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Pioglitazone: mechanism of action
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
PPARs, insulin resistance and type 2 diabetes
JOURNAL OF CARDIOVASCULAR RISK
Thiazolidinediones and liver toxicity
DIABETES & METABOLISM
Thiazolidinediones: clinical data and perspectives
DIABETES & METABOLISM
Type 2 diabetes mellitus: Which place for thiazolidinediones in the therapeutic strategy?
DIABETES & METABOLISM
Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
The impact of pioglitazone on glycemic control and atherogenic dyslipidemia in patients with type 2 diabetes mellitus
CORONARY ARTERY DISEASE
Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes
Hypertension research
Insulin resistance induced in dairy steers by tumor necrosis factor alpha is partially reversed by 2,4-thiazolidinedione
DOMESTIC ANIMAL ENDOCRINOLOGY
Enhancing insulin action: From chemical elements to thiazolidinediones
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
Effects of troglitazone and temocapril in spontaneously hypertensive rats with chronic renal failure
JOURNAL OF HYPERTENSION
Pioglitazone improves left ventricular diastolic function and decreases collagen accumulation in prediabetic stage of a type II diabetic rat
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Peroxisome proliferator-activated receptor-gamma ligands inhibit nuclear but not cytosolic extracellular signal-regulated kinase/mitogen-activated protein kinase-regulated steps in vascular smooth muscle cell migration
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
A systematic review of the clinical effectiveness of pioglitazone in the treatment of type 2 diabetes mellitus
CLINICAL THERAPEUTICS
Insulin-sensitizing effect of rosiglitazone (BRL-49653) by regulation of glucose transporters in muscle and fat of Zucker rats
METABOLISM-CLINICAL AND EXPERIMENTAL
The effect of 1,3-diaryl-[1H]-pyrazole-4-acetamides on glucose utilizationin ob/ob mice
JOURNAL OF MEDICINAL CHEMISTRY
Thiazolidinediones, peroxisome proliferator-activated receptor gamma agonists, regulate endothelial cell growth and secretion of vasoactive peptides
ATHEROSCLEROSIS
Glitazone - Profile of a new class of substances
INTERNIST
Ligands for peroxisome proliferator-activated receptor gamma inhibit growth of pancreatic cancers both in vitro and in vivo
INTERNATIONAL JOURNAL OF CANCER
Activation of mouse phosphodiesterase 3B gene promoter by adipocyte differentiation in 3T3-L1 cells
FEBS LETTERS
Stage-specific effects of a thiazolidinedione on proliferation, differentiation and PPAR gamma mRNA expression in 3T3-L1 adipocytes
EUROPEAN JOURNAL OF PHARMACOLOGY
Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-inducedapoptosis by induction of p21(waf1/cip1)
DIGESTION
The expression of the p85 alpha subunit of phosphatidylinositol 3-Kinase is induced by activation of the peroxisome proliferator-activated receptor gamma in human adipocytes
DIABETOLOGIA
Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability
DIABETES
Troglitazone not only increases GLUT4 but also induces its translocation in rat adipocytes
DIABETES
Ca2+-sensitizing effect is involved in the positive inotropic effect of troglitazone
BRITISH JOURNAL OF PHARMACOLOGY
Drug interactions - their impact on safe drug therapy as exemplified by the novel group of thiazolidinediones (glitazones)
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
Prevention of coronary heart disease in type 2 diabetes
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
Current treatment of insulin resistance in type 2 diabetes mellitus
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
The role of the liver on post-prandial glycaemia - emphasis on hepatic glucose uptake
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
Clinical efficacy of new thiazolidinediones and glinides in the treatment of type 2 diabetes mellitus
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Pioglitazone: From development to clinical practice
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
How pioglitazone affects glucose and lipid metabolism
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Clinical pharmacokinetics of pioglitazone
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Pioglitazone in the treatment of type 2 diabetes mellitus: US clinical experience
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Combining pioglitazone with a sulphonylurea or metformin in the managementof type 2 diabetes
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Safety and tolerability of pioglitazone
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Thiazolidinediones exert different effects on insulin resistance between dexamethasone-treated rats and Wistar fatty rats
ENDOCRINE JOURNAL
Pioglitazone attenuates basal and postprandial insulin concentrations and blood pressure in the spontaneously hypertensive rat
AMERICAN JOURNAL OF HYPERTENSION
Pioglitazone hydrochloride in combination with metformin in the treatment of type 2 diabetes melitus: A randomized, placebo-controlled study
CLINICAL THERAPEUTICS
JTT-501, a new oral hypoglycemic agent, reverses hypertriglyceridemia in Zucker fatty and ventromedial hypothalamus-lesioned obese rats
METABOLISM-CLINICAL AND EXPERIMENTAL
Alteration in expression profiles of a series of diabetes-related genes indb/db mice following treatment with thiazolidinediones
JAPANESE JOURNAL OF PHARMACOLOGY
Inhibitory action of troglitazone, an insulin-sensitizing agent, on the calcium current in cardiac ventricular cells of guinea pig
JAPANESE JOURNAL OF PHARMACOLOGY
Troglitazone induces apoptosis via the p53 and Gadd45 pathway in vascular smooth muscle cells
EUROPEAN JOURNAL OF PHARMACOLOGY
Acute hemodynamic effects of insulin-sensitizing agents in isolated perfused rat hearts
EUROPEAN JOURNAL OF PHARMACOLOGY
Pioglitazone
DRUGS
Evidence that pioglitazone, metformin and pentoxifylline are inhibitors ofglycation
CLINICA CHIMICA ACTA
Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
The emerging role of thiazolidinediones in the treatment of diabetes-mellitus and related disorders
CLINICAL AND EXPERIMENTAL HYPERTENSION
Lipogenic action of the novel oral antidiabetic agent HQL-975 in genetically obese diabetic KK-Ay mice
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Thiazolidinediones: a new class of antidiabetic drugs
DIABETIC MEDICINE
Pioglitazone prevents mice from multiple low-dose streptozotocin-induced insulitis and diabetes
DIABETES RESEARCH AND CLINICAL PRACTICE
Vasculo-protective effects of insulin sensitizing agent pioglitazone in neointimal thickening and hypertensive vascular hypertrophy
ATHEROSCLEROSIS
Troglitazone but not pioglitazone affects ATP-sensitive K+ channel activity
EUROPEAN JOURNAL OF PHARMACOLOGY
Triglyceride-lowering effect of a novel insulin-sensitizing agent, JTT-501
EUROPEAN JOURNAL OF PHARMACOLOGY
Differential effects of insulin-sensitizers troglitazone and rosiglitazoneon ion currents in rat vascular myocytes
EUROPEAN JOURNAL OF PHARMACOLOGY
Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative
EUROPEAN JOURNAL OF PHARMACOLOGY
A new antidiabetic agent (JTT-501) rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle
DIABETOLOGIA
The thiazolidinedione rosiglitazone (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats
DIABETES
Hemodynamic basis for the acute cardiac effects of troglitazone in isolated perfused rat hearts
DIABETES
Troglitazone and pioglitazone attenuate agonist-dependent Ca2+ mobilization and cell proliferation in vascular smooth muscle cells
BRITISH JOURNAL OF PHARMACOLOGY
Modes of action and clinical efficacy of pioglitazone as a new principle for the treatment of type 2 diabetes
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
TROGLITAZONE, AN INSULIN SENSITIZER, INCREASES FOREARM BLOOD-FLOW IN HUMANS
American journal of hypertension
INSULIN ACTION ON PROTEIN PHOSPHATASE-1 ACTIVATION IS ENHANCED BY THEANTIDIABETIC AGENT PIOGLITAZONE IN CULTURED DIABETIC HEPATOCYTES
Molecular and cellular biochemistry
SYNERGISTIC ACTIONS OF INSULIN AND TROGLITAZONE ON CONTRACTILITY IN ENDOTHELIUM-DENUDED RAT AORTIC RINGS
American journal of physiology: endocrinology and metabolism
ACTIONS OF THE NOVEL ORAL ANTIDIABETIC AGENT HQL-975 IN INSULIN-RESISTANT NON-INSULIN-DEPENDENT DIABETES-MELLITUS MODEL ANIMALS
Diabetes research and clinical practice
PIOGLITAZONE ENHANCES SPLANCHNIC GLUCOSE-UPTAKE AS WELL AS PERIPHERALGLUCOSE-UPTAKE IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS
Diabetes research and clinical practice
DIRECT VASODEPRESSOR EFFECTS OF PIOGLITAZONE IN SPONTANEOUSLY HYPERTENSIVE RATS
Pharmacology
EFFECTS OF TROGLITAZONE ON HEPATIC AND PERIPHERAL INSULIN-RESISTANCE INDUCED BY GROWTH-HORMONE EXCESS IN RATS
Metabolism, clinical and experimental
EFFECTS OF TROGLITAZONE ON DEXAMETHASONE-INDUCED INSULIN-RESISTANCE IN RATS
Metabolism, clinical and experimental
Cytosolic and nuclear distribution of PPAR gamma 2 in differentiating 3T3-L1 preadipocytes
JOURNAL OF LIPID RESEARCH
HIGH GLUCOSE-INDUCED ABNORMAL EPIDERMAL GROWTH-FACTOR SIGNALING
Journal of Biochemistry
TROGLITAZONE ENHANCES GLUCOSE-UPTAKE AND INHIBITS MITOGEN-ACTIVATED PROTEIN-KINASE IN HUMAN AORTIC SMOOTH-MUSCLE CELLS
Atherosclerosis
YM268 INCREASES THE GLUCOSE-UPTAKE, CELL-DIFFERENTIATION, AND MESSENGER-RNA EXPRESSION OF GLUCOSE-TRANSPORTER IN 3T3-L1 ADIPOCYTES
Hormone and Metabolic Research
EFFECTS OF TROGLITAZONE AND PIOGLITAZONE ON THE ACTION-POTENTIALS ANDMEMBRANE CURRENTS OF RABBIT VENTRICULAR MYOCYTES
European journal of pharmacology
TROGLITAZONE INCREASES SYSTEM-A AMINO-ACID-TRANSPORT IN 3T3-L1 CELLS
Endocrinology
PIOGLITAZONE TIME-DEPENDENTLY REDUCES TUMOR-NECROSIS-FACTOR-ALPHA LEVEL IN MUSCLE AND IMPROVES METABOLIC ABNORMALITIES IN WISTAR FATTY RATS
Diabetologia
DIFFERENTIAL VASOACTIVE EFFECTS OF THE INSULIN SENSITIZERS ROSIGLITAZONE (BRL-49653) AND TROGLITAZONE ON HUMAN SMALL ARTERIES IN-VITRO
Diabetes
INCREASED ADIPOSE EXPRESSION OF THE UNCOUPLING PROTEIN-3 GENE BY THIAZOLIDINEDIONES IN WISTAR FATTY RATS AND IN CULTURED ADIPOCYTES
Diabetes
ACTIONS OF NOVEL ANTIDIABETIC THIAZOLIDINEDIONE, T-174, IN ANIMAL-MODELS OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS (NIDDM) AND IN CULTUREDMUSCLE-CELLS
British Journal of Pharmacology
INHIBITORY-ACTION OF INSULIN-SENSITIZING AGENTS ON CALCIUM CHANNELS IN SMOOTH-MUSCLE CELLS FROM RESISTANCE ARTERIES OF GUINEA-PIG
British Journal of Pharmacology
PHARMACOLOGICAL AND PHARMACOKINETIC STUDIES OF THE NEWLY SYNTHESIZED THIAZOLIDINEDIONE DERIVATIVE ROPANECARBONYLAMINO)BENZYL)-THIAZOLIDINE-2,4-DIONE
Arzneimittel-Forschung
EFFECTS OF THE NOVEL ORAL ANTIDIABETIC AGENT HQL-975 ON GLUCOSE AND LIPID-METABOLISM IN DIABETIC DB DB MICE/
Arzneimittel-Forschung
ACUTE EFFECTS OF PIOGLITAZONE ON GLUCOSE-METABOLISM IN PERFUSED-RAT-LIVER
Acta diabetologica
INCREASING INSULIN SENSITIVITY LOWERS BLOOD-PRESSURE IN THE FRUCTOSE-FED RAT
American journal of hypertension
TROGLITAZONE LOWERS BLOOD-PRESSURE AND ENHANCES INSULIN SENSITIVITY IN WATANABE HERITABLE HYPERLIPIDEMIC RABBITS
American journal of hypertension
EFFECTS OF THIAZOLIDINEDIONES ON GROWTH AND DIFFERENTIATION OF HUMAN AORTA AND CORONARY MYOCYTES
American journal of hypertension
THIAZOLIDINEDIONES AND THEIR EFFECTS ON GLUCOSE TRANSPORTERS
European journal of endocrinology
INSULIN SENSITIZER YM268 AMELIORATES INSULIN-RESISTANCE BY NORMALIZING THE DECREASED CONTENT OF GLUT4 IN ADIPOSE-TISSUE OF OBESE ZUCKER RATS
European journal of endocrinology
SYNTHETIC APPROACHES TO BENZOFURAN CONTAINING INSULIN SENSITIVITY ENHANCER COMPOUNDS FOR TREATMENT OF TYPE-II DIABETES
Heterocycles
ROLE OF PLASMA-INSULIN CONCENTRATION IN REGULATING GLUCOSE AND LIPID-METABOLISM IN LEAN AND OBESE ZUCKER RATS
International journal of obesity
PIOGLITAZONE (AD-4833) AMELIORATES INSULIN-RESISTANCE IN PATIENTS WITH NIDDM
Tohoku Journal of Experimental Medicine
PIOGLITAZONE - IN-VITRO EFFECTS ON RAT HEPATOMA-CELLS AND IN-VIVO LIVER HYPERTROPHY IN KKA(Y) MICE
Pharmacology
THE INSULIN SENSITIZER, BRL-49653, REDUCES SYSTEMIC FATTY-ACID SUPPLYAND UTILIZATION AND TISSUE LIPID AVAILABILITY IN THE RAT
Metabolism, clinical and experimental
KB-R7785, A NOVEL MATRIX METALLOPROTEINASE INHIBITOR, EXERTS ITS ANTIDIABETIC EFFECT BY INHIBITING TUMOR-NECROSIS-FACTOR-ALPHA PRODUCTION
Life sciences
REDUCTION OF INSULIN-RESISTANCE ATTENUATES THE DEVELOPMENT OF HYPERTENSION IN SUCROSE-FED SHR
Life sciences
COORDINATE REGULATION OF THE EXPRESSION OF THE FATTY-ACID TRANSPORT PROTEIN AND ACYL-COA SYNTHETASE GENES BY PPAR-ALPHA AND PPAR-GAMMA ACTIVATORS
The Journal of biological chemistry
EFFECT OF AN INSULIN SENSITIZER, PIOGLITAZONE, ON HYPERTENSION IN FRUCTOSE-DRINKING RATS
Japanese Journal of Pharmacology
PIOGLITAZONE REDUCES SMOOTH-MUSCLE CELL-DENSITY OF RAT CAROTID ARTERIAL INTIMA INDUCED BY BALLOON CATHETERIZATION
Hormone and Metabolic Research
TROGLITAZONE INHIBITS ANGIOTENSIN-II-INDUCED DNA-SYNTHESIS AND MIGRATION IN VASCULAR SMOOTH-MUSCLE CELLS
FEBS letters