL
Concentration of the complement activation product, acylation-stimulating protein, is related to C-reactive protein in patients with type 2 diabetes
METABOLISM-CLINICAL AND EXPERIMENTAL
Bezafibrate attenuates the overexpression of plasminogen activator inhibitor-1 messenger RNA by a combination of mono-unsaturated fatty acid and insulin in HepG2 cells
LIFE SCIENCES
Toxic effect of troglitazone on cultured rat hepatocytes
LIFE SCIENCES
Inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: A multicenter, double blind, placebo-controlled trial
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Rosiglitazone monotherapy is effective in patients with type 2 diabetes
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Expression and characterization of recombinant rat acyl-CoA synthetases 1,4, and 5 - Selective inhibition by triacsin C and thiazolidinediones
JOURNAL OF BIOLOGICAL CHEMISTRY
Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3 beta-hydroxysteroid dehydrogenase
JOURNAL OF BIOLOGICAL CHEMISTRY
Thiazolidinediones, peroxisome proliferator-activated receptor gamma agonists, regulate endothelial cell growth and secretion of vasoactive peptides
ATHEROSCLEROSIS
Glitazone - Profile of a new class of substances
INTERNIST
Ligands for peroxisome proliferator-activated receptor gamma inhibit growth of pancreatic cancers both in vitro and in vivo
INTERNATIONAL JOURNAL OF CANCER
Prevention of pancreatic cancer induction in hamsters by metformin
GASTROENTEROLOGY
Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone
FERTILITY AND STERILITY
Troglitazone corrects metabolic changes but not vascular dysfunction in dietary-obese rats
EUROPEAN JOURNAL OF PHARMACOLOGY
A novel potent antagonist of peroxisome proliferator-activated receptor gamma blocks adipocyte differentiation but does not revert the phenotype of terminally differentiated adipocytes
ENDOCRINOLOGY
Comprehensive messenger ribonucleic acid profiling reveals that peroxisomeproliferator-activated receptor gamma activation has coordinate effects ongene expression in multiple insulin-sensitive tissues
ENDOCRINOLOGY
Expression and localization of PPARs in the rat ovary during follicular development and the periovulatory period
ENDOCRINOLOGY
Effects of type-2 diabetes and troglitazone on the expression patterns of small intestinal sugar transporters and PPAR-gamma in the Zucker diabetic fatty rat
DIGESTION
Peroxisome proliferator-activated receptor (PPAR) gamma and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle
DIABETOLOGIA
Distinct long-term regulation of glycerol and non-esterified fatty acid release by insulin and TNF-alpha in 3T3-L1 adipocytes
DIABETOLOGIA
Effects of pioglitazone on adipose tissue remodeling within the setting ofobesity and insulin resistance
DIABETES
Direct thiazolidinedione action on isolated rat skeletal muscle fuel handling is independent of peroxisome proliferator-activated receptor-gamma-mediated changes in gene expression
DIABETES
In vivo myocardial protection from ischemia/reperfusion injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone
CIRCULATION
Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes
CIRCULATION
Acceleration of restenosis by diabetes - Pathogenetic implications
CIRCULATION
Metabolic, idiosyncratic toxicity of drugs: overview of the hepatic toxicity induced by the anxiolytic, panadiplon
CHEMICO-BIOLOGICAL INTERACTIONS
Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation
CANCER RESEARCH
Ca2+-sensitizing effect is involved in the positive inotropic effect of troglitazone
BRITISH JOURNAL OF PHARMACOLOGY
Inhibition of phosphoenolpyruvate carboxykinase (PEPCK) gene expression bytroglitazone: a peroxisome proliferator-activated receptor-gamma (PPAR gamma)-independent, antioxidant-related mechanism
BIOCHEMICAL PHARMACOLOGY