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La ricerca find articoli where soggetti phrase all words 'thermotolerance' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 862 riferimenti
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    1. Kim, M; Geum, D; Khang, I; Park, YM; Kang, BM; Lee, KA; Kim, K
      Expression pattern of HSP25 in mouse preimplantation embryo: Heat shock responses during oocyte maturation

      MOLECULAR REPRODUCTION AND DEVELOPMENT
    2. Aron, Y; Vayssier-Taussat, M; Bachelet, M; Polla, BS
      Geranylgeranylacetone protects human monocytes from mitochondrial membranedepolarization independently of Hsp70 expression

      CELLULAR AND MOLECULAR LIFE SCIENCES
    3. Le Bourg, E; Valenti, P; Lucchetta, P; Payre, F
      Effects of mild heat shocks at young age on aging and longevity in Drosophila melanogaster

      BIOGERONTOLOGY
    4. Michalski, AI; Johnson, ME; Cypser, JR; Yashin, AI
      Heating stress patterns in Caenorhabditis elegans longevity and survivorship

      BIOGERONTOLOGY
    5. Walsh, D; Sheridan, JJ; Duffy, G; Blair, IS; McDowell, DA; Harrington, D
      Thermal resistance of wild-type and anti biotic-resistant Listeria monocytogenes in meat and potato substrates

      JOURNAL OF APPLIED MICROBIOLOGY
    6. Barnes, JA; Dix, DJ; Collins, BW; Luft, C; Allen, JW
      Expression of inducible Hsp70 enhances the proliferation of MCF-7 breast cancer cells and protects against the cytotoxic effects of hyperthermia

      CELL STRESS & CHAPERONES
    7. Agarwal, M; Katiyar-Agarwal, S; Sahi, C; Gallie, DR; Grover, A
      Arabidopsis thaliana Hsp100 proteins: kith and kin

      CELL STRESS & CHAPERONES
    8. Lee, SJ; Choi, SA; Lee, KH; Chung, HY; Kim, TH; Cho, CK; Lee, YS
      Role of inducible heat shock protein 70 in radiation-induced cell death

      CELL STRESS & CHAPERONES
    9. Wu, TC; Chen, S; Xiao, CF; Wang, CL; Pan, Q; Wang, ZZ; Xie, MY; Mao, ZC; Wu, Y; Tanguay, RM
      Presence of antibody against the inducible Hsp71 in patients with acute heat-induced illness

      CELL STRESS & CHAPERONES
    10. Viner, RI; Clegg, JS
      Influence of trehalose on the molecular chaperone activity of p26, a smallheat shock/alpha-crystallin protein

      CELL STRESS & CHAPERONES
    11. Lepock, JR; Frey, HE; Heynen, ML; Senisterra, GA; Warters, RL
      The nuclear matrix is a thermolabile cellular structure

      CELL STRESS & CHAPERONES
    12. Ip, SP; Che, CT; Kong, YC; Ko, KM
      Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver

      CELL STRESS & CHAPERONES
    13. Lee, SY; Song, EJ; Kim, HJ; Kang, HJ; Kim, JH; Lee, KJ
      Rac1 regulates heat shock responses by reorganization of vimentin filaments: Identification using MALDI-TOF MS

      CELL DEATH AND DIFFERENTIATION
    14. Hayashi, S; Kano, E; Tsuji, K; Furukawa-Furuya, M; Yoshikawa, S; Hatashita, M; Matsumoto, H; Jin, ZH; Ohtsubo, T; Kitai, R
      Modification of thermosensitivity and chemosensitivity induced by combinedtreatments with hyperthermia and adriamycin

      INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
    15. Dinh, HKB; Zhao, BT; Schuschereba, ST; Merrill, G; Bowman, PD
      Gene expression profiling of the response to thermal injury in human cells

      PHYSIOLOGICAL GENOMICS
    16. Frankel, J; Nelsen, EM
      The effects of supraoptimal temperatures on population growth and corticalpatterning in Tetrahymena pyriformis and Tetrahymena thermophila: A comparison

      JOURNAL OF EUKARYOTIC MICROBIOLOGY
    17. Sharkova, VE
      The effect of heat shock on the capacity of wheat plants to restore their photosynthetic electron transport after photoinhibition or repeated heating

      RUSSIAN JOURNAL OF PLANT PHYSIOLOGY
    18. Korotaeva, NE; Antipina, AI; Grabelnykh, OI; Varakina, NN; Borovskii, GB; Voinikov, VK
      Mitochondrial low-molecular-weight heat-shock proteins and the tolerance of cereal mitochondria to hyperthermia

      RUSSIAN JOURNAL OF PLANT PHYSIOLOGY
    19. Lyutova, MI; Kamentseva, IE
      Heat-induced increase in the stability of nitrate reductase from wheat leaves against inactivating factors

      RUSSIAN JOURNAL OF PLANT PHYSIOLOGY
    20. Kuun, KG; Okole, B; Bornman, L
      Protection of phenylpropanoid metabolism by prior heat treatment in Lycopersicon esculentum exposed to Ralstonia solanacearum

      PLANT PHYSIOLOGY AND BIOCHEMISTRY
    21. La Terza, A; Papa, G; Miceli, C; Luporini, P
      Divergence between two Antarctic species of the ciliate Euplotes, E-focardii and E-nobilii, in the expression of heat-shock protein 70 genes

      MOLECULAR ECOLOGY
    22. Sun, WN; Bernard, C; van de Cotte, B; Van Montagu, M; Verbruggen, N
      At-HSP17.6A, encoding a small heat-shock protein in Arabidopsis, can enhance osmotolerance upon overexpression

      PLANT JOURNAL
    23. Hong, SW; Vierling, E
      Hsp101 is necessary for heat tolerance but dispensable for development andgermination in the absence of stress

      PLANT JOURNAL
    24. Jazwinski, SM
      Commentary on "Applying hormesis in aging research and therapy"

      HUMAN & EXPERIMENTAL TOXICOLOGY
    25. Lithgow, GJ
      Hormesis - a new hope for ageing studies or a poor second to genetics?

      HUMAN & EXPERIMENTAL TOXICOLOGY
    26. Hercus, M; Loeschcke, V
      Comments to paper by S. Rattan: applying hormesis in aging research and therapy - a perspective from evolutionary biology

      HUMAN & EXPERIMENTAL TOXICOLOGY
    27. Toussaint, O; Remacle, J; Dierick, JF; Pascal, T; Frippiat, C; Magalhaes, JP; Chainaux, F
      Hormesis: a quest for virtuality?

      HUMAN & EXPERIMENTAL TOXICOLOGY
    28. Viswanathan, C; Khanna-Chopra, R
      Effect of heat stress on grain growth, starch synthesis and protein synthesis in grains of wheat (Triticum aestivum L.) varieties differing in grain weight stability

      JOURNAL OF AGRONOMY AND CROP SCIENCE-ZEITSCHRIFT FUR ACKER UND PFLANZENBAU
    29. Kakinuma, M; Shibahara, N; Ikeda, H; Maegawa, M; Amano, H
      Thermal stress responses of a sterile mutant of Ulva pertusa (Chlorophyta)

      FISHERIES SCIENCE
    30. Kim, SY; Hong, CB; Lee, I
      Heat shock stress causes stage-specific male sterility in Arabidopsis thaliana

      JOURNAL OF PLANT RESEARCH
    31. Shui, CX; Scutt, A
      Mild heat shock induces proliferation, alkaline phosphatase activity, and mineralization in human bone marrow stromal cells and Mg-63 cells in vitro

      JOURNAL OF BONE AND MINERAL RESEARCH
    32. Fehrenbach, E; Niess, AM; Veith, R; Dickhuth, HH; Northoff, H
      Changes of HSP72-expression in leukocytes are associated with adaptation to exercise under conditions of high environmental temperature

      JOURNAL OF LEUKOCYTE BIOLOGY
    33. Uyttendaele, M; Vankeirsbilck, S; Debevere, J
      Recovery of heat-stressed E-coli O157 : H7 from ground beef and survival of E-coli O157 : H7 in refrigerated and frozen ground beef and in fermented sausage kept at 7 degrees C and 22 degrees C

      FOOD MICROBIOLOGY
    34. Bettencourt, BR; Feder, ME
      Hsp70 duplication in the Drosophila melanogaster species group: How and when did two become five?

      MOLECULAR BIOLOGY AND EVOLUTION
    35. Katiyar-Agarwal, S; Agarwal, M; Gallie, DR; Grover, A
      Search for the cellular functions of plant Hsp100/Clp family proteins

      CRITICAL REVIEWS IN PLANT SCIENCES
    36. Minois, N; Khazaeli, AA; Curtsinger, JW
      Locomotor activity as a function of age and life span in Drosophila melanogaster overexpressing hsp70

      EXPERIMENTAL GERONTOLOGY
    37. Johnson, TE; de Castro, E; de Castro, SH; Cypser, J; Henderson, S; Tedesco, P
      Relationship between increased longevity and stress resistance as assessedthrough gerontogene mutations in Caenorhabditis elegans

      EXPERIMENTAL GERONTOLOGY
    38. Shi, WM; Muramoto, Y; Ueda, A; Takabe, T
      Cloning of peroxisomal ascorbate peroxidase gene from barley and enhanced thermotolerance by overexpressing in Arabidopsis thaliana

      GENE
    39. Jamai, L; Sendide, K; Ettayebi, K; Errachidi, F; Hamdouni-Alami, O; Tahri-Jouti, MA; McDermott, T; Ettayebi, M
      Physiological difference during ethanol fermentation between calcium alginate-immobilized Candida tropicalis and Saccharomyces cerevisiae

      FEMS MICROBIOLOGY LETTERS
    40. de Pinho, CA; de Lourdes, M; Polizeli, TM; Jorge, JA; Terenzi, HF
      Mobilisation of trehalose in mutants of the cyclic AMP signalling pathway,cr-1 (CRISP-1) and mcb (microcycle conidiation), of Neurospora crassa

      FEMS MICROBIOLOGY LETTERS
    41. Meldrum, KK; Meldrum, DR; Sezen, SF; Crone, JK; Burnett, AL
      Heat shock prevents simulated ischemia-induced apoptosis in renal tubular cells via a PKC-dependent mechanism

      AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
    42. Doyle, ME; Mazzotta, AS; Wang, T; Wiseman, DW; Scott, VN
      Heat resistance of Listeria monocytogenes

      JOURNAL OF FOOD PROTECTION
    43. Jung, GM; Masison, DC
      Guanidine hydrochloride inhibits Hsp104 activity in vivo: A possible explanation for its effect in curing yeast prions

      CURRENT MICROBIOLOGY
    44. Sorensen, JG; Dahlgaard, J; Loeschcke, V
      Genetic variation in thermal tolerance among natural populations of Drosophila buzzatii: down regulation of Hsp70 expression and variation in heat stress resistance traits

      FUNCTIONAL ECOLOGY
    45. Thomson, LJ; Robinson, M; Hoffmann, AA
      Field and laboratory evidence for acclimation without costs in an egg parasitoid

      FUNCTIONAL ECOLOGY
    46. Asea, A; Mallick, R; Lechpammer, S; Ara, G; Teicher, BA; Fiorentino, S; Stevenson, MA; Calderwood, SK
      Cyclooxygenase inhibitors are potent sensitizers of prostate tumours to hyperthermia and radiation

      INTERNATIONAL JOURNAL OF HYPERTHERMIA
    47. Shibuya, K; Kawasaki, S; Kuroda, M; Asaumi, J; Kanazawa, S; Hiraki, Y
      Effects of PKC inhibitors on suppression of thermotolerance development intsAF8 cells

      INTERNATIONAL JOURNAL OF HYPERTHERMIA
    48. Rai, SP; Luthra, R; Gupta, MM; Kumar, S
      Pleiotropic morphological and abiotic stress resistance phenotypes of the hyper-abscisic acid producing Abo(-) mutant in the periwinkle Catharanthus roseus

      JOURNAL OF BIOSCIENCES
    49. Dash, S; Mohanty, N
      Evaluation of assays for the analysis of thermo-tolerance and recovery potentials of seedlings of wheat (Triticum aestivum L.) cultivars

      JOURNAL OF PLANT PHYSIOLOGY
    50. Ono, K; Hibino, T; Kohinata, T; Suzuki, S; Tanaka, Y; Nakamura, T; Takabe, T; Takabe, T
      Overexpression of DnaK from a halotolerant cyanobacterium Aphanothece halophytica enhances the high-temperature tolerance of tobacco during germination and early growth

      PLANT SCIENCE
    51. Sampedro, JG; Cortes, P; Munoz-Clares, RA; Fernandez, A; Uribe, S
      Thermal inactivation of the plasma membrane H+-ATPase from Kluyveromyces lactis. Protection by trehalose

      BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
    52. Campbell, JL; Klueva, NY; Zheng, HG; Nieto-Sotelo, J; Ho, THD; Nguyen, HT
      Cloning of new members of heat shock protein HSP101 gene family in wheat (Triticum aestivum (L.) Moench) inducible by heat, dehydration, and ABA

      BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
    53. Techapun, C; Sinsuwongwat, S; Poosaran, N; Watanabe, M; Sasaki, K
      Production of a cellulase-free xylanase from agricultural waste materials by a thermotolerant Streptomyces sp.

      BIOTECHNOLOGY LETTERS
    54. Kim, WS; Ren, J; Dunn, NW
      Assessment of the tolerance of Lactococcus lactis cells at elevated temperatures

      BIOTECHNOLOGY LETTERS
    55. de Souza, MA; Ramalho, MAP
      Genetic control and tolerance to the heat stress in wheat hybrid population and cultivars

      PESQUISA AGROPECUARIA BRASILEIRA
    56. Edwards, JL; King, WA; Kawarsky, SJ; Ealy, AD
      Responsiveness of early embryos to environmental insults: Potential protective roles of HSP70 and glutathione

      THERIOGENOLOGY
    57. Yashin, AI; Cypser, JR; Johnson, TE; Michalski, AI; Boyko, SI; Novoseltsev, VN
      Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans

      MECHANISMS OF AGEING AND DEVELOPMENT
    58. Song, CW; Park, H; Griffin, RJ
      Improvement of tumor oxygenation by mild hyperthermia

      RADIATION RESEARCH
    59. De Basilio, V; Vilarino, M; Yahav, S; Picard, M
      Early age thermal conditioning and a dual feeding program for male broilers challenged by heat stress

      POULTRY SCIENCE
    60. Miller, B; Oschinski, C; Zimmer, W
      First isolation of an isoprene synthase gene from poplar and successful expression of the gene in Escherichia coli

      PLANTA
    61. Young, TE; Ling, J; Geisler-Lee, CJ; Tanguay, RL; Caldwell, C; Gallie, DR
      Developmental and thermal regulation of the maize heat shock protein, HSP101

      PLANT PHYSIOLOGY
    62. Loreto, F; Mannozzi, M; Maris, C; Nascetti, P; Ferranti, F; Pasqualini, S
      Ozone quenching properties of isoprene and its antioxidant role in leaves

      PLANT PHYSIOLOGY
    63. Kerstiens, G; Possell, M
      Is competence for isoprene emission related to the mode of phloem loading?

      NEW PHYTOLOGIST
    64. Schirmer, EC; Ware, DM; Queitsch, C; Kowal, AS; Lindquist, SL
      Subunit interactions influence the biochemical and biological properties of Hsp104

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    65. Michalak, P; Minkov, I; Helin, A; Lerman, DN; Bettencourt, BR; Feder, ME; Korol, AB; Nevo, E
      Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in "Evolution Canyon," Israel

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    66. Rikhvanov, EG; Varakina, NN; Rusaleva, TM; Rachenko, EI; Kiseleva, VA; Voinikov, VK
      Heat shock-induced changes in the respiration of the yeast Saccharomyces cerevisiae

      MICROBIOLOGY
    67. Rikhvanov, EG; Varakina, NN; Rusaleva, TM; Rachenko, EI; Kiseleva, VA; Voinikov, VK
      Effect of sodium azide on the thermotolerance of the yeasts Saccharomyces cerevisiae and Debaryomyces vanriji

      MICROBIOLOGY
    68. Yata, T; Endo, Y; Sone, M; Ogawara, KI; Higaki, K; Kimura, T
      Amino acids protect epithelial cells from local toxicity by absorption enhancer, sodium laurate

      JOURNAL OF PHARMACEUTICAL SCIENCES
    69. Wu, BS; Walker, VK; Robertson, RM
      Heat shock-induced thermoprotection of action potentials in the locust flight system

      JOURNAL OF NEUROBIOLOGY
    70. Garcia, SL; Mello, MLS; Garcia, NL; Rodrigues, VLCC
      Experimentally induced heat-shock tolerance in Panstrongylus megistus (Hemiptera : Reduviidae)

      JOURNAL OF MEDICAL ENTOMOLOGY
    71. Minois, N
      Resistance to stress as a function of age in transgenic Drosophila melanogaster overexpressing Hsp70

      JOURNAL OF INSECT PHYSIOLOGY
    72. Sorensen, JG; Loeschcke, V
      Larval crowding in Drosophila melanogaster induces Hsp70 expression, and leads to increased adult longevity and adult thermal stress resistance

      JOURNAL OF INSECT PHYSIOLOGY
    73. Gaudette, MF; Lowther, JL; Pechenik, JA
      Heat shock induces metamorphosis in the larvae of the prosobranch gastropod Crepidula fornicata

      JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY
    74. Ortiz, C; Cardemil, L
      Heat-shock responses in two leguminous plants: a comparative study

      JOURNAL OF EXPERIMENTAL BOTANY
    75. Buckley, BA; Owen, ME; Hofmann, GE
      Adjusting the thermostat: the threshold induction temperature for the heatshock response in intertidal mussels (genus Mytilus) changes as a function of thermal history

      JOURNAL OF EXPERIMENTAL BIOLOGY
    76. Lerman, DN; Feder, ME
      Laboratory selection at different temperatures modifies heat-shock transcription factor (HSF) activation in Drosophila melanogaster

      JOURNAL OF EXPERIMENTAL BIOLOGY
    77. Lacoste, A; De Cian, MC; Cueff, A; Poulet, SA
      Noradrenaline and alpha-adrenergic signaling induce the hsp70 gene promoter in mollusc immune cells

      JOURNAL OF CELL SCIENCE
    78. Nollen, EAA; Kabakov, AE; Brunsting, JF; Kanon, B; Hohfeld, J; Kampinga, HH
      Modulation of in vivo Hsp70 chaperone activity by Hip and Bag-1

      JOURNAL OF BIOLOGICAL CHEMISTRY
    79. Leppa, S; Kajanne, R; Arminen, L; Sistonen, L
      Differential induction of Hsp70-encoding genes in human hematopoietic cells

      JOURNAL OF BIOLOGICAL CHEMISTRY
    80. Eriksson, MJ; Schelin, J; Miskiewicz, E; Clarke, AK
      Novel form of ClpB/HSP100 protein in the cyanobacterium Synechococcus

      JOURNAL OF BACTERIOLOGY
    81. Laksanalamai, P; Maeder, DL; Robb, FT
      Regulation and mechanism of action of the small heat shock protein from the hyperthermophilic archaeon Pyrococcus furiosus

      JOURNAL OF BACTERIOLOGY
    82. Canovas, D; Fletcher, SA; Hayashi, M; Csonka, LN
      Role of trehalose in growth at high temperature of Salmonella enterica serovar typhimurium

      JOURNAL OF BACTERIOLOGY
    83. Krzewska, J; Langer, T; Liberek, K
      Mitochondrial Hsp78, a member of the Clp/Hsp100 family in Saccharomyces cerevisiae, cooperates with Hsp70 in protein refolding

      FEBS LETTERS
    84. Borrelli, MJ; Schoenherr, DM; Wong, A; Bernock, LJ; Corry, PM
      Heat-activated transgene expression from adenovirus vectors infected into human prostate cancer cells

      CANCER RESEARCH
    85. Givisiez, PEN; da Silva, MM; Mazzi, CM; Ferro, MIT; Ferro, JA; Gonzales, E; Macari, M
      Heat or cold chronic stress affects organ weights and Hsp70 levels in chicken embryos

      CANADIAN JOURNAL OF ANIMAL SCIENCE
    86. Yalcin, S; Ozkan, S; Turkmut, L; Siegel, PB
      Responses to heat stress in commercial and local broiler stocks. 1. Performance traits

      BRITISH POULTRY SCIENCE
    87. Chang, PFL; Huang, CY; Chang, FC; Tseng, TS; Lin, WC; Lin, CY
      Isolation and characterization of the third gene encoding a 16.9 kDa classI low-molecular-mass heat shock protein, Oshsp 16.9C, in rice

      BOTANICAL BULLETIN OF ACADEMIA SINICA
    88. Krebs, RA; Holbrook, SH
      Reduced enzyme activity following Hsp70 overexpression in Drosophila melanogaster

      BIOCHEMICAL GENETICS
    89. Lopes, DHJ; Sola-Penna, M
      Urea increases tolerance of yeast inorganic pyrophosphatase activity to ethanol: The other side of urea interaction with proteins

      ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
    90. Tatar, M; Chien, SA; Priest, NK
      Negligible senescence during reproductive dormancy in Drosophila melanogaster

      AMERICAN NATURALIST
    91. Knight, CA; Ackerly, DD
      Correlated evolution of chloroplast heat shock protein expression in closely related plant species

      AMERICAN JOURNAL OF BOTANY
    92. Hayashi, S; Kano, E; Hatashita, M; Ohtsubo, T; Katayama, K; Matsumoto, H
      Fundamental aspects of hyperthermia on cellular and molecular levels

      THERMOTHERAPY FOR NEOPLASIA INFLAMMATION, AND PAIN
    93. Hatayama, T
      Modifications of stress response in mammalian cells incubated at low temperature, thermotolerant cells, and neuronal cells during differentiation

      THERMOTHERAPY FOR NEOPLASIA INFLAMMATION, AND PAIN
    94. Hasegawa, T; Gu, YH; Takahashi, T; Hasegawa, T; Tanaka, Y
      Effects of hyperthermia-induced changes in pH value on tumor response and thermotolerance

      THERMOTHERAPY FOR NEOPLASIA INFLAMMATION, AND PAIN
    95. Ohtsubo, T; Kano, E; Hayashi, S; Hatashita, M; Matsumoto, H; Kitai, R; Saito, T; Saito, H
      Enhancement of cytotoxic effects of chemotherapeutic agents with hyperthermia in vitro

      THERMOTHERAPY FOR NEOPLASIA INFLAMMATION, AND PAIN
    96. Cabrera, BJ; Rust, MK
      Behavioral responses to heat in artificial galleries by the western drywood termite (Isoptera : Kalotermitidae)

      JOURNAL OF AGRICULTURAL AND URBAN ENTOMOLOGY
    97. Beere, HM; Wolf, BB; Cain, K; Mosser, DD; Mahboubi, A; Kuwana, T; Tailor, P; Morimoto, RI; Cohen, GM; Green, DR
      Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

      NATURE CELL BIOLOGY
    98. Cerchia, L; Rossi, M; Guagliardi, A
      An archaeal chaperonin-based reactor for renaturation of denatured proteins

      EXTREMOPHILES
    99. Kuhl, NM; Rensing, L
      Heat shock effects on cell cycle progression

      CELLULAR AND MOLECULAR LIFE SCIENCES
    100. Le Bourg, E; Minois, N; Bullens, P; Baret, P
      A mild stress due to hypergravity exposure at young age increases longevity in Drosophila melanogaster males

      BIOGERONTOLOGY


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Documento generato il 24/10/20 alle ore 20:41:48