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Transient up-regulation of liver mitochondrial thymidine kinase activity in proliferating mitochondria
IUBMB LIFE
Peroxisome proliferators: Their biological and toxicological effects
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
The expression of PPAR-associated genes is modulated through postnatal development of PPAR subtypes in the small intestine
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Chlorophyll-derived fatty acids regulate expression of lipid metabolizing enzymes in liver - a nutritional opportunity
OCL-OLEAGINEUX CORPS GRAS LIPIDES
Reactivation of liver-specific gene expression in an immortalized human hepatocyte cell line by introduction of the human HNF4 alpha 2 gene
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats
TOXICOLOGICAL SCIENCES
Expression pattern of fatty acid-binding proteins in human normal and cancer prostate cells and tissues
CLINICAL CANCER RESEARCH
Peroxisome proliferators and fatty acids negatively regulate liver X receptor-mediated activity and sterol biosynthesis
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Unravelling the significance of cellular fatty acid-binding proteins
CURRENT OPINION IN LIPIDOLOGY
Fibrate treatment can increase serum creatinine levels
NEPHROLOGY DIALYSIS TRANSPLANTATION
PPAR delta agonists stimulate oligodendrocyte differentiation in tissue culture
GLIA
Temporal gene expression analysis of monolayer cultured rat hepatocytes
CHEMICAL RESEARCH IN TOXICOLOGY
Five-lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions
FASEB JOURNAL
Mechanism of clofibrate hepatotoxicity: Mitochondrial damage and oxidativestress in hepatocytes
FREE RADICAL BIOLOGY AND MEDICINE
Comparative study of the leachability of di(2-ethylhexyl) phthalate and tri(2-ethylhexyl) trimellitate from haemodialysis tubing
INTERNATIONAL JOURNAL OF PHARMACEUTICS
The transcription of the peroxisome proliferator- activated receptor a gene is regulated by protein kinase C
TOXICOLOGY LETTERS
Effects on male rats of di-(2-ethylhexyl) phthalate and di-n-hexylphthalate administered alone or in combination
TOXICOLOGY LETTERS
The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis
TOXICOLOGY LETTERS
Differential induction of peroxisomal beta-oxidation enzymes by clofibric acid and aspirin in piglet tissues
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
Mouse hepatocyte response to peroxisome proliferators: dependency on hepatic nonparenchymal cells and peroxisome proliferator activated receptor alpha (PPAR alpha)
ARCHIVES OF TOXICOLOGY
Expression of liver fatty acid binding protein alters growth and differentiation of embryonic stem cells
MOLECULAR AND CELLULAR BIOCHEMISTRY
Induction of sister chromatid exchanges by 2,4-dichlorophenoxyacetic acid in somatic and germ cells of mice exposed in vivo
FOOD AND CHEMICAL TOXICOLOGY
Health risks posed by use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: A critical review
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
COMPACT: a structural approach to the modelling of cytochromes P450 and their interactions with xenobiotics
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
Phenobarbital, oxazepam and Wyeth 14,643 cause DNA damage as measured by the Comet assay
MUTAGENESIS
A potent PPAR alpha agonist stimulates mitochondrial fatty acid beta-oxidation in liver and skeletal muscle
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Proteome analysis of rat hepatomas: Carcinogen-dependent tumor-associated protein variants
ELECTROPHORESIS
The roles of PPARs in adipocyte differentiation
PROGRESS IN LIPID RESEARCH
Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells
CARCINOGENESIS
Transcription and replication of a natural hepatitis B virus nucleocapsid promoter variant is regulated in vivo by peroxisome proliferators
VIROLOGY
Activation of the activator protein-1 by the peroxisome proliferator clofibric acid in rat H4IIEC3 hepatoma cells
TOXICOLOGY AND APPLIED PHARMACOLOGY
Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells
TOXICOLOGY AND APPLIED PHARMACOLOGY
Effects of peroxisome proliferators on glutathione and glutathione-relatedenzymes in rats and hamsters
TOXICOLOGY AND APPLIED PHARMACOLOGY
Major clofibrate effects on liver and plasma lipids are independent of changes in polyunsaturated fatty acid composition induced by dietary fat
LIPIDS
Differential effects of non-genotoxic carcinogens and proliferating agentson cell growth, survival and apoptosis in hepatic cells in vitro
LIFE SCIENCES
Cerebral protein kinase C and its mRNA level in apolipoprotein E-deficientmice
LIFE SCIENCES
Stimulatory effect of clofibrate and gemfibrozil administration on the formation of fatty acid esters of estradiol by rat liver microsomes
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Modulation of cytosolic phospholipase A(2) by PPAR activators in human preadipocytes
JOURNAL OF LIPID RESEARCH
PPAR alpha deficiency increases secretion and serum levels of apolipoprotein B-containing lipoproteins
JOURNAL OF LIPID RESEARCH
Effect of sesame seeds rich in sesamin and sesamolin on fatty acid oxidation in rat liver
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats
FEBS LETTERS
Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells
EXPERIMENTAL CELL RESEARCH
Expression and localization of PPARs in the rat ovary during follicular development and the periovulatory period
ENDOCRINOLOGY
Metabolic alterations by clofibric acid in the formation of molecular species of phosphatidylcholine in rat liver
BIOCHEMICAL PHARMACOLOGY
Comparison of the mutant frequencies and mutation spectra of three non-genotoxic carcinogens, oxazepam, phenobarbital, and Wyeth 14,643, at the lambda cII locus in Big Blue (R) transgenic mice
BIOCHEMICAL PHARMACOLOGY
Induction of hepatic cytosolic fatty acid binding protein with clofibrate accelerates both membrane and cytoplasmic transport of palmitate
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Comparative effects of perilla and fish oils on the activity and gene expression of fatty acid oxidation enzymes in rat liver
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Central role of PPAR alpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
The genetic toxicity of the peroxisome proliferator class of rodent hepatocarcinogen
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Species differences in peroxisome proliferation; mechanisms and relevance
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Dioctyl phthalate increases the percentage of unsaturated fatty acids witha concomitant decrease in cellular heat shock sensitivity in the yeast Saccharomyces cerevisiae
MICROBIOLOGY-UK
Nafenopin causes protein kinase c-mediated serine phosphorylation and lossof function of connexin 32 protein in rat hepatocytes without aberrant expression or localization
TOXICOLOGICAL SCIENCES
Genomics and proteomics - The new millennium of drug discovery and development
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
PPAR delta functions as a prostacyclin receptor in blastocyst implantation
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Peroxisome proliferators induce apoptosis and decrease DNA synthesis in hepatoma cell lines
HUMAN & EXPERIMENTAL TOXICOLOGY
Epigenetic mechanisms of chemical carcinogenesis
HUMAN & EXPERIMENTAL TOXICOLOGY
Fibrate-induced increase in blood urea and creatinine: is gemfibrozil the only innocuous agent?
NEPHROLOGY DIALYSIS TRANSPLANTATION
Regulation of ubiquinone metabolism
FREE RADICAL BIOLOGY AND MEDICINE
Morphological transformation and effect on gap junction intercellular communication in Syrian hamster embryo cells as screening tests for carcinogensdevoid of mutagenic activity
TOXICOLOGY IN VITRO
Apoptosis and proliferation in nongenotoxic carcinogenesis: species differences and role of PPAR alpha
TOXICOLOGY LETTERS
Ciprofibrate and triiodothyronine do not suppress in vivo induction of placental glutathione S-transferase expression in rat hepatocytes
CANCER LETTERS
Oxidative DNA damage: Endogenous and chemically induced
REGULATORY TOXICOLOGY AND PHARMACOLOGY
The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor alpha-mediated rat hepatocyte survival and apoptosis
HEPATOLOGY
The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR
MOLECULAR AND CELLULAR BIOLOGY
Nongenotoxic (epigenetic) carcinogens: Pesticides as an example. A critical review
TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS
Fatty acid cycling in the fasting rat
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
The nongenotoxic hepatocarcinogens diethylhexylphthalate and methylclofenapate induce DNA synthesis preferentially in octoploid rat hepatocytes
TOXICOLOGIC PATHOLOGY
Proteomics: Applications and opportunities in preclinical drug development
ELECTROPHORESIS
Two-dimensional electrophoresis of liver proteins: Characterization of a drug-induced hepatomegaly in rats
ELECTROPHORESIS
Mouse liver selenium-binding protein decreased in abundance by peroxisome proliferators
ELECTROPHORESIS
Effects of clofibrate and indocyanine green on the hepatobiliary disposition of acetaminophen and its metabolites in male CD-1 mice
XENOBIOTICA
A plasticizer released from IV drip chambers elevates calcium levels in neurosecretory terminals
TOXICOLOGY AND APPLIED PHARMACOLOGY
NMR spectroscopic analyses of liver phosphatidylcholine and phosphatidylethanolamine biosynthesis in rats exposed to peroxisome proliferators - A class of nongenotoxic hepatocarcinogens
TOXICOLOGY AND APPLIED PHARMACOLOGY
Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
Molecular nutrition: regulation of lipid metabolism by peroxisome proliferator activated receptors (PPAR). Their relatioship to obesity and diabetes mellitus
REVISTA MEDICA DE CHILE
Ligand-dependent interaction of hepatic fatty acid-binding protein with the nucleus
JOURNAL OF LIPID RESEARCH
Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts
JOURNAL OF LIPID RESEARCH
Prostaglandin E-2 regulation of cyclooxygenase expression in keratinocytesis mediated via cyclic nucleotide-linked prostaglandin receptors
JOURNAL OF LIPID RESEARCH
Molecular scanning of the human PPAR alpha gene: association of the L162V mutation with hyperapobetalipoproteinemia
JOURNAL OF LIPID RESEARCH
Evidence against the peroxisome proliferator-activated receptor alpha (PPAR alpha) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription
JOURNAL OF LIPID RESEARCH
Peroxisome proliferator-activated receptor alpha (PPAR alpha) and agonist inhibit cholesterol 7 alpha-hydroxylase gene (CYP7A1) transcription
JOURNAL OF LIPID RESEARCH
Stimulation of PPAR alpha promotes epidermal keratinocyte differentiation in vivo
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Keratinocyte differentiation in hyperproliferative epidermis: Topical application of PPAR alpha activators restores tissue homeostasis
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1 alpha (HNF1 alpha) - Alterations in fatty acid homeostasis in HNF1 alpha-deficient mice
JOURNAL OF BIOLOGICAL CHEMISTRY
GRAS flavoring substances 19
FOOD TECHNOLOGY
New molecular aspects of regulation of mitochondrial activity by fenofibrate and fasting
FEBS LETTERS
Lead stimulates intercellular signalling between hepatocytes and Kupffer cells
EUROPEAN JOURNAL OF PHARMACOLOGY
Effects of peroxisome proliferators on the thymus and spleen of mice
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Cell proliferation induced by triiodothyronine in rat liver is associated with nodule regression and reduction of hepatocellular carcinomas
CANCER RESEARCH
High-fat diets affect the expression of nuclear retinoic acid receptor in rat liver
BRITISH JOURNAL OF NUTRITION
Polyunsaturated fatty acid regulation of gene transcription: a mechanism to improve energy balance and insulin resistance
BRITISH JOURNAL OF NUTRITION
Activation of nuclear factor-kappa B by the peroxisome proliferator ciprofibrate in H4IIEC3 rat hepatoma cells and its inhibition by the antioxidantsN-acetylcysteine and vitamin E
BIOCHEMICAL PHARMACOLOGY
Less extrahepatic induction of fatty acid beta-oxidation enzymes by PPAR alpha
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
PPAR alpha-dependent alteration of GRP94 expression in mouse hepatocytes
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Genetic control of carbon utilization during hibernation: Mechanistic considerations
LIFE IN THE COLD
Hepatocarcinogenicity in the male B6C3F(1) mouse following a lifetime exposure to dichloroacetic acid in the drinking water: Dose-response determination and modes of action
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
The PPAR activator docosahexaenoic acid prevents acetaminophen hepatotoxicity in male CD-1 mice
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
Microsomal long-chain acyl-CoA thioesterase (carboxylesterase ES-4) is regulated by thyroxine
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS