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La ricerca find articoli where soggetti phrase all words 'opioid peptides' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 805 riferimenti
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    1. Deschamps, JR; Flippen-Anderson, JL; George, C
      2-[N-(tert-butoxycarbonyl)tyrosyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid nitromethane solvate

      ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE
    2. Jeric, I; Novak, P; Vinkovic, M; Horvat, S
      Conformational analysis of sugar-peptide adducts in the solution state by NMR spectroscopy and molecular modelling

      JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
    3. Jeric, I; Horvat, S
      Novel ester-linked carbohydrate-peptide adducts: Effect of the peptide substituent on the pathways of intramolecular reactions

      EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
    4. Liao, S; Shenderovich, M; Kover, KE; Zhang, Z; Hosohata, K; Davis, P; Porreca, F; Yamamura, HI; Hruby, VJ
      Synthesis, biology, NMR and conformation studies of the topographically constrained delta-opioid selective peptide analogs of [beta-iPrPhe(3)]deltorphin I

      JOURNAL OF PEPTIDE RESEARCH
    5. Hettiarachchi, K; Ridge, S; Thomas, DW; Olson, L; Obi, CR; Singh, D
      Characterization and analysis of biphalin: an opioid peptide with a palindromic sequence

      JOURNAL OF PEPTIDE RESEARCH
    6. Kovacs, KA; Oszter, A; Gocze, PM; Kornyei, JL; Szabo, I
      Comparative analysis of cyclin D1 and oestrogen receptor (alpha and beta) levels in human leiomyoma and adjacent myometrium

      MOLECULAR HUMAN REPRODUCTION
    7. Gianoulakis, C
      Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism

      JOURNAL OF PSYCHIATRY & NEUROSCIENCE
    8. Karakaya, D; Buyukgoz, F; Baris, S; Guldogus, F; Tur, A
      Addition of fentanyl to bupivacaine prolongs anesthesia and analgesia in axillary brachial plexus block

      REGIONAL ANESTHESIA AND PAIN MEDICINE
    9. Pawlak, D; Oleszczuk, M; Wojcik, J; Pachulska, M; Chung, NN; Schiller, PW; Izdebski, J
      Highly potent side-chain to side-chain cyclized enkephalin analogues containing a carbonyl bridge: Synthesis, biology and conformation

      JOURNAL OF PEPTIDE SCIENCE
    10. Navolotskaya, EV; Malkova, NV; Lepikhova, TN; Krasnova, SB; Zargarova, TA; Zav'yalov, VP; Lipkin, VM
      The interaction of synthetic decapeptide SLTCLVKGFY with human T lymphocytes

      RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
    11. Sasaki, Y; Hirabuki, M; Ambo, A; Ouchi, H; Yamamoto, Y
      Enkephalin analogues with 2 ',6 '-dimethylphenylalanine replacing phenylalanine in position 4

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    12. Martinez-Guisasola, J; Guerrero, M; Alonso, F; Diaz, F; Cordero, J; Ferrer, J
      Plasma beta-endorphin levels in obese and non-obese patients with polycystic ovary disease

      GYNECOLOGICAL ENDOCRINOLOGY
    13. Misztal, T; Romanowicz, K; Barcikowski, B
      Short-term modulation of prolactin secretion by melatonin in anestrous ewes following dopamine- and opiate receptor blockade

      EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
    14. Cano-Martinez, A; Villalobos-Molina, R; Rocha, L
      Effects of chronic morphine and N-6-cyclopentyl-adenosine administration on kainic acid-induced status epilepticus

      EPILEPSY RESEARCH
    15. Froidevaux, R; Nedjar-Arroume, N; Choisnard, L; Bigan, M; Guillochon, D
      Using an experimental design for the optimization of LVV-haemorphin-7 and VV-haemorphin-7 extraction by an organic solvent mixture in the course of bovine haemoglobin peptic hydrolysis

      BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
    16. Tomboly, C; Dixit, R; Lengyel, I; Borsodi, A; Toth, G
      Preparation of specifically tritiated endomorphins

      JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
    17. Narita, M; Ozaki, S; Ioka, M; Mizoguchi, H; Nagase, H; Tseng, LF; Suzuki, T
      Different motivational effects induced by the endogenous mu-opioid receptor ligands endomorphin-1 and-2 in the mouse

      NEUROSCIENCE
    18. Coccia, R; Foppoli, C; Blarzino, C; De Marco, C; Rosei, MA
      Interaction of enkephalin derivatives with reactive oxygen species

      BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
    19. Komjati, K; Greenberg, JH; Reivich, M; Sandor, P
      Interactions between the endothelium-derived relaxing factor/nitric oxide system and the endogenous opiate system in the modulation of cerebral and spinal vascular CO2 responsiveness

      JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
    20. Kaminski, T; Okrasa, S; Bogacka, I; Siawrys, G; Przala, J
      Porcine theca cells produce immunoreactive beta-endorphin and change steroidogenesis in response to opioid agonist

      ACTA VETERINARIA HUNGARICA
    21. Rosei, MA
      Opiomelanins synthesis and properties

      HISTOLOGY AND HISTOPATHOLOGY
    22. Krondahl, E; von Euler-Chelpin, H; Orzechowski, A; Ekstrom, G; Lennernas, H
      In vitro metabolism of opioid tetrapeptide agonists in various tissues andsubcellular fractions from rats

      PEPTIDES
    23. Bickel, U; Yoshikawa, T; Pardridge, WM
      Delivery of peptides and proteins through the blood-brain barrier

      ADVANCED DRUG DELIVERY REVIEWS
    24. Makarenkova, VP; Esche, C; Kost, NV; Shurin, GV; Rabin, BS; Zozulya, AA; Shurin, MR
      Identification of delta- and mu-type opioid receptors on human and murine dendritic cells

      JOURNAL OF NEUROIMMUNOLOGY
    25. Schultz, JE; Gross, GJ
      Opioids and cardioprotection

      PHARMACOLOGY & THERAPEUTICS
    26. Lorinczy, D; Vertes, Z; Belagyi, J
      The effect of nucleotides (ADP and ADP+V-i) on the thermal stability of rat uterus

      THERMOCHIMICA ACTA
    27. Zhang, Y; Wu, YX; Hao, YB; Dun, Y; Yang, SP
      Role of endogenous opioid peptides in protection of ischemic preconditioning in rat small intestine

      LIFE SCIENCES
    28. Lipkowski, AW; Misicka, A; Hosohata, K; Davis, P; Yamamura, HI; Porreca, F; Hruby, VJ
      Biological properties of Phe(o)-opioid peptide analogues

      LIFE SCIENCES
    29. Ackermann, PW; Spetea, M; Nylander, I; Ploj, K; Ahmed, M; Kreicbergs, A
      An opioid system in connective tissue: A study of Achilles tendon in the rat

      JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
    30. Coventry, TL; Jessop, DS; Finn, DP; Crabb, MD; Kinoshita, H; Harbuz, MS
      Endomorphins and activation of the hypothalamo-pituitary-adrenal axis

      JOURNAL OF ENDOCRINOLOGY
    31. Sciorsci, RL; Dell'Aquila, ME; Minoia, P
      Effects of naloxone on calcium turnover in cows affected by milk fever

      JOURNAL OF DAIRY SCIENCE
    32. Messer, LA; Cargill, EJ; Pomp, D
      Rapid communication: Mapping of the pro-opiomelanocortin (POMC) gene to pig chromosome by linkage analysis using a PCR-RFLP

      JOURNAL OF ANIMAL SCIENCE
    33. Hille, CJ; Fox, SH; Maneuf, YP; Crossman, AR; Brotchie, JM
      Antiparkinsonian action of a delta opioid agonist in rodent and primate models of Parkinson's disease

      EXPERIMENTAL NEUROLOGY
    34. Henry, B; Fox, SH; Crossman, AR; Brotchie, JM
      mu- and delta-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease

      EXPERIMENTAL NEUROLOGY
    35. Homayoun, H; Khavandgar, S; Zarrindast, MR
      Effects of adenosine receptor agonists and antagonists on pentylenetetrazole-induced amnesia

      EUROPEAN JOURNAL OF PHARMACOLOGY
    36. Kornyei, JL; Oszter, A; Kovacs, KA; Vertes, Z; Komlosi, KM; Gocze, PM; Vertes, M
      Anti-mitogenic action of opioid peptides on epidermal growth factor-stimulated uterine cells

      EUROPEAN JOURNAL OF PHARMACOLOGY
    37. Adam, F; Le Bars, D; Chauvin, M; Guirimand, F
      Effects of intravenous and intrathecal sufentanil on a C-fibre reflex elicited by a wide range of stimulus intensities in the rat

      EUROPEAN JOURNAL OF PHARMACOLOGY
    38. Bergasa, NV; Mehlman, JK; Jones, EA
      Pruritus and fatigue in primary biliary cirrhosis

      BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
    39. McFadyen, IJ; Ho, JC; Mosberg, HI; Traynor, JR
      Modifications of the cyclic mu receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]NH2 (Et): effects on opioid receptor binding and activation

      JOURNAL OF PEPTIDE RESEARCH
    40. Vass, E; Hollosi, M; Kveder, M; Kojic-Prodic, B; Cudic, M; Horvat, S
      Spectroscopic evidence of beta-turn in N-glycated peptidomimetics related to leucine-enkephalin

      SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
    41. Kim, TG; Choung, JJ; Wallace, RJ; Chamberlain, DG
      Effects of intra-abomasal infusion of beta-casomorphins on circulating concentrations of hyperglycaemic insulin and glucose in dairy cows

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
    42. Watanuki, H; Gushiken, Y; Takahashi, A; Yasuda, A; Sakai, M
      In vitro modulation of fish phagocytic cells by beta-endorphin

      FISH & SHELLFISH IMMUNOLOGY
    43. Kimmel, PL; Peterson, RA; Weihs, KL; Shidler, N; Simmens, SJ; Alleyne, S; Cruz, I; Yanovski, JA; Veis, JH; Phillips, TM
      Dyadic relationship conflict, gender, and mortality in urban hemodialysis patients

      JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
    44. Cahill, FJ; Ellenberger, EA; Mueller, JL; Tseng, LF; Quock, RM
      Antagonism of nitrous oxide antinociception in mice by intrathecally administered antisera to endogenous opioid peptides

      JOURNAL OF BIOMEDICAL SCIENCE
    45. Narita, M; Mizoguchi, H; Narita, M; Dun, NJ; Hwang, BH; Endoh, T; Suzuki, T; Nagase, H; Suzuki, T; Tseng, LF
      G protein activation by endomorphins in the mouse periaqueductal gray matter

      JOURNAL OF BIOMEDICAL SCIENCE
    46. Oszter, A; Vertes, Z; Torocsik, B; Kornyei, JL; Kovacs, KA; Vertes, M
      Antiestrogenic effect of opioid peptides in rat uterus

      JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
    47. Andrianov, GN; Ryzhova, IV
      Effects of dalargin on excitation induced by L-glutamate agonists in the frog vestibular organs

      NEUROREPORT
    48. Kriss, CT; Lou, BS; Szabo, LZ; Mitchell, SA; Hruby, VJ; Polt, R
      Enkephalin-based drug design: conformational analysis of O-linked glycopeptides by NMR and molecular modeling

      TETRAHEDRON-ASYMMETRY
    49. Monory, K; Bourin, MC; Spetea, M; Tomboly, C; Toth, G; Matthes, HW; Kieffer, BL; Hanoune, J; Borsodi, A
      Specific activation of the mu opioid receptor (MOR) by endomorphin 1 and endomorphin 2

      EUROPEAN JOURNAL OF NEUROSCIENCE
    50. Kaminski, T; Siawrys, G; Bogacka, I; Przala, J
      The physiological role of beta-endorphin in porcine ovarian follicles

      REPRODUCTION NUTRITION DEVELOPMENT
    51. de Carvalho, LAV; de Azevedo, LO
      A model for the cellular mechanisms of morphine tolerance and dependence

      MATHEMATICAL AND COMPUTER MODELLING
    52. Yadid, G; Zangen, A; Herzberg, U; Nakash, R; Sagen, J
      Alterations in endogenous brain beta-endorphin release by adrenal medullary transplants in the spinal cord

      NEUROPSYCHOPHARMACOLOGY
    53. Kang, W; Wilson, SP; Wilson, MA
      Overexpression of proenkephalin in the amygdala potentiates the anxiolyticeffects of benzodiazepines

      NEUROPSYCHOPHARMACOLOGY
    54. Symons, FJ; Davis, ML; Thompson, T
      Self-injurious behavior and sleep disturbance in adults with developmentaldisabilities

      RESEARCH IN DEVELOPMENTAL DISABILITIES
    55. Pierce, TL; Wessendorf, MW
      Immunocytochemical mapping of endomorphin-2-immunoreactivity in rat brain

      JOURNAL OF CHEMICAL NEUROANATOMY
    56. Park, M; Tokunaga, Y; Kimura, H; Tooyama, I; Maeda, T; Renda, TG
      Ontogeny of (D-Ala(2))-deltorphin I-like immunoreactive neurones in foetalrat brain

      JOURNAL OF CHEMICAL NEUROANATOMY
    57. Gouarderes, C; Roumy, M; Advokat, C; Jhamandas, K; Zajac, JM
      Dual localization of neuropeptide FF receptors in the rat dorsal horn

      SYNAPSE
    58. Vercaigne-Marko, D; Kosciarz, E; Nedjar-Arroume, N; Guillochon, D
      Improvement of Staphylococcus aureus-V8-protease hydrolysis of bovine haemoglobin by its adsorption on to a solid phase in the presence of SDS: peptide mapping and obtention of two haemopoietic peptides

      BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
    59. Kaminski, T; Gawronska, B; Derecka, K; Okrasa, S; Przala, J
      Gene expression and peptide localization for LH/hCG receptor in porcine small and large luteal cells: Possible regulation by opioid peptides

      JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
    60. Jonsdottir, IH
      Neuropeptides and their interaction with exercise and immune function

      IMMUNOLOGY AND CELL BIOLOGY
    61. Nakao, K; Itoh, H; Takaya, K
      Current topics in pheochromocytoma

      BIOMEDICINE & PHARMACOTHERAPY
    62. Jackson, GL; Kuehl, DE
      Interactions of photoperiod, testosterone, and naloxone on GnRH and LH pulse parameters in the male sheep

      DOMESTIC ANIMAL ENDOCRINOLOGY
    63. Vertes, Z; Sandor, A; Kovacs, KA; Oszter, A; Kornyei, JL; Kovacs, S; Vertes, M
      Epidermal growth factor influenced by opioid peptides in immature rat uterus

      JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
    64. Karuri, AR; Ayres, S; Kumar, MSA
      Regional distribution of gonadotropin-releasing hormone-like, beta-endorphin-like, and methionine-enkephalin-like immunoreactivities in the central nervous system of the goat

      BRAIN RESEARCH BULLETIN
    65. Myojin, T; Kitamura, N; Hondo, E; Baltazar, ET; Pearson, GT; Yamada, J
      Immunohistochemical localization of neuropeptides in bovine pancreas

      Anatomia, histologia, embryologia
    66. Harbach, H; Hell, K; Gramsch, C; Katz, N; Hempelmann, G; Teschemacher, H
      beta-endorphin (1-31) in the plasma of male volunteers undergoing physicalexercise

      PSYCHONEUROENDOCRINOLOGY
    67. Sternini, C; Brecha, NC; Minnis, J; D'Agostino, G; Balestra, B; Fiori, E; Tonini, M
      Role of agonist-dependent receptor internalization in the regulation of muopioid receptors

      NEUROSCIENCE
    68. Wang, D; Lundeberg, T; Yu, LC
      Antinociceptive role of galanin in periaqueductal grey of rats with experimentally induced mononeuropathy

      NEUROSCIENCE
    69. Mizoguchi, H; Narita, M; Wu, HE; Narita, M; Suzuki, T; Nagase, H; Tseng, LF
      Differential involvement of mu(1)-opioid receptors in endomorphin- and beta-endorphin-induced G-protein activation in the mouse pons/medulla

      NEUROSCIENCE
    70. Machelska, H; Stein, C
      Pain control by immune-derived opioids

      CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
    71. Von Agoston, D; Dobi, A
      Complexity of transcriptional control in neuropeptide gene expression; enkephalin gene regulation during neurodevelopment

      BIOCHEMICAL SOCIETY TRANSACTIONS
    72. Rialas, CM; Weeks, B; Cadet, P; Goumon, Y; Stefano, GB
      Nociceptin, endomorphin-1 and-2 do not interact with invertebrate immune and neural mu(3) opiate receptor

      ACTA PHARMACOLOGICA SINICA
    73. Taguchi, K; Abe, K; Chyuma, T; Kato, M; Shigenaga, T; Kushida, K; Chikuma, T
      Effects of microiontophoretically-applied opioid peptides on Purkinje cells in the cat cerebellum

      ACTA PHARMACOLOGICA SINICA
    74. Rozsa, KS
      Modulation in firing pattern and oscillation in nerve cells of Lymnaea during network reconstruction

      ACTA BIOLOGICA HUNGARICA
    75. Molnar, G; Szucs, A; Rozsa, KS
      Analysis and modulation of spike trains and oscillations in identified neural network of Lymnaea stagnalis L.

      ACTA BIOLOGICA HUNGARICA
    76. Liu, ZR; Welin, M; Bragee, B; Nyberg, F
      A high-recovery extraction procedure for quantitative analysis of substance P and opioid peptides in human cerebrospinal fluid

      PEPTIDES
    77. Schulte-Frohlinde, E; Reindl, W; Bierling, D; Lersch, C; Brantl, V; Teschemacher, H; Schusdziarra, V
      Effects of oral casokefamide on plasma levels, tolerance, and intestinal transit in man

      PEPTIDES
    78. Tooyama, I; Abe, H; Renda, TG; Kimura, H
      Production and immunohistochemical application of antiserum against Tyr-D-Ala-Phe, a N-terminal tripeptide common to dermorphin/deltorphin family

      PEPTIDES
    79. Balboni, G; Salvadori, S; Guerrini, R; Bianchi, C; Santagada, V; Calliendo, G; Bryant, SD; Lazarus, LH
      Opioid pseudopeptides containing heteroaromatic or heteroaliphatic nuclei

      PEPTIDES
    80. Marini, M; Roda, LG
      Enkephalin-degrading enzymes and their inhibitors in human saliva

      PEPTIDES
    81. Jamurtas, AZ; Goldfarb, AH; Chung, SC; Hegde, S; Marino, C
      beta-endorphin infusion during exercise in rats: blood metabolic effects

      MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
    82. Pacifici, R; di Carlo, S; Bacosi, A; Pichini, S; Zuccaro, P
      Pharmacokinetics and cytokine production in heroin and morphine-treated mice

      INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY
    83. Schulz, A; Harbach, H; Katz, N; Geiger, L; Teschemacher, H
      beta-endorphin immunoreactive material and authentic beta-endorphin in theplasma of males undergoing anaerobic exercise on a rowing ergometer

      INTERNATIONAL JOURNAL OF SPORTS MEDICINE
    84. Woods, JA
      Exercise and neuroendocrine modulation of macrophage function

      INTERNATIONAL JOURNAL OF SPORTS MEDICINE
    85. Broberger, C; Nylander, I; Geijer, T; Terenius, L; Hokfelt, T; Georgieva, J
      Differential effects of intrastriatally infused fully and endcap phosphorothioate antisense oligonucleotides on morphology, histochemistry and prodynorphin expression in rat brain

      MOLECULAR BRAIN RESEARCH
    86. Gibbins, IL; Morris, JL
      Pathway specific expression of neuropeptides and autonomic control of the vasculature

      REGULATORY PEPTIDES
    87. Mousa, SA; Machelska, H; Schafer, M; Stein, C
      Co-expression of beta-endorphin with adhesion molecules in a model of inflammatory pain

      JOURNAL OF NEUROIMMUNOLOGY
    88. Azuma, Y; Wang, PL; Shinohara, M; Ohura, K
      Immunomodulation of the neutrophil respiratory burst by endomorphins 1 and2

      IMMUNOLOGY LETTERS
    89. Loyga-Chruscinska, E; Brzezinska-Blaszczyk, E; Micera, G; Sanna, D; Kozlowski, H; Olczak, J; Zabrocki, J; Olejnik, AK
      Can the 1,5-disubstituted tetrazole ring modify the co-ordinating ability and biological activity of opiate-like peptides?

      JOURNAL OF INORGANIC BIOCHEMISTRY
    90. Tsuda, K; Tsuda, S; Nishio, I; Masuyama, Y
      Effects of beta-endorphin on norepinephrine release in hypertension

      JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
    91. Sinha, R; O'Malley, SS
      Alcohol and eating disorders: Implications for alcohol treatment and health services research

      ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
    92. Kowalski, J; Makowiecka, K; Belowski, D; Herman, ZS
      Augmenting effect of methionine-enkephalin on interleukin-6 production by cytokine-stimulated murine macrophages

      NEUROPEPTIDES
    93. Mhatre, MC; Carl, K; Garrett, KM; Holloway, FA
      Opiate delta-2-receptor antagonist naltriben does not alter discriminativestimulus effects of ethanol

      PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
    94. Branda, EM; Ramza, JT; Cahill, FJ; Tseng, LF; Quock, RM
      Role of brain dynorphin in nitrous oxide antinociception in mice

      PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
    95. Bakker, J; Baum, MJ
      Neuroendocrine regulation of GnRH release in induced ovulators

      FRONTIERS IN NEUROENDOCRINOLOGY
    96. Napolitano, LM
      Naloxone therapy in shock: The controversy continues

      CRITICAL CARE MEDICINE
    97. Hollmann, W; Struder, HK
      Brain, psyche and physical activity

      ORTHOPADE
    98. Wasmuth, HE; Kolb, H
      Cow's milk and immune-mediated diabetes

      PROCEEDINGS OF THE NUTRITION SOCIETY
    99. Priest, CA; Roberts, JL
      Estrogen and tamoxifen differentially regulate beta-endorphin and cFos expression and neuronal colocalization in the arcuate nucleus of the rat

      NEUROENDOCRINOLOGY
    100. Slugg, RM; Hayward, MD; Ronnekleiv, OK; Low, MJ; Kelly, MJ
      Effect of the mu-opioid agonist DAMGO on medial basal hypothalamic neuronsin beta-endorphin knockout mice

      NEUROENDOCRINOLOGY


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Documento generato il 24/10/20 alle ore 20:45:29