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La ricerca find articoli where soggetti phrase all words 'receptor regulation' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 330 riferimenti
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    1. Martin-Kleiner, I; Bidlack, JM
      Chronic opioid treatment of the mouse thymoma cell lines R1.G1 and R1EGO leads to down-regulation of the kappa opioid receptor without desensitization of adenylyl cyclase activity

      INTERNATIONAL IMMUNOPHARMACOLOGY
    2. Lanzavecchia, A; Sallusto, F
      Antigen decoding by T lymphocytes: from synapses to fate determination

      NATURE IMMUNOLOGY
    3. von Zastrow, M
      Endocytosis and downregulation of G protein-coupled receptors

      PARKINSONISM & RELATED DISORDERS
    4. Hoel, NL; Hansen-Schwartz, J; Edvinsson, L
      Selective up-regulation of 5-HT1B/1D receptors during organ culture of cerebral arteries

      NEUROREPORT
    5. Ohlsson, B; Borg, K; Rehfeld, JF; Axelson, J; Sundler, F
      The method of administration of cholecystokinin determines the effects evoked in the pancreas

      PANCREAS
    6. McMahon, CD; Radcliff, RP; Lookingland, KJ; Tucker, HA
      Neuroregulation of growth hormone secretion in domestic animals

      DOMESTIC ANIMAL ENDOCRINOLOGY
    7. Pacheco, MA; Pastoor, TE; Lukas, RJ; Wecker, L
      Characterization of human alpha 4 beta 2 neuronal nicotinic receptors stably expressed in SH-EP1 cells

      NEUROCHEMICAL RESEARCH
    8. Dautzenberg, FM; Braun, S; Hauger, RL
      GRK3 mediates desensitization of CRF1 receptors: a potential mechanism regulating stress adaptation

      AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
    9. Shieh, KR; Pan, JT
      Effects of orphanin FQ on central dopaminergic neuronal activities and prolactin secretion

      AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
    10. Kane, JK; Parker, SL; Li, MD
      Hypothalamic orexin-A binding sites are downregulated by chronic nicotine treatment in the rat

      NEUROSCIENCE LETTERS
    11. Bolander, FF
      The role of nitric oxide in the biological activity of prolactin in the mouse mammary gland

      MOLECULAR AND CELLULAR ENDOCRINOLOGY
    12. Vohringer, C; Reiser, G
      Pharmacological characterization of the rat brain P2Y(1) receptor expressed in HEK293 cells: Ca2+ signaling and receptor regulation

      DRUG DEVELOPMENT RESEARCH
    13. Choi, RCY; Man, MLS; Ling, KKY; Ip, NY; Simon, J; Barnard, EA; Tsim, KWK
      Expression of the P2Y(1) nucleotide receptor in chick muscle: Its functional role in the regulation of acetylcholinesterase and acetylcholine receptor

      JOURNAL OF NEUROSCIENCE
    14. Wang, Y
      The role and regulation of urokinase-type plasminogen activator receptor gene expression in cancer invasion and metastasis

      MEDICINAL RESEARCH REVIEWS
    15. Aguilera, G; Rabadan-Diehl, C; Nikodemova, M
      Regulation of pituitary corticotropin releasing hormone receptors

      PEPTIDES
    16. Trivedi, PG; Yu, H; Trumbauer, M; Chen, H; Van der Ploeg, LHT; Guan, XM
      Differential regulation of neuropeptide Y receptors in the brains of NPY knock-out mice

      PEPTIDES
    17. Roseboom, PH; Uban, CM; Kalin, NH
      Persistent corticotropin-releasing factor, receptor desensitization and downregulation in the human neuroblastoma cell line IMR-32

      MOLECULAR BRAIN RESEARCH
    18. Lombardi, WL; Gilbert, EM
      Carvedilol in the failing heart

      CLINICAL CARDIOLOGY
    19. McMahon, CD; Chapin, LT; Radcliff, RP; Lookingland, KJ; Tucker, HA
      Somatostatin inhibits alpha-2-adrenergic-induced secretion of growth hormone-releasing hormone

      NEUROENDOCRINOLOGY
    20. Taylor, DA; Fleming, WW
      Unifying perspectives of the mechanisms underlying the development of tolerance and physical dependence to opioids

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    21. Hurle, MA
      Changes in the expression of G protein-coupled receptor kinases and beta-arrestin 2 in rat brain during opioid tolerance and supersensitivity

      JOURNAL OF NEUROCHEMISTRY
    22. Anji, A; Hanley, NRS; Kumari, M; Hensler, JG
      The role of protein kinase C in the regulation of serotonin-2A receptor expression

      JOURNAL OF NEUROCHEMISTRY
    23. Wecker, L; Guo, X; Rycerz, AM; Edwards, SC
      Cyclic AMP-dependent protein kinase (PKA) and protein kinase C phosphorylate sites in the amino acid sequence corresponding to the M3/M4 cytoplasmic domain of alpha 4 neuronal nicotinic receptor subunits

      JOURNAL OF NEUROCHEMISTRY
    24. McMahon, CD; Chapin, LT; Radcliff, RP; Lookingland, KJ; Tucker, HA
      GH-releasing peptide-6 overcomes refractoriness of somatotropes to GHRH after feeding

      JOURNAL OF ENDOCRINOLOGY
    25. Sakaguchi, M; Fujimori, T; Satoh, T; Matsumura, E
      Effects of beta-casomorphins on neuronal survival in culture of embryonic chick dorsal root ganglion neurons

      JAPANESE JOURNAL OF PHARMACOLOGY
    26. Oxenius, A; Gunthard, HF; Hirschel, B; Fidler, S; Weber, JN; Easterbrook, PJ; Bell, JI; Phillips, RE; Price, DA
      Direct ex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8+ T lymphocyte activation in response to therapeutic manipulation of virus load

      EUROPEAN JOURNAL OF IMMUNOLOGY
    27. Mager, DE; Jusko, WJ
      Pharmacodynamic modeling of time-dependent transduction systems

      CLINICAL PHARMACOLOGY & THERAPEUTICS
    28. Rowlands, DK; Kao, CL; Wise, H
      Regulation of prostacyclin and prostaglandin E-2 receptor mediated responses in adult rat dorsal root ganglion cells, in vitro

      BRITISH JOURNAL OF PHARMACOLOGY
    29. Cabrini, DA; Campos, MM; Tratsk, KS; Merino, VF; Silva, JA; Souza, GEP; Avellar, MCW; Pesquero, JB; Calixto, JB
      Molecular and pharmacological evidence for modulation of kinin B-1 receptor expression by endogenous glucocorticoids hormones in rats

      BRITISH JOURNAL OF PHARMACOLOGY
    30. Unterwald, EM; Kreek, MJ; Cuntapay, M
      The frequency of cocaine administration impacts cocaine-induced receptor alterations

      BRAIN RESEARCH
    31. Shiraishi, S; Yamamoto, R; Yanagita, T; Yokoo, H; Kobayashi, H; Uezono, Y; Wada, A
      Down-regulation of cell surface insulin receptors by sarco(endo)plasmic reticulum Ca2+-ATPase inhibitor in adrenal chromaffin cells

      BRAIN RESEARCH
    32. Misra, UK; Pizzo, SV
      Receptor-associated protein binding blocks ubiquitinylation of the low density lipoprotein receptor-related protein

      ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
    33. Zingg, JM; Ricciarelli, R; Azzi, A
      Scavenger receptors and modified lipoproteins: Fatal attractions?

      IUBMB LIFE
    34. Babst, M; Odorizzi, G; Estepa, EJ; Emr, SD
      Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking

      TRAFFIC
    35. Li, T; Liu, XH; Zhu, ZH; Zhao, JH; Hu, X; Sham, PC; Collier, DA
      Association analysis of polymorphisms in the mu opioid gene and heroin abuse in Chinese subjects

      ADDICTION BIOLOGY
    36. Kassack, MU
      G-protein coupled receptor kinases and their inhibitors

      EXPERT OPINION ON THERAPEUTIC PATENTS
    37. Liu, HY; Rhodes, M; Wiest, DL; Vignali, DAA
      On the dynamics of TCR : CD3 complex cell surface expression and downmodulation

      IMMUNITY
    38. Zhelyazkova-Savova, MD; Negrev, N
      Isoteoline, a putative serotonin antagonist, inhibits meta-chlorophenylpiperazine, but not 1-(2,5-dimethoxy-4-iodphenyl)-2-aminopropane and 8-hydroxy-2-(Di-n-propylamino)-tetraline-induced increase of serum prolactin levels

      PHARMACOLOGICAL RESEARCH
    39. Martel, JC; Chopin, P; Colpaert, F; Marien, M
      Drug treatments to reduce excitotoxicity in vivo: a potential for alpha 2-adrenoceptor antagonists?

      AMINO ACIDS
    40. Burgert, HG; Blusch, JH
      Immunomodulatory functions encoded by the E3 transcription unit of adenoviruses

      VIRUS GENES
    41. Creighton, AJ; Baird, A; Kilpatrick, IC; Irvine, R; Milne, E; John, HA
      Decreased glutamate content and abnormal distribution of glutamate dehydrogenase and glutamine synthetase in superior cervical ganglia in equine dysautonomia (grass sickness)

      NEUROSCIENCE RESEARCH COMMUNICATIONS
    42. Siddiqui, RA; Burtschi, DJ; Kovacs, R
      Phosphatidic acid induces calcium influx in neutrophils via verapamil-sensitive calcium channels

      JOURNAL OF CELLULAR BIOCHEMISTRY
    43. Saito, Y; Takashima, S
      Neurotransmitter changes in the pathophysiology of Lesch-Nyhan syndrome

      BRAIN & DEVELOPMENT
    44. Derks, MGM; Koopmans, RP; Oosterhoff, E; Van Boxtel, CJ
      Prevention by theophylline of beta-2-receptor down regulation in healthy subjects

      EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
    45. Ahn, JS; Camden, JM; Schrader, AM; Redman, RS; Turner, JT
      Reversible regulation of P2Y(2) nucleotide receptor expression in the duct-ligated rat submandibular gland

      AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
    46. Zamanillo, D; Andreu, F; Ovalle, S; Perez, MP; Romero, G; Farre, AJ; Guitart, X
      Up-regulation of sigma(1) receptor mRNA in rat brain by a putative atypical antipsychotic and sigma receptor ligand

      NEUROSCIENCE LETTERS
    47. Munger, MA; Cheang, KI
      beta-blocker therapy: A standard of care for heart failure

      PHARMACOTHERAPY
    48. Scrutinio, D; Napoli, V; Passantino, A; Ricci, A; Lagioia, R; Rizzon, P
      Low-dose dobutamine responsiveness in idiopathic dilated cardiomyopathy: relation to exercise capacity and clinical outcome

      EUROPEAN HEART JOURNAL
    49. Chaturvedi, K; Jiang, XJ; Christoffers, KH; Chinen, N; Bandari, P; Raveglia, LF; Ronzoni, S; Dondio, G; Howells, RD
      Pharmacological profiles of selective non-peptidic delta opioid receptor ligands

      MOLECULAR BRAIN RESEARCH
    50. Lee, SC; Yoburn, BC
      The effect of nimodipine on opioid antagonist-induced upregulation and supersensitivity

      PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
    51. Thornton, SR; Lohmann, AB; Nicholson, RA; Smith, FL
      Fentanyl self-administration in juvenile rats that were tolerant and dependent to fentanyl as infants

      PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
    52. Ohlsson, B; Borg, K; Mulder, H; Rehfeld, JF; Axelson, J; Sundler, F
      Continuous infusion of cholecystokinin leads to down-regulation of the cholecystokinin-A receptor in the rat pancreas

      SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
    53. Liu, QH; Williams, DA; McManus, C; Baribaud, F; Doms, RW; Schols, D; De Clercq, E; Kotlikoff, MI; Collman, RG; Freedman, BD
      HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    54. Thompson, CL; Razzini, G; Pollard, S; Stephenson, FA
      Cyclic AMP-mediated regulation of GABA(A) receptor subunit expression in mature rat cerebellar granule cells: Evidence for transcriptional and translational control

      JOURNAL OF NEUROCHEMISTRY
    55. Fareh, J; Touyz, RM; Schiffrin, EL; Thibault, G
      Altered cardiac endothelin receptors and protein kinase C in deoxycorticosterone-salt hypertensive rats

      JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
    56. Yeung, MMW; Melgar, S; Baranov, V; Oberg, A; Danielsson, A; Hammarstrom, S; Hammarstrom, ML
      Characterisation of mucosal lymphoid aggregates in ulcerative colitis: immune cell phenotype and TcR-gamma delta expression

      GUT
    57. Seo, DO; Shin, CY; Ryu, JR; Cheong, JH; Choi, CR; Dailey, JW; Reith, MEA; Jobe, PC; Ko, KH
      Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats

      EUROPEAN JOURNAL OF PHARMACOLOGY
    58. Penela, P; Alvarez-Dolado, M; Munoz, A; Mayor, F
      Expression patterns of the regulatory proteins G protein-coupled receptor kinase 2 and beta-arrestin 1 during rat postnatal brain development - Effect of hypothyroidism

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    59. Torrao, AS; Ferro, ES; Lindstrom, JM; Britto, LRG
      Effects of cholinergic deafferentation upon the expression of the alpha 2 subunit of the nicotinic acetylcholine receptors in the chick lateral spiriform nucleus

      BRAIN RESEARCH
    60. Hentschel, K; Fleckenstein, AE; Toney, TW; Lawson, DM; Moore, KE; Lookingland, KJ
      Prolactin regulation of tuberoinfundibular dopaminergic neurons: immunoneutralization studies

      BRAIN RESEARCH
    61. Gessler, P; Neu, S; Brockmann, Y; Speer, CP
      Decreased mRNA expression of G-CSF receptor in cord blood neutrophils of term newborns - Regulation of expression by G-CSF and TNF-alpha

      BIOLOGY OF THE NEONATE
    62. Metra, M; Nodari, S; D'Aloia, A; Bontempi, L; Boldi, E; Dei Cas, L
      A rationale for the use of beta-blockers as standard treatment for heart failure

      AMERICAN HEART JOURNAL
    63. Skelton, KH; Nemeroff, CB; Owens, MJ
      A comparison of plasma alprazolam concentrations following different routes of chronic administration in the Sprague-Dawley rat: implications for psychotropic drug research

      PSYCHOPHARMACOLOGY
    64. Marissal-Arvy, N; Mormede, P; Sarrieau, A
      Strain differences in corticosteroid receptor efficiencies and regulation in brown Norway and Fischer 344 rats

      JOURNAL OF NEUROENDOCRINOLOGY
    65. Thorlin, T; Persson, PAI; Eriksson, PS; Hansson, E; Ronnback, L
      Delta-opioid receptor immunoreactivity on astrocytes is upregulated duringmitosis

      GLIA
    66. Kleeff, J; Wildi, S; Friess, H; Korc, M
      Ligand induced upregulation of the type II transforming growth factor (TGF-beta) receptor enhances TGF-beta responsiveness in COLO-357 cells

      PANCREAS
    67. Carramolino, L; Kremer, L; Goya, I; Varona, R; Buesa, JM; Gutierrez, J; Zaballos, A; Martinez-A, C; Marquez, G
      Down-regulation of the beta-chemokine receptor CCR6 in dendritic cells mediated by TNF-alpha and IL-4

      JOURNAL OF LEUKOCYTE BIOLOGY
    68. Baselli, EC; Brandes, SB; Luthin, GR; Ruggieri, MR
      The effect of pregnancy and contractile activity on bladder muscarinic receptor subtypes

      NEUROUROLOGY AND URODYNAMICS
    69. Ghosh, S; Grasing, K
      Presynaptic dopaminergic function in the nucleus accumbens following chronic opiate treatment and precipitated withdrawal

      NEUROCHEMICAL RESEARCH
    70. Clarke, LL; Harline, MC; Otero, MA; Glover, GG; Garrad, RC; Krugh, B; Walker, NM; Gonzalez, FA; Turner, JT; Weisman, GA
      Desensitization of P2Y(2) receptor-activated transepithelial anion secretion

      AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
    71. McEachern, JC; Shaw, CA
      The plasticity-pathology continuum: Defining a role for the LTP phenomenon

      JOURNAL OF NEUROSCIENCE RESEARCH
    72. Bolander, FF
      Regulation of prolactin receptor glycosylation and its role in receptor location

      MOLECULAR AND CELLULAR ENDOCRINOLOGY
    73. Lissin, DV; Carroll, RC; Nicoll, RA; Malenka, RC; von Zastrow, M
      Rapid, activation-induced redistribution of ionotropic glutamate receptorsin cultured hippocampal neurons

      JOURNAL OF NEUROSCIENCE
    74. Qian, HW; Pipolo, L; Thomas, WG
      Identification of protein kinase C phosphorylation sites in the angiotensin II (AT(1A)) receptor

      BIOCHEMICAL JOURNAL
    75. Curras-Collazo, M; Dao, J
      Osmotic activation of the hypothalamo-neurohypophysial system reversibly downregulates the NMDA receptor subunit, NR2B, in the supraoptic nucleus of the hypothalamus

      MOLECULAR BRAIN RESEARCH
    76. Kalluri, HSG; Ticku, MK
      Effect of ethanol on phosphorylation of the NMDAR2B subunit in mouse cortical neurons

      MOLECULAR BRAIN RESEARCH
    77. Kalluri, HSG; Ticku, MK
      Potential involvement of tyrosine kinase pathway in the antagonist inducedupregulation of the NMDA receptor NR2B subunit in cortical neurons

      MOLECULAR BRAIN RESEARCH
    78. Chiou, WJ; Wang, JH; Berg, CE; Wu-Wong, JR
      SV40 virus transformation down-regulates endothelin receptor

      BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
    79. Heijnen, CJ; Kavelaars, A
      The importance of being receptive

      JOURNAL OF NEUROIMMUNOLOGY
    80. Sabbah, HN
      The cellular and physiologic effects of beta blockers in heart failure

      CLINICAL CARDIOLOGY
    81. Hancox, RJ; Stevens, DA; Adcock, IM; Barnes, PJ; Taylor, DR
      Effects of inhaled beta agonist and corticosteroid treatment on nuclear transcription factors in bronchial mucosa in asthma

      THORAX
    82. Zanotti, A; Natolino, F; Contarino, A; Lipartiti, M; Giusti, P
      Abecarnil enhances recovery from diazepam tolerance

      NEUROPHARMACOLOGY
    83. Hyytia, P; Ingman, K; Soini, SL; Laitinen, JT; Korpi, ER
      Effects of continuous opioid receptor blockade on alcohol intake and up-regulation of opioid receptor subtype signalling in a genetic model of high alcohol drinking

      NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
    84. Felker, GM; Hu, WM; Hare, JM; Hruban, RH; Baughman, KL; Kasper, EK
      The spectrum of dilated cardiomyopathy - The Johns Hopkins experience with1,278 patients

      MEDICINE
    85. Hsieh, C; Brown, S; Derleth, C; Mackie, K
      Internalization and recycling of the CB1 cannabinoid receptor

      JOURNAL OF NEUROCHEMISTRY
    86. Auphan, N; Ghosh, S; Flavell, RA; Schmitt-Verhulst, AM
      Differential requirements for NF-kappa B and AP-1 trans-activation in response to minimal TCR engagement by a partial agonist in naive CD8 T cells

      JOURNAL OF IMMUNOLOGY
    87. Shockley, MS; Tolbert, LM; Tobin, AB; Nahorski, SR; Sadee, W; Lameh, J
      Differential regulation of muscarinic M-1 and M-3 receptors by a putative phosphorylation domain

      EUROPEAN JOURNAL OF PHARMACOLOGY
    88. Sutton, HG; Fusco, A; Cornwall, GA
      Cystatin-related epididymal spermatogenic protein colocalizes with luteinizing hormone-beta protein in mouse anterior pituitary gonadotropes

      ENDOCRINOLOGY
    89. Ly, LH; Zhao, XY; Holloway, L; Feldman, D
      Liarozole acts synergistically with 1 alpha,25-dihydroxyvitamin D-3 to inhibit growth of DU 145 human prostate cancer cells by blocking 24-hydroxylase activity

      ENDOCRINOLOGY
    90. Wang, T; Plumpton, C; Brown, MJ
      Selective beta(1)-adrenoceptor blockade enhances the activity of the stimulatory G-protein in human atrial myocardium

      BRITISH JOURNAL OF PHARMACOLOGY
    91. Chen, BC; Lin, WW
      PKC beta I mediates the inhibition of P2Y receptor-induced inositol phosphate formation in endothelial cells

      BRITISH JOURNAL OF PHARMACOLOGY
    92. Navarro, A; Zapata, R; Canela, EI; Mallol, J; Lluis, C; Franco, R
      Epidermal growth factor (EGF)-induced up-regulation and agonist- and antagonist-induced desensitization and internalization of A(1) adenosine receptors in a pituitary-derived cell line

      BRAIN RESEARCH
    93. Holter, SM; Spanagel, R
      Effects of opiate antagonist treatment on the alcohol deprivation effect in long-term ethanol-experienced rats

      PSYCHOPHARMACOLOGY
    94. BRISTOW M; PORT JD
      BETA-ADRENERGIC-BLOCKADE IN CHRONIC HEART-FAILURE

      SCANDINAVIAN CARDIOVASCULAR JOURNAL
    95. LEHOUEZEC J
      NICOTINE - ABUSED SUBSTANCE AND THERAPEUTIC AGENT

      Journal of psychiatry & neuroscience
    96. ZHOU YY; LAKATTA EG; XIAO RP
      AGE-ASSOCIATED ALTERATIONS IN CALCIUM CURRENT AND ITS MODULATION IN CARDIAC MYOCYTES

      Drugs & aging
    97. KOLONKO A; WIECEK A; KOKOT F
      THE NONSELECTIVE ADENOSINE ANTAGONIST THEOPHYLLINE DOES PREVENT RENALDYSFUNCTION INDUCED BY RADIOGRAPHIC CONTRAST AGENTS

      JN. Journal of nephrology
    98. HOLLANDE E; FANJUL M; HOUTI N; FAYE JC; COURRIERE P
      EXPRESSION OF ESTROGEN-RECEPTORS DURING GROWTH OF HUMAN PANCREATIC ADENOCARCINOMA CELLS (CAPAN-1)-RELATIONSHIP WITH DIFFERENTIATION

      In vitro cellular & developmental biology. Animal
    99. SIEGEL RE
      DEVELOPMENTAL EXPRESSION OF CEREBELLAR GABA(A)-RECEPTOR SUBUNIT MESSENGER-RNAS

      Perspectives on developmental neurobiology
    100. SMILEY RM; KWATRA MM; SCHWINN DA
      NEW DEVELOPMENTS IN CARDIOVASCULAR ADRENERGIC-RECEPTOR PHARMACOLOGY -MOLECULAR MECHANISMS AND CLINICAL RELEVANCE

      Journal of cardiothoracic and vascular anesthesia


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/08/20 alle ore 21:24:27