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1. Gail, R; Costisella, B; Ahmadian, MR; Wittinghofer, A
   Ras-mediated cleavage of a GTP analogue by a novel mechanism
   CHEMBIOCHEM
   
   R. Gail et al., "Ras-mediated cleavage of a GTP analogue by a novel mechanism", CHEMBIOCHEM, 2(7-8), 2001, pp. 570-575
2. van der Woerd, MJ; Pelletier, JJ; Xu, SY; Friedman, AM
   Restriction enzyme BsoBI-DNA complex: A tunnel for recognition of degenerate DNA sequences and potential histidine catalysis
   STRUCTURE
   
   M.J. van der Woerd et al., "Restriction enzyme BsoBI-DNA complex: A tunnel for recognition of degenerate DNA sequences and potential histidine catalysis", STRUCTURE, 9(2), 2001, pp. 133-144
3. Sakamoto, J; Watanabe, T; Ariga, Y; Kobayashi, S
   Ring-opening glycosylation of a chitobiose oxazoline catalyzed by a non-chitinolytic mutant of chitinase
   CHEMISTRY LETTERS
   
   J. Sakamoto et al., "Ring-opening glycosylation of a chitobiose oxazoline catalyzed by a non-chitinolytic mutant of chitinase", CHEM LETT, (11), 2001, pp. 1180-1181
4. Pingoud, A; Jeltsch, A
   Structure and function of type II restriction endonucleases
   NUCLEIC ACIDS RESEARCH
   
   A. Pingoud e A. Jeltsch, "Structure and function of type II restriction endonucleases", NUCL ACID R, 29(18), 2001, pp. 3705-3727
5. Tsutakawa, SE; Morikawa, K
   The structural basis of damaged DNA recognition and endonucleolytic cleavage for very short patch repair endonuclease
   NUCLEIC ACIDS RESEARCH
   
   S.E. Tsutakawa e K. Morikawa, "The structural basis of damaged DNA recognition and endonucleolytic cleavage for very short patch repair endonuclease", NUCL ACID R, 29(18), 2001, pp. 3775-3783
6. Viladot, JL; Canals, F; Batllori, X; Planas, A
   Long-lived glycosyl-enzyme intermediate mimic produced by formate re-activation of a mutant endoglucanase lacking its catalytic nucleophile
   BIOCHEMICAL JOURNAL
   
   J.L. Viladot et al., "Long-lived glycosyl-enzyme intermediate mimic produced by formate re-activation of a mutant endoglucanase lacking its catalytic nucleophile", BIOCHEM J, 355, 2001, pp. 79-86
7. Takahashi, M; Hasuura, Y; Nakamori, S; Takagi, H
   Improved autoprocessing efficiency of mutant subtilisins E with altered specificity by engineering of the pro-region
   JOURNAL OF BIOCHEMISTRY
   
   M. Takahashi et al., "Improved autoprocessing efficiency of mutant subtilisins E with altered specificity by engineering of the pro-region", J BIOCHEM, 130(1), 2001, pp. 99-106
8. Schneider, B; Babolat, M; Xu, YW; Janin, J; Veron, M; Deville-Bonne, D
   Mechanism of phosphoryl transfer by nucleoside diphosphate kinase - pH dependence and role of the active site Lys16 and Tyr56 residues
   EUROPEAN JOURNAL OF BIOCHEMISTRY
   
   B. Schneider et al., "Mechanism of phosphoryl transfer by nucleoside diphosphate kinase - pH dependence and role of the active site Lys16 and Tyr56 residues", EUR J BIOCH, 268(7), 2001, pp. 1964-1971
9. Fuxreiter, M; Osman, R
   Probing the general base catalysis in the first step of BamHI action by computer simulations
   BIOCHEMISTRY
   
   M. Fuxreiter e R. Osman, "Probing the general base catalysis in the first step of BamHI action by computer simulations", BIOCHEM, 40(49), 2001, pp. 15017-15023
10. Wittinghofer, A; Waldmann, H
    Ras - A molecular switch involved in tumor formation
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    
    A. Wittinghofer e H. Waldmann, "Ras - A molecular switch involved in tumor formation", ANGEW CHEM, 39(23), 2000, pp. 4193-4214
11. Hashimoto, M; Honda, Y; Nikaidou, N; Fukamizo, T; Watanabe, T
    Site-directed mutagenesis of Asp280 suggests substrate-assisted catalysis of chitinase A1 from Bacillus circulans WL-12
    JOURNAL OF BIOSCIENCE AND BIOENGINEERING
    
    M. Hashimoto et al., "Site-directed mutagenesis of Asp280 suggests substrate-assisted catalysis of chitinase A1 from Bacillus circulans WL-12", J BIOSCI BI, 89(1), 2000, pp. 100-102
12. Dall'Acqua, W; Carter, P
    Substrate-assisted catalysis: Molecular basis and biological significance
    PROTEIN SCIENCE
    
    W. Dall'Acqua e P. Carter, "Substrate-assisted catalysis: Molecular basis and biological significance", PROTEIN SCI, 9(1), 2000, pp. 1-9
13. Kosloff, M; Zor, T; Selinger, Z
    Substrate-assisted catalysis: Implications for biotechnology and drug design
    DRUG DEVELOPMENT RESEARCH
    
    M. Kosloff et al., "Substrate-assisted catalysis: Implications for biotechnology and drug design", DRUG DEV R, 50(3-4), 2000, pp. 250-257
14. Bryan, PN
    Protein engineering of subtilisin
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
    
    P.N. Bryan, "Protein engineering of subtilisin", BBA-PROT ST, 1543(2), 2000, pp. 203-222
15. Planas, N
    Bacterial 1,3-1,4-beta-glucanases: structure, function and protein engineering
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
    
    N. Planas, "Bacterial 1,3-1,4-beta-glucanases: structure, function and protein engineering", BBA-PROT ST, 1543(2), 2000, pp. 361-382
16. Janin, J; Dumas, C; Morera, S; Xu, YW; Meyer, P; Chiadmi, M; Cherfils, J
    Three-dimensional structure of nucleoside diphosphate kinase
    JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
    
    J. Janin et al., "Three-dimensional structure of nucleoside diphosphate kinase", J BIOENER B, 32(3), 2000, pp. 215-225
17. Lascu, I; Gonin, P
    The catalytic mechanism of nucleoside diphosphate kinases
    JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
    
    I. Lascu e P. Gonin, "The catalytic mechanism of nucleoside diphosphate kinases", J BIOENER B, 32(3), 2000, pp. 237-246
18. van Aalten, DMF; Synstad, B; Brurberg, MB; Hough, E; Riise, BW; Eijsink, VGH; Wierenga, RK
    Structure of a two-domain chitotriosidase from Serratia marcescens at 1.9-angstrom resolution
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    
    D.M.F. van Aalten et al., "Structure of a two-domain chitotriosidase from Serratia marcescens at 1.9-angstrom resolution", P NAS US, 97(11), 2000, pp. 5842-5847
19. Bokma, E; Barends, T; van Scheltinga, ACT; Dijkstra, BW; Beintema, JJ
    Enzyme kinetics of hevamine, a chitinase from the rubber tree Hevea brasiliensis
    FEBS LETTERS
    
    E. Bokma et al., "Enzyme kinetics of hevamine, a chitinase from the rubber tree Hevea brasiliensis", FEBS LETTER, 478(1-2), 2000, pp. 119-122
20. van Asselt, EJ; Kalk, KH; Dijkstra, BW
    Crystallographic studies of the interactions of Escherichia coli lytic transglycosylase Slt35 with peptidoglycan
    BIOCHEMISTRY
    
    E.J. van Asselt et al., "Crystallographic studies of the interactions of Escherichia coli lytic transglycosylase Slt35 with peptidoglycan", BIOCHEM, 39(8), 2000, pp. 1924-1934
21. Hart, DO; He, SM; Chany, CJ; Withers, SG; Sims, PFG; Sinnott, ML; Brumer, H
    Identification of Asp-130 as the catalytic nucleophile in the main alpha-galactosidase from Phanerochaete chrysosporium, a family 27 glycosyl hydrolase
    BIOCHEMISTRY
    
    D.O. Hart et al., "Identification of Asp-130 as the catalytic nucleophile in the main alpha-galactosidase from Phanerochaete chrysosporium, a family 27 glycosyl hydrolase", BIOCHEM, 39(32), 2000, pp. 9826-9836
22. Hollfelder, F; Kirby, AJ; Tawfik, DS; Kikuchi, K; Hilvert, D
    Characterization of proton-transfer catalysis by serum albumins
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
    
    F. Hollfelder et al., "Characterization of proton-transfer catalysis by serum albumins", J AM CHEM S, 122(6), 2000, pp. 1022-1029
23. Rottmann, A; Synstad, B; Eijsink, V; Peter, MG
    Synthesis of N-acetylglucosaminyl and diacetylchitobiosyl amides of heterocyclic carboxylic acids as potential chitinase inhibitors
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
    
    A. Rottmann et al., "Synthesis of N-acetylglucosaminyl and diacetylchitobiosyl amides of heterocyclic carboxylic acids as potential chitinase inhibitors", EUR J ORG C, (9), 1999, pp. 2293-2297
24. Kovall, RA; Matthews, BW
    Type II restriction endonucleases: structural, functional and evolutionaryrelationships
    CURRENT OPINION IN CHEMICAL BIOLOGY
    
    R.A. Kovall e B.W. Matthews, "Type II restriction endonucleases: structural, functional and evolutionaryrelationships", CURR OP C B, 3(5), 1999, pp. 578-583
25. van Asselt, EJ; Dijkstra, AJ; Kalk, KH; Takacs, B; Keck, W; Dijkstra, BW
    Crystal structure of Escherichia coli lytic transglycosylase Slt35 revealsa lysozyme-like catalytic domain with an EF-hand
    STRUCTURE WITH FOLDING & DESIGN
    
    E.J. van Asselt et al., "Crystal structure of Escherichia coli lytic transglycosylase Slt35 revealsa lysozyme-like catalytic domain with an EF-hand", STRUCT F D, 7(10), 1999, pp. 1167-1180
26. A-Banat, BMA; Kameyama, Y; Yoshioka, T; Koga, D
    Purification and characterization of a 54 kDa chitinase from Bombyx mori
    INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
    
    B.M.A. A-Banat et al., "Purification and characterization of a 54 kDa chitinase from Bombyx mori", INSEC BIO M, 29(6), 1999, pp. 537-547
27. Rao, V; Cui, T; Guan, CD; Van Roey, P
    Mutations of endo-beta-N-acetylglucosaminidase H active site residues Asp130 and Glu132: Activities and conformations
    PROTEIN SCIENCE
    
    V. Rao et al., "Mutations of endo-beta-N-acetylglucosaminidase H active site residues Asp130 and Glu132: Activities and conformations", PROTEIN SCI, 8(11), 1999, pp. 2338-2346
28. Thomas, MP; Brady, RL; Halford, SE; Sessions, RB; Baldwin, GS
    Structural analysis of a mutational hot-spot in the EcoRV restriction endonuclease: a catalytic role for a main chain carbonyl group
    NUCLEIC ACIDS RESEARCH
    
    M.P. Thomas et al., "Structural analysis of a mutational hot-spot in the EcoRV restriction endonuclease: a catalytic role for a main chain carbonyl group", NUCL ACID R, 27(17), 1999, pp. 3438-3445
29. Dall'Acqua, W; Halin, C; Rodrigues, ML; Carter, P
    Elastase substrate specificity tailored through substrate-assisted catalysis and phage display
    PROTEIN ENGINEERING
    
    W. Dall'Acqua et al., "Elastase substrate specificity tailored through substrate-assisted catalysis and phage display", PROTEIN ENG, 12(11), 1999, pp. 981-987
30. Deibert, M; Grazulis, S; Janulaitis, A; Siksnys, V; Huber, R
    Crystal structure of MunI restriction endonuclease in complex with cognateDNA at 1.7 angstrom resolution
    EMBO JOURNAL
    
    M. Deibert et al., "Crystal structure of MunI restriction endonuclease in complex with cognateDNA at 1.7 angstrom resolution", EMBO J, 18(21), 1999, pp. 5805-5816
31. Ahmadian, MR; Zor, T; Vogt, D; Kabsch, W; Selinger, Z; Wittinghofer, A; Scheffzek, K
    Guanosine triphosphatase stimulation of oncogenic Ras mutants
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    
    M.R. Ahmadian et al., "Guanosine triphosphatase stimulation of oncogenic Ras mutants", P NAS US, 96(12), 1999, pp. 7065-7070
32. Stanford, NP; Halford, SE; Baldwin, GS
    DNA cleavage by the EcoRV restriction endonuclease: pH dependence and proton transfers in catalysis
    JOURNAL OF MOLECULAR BIOLOGY
    
    N.P. Stanford et al., "DNA cleavage by the EcoRV restriction endonuclease: pH dependence and proton transfers in catalysis", J MOL BIOL, 288(1), 1999, pp. 105-116
33. Mannino, SJ; Jenkins, CL; Raines, RT
    Chemical mechanism of DNA cleavage by the homing endonuclease I-PpoI
    BIOCHEMISTRY
    
    S.J. Mannino et al., "Chemical mechanism of DNA cleavage by the homing endonuclease I-PpoI", BIOCHEM, 38(49), 1999, pp. 16178-16186
34. Patricelli, MP; Cravatt, BF
    Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism
    BIOCHEMISTRY
    
    M.P. Patricelli e B.F. Cravatt, "Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism", BIOCHEM, 38(43), 1999, pp. 14125-14130
35. Yuen, MH; Wang, XL; Mizuguchi, H; Uyeda, K; Hasemann, CA
    A switch in the kinase domain of rat testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
    BIOCHEMISTRY
    
    M.H. Yuen et al., "A switch in the kinase domain of rat testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase", BIOCHEM, 38(38), 1999, pp. 12333-12342
36. Gonin, P; Xu, YW; Milon, L; Dabernat, S; Morr, M; Kumar, R; Lacombe, ML; Janin, J; Lascu, I
    Catalytic mechanism of nucleoside diphosphate kinase investigated using nucleotide analogues, viscosity effects, and X-ray crystallography
    BIOCHEMISTRY
    
    P. Gonin et al., "Catalytic mechanism of nucleoside diphosphate kinase investigated using nucleotide analogues, viscosity effects, and X-ray crystallography", BIOCHEM, 38(22), 1999, pp. 7265-7272
37. Sam, MD; Perona, JJ
    Catalytic roles of divalent metal ions in phosphoryl transfer by EcoRV endonuclease
    BIOCHEMISTRY
    
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38. Admiraal, SJ; Schneider, B; Meyer, P; Janin, J; Veron, M; Deville-Bonne, D; Herschlag, D
    Nucleophilic activation by positioning in phosphoryl transfer catalyzed bynucleoside diphosphate kinase
    BIOCHEMISTRY
    
    S.J. Admiraal et al., "Nucleophilic activation by positioning in phosphoryl transfer catalyzed bynucleoside diphosphate kinase", BIOCHEM, 38(15), 1999, pp. 4701-4711
39. STAHL F; WENDE W; JELTSCH A; PINGOUD A
    THE MECHANISM OF DNA CLEAVAGE BY THE TYPE-II RESTRICTION ENZYME ECORV- ASP36 IS NOT DIRECTLY INVOLVED IN DNA CLEAVAGE BUT SERVES TO COUPLEINDIRECT READOUT TO CATALYSIS
    Biological chemistry
    
    F. Stahl et al., "THE MECHANISM OF DNA CLEAVAGE BY THE TYPE-II RESTRICTION ENZYME ECORV- ASP36 IS NOT DIRECTLY INVOLVED IN DNA CLEAVAGE BUT SERVES TO COUPLEINDIRECT READOUT TO CATALYSIS", Biological chemistry, 379(4-5), 1998, pp. 467-473
40. KOGA D; YOSHIOKA K; ARAKANE Y
    HPLC ANALYSIS OF ANOMERIC FORMATION AND CLEAVAGE PATTERN BY CHITINOLYTIC ENZYME
    Bioscience, biotechnology, and biochemistry
    
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41. ZOR T; ANDORN R; SOFER I; CHOREV M; SELINGER Z
    GTP ANALOG HYDROLYSIS BY THE GS PROTEIN - IMPLICATION FOR THE ROLE OFCATALYTIC GLUTAMINE IN THE GTPASE REACTION
    FEBS letters
    
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42. THUNNISSEN MMGM; TADDEI N; LIGURI G; RAMPONI G; NORDLUND P
    CRYSTAL-STRUCTURE OF COMMON TYPE ACYLPHOSPHATASE FROM BOVINE TESTIS
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43. ZOR T; BARYAACOV M; ELGAVISH S; SHAANAN B; SELINGER Z
    RESCUE OF A MUTANT G-PROTEIN BY SUBSTRATE-ASSISTED CATALYSIS
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44. PINGOUD A; JELTSCH A
    RECOGNITION AND CLEAVAGE OF DNA BY TYPE-II RESTRICTION ENDONUCLEASES
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45. SHAO ZX; ARNOLD FH
    ENGINEERING NEW FUNCTIONS AND ALTERING EXISTING FUNCTIONS
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46. FRIEDHOFF P; KOLMES B; GIMADUTDINOW O; WENDE W; KRAUSE KL; PINGOUD A
    ANALYSIS OF THE MECHANISM OF THE SERRATIA NUCLEASE USING SITE-DIRECTED MUTAGENESIS
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47. COREY MJ; COREY E
    ON THE FAILURE OF DE NOVO-DESIGNED PEPTIDES AS BIOCATALYSTS
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48. PRATT RF; DRYJANSKI M; WUN ES; MARATHIAS VM
    8-HYDROXYPENILLIC ACID FROM 6-AMINOPENICILLANIC ACID - A NEW REACTIONCATALYZED BY A CLASS-C BETA-LACTAMASE
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49. SHINDE U; INOUYE M
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50. NYGREN PA; STAHL S; UHLEN M
    ENGINEERING PROTEINS TO FACILITATE BIOPROCESSING
    Trends in biotechnology
    
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51. BECK JT; MARSTERS SA; HARRIS RJ; CARTER P; ASHKENAZI A; CHAMOW SM
    GENERATION OF SOLUBLE INTERLEUKIN-1 RECEPTOR FROM AN IMMUNOADHESIN BYSPECIFIC CLEAVAGE
    Molecular immunology
    
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52. RHEINNECKER M; EDER J; PANDEY PS; FERSHT AR
    VARIANTS OF SUBTILISIN BPN' WITH ALTERED SPECIFICITY PROFILES
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53. MHASHILKAR AM; VISWANATHA T; CHIBBER BAK; CASTELLINO FJ
    BREACHING THE CONFORMATIONAL INTEGRITY OF THE CATALYTIC TRIAD OF THE SERINE-PROTEASE PLASMIN - LOCALIZED DISRUPTION OF A SIDE-CHAIN OF HIS-603 STRONGLY INHIBITS THE AMIDOLYTIC ACTIVITY OF HUMAN PLASMIN
    Proceedings of the National Academy of Sciences of the United Statesof America
    
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