Le informazioni sugli articoli di fonte ISI sono coperte da copyright

Per ulteriori informazioni selezionare i riferimenti di interesse.

1. Sastre, M; Steiner, H; Fuchs, K; Capell, A; Multhaup, G; Condron, MM; Teplow, DB; Haass, C
   Presenilin dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
   EMBO REPORTS
   
   M. Sastre et al., "Presenilin dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch", EMBO REP, 2(9), 2001, pp. 835-841
2. Chen, FS; Yu, G; Arawaka, S; Nishimura, M; Kawarai, T; Yu, H; Tandon, A; Supala, A; Song, YQ; Rogaeva, E; Milman, P; Sato, C; Yu, C; Janus, C; Lee, J; Song, LX; Zhang, LL; Fraser, PE; St George-Hyslop, PH
   Nicastrin binds to membrane tethered Notch
   NATURE CELL BIOLOGY
   
   F.S. Chen et al., "Nicastrin binds to membrane tethered Notch", NAT CELL BI, 3(8), 2001, pp. 751-754
3. Petit, A; Bihel, F; da Costa, CA; Pourquie, O; Checler, F; Kraus, JL
   New protease inhibitors prevent gamma-secretase-mediated production of A beta 40/42 without affecting Notch cleavage
   NATURE CELL BIOLOGY
   
   A. Petit et al., "New protease inhibitors prevent gamma-secretase-mediated production of A beta 40/42 without affecting Notch cleavage", NAT CELL BI, 3(5), 2001, pp. 507-511
4. Davidsson, P; Bogdanovic, N; Lannfelt, L; Blennow, K
   Reduced expression of amyloid precursor protein, presenilin-1 and rab3a incortical brain regions in Alzheimer's disease
   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
   
   P. Davidsson et al., "Reduced expression of amyloid precursor protein, presenilin-1 and rab3a incortical brain regions in Alzheimer's disease", DEMENT G C, 12(4), 2001, pp. 243-250
5. Huse, JT; Doms, RW
   Neurotoxic traffic: Uncovering the mechanics of amyloid production in Alzheimer's disease
   TRAFFIC
   
   J.T. Huse e R.W. Doms, "Neurotoxic traffic: Uncovering the mechanics of amyloid production in Alzheimer's disease", TRAFFIC, 2(2), 2001, pp. 75-81
6. Jankowsky, JL; Slunt, HH; Ratovitski, T; Jenkins, NA; Copeland, NG; Borchelt, DR
   Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
   BIOMOLECULAR ENGINEERING
   
   J.L. Jankowsky et al., "Co-expression of multiple transgenes in mouse CNS: a comparison of strategies", BIOMOL ENG, 17(6), 2001, pp. 157-165
7. Jhee, S; Shiovitz, T; Crawford, AW; Cutler, NR
   beta-amyloid therapies in Alzheimer's disease
   EXPERT OPINION ON INVESTIGATIONAL DRUGS
   
   S. Jhee et al., "beta-amyloid therapies in Alzheimer's disease", EXPERT OP I, 10(4), 2001, pp. 593-605
8. Dominguez, DI; De Strooper, B; Annaert, W
   Secretases as therapeutic targets for the treatment of Alzheimer's disease
   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
   
   D.I. Dominguez et al., "Secretases as therapeutic targets for the treatment of Alzheimer's disease", AMYLOID, 8(2), 2001, pp. 124-142
9. Calabrese, EJ
   Amyloid beta-peptide: Biphasic dose responses
   CRITICAL REVIEWS IN TOXICOLOGY
   
   E.J. Calabrese, "Amyloid beta-peptide: Biphasic dose responses", CR R TOXIC, 31(4-5), 2001, pp. 605-606
10. Refolo, LM; Pappolla, MA; LaFrancois, J; Malester, B; Schmidt, SD; Thomas-Bryant, T; Tint, GS; Wang, R; Mercken, M; Petanceska, SS; Duff, KE
    A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenicmouse model of Alzheimer's disease
    NEUROBIOLOGY OF DISEASE
    
    L.M. Refolo et al., "A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenicmouse model of Alzheimer's disease", NEUROBIOL D, 8(5), 2001, pp. 890-899
11. Poduslo, JF; Curran, GL; Wengenack, TM; Malester, B; Duff, K
    Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease
    NEUROBIOLOGY OF DISEASE
    
    J.F. Poduslo et al., "Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease", NEUROBIOL D, 8(4), 2001, pp. 555-567
12. Leissring, MA; LaFerla, FM; Callamaras, N; Parker, I
    Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling
    NEUROBIOLOGY OF DISEASE
    
    M.A. Leissring et al., "Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling", NEUROBIOL D, 8(3), 2001, pp. 469-478
13. Eckert, A; Schindowski, K; Leutner, S; Luckhaus, C; Touchet, N; Czech, C; Muller, WE
    Alzheimer's disease-like alterations in peripheral cells from presenilin-1transgenic mice
    NEUROBIOLOGY OF DISEASE
    
    A. Eckert et al., "Alzheimer's disease-like alterations in peripheral cells from presenilin-1transgenic mice", NEUROBIOL D, 8(2), 2001, pp. 331-342
14. Russo, C; Salis, S; Dolcini, V; Venezia, V; Song, XH; Teller, JK; Schettini, G
    Identification of amino-terminally and phosphotyrosine-modified carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain
    NEUROBIOLOGY OF DISEASE
    
    C. Russo et al., "Identification of amino-terminally and phosphotyrosine-modified carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain", NEUROBIOL D, 8(1), 2001, pp. 173-180
15. De Jonghe, C; Esselens, C; Kumar-Singh, S; Craessaerts, K; Serneels, S; Checler, F; Annaert, W; Van Broeckhoven, C; De Strooper, B
    Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect A beta secretion and APP C-terminal fragment stability
    HUMAN MOLECULAR GENETICS
    
    C. De Jonghe et al., "Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect A beta secretion and APP C-terminal fragment stability", HUM MOL GEN, 10(16), 2001, pp. 1665-1671
16. Roberds, SL; Anderson, J; Basi, G; Bienkowski, MJ; Branstetter, DG; Chen, KS; Freedman, SB; Frigon, NL; Games, D; Hu, K; Johnson-Wood, K; Kappenman, KE; Kawabe, TT; Kola, I; Kuehn, R; Lee, M; Liu, WQ; Motter, R; Nichols, NF; Power, M; Robertson, DW; Schenk, D; Schoor, M; Shopp, GM; Shuck, ME; Sinha, S; Svensson, KA; Tatsuno, G; Tintrup, H; Wijsman, J; Wright, S; McConlogue, L
    BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics
    HUMAN MOLECULAR GENETICS
    
    S.L. Roberds et al., "BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics", HUM MOL GEN, 10(12), 2001, pp. 1317-1324
17. Presente, A; Andres, A; Nye, JS
    Requirement of Notch in adulthood for neurological function and longevity
    NEUROREPORT
    
    A. Presente et al., "Requirement of Notch in adulthood for neurological function and longevity", NEUROREPORT, 12(15), 2001, pp. 3321-3325
18. Lukiw, WJ; Gordon, WC; Rogaev, EI; Thompson, H; Bazan, NG
    Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis
    NEUROREPORT
    
    W.J. Lukiw et al., "Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis", NEUROREPORT, 12(1), 2001, pp. 53-57
19. Walter, J; Kaether, C; Steiner, H; Haass, C
    The cell biology of Alzheimer's disease: uncovering the secrets of secretases
    CURRENT OPINION IN NEUROBIOLOGY
    
    J. Walter et al., "The cell biology of Alzheimer's disease: uncovering the secrets of secretases", CUR OP NEUR, 11(5), 2001, pp. 585-590
20. Fortini, ME
    Notch and Presenilin: a proteolytic mechanism emerges
    CURRENT OPINION IN CELL BIOLOGY
    
    M.E. Fortini, "Notch and Presenilin: a proteolytic mechanism emerges", CURR OP CEL, 13(5), 2001, pp. 627-634
21. Matsumoto, A; Itoh, K; Seki, T; Motozaki, K; Matsuyama, S
    Human brain carboxypeptidase B, which cleaves beta-amyloid peptides in vitro, is expressed in the endoplasmic reticulum of neurons
    EUROPEAN JOURNAL OF NEUROSCIENCE
    
    A. Matsumoto et al., "Human brain carboxypeptidase B, which cleaves beta-amyloid peptides in vitro, is expressed in the endoplasmic reticulum of neurons", EUR J NEURO, 13(9), 2001, pp. 1653-1657
22. Demeester, N; Mertens, C; Caster, H; Goethals, M; Vandekerckhove, J; Rosseneu, M; Labeur, C
    Comparison of the aggregation properties, secondary structure and apoptotic effects of wild-type, Flemish and Dutch N-terminally truncated amyloid beta peptides
    EUROPEAN JOURNAL OF NEUROSCIENCE
    
    N. Demeester et al., "Comparison of the aggregation properties, secondary structure and apoptotic effects of wild-type, Flemish and Dutch N-terminally truncated amyloid beta peptides", EUR J NEURO, 13(11), 2001, pp. 2015-2024
23. Koizumi, K; Nakajima, M; Yuasa, S; Saga, Y; Sakai, T; Kuriyama, T; Shirasawa, T; Koseki, H
    The role of presenilin 1 during somite segmentation
    DEVELOPMENT
    
    K. Koizumi et al., "The role of presenilin 1 during somite segmentation", DEVELOPMENT, 128(8), 2001, pp. 1391-1402
24. Paganelli, AR; Ocana, OH; Prat, MI; Franco, PG; Lopez, SL; Morelli, L; Adamo, AM; Riccomagno, MM; Matsubara, E; Shoji, M; Affranchino, JL; Castano, EM; Carrasco, AE
    The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis
    MECHANISMS OF DEVELOPMENT
    
    A.R. Paganelli et al., "The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis", MECH DEVEL, 107(1-2), 2001, pp. 119-131
25. Imaizumi, K; Miyoshi, K; Katayama, T; Yoneda, T; Taniguchi, M; Kudo, T; Tohyama, M
    The unfolded protein response and Alzheimer's disease
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
    
    K. Imaizumi et al., "The unfolded protein response and Alzheimer's disease", BBA-MOL BAS, 1536(2-3), 2001, pp. 85-96
26. Bertram, L; Tanzi, RE
    Dancing in the dark? The status of late-onset Alzheimer's disease genetics
    JOURNAL OF MOLECULAR NEUROSCIENCE
    
    L. Bertram e R.E. Tanzi, "Dancing in the dark? The status of late-onset Alzheimer's disease genetics", J MOL NEURO, 17(2), 2001, pp. 127-136
27. Hartmann, D; Tournoy, J; Saftig, P; Annaert, W; De Strooper, B
    Implication of APP secretases in notch signaling
    JOURNAL OF MOLECULAR NEUROSCIENCE
    
    D. Hartmann et al., "Implication of APP secretases in notch signaling", J MOL NEURO, 17(2), 2001, pp. 171-181
28. Thinakaran, G
    Metabolism of presenilins
    JOURNAL OF MOLECULAR NEUROSCIENCE
    
    G. Thinakaran, "Metabolism of presenilins", J MOL NEURO, 17(2), 2001, pp. 183-192
29. Steiner, H; Haass, C
    Nuclear signaling - A common function of presenilin substrates?
    JOURNAL OF MOLECULAR NEUROSCIENCE
    
    H. Steiner e C. Haass, "Nuclear signaling - A common function of presenilin substrates?", J MOL NEURO, 17(2), 2001, pp. 193-198
30. Mattson, MP; Chan, SL
    Dysregulation of cellular calcium homeostasis in Alzheimer's disease - Badgenes and bad habits
    JOURNAL OF MOLECULAR NEUROSCIENCE
    
    M.P. Mattson e S.L. Chan, "Dysregulation of cellular calcium homeostasis in Alzheimer's disease - Badgenes and bad habits", J MOL NEURO, 17(2), 2001, pp. 205-224
31. Schenk, D; Games, D; Seubert, P
    Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and A beta immunization
    JOURNAL OF MOLECULAR NEUROSCIENCE
    
    D. Schenk et al., "Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and A beta immunization", J MOL NEURO, 17(2), 2001, pp. 259-267
32. Pinnix, I; Council, JE; Roseberry, B; Onstead, L; Mallender, W; Sucic, J; Sambamurti, K
    Convertases other than furin cleave beta-secretase to its mature form
    FASEB JOURNAL
    
    I. Pinnix et al., "Convertases other than furin cleave beta-secretase to its mature form", FASEB J, 15(8), 2001, pp. NIL_515-NIL_532
33. Russo, E
    Hot papers - Interpreting the signaling of notch - Comment
    SCIENTIST
    
    E. Russo, "Hot papers - Interpreting the signaling of notch - Comment", SCIENTIST, 15(4), 2001, pp. 19-20
34. Ertekin-Taner, N; Graff-Radford, N; Younkin, LH; Eckman, C; Adamson, J; Schaid, DJ; Blangero, J; Hutton, M; Younkin, SG
    Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees
    GENETIC EPIDEMIOLOGY
    
    N. Ertekin-Taner et al., "Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees", GENET EPID, 21(1), 2001, pp. 19-30
35. Vidal, R; Calero, M; Revesz, T; Plant, G; Ghiso, J; Frangione, B
    Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family
    GENE
    
    R. Vidal et al., "Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family", GENE, 266(1-2), 2001, pp. 95-102
36. Smith, MJ; Kwok, JBJ; McLean, CA; Kril, JJ; Broe, GA; Nicholson, GA; Cappai, R; Hallupp, M; Cotton, RGH; Masters, CL; Schofield, PR; Brooks, WS
    Variable phenotype of Alzheimer's disease with spastic paraparesis
    ANNALS OF NEUROLOGY
    
    M.J. Smith et al., "Variable phenotype of Alzheimer's disease with spastic paraparesis", ANN NEUROL, 49(1), 2001, pp. 125-129
37. Vestling, M; Wiehager, B; Tanii, H; Cowburn, RF
    Akt activity in presenilin 1 wild-type and mutation transfected human SH-SY5Y neuroblastoma cells after serum deprivation and high glucose stress
    JOURNAL OF NEUROSCIENCE RESEARCH
    
    M. Vestling et al., "Akt activity in presenilin 1 wild-type and mutation transfected human SH-SY5Y neuroblastoma cells after serum deprivation and high glucose stress", J NEUROSC R, 66(3), 2001, pp. 448-456
38. Popescu, BO; Cedazo-Minguez, A; Popescu, LM; Winblad, B; Cowburn, RF; Ankarcrona, M
    Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells
    JOURNAL OF NEUROSCIENCE RESEARCH
    
    B.O. Popescu et al., "Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells", J NEUROSC R, 66(1), 2001, pp. 122-134
39. Dermaut, B; Roks, G; Theuns, J; Rademakers, R; Houwing-Duistermaat, JJ; Serneels, S; Hofman, A; Breteler, MMB; Cruts, M; Van Broeckhoven, C; van Duijn, CM
    Variable expression of presenilin 1 is not a major determinant of risk forlate-onset Alzheimer's Disease
    JOURNAL OF NEUROLOGY
    
    B. Dermaut et al., "Variable expression of presenilin 1 is not a major determinant of risk forlate-onset Alzheimer's Disease", J NEUROL, 248(11), 2001, pp. 935-939
40. D'Andrea, MR; Nagele, RG; Wang, HY; Peterson, PA; Lee, DHS
    Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease
    HISTOPATHOLOGY
    
    M.R. D'Andrea et al., "Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease", HISTOPATHOL, 38(2), 2001, pp. 120-134
41. Layfield, R
    Does an inhibition of the uhiquitin/26S proteasome pathway of protein degradation underlie the pathogenesis of non-familial Alzheimer's disease?
    MEDICAL HYPOTHESES
    
    R. Layfield, "Does an inhibition of the uhiquitin/26S proteasome pathway of protein degradation underlie the pathogenesis of non-familial Alzheimer's disease?", MED HYPOTH, 56(3), 2001, pp. 395-399
42. Matsuoka, Y; Picciano, M; La Francois, J; Duff, K
    Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse modelof Alzheimer's disease
    NEUROSCIENCE
    
    Y. Matsuoka et al., "Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse modelof Alzheimer's disease", NEUROSCIENC, 104(3), 2001, pp. 609-613
43. Kostyszyn, B; Cowburn, RF; Seiger, A; Kjaeldgaard, A; Sundstrom, E
    Expression of presenilin-1 and notch-1 receptor in human embryonic CNS
    NEUROSCIENCE
    
    B. Kostyszyn et al., "Expression of presenilin-1 and notch-1 receptor in human embryonic CNS", NEUROSCIENC, 103(4), 2001, pp. 885-898
44. Dowjat, WK; Wisniewski, H; Wisniewski, T
    Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments
    NEUROSCIENCE
    
    W.K. Dowjat et al., "Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments", NEUROSCIENC, 103(1), 2001, pp. 1-8
45. Luetjens, CM; Lankiewicz, S; Bui, NT; Krohn, AJ; Poppe, M; Prehn, JHM
    Up-regulation of Bcl-xL in response to subtoxic beta-amyloid: Role in neuronal resistance against apoptotic and oxidative injury
    NEUROSCIENCE
    
    C.M. Luetjens et al., "Up-regulation of Bcl-xL in response to subtoxic beta-amyloid: Role in neuronal resistance against apoptotic and oxidative injury", NEUROSCIENC, 102(1), 2001, pp. 139-150
46. Mann, DMA; Takeuchi, A; Sato, S; Cairns, NJ; Lantos, PL; Rossor, MN; Haltia, M; Kalimo, H; Iwatsubo, T
    Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1gene show an unusual but characteristic beta-amyloid pathology known as 'cotton wool' plaques
    NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
    
    D.M.A. Mann et al., "Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1gene show an unusual but characteristic beta-amyloid pathology known as 'cotton wool' plaques", NEUROP AP N, 27(3), 2001, pp. 189-196
47. Queralt, R; Ezquerra, M; Castellvi, M; Lleo, A; Blesa, R; Oliva, R
    Detection of the presenilin 1 gene mutation (M139T) in early-onset familial Alzheimer disease in Spain
    NEUROSCIENCE LETTERS
    
    R. Queralt et al., "Detection of the presenilin 1 gene mutation (M139T) in early-onset familial Alzheimer disease in Spain", NEUROSCI L, 299(3), 2001, pp. 239-241
48. Wiltfang, J; Esselmann, H; Maler, JM; Bleich, S; Huther, G; Kornhuber, J
    Molecular biology of Alzheimer's dementia and its clinical relevance to early diagnosis and new therapeutic strategies
    GERONTOLOGY
    
    J. Wiltfang et al., "Molecular biology of Alzheimer's dementia and its clinical relevance to early diagnosis and new therapeutic strategies", GERONTOLOGY, 47(2), 2001, pp. 65-71
49. Zhou, SF; Hayward, SD
    Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex
    MOLECULAR AND CELLULAR BIOLOGY
    
    S.F. Zhou e S.D. Hayward, "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex", MOL CELL B, 21(18), 2001, pp. 6222-6232
50. Pigino, G; Pelsman, A; Mori, H; Busciglio, J
    Presenilin-1 mutations reduce cytoskeletal association, deregulate neuritegrowth, and potentiate neuronal dystrophy and tau phosphorylation
    JOURNAL OF NEUROSCIENCE
    
    G. Pigino et al., "Presenilin-1 mutations reduce cytoskeletal association, deregulate neuritegrowth, and potentiate neuronal dystrophy and tau phosphorylation", J NEUROSC, 21(3), 2001, pp. 834-842
51. Fitzjohn, SM; Morton, RA; Kuenzi, F; Rosahl, TW; Shearman, M; Lewis, H; Smith, D; Reynolds, DS; Davies, CH; Collingridge, GL; Seabrook, GR
    Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant formof amyloid precursor protein
    JOURNAL OF NEUROSCIENCE
    
    S.M. Fitzjohn et al., "Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant formof amyloid precursor protein", J NEUROSC, 21(13), 2001, pp. 4691-4698
52. Mattson, MP; Chan, SL; Camandola, S
    Presenilin mutations and calcium signaling defects in the nervous and immune systems
    BIOESSAYS
    
    M.P. Mattson et al., "Presenilin mutations and calcium signaling defects in the nervous and immune systems", BIOESSAYS, 23(8), 2001, pp. 733-744
53. Frisen, J; Lendahl, U
    Oh no, Notch again!
    BIOESSAYS
    
    J. Frisen e U. Lendahl, "Oh no, Notch again!", BIOESSAYS, 23(1), 2001, pp. 3-7
54. Lucas, JL; Hernandez, F; Gomez-Ramos, P; Moran, MA; Hen, R; Avila, J
    Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3 beta conditional transgenic mice
    EMBO JOURNAL
    
    J.L. Lucas et al., "Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3 beta conditional transgenic mice", EMBO J, 20(1-2), 2001, pp. 27-39
55. Ishii, K; Lippa, C; Tomiyama, T; Miyatake, F; Ozawa, K; Tamaoka, A; Hasegawa, T; Fraser, PE; Shoji, S; Nee, LE; Pollen, DA; St George-Hyslop, PH; Ii, K; Ohtake, T; Kalaria, RN; Rossor, MN; Lantos, PL; Cairns, NJ; Farrer, LA; Mori, H
    Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition
    NEUROBIOLOGY OF AGING
    
    K. Ishii et al., "Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition", NEUROBIOL A, 22(3), 2001, pp. 367-376
56. Gordon, MN; King, DL; Diamond, DM; Jantzen, PT; Boyett, KV; Hope, CE; Hatcher, JM; DiCarlo, G; Gottschall, WPE; Morgan, D; Arendash, GW
    Correlation between cognitive deficits and A beta deposits in transgenic APP+PS1 mice
    NEUROBIOLOGY OF AGING
    
    M.N. Gordon et al., "Correlation between cognitive deficits and A beta deposits in transgenic APP+PS1 mice", NEUROBIOL A, 22(3), 2001, pp. 377-385
57. Dirami, G; Ravindranath, N; Achi, MV; Dym, M
    Expression of Notch pathway components in spermatogonia and Sertoli cells of neonatal mice
    JOURNAL OF ANDROLOGY
    
    G. Dirami et al., "Expression of Notch pathway components in spermatogonia and Sertoli cells of neonatal mice", J ANDROLOGY, 22(6), 2001, pp. 944-952
58. Jack, C; Berezovska, O; Wolfe, MS; Hyman, BT
    Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons
    MOLECULAR BRAIN RESEARCH
    
    C. Jack et al., "Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons", MOL BRAIN R, 87(2), 2001, pp. 166-174
59. Chapman, PF; Falinska, AM; Knevett, SG; Ramsay, MF
    Genes, models and Alzheimer's disease
    TRENDS IN GENETICS
    
    P.F. Chapman et al., "Genes, models and Alzheimer's disease", TRENDS GEN, 17(5), 2001, pp. 254-261
60. Janson, CG; McPhee, SWJ; Leone, P; Freese, A; During, MJ
    Viral-based gene transfer to the mammalian CNS for functional genomic studies
    TRENDS IN NEUROSCIENCES
    
    C.G. Janson et al., "Viral-based gene transfer to the mammalian CNS for functional genomic studies", TRENDS NEUR, 24(12), 2001, pp. 706-712
61. Sisodia, SS; Annaert, W; Kim, SH; De Strooper, B
    gamma-secretase: Never more enigmatic
    TRENDS IN NEUROSCIENCES
    
    S.S. Sisodia et al., "gamma-secretase: Never more enigmatic", TRENDS NEUR, 24(11), 2001, pp. S2-S6
62. Fishman, CE; Cummins, DJ; Bales, KR; DeLong, CA; Esterman, MA; Hanson, JC; White, SL; Paul, SM; Jordan, WH
    Statistical aspects of quantitative image analysis of beta-amyloid in the APP(V717F) transgenic mouse model of Alzheimer's disease
    JOURNAL OF NEUROSCIENCE METHODS
    
    C.E. Fishman et al., "Statistical aspects of quantitative image analysis of beta-amyloid in the APP(V717F) transgenic mouse model of Alzheimer's disease", J NEUROSC M, 108(2), 2001, pp. 145-152
63. Law, A; Gauthier, S; Quirion, R
    Say NO to Alzheimer's disease: the putative links between nitric oxide anddementia of the Alzheimer's type
    BRAIN RESEARCH REVIEWS
    
    A. Law et al., "Say NO to Alzheimer's disease: the putative links between nitric oxide anddementia of the Alzheimer's type", BRAIN RES R, 35(1), 2001, pp. 73-96
64. Sorbi, S; Forleo, P; Tedde, A; Cellini, E; Ciantelli, M; Bagnoli, S; Nacmias, B
    Genetic risk factors in familial Alzheimer's disease
    MECHANISMS OF AGEING AND DEVELOPMENT
    
    S. Sorbi et al., "Genetic risk factors in familial Alzheimer's disease", MECH AGE D, 122(16), 2001, pp. 1951-1960
65. Esler, WP; Wolfe, MS
    Biomedicine - A portrait of Alzheimer secretases - New features and familiar faces
    SCIENCE
    
    W.P. Esler e M.S. Wolfe, "Biomedicine - A portrait of Alzheimer secretases - New features and familiar faces", SCIENCE, 293(5534), 2001, pp. 1449-1454
66. Lewis, J; Dickson, DW; Lin, WL; Chisholm, L; Corral, A; Jones, G; Yen, SH; Sahara, N; Skipper, L; Yager, D; Eckman, C; Hardy, J; Hutton, M; McGowan, E
    Enhanced neurofibrillary degeneration in transgenic mice expressing mutanttau and APP
    SCIENCE
    
    J. Lewis et al., "Enhanced neurofibrillary degeneration in transgenic mice expressing mutanttau and APP", SCIENCE, 293(5534), 2001, pp. 1487-1491
67. Cao, XW; Sudhof, TC
    A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60
    SCIENCE
    
    X.W. Cao e T.C. Sudhof, "A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60", SCIENCE, 293(5527), 2001, pp. 115-120
68. Iwata, N; Tsubuki, S; Takaki, Y; Shirotani, K; Lu, B; Gerard, NP; Gerard, C; Hama, E; Lee, HJ; Saido, TC
    Metabolic regulation of brain A beta by neprilysin
    SCIENCE
    
    N. Iwata et al., "Metabolic regulation of brain A beta by neprilysin", SCIENCE, 292(5521), 2001, pp. 1550-1552
69. Hannequin, D; Campion, D
    Dominant forms of Alzheimer's disease: from genotype to phenotype.
    REVUE NEUROLOGIQUE
    
    D. Hannequin e D. Campion, "Dominant forms of Alzheimer's disease: from genotype to phenotype.", REV NEUROL, 157(4), 2001, pp. 384-392
70. Janus, C; Westaway, D
    Transgenic mouse models of Alzheimer's disease
    PHYSIOLOGY & BEHAVIOR
    
    C. Janus e D. Westaway, "Transgenic mouse models of Alzheimer's disease", PHYSL BEHAV, 73(5), 2001, pp. 873-886
71. Rogaeva, EA; Fafel, KC; Song, YQ; Medeiros, H; Sato, C; Liang, Y; Richard, E; Rogaev, EI; Frommelt, P; Sadovnick, AD; Meschino, W; Rockwood, K; Boss, MA; Mayeux, R; St George-Hyslop, P
    Screening for PS1 mutations in a referral-based series of AD cases - 21 Novel mutations
    NEUROLOGY
    
    E.A. Rogaeva et al., "Screening for PS1 mutations in a referral-based series of AD cases - 21 Novel mutations", NEUROLOGY, 57(4), 2001, pp. 621-625
72. De Strooper, B; Konig, G
    Alzheimer's disease - An inflammatory drug prospect
    NATURE
    
    B. De Strooper e G. Konig, "Alzheimer's disease - An inflammatory drug prospect", NATURE, 414(6860), 2001, pp. 159-160
73. Weggen, S; Eriksen, JL; Das, P; Sagi, SA; Wang, R; Pietrzik, CU; Findlay, KA; Smith, TW; Murphy, MP; Butler, T; Kang, DE; Marquez-Sterling, N; Golde, TE; Koo, EH
    A subset of NSAIDs lower amyloidogenic A beta 42 independently of cyclooxygenase activity
    NATURE
    
    S. Weggen et al., "A subset of NSAIDs lower amyloidogenic A beta 42 independently of cyclooxygenase activity", NATURE, 414(6860), 2001, pp. 212-216
74. Kitazume, S; Tachida, Y; Oka, R; Shirotani, K; Saido, TC; Hashimoto, Y
    Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    
    S. Kitazume et al., "Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase", P NAS US, 98(24), 2001, pp. 13554-13559
75. Levitan, D; Lee, J; Song, LX; Manning, R; Wong, G; Parker, E; Zhang, LL
    PS1N-and C-terminal fragments form a complex that functions in APP processing and Notch signaling
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    
    D. Levitan et al., "PS1N-and C-terminal fragments form a complex that functions in APP processing and Notch signaling", P NAS US, 98(21), 2001, pp. 12186-12190
76. Hartmann, D
    From Alzheimer's disease to skin tumors: The catenin connection
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    
    D. Hartmann, "From Alzheimer's disease to skin tumors: The catenin connection", P NAS US, 98(19), 2001, pp. 10522-10523
77. Monsonego, A; Maron, R; Zota, V; Selkoe, DJ; Weiner, HL
    Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    
    A. Monsonego et al., "Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease", P NAS US, 98(18), 2001, pp. 10273-10278
78. Hadland, BK; Manley, NR; Su, DM; Longmore, GD; Moore, CL; Wolfe, MS; Schroeter, EH; Kopan, R
    gamma-secretase inhibitors repress thymocyte development
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    
    B.K. Hadland et al., "gamma-secretase inhibitors repress thymocyte development", P NAS US, 98(13), 2001, pp. 7487-7491
79. Fassbender, K; Simons, M; Bergmann, C; Stroick, M; Lutjohann, D; Keller, P; Runz, H; Kuhl, S; Bertsch, T; von Bergmannn, K; Hennerici, M; Beyreuther, K; Hartmann, T
    Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides A beta 42 and A beta 40 in vitro and in vivo
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    
    K. Fassbender et al., "Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides A beta 42 and A beta 40 in vitro and in vivo", P NAS US, 98(10), 2001, pp. 5856-5861
80. Kametani, F; Tanaka, K; Usami, M; Maruyama, K; Mori, H
    Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the processing of Alzheimer's amyloid precursor protein in PC12D cells
    JOURNAL OF THE NEUROLOGICAL SCIENCES
    
    F. Kametani et al., "Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the processing of Alzheimer's amyloid precursor protein in PC12D cells", J NEUR SCI, 188(1-2), 2001, pp. 27-31
81. Baskin, F; Rosenberg, RN; Iyer, L; Schellenberg, GD; Hynan, L; Nee, LE
    Platelet APP isoform ratios in asymptomatic young adults expressing an AD-related presenilin-1 mutation
    JOURNAL OF THE NEUROLOGICAL SCIENCES
    
    F. Baskin et al., "Platelet APP isoform ratios in asymptomatic young adults expressing an AD-related presenilin-1 mutation", J NEUR SCI, 183(1), 2001, pp. 85-88
82. Tomidokoro, Y; Harigaya, Y; Matsubara, E; Ikeda, M; Kawarabayashi, T; Shirao, T; Ishiguro, K; Okamoto, K; Younkin, SG; Shoji, M
    Brain A beta amyloidosis in APPsw mice induces accumulation of presenilin-I and tau
    JOURNAL OF PATHOLOGY
    
    Y. Tomidokoro et al., "Brain A beta amyloidosis in APPsw mice induces accumulation of presenilin-I and tau", J PATHOLOGY, 194(4), 2001, pp. 500-506
83. Le, R; Cruz, L; Urbanc, B; Knowles, RB; Hsiao-Ashe, K; Duff, K; Irizarry, MC; Stanley, HE; Hyman, BT
    Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: Implications for neural system disruption
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
    
    R. Le et al., "Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: Implications for neural system disruption", J NE EXP NE, 60(8), 2001, pp. 753-758
84. Verkkoniemi, A; Kalimo, H; Paetau, A; Somer, M; Iwatsubo, T; Hardy, J; Haltia, M
    Variant Alzheimer disease with spastic paraparesis: Neuropathological phenotype
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
    
    A. Verkkoniemi et al., "Variant Alzheimer disease with spastic paraparesis: Neuropathological phenotype", J NE EXP NE, 60(5), 2001, pp. 483-492
85. Takao, M; Ghetti, B; Murrell, JR; Unverzagt, FW; Giaccone, G; Tagliavini, F; Bugiani, O; Piccardo, P; Hulette, CM; Crain, BJ; Farlow, MR; Heyman, A
    Ectopic white matter neurons, a developmental abnormality that may be caused by the PSEN1 S169L mutation in a case of familial AD with myoclonus and seizures
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
    
    M. Takao et al., "Ectopic white matter neurons, a developmental abnormality that may be caused by the PSEN1 S169L mutation in a case of familial AD with myoclonus and seizures", J NE EXP NE, 60(12), 2001, pp. 1137-1152
86. Le, TV; Crook, R; Hardy, J; Dickson, DW
    Cotton wool plaques in non-familial late-onset Alzheimer disease
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
    
    T.V. Le et al., "Cotton wool plaques in non-familial late-onset Alzheimer disease", J NE EXP NE, 60(11), 2001, pp. 1051-1061
87. Smith, IF; Boyle, JP; Vaughan, PFT; Pearson, HA; Peers, C
    Effects of chronic hypoxia on Ca2+ stores and capacitative Ca2+ entry in human neuroblastoma (SH-SY5Y) cells
    JOURNAL OF NEUROCHEMISTRY
    
    I.F. Smith et al., "Effects of chronic hypoxia on Ca2+ stores and capacitative Ca2+ entry in human neuroblastoma (SH-SY5Y) cells", J NEUROCHEM, 79(4), 2001, pp. 877-884
88. Dumanchin-Njock, C; da Costa, CA; Mercken, L; Pradier, L; Checler, F
    The caspase-derived C-terminal fragment of beta APP induces caspase-independent toxicity and triggers selective increase of A beta 42 in mammalian cells
    JOURNAL OF NEUROCHEMISTRY
    
    C. Dumanchin-Njock et al., "The caspase-derived C-terminal fragment of beta APP induces caspase-independent toxicity and triggers selective increase of A beta 42 in mammalian cells", J NEUROCHEM, 78(5), 2001, pp. 1153-1161
89. Cupers, P; Orlans, I; Craessaerts, K; Annaert, W; De Strooper, B
    The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture
    JOURNAL OF NEUROCHEMISTRY
    
    P. Cupers et al., "The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture", J NEUROCHEM, 78(5), 2001, pp. 1168-1178
90. Nakajima, M; Miura, M; Aosaki, T; Shirasawa, T
    Deficiency of presenilin-1 increases calcium-dependent vulnerability of neurons to oxidative stress in vitro
    JOURNAL OF NEUROCHEMISTRY
    
    M. Nakajima et al., "Deficiency of presenilin-1 increases calcium-dependent vulnerability of neurons to oxidative stress in vitro", J NEUROCHEM, 78(4), 2001, pp. 807-814
91. Wolfe, MS
    Presenilin and gamma-secretase: structure meets function
    JOURNAL OF NEUROCHEMISTRY
    
    M.S. Wolfe, "Presenilin and gamma-secretase: structure meets function", J NEUROCHEM, 76(6), 2001, pp. 1615-1620
92. Counts, SE; Lah, JJ; Levey, AI
    The regulation of presenilin-1 by nerve growth factor
    JOURNAL OF NEUROCHEMISTRY
    
    S.E. Counts et al., "The regulation of presenilin-1 by nerve growth factor", J NEUROCHEM, 76(3), 2001, pp. 679-689
93. Skovronsky, DM; Fath, S; Lee, VMY; Milla, ME
    Neuronal localization of the TNF alpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques
    JOURNAL OF NEUROBIOLOGY
    
    D.M. Skovronsky et al., "Neuronal localization of the TNF alpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques", J NEUROBIOL, 49(1), 2001, pp. 40-46
94. Lambert, JC; Mann, DMA; Harris, JM; Chartier-Harlin, MC; Cumming, A; Coates, J; Lemmon, H; StClair, D; Iwatsubo, T; Lendon, C
    The-48 C/T polymorphism in the presenilin 1 promoter is associated with anincreased risk of developing Alzheimer's disease and an increased A beta load in brain
    JOURNAL OF MEDICAL GENETICS
    
    J.C. Lambert et al., "The-48 C/T polymorphism in the presenilin 1 promoter is associated with anincreased risk of developing Alzheimer's disease and an increased A beta load in brain", J MED GENET, 38(6), 2001, pp. 353-355
95. Vezina, J; Grossmuller, F; Muller, K
    Influence of a transiently transfected gene on apoptosis, measurements guided by cotransfected GFP
    JOURNAL OF IMMUNOLOGICAL METHODS
    
    J. Vezina et al., "Influence of a transiently transfected gene on apoptosis, measurements guided by cotransfected GFP", J IMMUNOL M, 252(1-2), 2001, pp. 163-169
96. Tomita, M; Sugi, K; Ozawa, K; Tsong, TY; Yoshimura, T
    Targeting antigen-specific receptors on B lymphocytes to generate high yields of specific monoclonal antibodies directed against biologically active lower antigenic peptides within presenilin 1
    JOURNAL OF IMMUNOLOGICAL METHODS
    
    M. Tomita et al., "Targeting antigen-specific receptors on B lymphocytes to generate high yields of specific monoclonal antibodies directed against biologically active lower antigenic peptides within presenilin 1", J IMMUNOL M, 251(1-2), 2001, pp. 31-43
97. Dingwall, C
    Spotlight on BACE: The secretases as targets for treatment in Alzheimer disease
    JOURNAL OF CLINICAL INVESTIGATION
    
    C. Dingwall, "Spotlight on BACE: The secretases as targets for treatment in Alzheimer disease", J CLIN INV, 108(9), 2001, pp. 1243-1246
98. Cupers, P; Bentahir, M; Craessaerts, K; Orlans, I; Vanderstichele, H; Saftig, P; De Strooper, B; Annaert, W
    The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein
    JOURNAL OF CELL BIOLOGY
    
    P. Cupers et al., "The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein", J CELL BIOL, 154(4), 2001, pp. 731-740
99. Kim, JW; Chang, TS; Lee, JE; Huh, SH; Yeon, SW; Yang, WS; Joe, CO; Mook-Jung, I; Tanzi, RE; Kim, TW; Choi, EJ
    Negative regulation of the SAPK/JNK signaling pathway by presenilin 1
    JOURNAL OF CELL BIOLOGY
    
    J.W. Kim et al., "Negative regulation of the SAPK/JNK signaling pathway by presenilin 1", J CELL BIOL, 153(3), 2001, pp. 457-463
100. Soriano, S; Kang, DE; Fu, MF; Pestell, R; Chevallier, N; Zheng, H; Koo, EH
     Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein andNotch processing
     JOURNAL OF CELL BIOLOGY
     
     S. Soriano et al., "Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein andNotch processing", J CELL BIOL, 152(4), 2001, pp. 785-794