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RETMen2B-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1-/- mice
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
GFRalpha3 is expressed predominantly in nociceptive sensory neurons
EUROPEAN JOURNAL OF NEUROSCIENCE
RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons
DEVELOPMENT
GDNF and neurturin are target-derived factors essential for cranial parasympathetic neuron development
DEVELOPMENT
Expression of glial cell line-derived neurotrophic factor (GDNF) in the developing human fetal brain
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
Glial cell line-derived neurotrophic factor (GDNF) and its receptor complex are expressed in the auditory nerve of the mature rat cochlea
HEARING RESEARCH
Evidence for a ligand-specific signaling through GFR alpha-1, but not GFR alpha-2, in the absence of ret
JOURNAL OF NEUROSCIENCE RESEARCH
Cloning and characterization of the human GFRA2 locus and investigation ofthe gene in Hirschsprung disease
HUMAN GENETICS
Rat tooth pulp cells elicit neurite growth from trigeminal neurones and express mRNAs for neurotrophic factors in vitro
NEUROSCIENCE LETTERS
Transient disruption of spermatogenesis by deregulated expression of neurturin in testis
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Glial cell line-derived neurotrophic factor administration in postnatal life results in motor unit enlargement and continuous synaptic remodeling at the neuromuscular junction
JOURNAL OF NEUROSCIENCE
The 5 '-untranslated region of the mouse glial cell line-derived neurotrophic factor gene regulates expression at both the transcriptional and translational levels
MOLECULAR BRAIN RESEARCH
The RET receptor: function in development and dysfunction in congenital malformation
TRENDS IN GENETICS
GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia
JOURNAL OF COMPARATIVE NEUROLOGY
Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells
JOURNAL OF BIOLOGICAL CHEMISTRY
Functional analysis of zebrafish GDNF
DEVELOPMENTAL BIOLOGY
Glial cell line-derived neurotrophic factor (GDNF) and its receptors GFR alpha-1 and GFR alpha-2 in the human testis
MOLECULAR, CELLULAR AND DEVELOPMENTAL BIOLOGY OF REPRODUCTION
Expression analysis of RET and the GDNF/GFRa-1 and NTN/GFRa-2 ligand complexes in pheochromocytomas and paragangliomas
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
GDNF family receptors in the embryonic and postnatal rat heart and reducedcholinergic innervation in mice hearts lacking Ret or GFR alpha 2
DEVELOPMENTAL DYNAMICS
Expression and alternative splicing of mouse Gfra4 suggest roles in endocrine cell development
MOLECULAR AND CELLULAR NEUROSCIENCE
In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin
MOLECULAR AND CELLULAR NEUROSCIENCE
Glial cell line-derived neutrotrophic factor and neurturin can act as paracrine growth factors stimulating DNA synthesis of Ret-expressing spermatogonia
INTERNATIONAL JOURNAL OF ONCOLOGY
Expression of glial cell line-derived neurotrophic factor family of growthfactors in peripheral nerve injury in rats
NEUROREPORT
Differential expression of mRNAs of GDNF family in the striatum following 6-OHDA-induced lesion
NEUROREPORT
Distinct roles for GFR alpha 1 and GFR alpha 2 signalling in different cranial parasympathetic ganglia in vivo
EUROPEAN JOURNAL OF NEUROSCIENCE
Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor
ONCOGENE
A novel type of mutation in the cysteine rich domain of the RET receptor causes ligand independent activation
ONCOGENE
Depolarisation causes reciprocal changes in GFR alpha-1 and GFR alpha-2 receptor expression and shifts responsiveness to GDNF and neurturin in developing neurons
DEVELOPMENT
Development of cranial parasympathetic ganglia requires sequential actionsof GDNF and neurturin
DEVELOPMENT
Positive and negative interactions of GDNF, NTN and ART in developing sensory neuron subpopulations, and their collaboration with neurotrophins
DEVELOPMENT
Developmental regulation of GDNF response and receptor expression in the enteric nervous system
DEVELOPMENT
GFR alpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival
NEURON
Expression of RET and its ligand complexes, GDNF/GFRalpha-1 and NTN/GFRalpha-2, in medullary thyroid carcinomas
EUROPEAN JOURNAL OF ENDOCRINOLOGY
Expression of receptors for glial cell line-derived neurotrophic factor (GDNF) and neurturin in the inner blood-retinal barrier of rats
CELL STRUCTURE AND FUNCTION
Medullary carcinoma of the thyroid gland
WORLD JOURNAL OF SURGERY
Broad specificity of GDNF family receptors GFR alpha 1 and GFR alpha 2 forGDNF and NTN in neurons and transfected cells
JOURNAL OF NEUROSCIENCE RESEARCH
Expression of GFR alpha-1, GFR alpha-2 and c-Ret mRNAs in rat adrenal gland
JOURNAL OF NEUROCYTOLOGY
GFR alpha 1 is required for development of distinct subpopulations of motoneuron
JOURNAL OF NEUROSCIENCE
Glial cell line-derived neurotrophic factor and developing mammalian motoneurons: Regulation of programmed cell death among motoneuron subtypes
JOURNAL OF NEUROSCIENCE
The glial cell line-derived neurotrophic factor family receptor componentsare differentially regulated within sensory neurons after nerve injury
JOURNAL OF NEUROSCIENCE
The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease
EMBO JOURNAL
Expression of the GDNF family members and their receptors in the mature rat cochlea
MOLECULAR BRAIN RESEARCH
Neurturin is a neurotrophic factor for penile parasympathetic neurons in adult rat
JOURNAL OF NEUROBIOLOGY
Characterisation of the human GFRa-3 locus and investigation of the gene in Hirschsprung disease
JOURNAL OF MEDICAL GENETICS
Dual fluorescent in situ hybridization and immunohistochemical detection with tyramide signal amplification
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
Mammalian GFR alpha-4, a divergent member of the GFR alpha family of coreceptors for glial cell line-derived neurotrophic factor family ligands, is areceptor for the neurotrophic factor persephin
JOURNAL OF BIOLOGICAL CHEMISTRY
Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor (GDNF) family ligands and production of GFR alpha 1RET-specific agonists
JOURNAL OF BIOLOGICAL CHEMISTRY
Analysis of the domain requirement in Gas1 growth suppressing activity
FEBS LETTERS
Mammalian-cell-produced neurturin (NTN) is more potent than purified Escherichia coli-produced NTN
EXPERIMENTAL NEUROLOGY
TGF beta trophic factors differentially modulate motor axon outgrowth and protection from excitotoxicity
EXPERIMENTAL NEUROLOGY
GDNF - a stranger in the TGF-beta superfamily?
EUROPEAN JOURNAL OF BIOCHEMISTRY
GDNF and RET-gene expression in anterior pituitary-cell types
ENDOCRINOLOGY
GDNF and GFR alpha-1 are components of the axolotl pronephric duct guidance system
DEVELOPMENTAL BIOLOGY
Glial cell line-derived neurotrophic factor protects against ischemia/hypoxia-induced brain injury in neonatal rat
ACTA NEUROPATHOLOGICA
Other neurotrophic factors: Glial cell line-derived neurotrophic factor (GDNF)
MICROSCOPY RESEARCH AND TECHNIQUE
Neurturin enhances the survival of intrastriatal fetal dopaminergic transplants
NEUROREPORT
GDNF, RET and GFR alpha-1-3 mRNA expression in the developing human spinalcord and ganglia
NEUROREPORT
Evidence for increased GDNF signaling in aged sensory and motor neurons
NEUROREPORT
Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system
DEVELOPMENT
GFR alpha 3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion
NEURON
GDNF family members and their receptors: Expression and functions in two oligodendroglial cell lines representing distinct stages of oligodendroglialdevelopment
GLIA
Expression of glial cell line-derived neurotrophic factor in the brain andcerebrospinal fluid of the developing rat
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
Rat primary cultured microglia express glial cell line-derived neurotrophic factor receptors
NEUROSCIENCE LETTERS
Different mutations of the RET gene cause different human tumoral diseases
BIOCHIMIE
The intermolecular disulfide bridge of human glial cell line-derived neurotrophic factor: Its selective reduction and biological activity of the modified protein
JOURNAL OF PROTEIN CHEMISTRY
Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons
JOURNAL OF NEUROSCIENCE
Multiple actions of neurturin correlate with spatiotemporal patterns of ret expression in developing chick cranial ganglion neurons
JOURNAL OF NEUROSCIENCE
Distinct structure elements in GDNF mediate binding to GFR alpha 1 and activation of the GFR alpha 1-c-Ret receptor complex
EMBO JOURNAL
GDNF and its receptors in the regulation of the ureteric branching
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
Neurturin: An autocrine regulator of renal collecting duct development
DEVELOPMENTAL GENETICS
Localization of GDNF/neurturin receptor (c-ret, GFR alpha-1 and alpha-2) mRNAs in postnatal rat brain: differential regional and temporal expression in hippocampus, cortex and cerebellum
MOLECULAR BRAIN RESEARCH
Investigation of germline GFR alpha-1 mutations in Hirschsprung disease
JOURNAL OF MEDICAL GENETICS
High prevalence of the C634Y mutation in the RET proto-oncogene in MEN 2A families in Spain
JOURNAL OF MEDICAL GENETICS
Differential in vivo effects olf neurturin and glial cell-line-derived neurotrophic factor
EXPERIMENTAL NEUROLOGY
Implication of expression of GDNF/Ret signalling components in differentiation of bone marrow haemopoietic cells
BRITISH JOURNAL OF HAEMATOLOGY
Mutation and deletion analysis of GFR alpha-1, encoding the co-receptor for the GDNF/RET complex, in human brain tumours
BRITISH JOURNAL OF CANCER
Induction of glial cell line-derived neurotrophic factor receptor proteinsin cerebral cortex and striatum after permanent middle cerebral artery occlusion in rats
BRAIN RESEARCH
The ret-activating ligand GDNF is differentiative and not mitogenic for normal and neoplastic human chromaffin cells in vitro
ENDOCRINE PATHOLOGY
GFR-ALPHA-4 AND THE TYROSINE KINASE RET FORM A FUNCTIONAL RECEPTOR COMPLEX FOR PERSEPHIN
Current biology
NEURTURIN PROTECTS DOPAMINERGIC-NEURONS FOLLOWING MEDIAL FOREBRAIN-BUNDLE AXOTOMY
NeuroReport
Identification of mammalian GFR alpha-2 splice isoforms
NEUROREPORT
CALCIUM-DEPENDENT RET ACTIVATION BY GDNF AND NEURTURIN
Oncogene
Differential expression of the RET gene in human acute myeloid leukemia
ANNALS OF HEMATOLOGY
GFR-ALPHA-1-DEFICIENT MICE HAVE DEFICITS IN THE ENTERIC NERVOUS-SYSTEM AND KIDNEYS
Neuron (Cambridge, Mass.)
Artemin, a novel member of the GDNF ligand family, supports peripheral andcentral neurons and signals through the GFR alpha 3-RET receptor complex
NEURON
NGF BUT NOT GDNF OR NEURTURIN ENHANCE ACETYLCHOLINE TISSUE-LEVELS IN STRIATAL ORGANOTYPIC BRAIN-SLICES
International journal of developmental neuroscience
CLONING AND CHARACTERIZATION OF GLIAL-CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTOR-B - A NOVEL RECEPTOR FOR MEMBERS OF GLIAL-CELL LINE-DERIVED NEUROTROPHIC FACTOR FAMILY OF NEUROTROPHIC FACTORS
Neuroscience
Assignment of persephin (PSPN), a human neurotrophic factor, to chromosome19p13.3 by radiation hybrid mapping and somatic cell hybrid PCR
CYTOGENETICS AND CELL GENETICS
NEURTURIN EXERTS POTENT ACTIONS ON SURVIVAL AND FUNCTION OF MIDBRAIN DOPAMINERGIC-NEURONS
The Journal of neuroscience
EXPRESSION OF GDNF FAMILY RECEPTOR COMPONENTS DURING DEVELOPMENT - IMPLICATIONS IN THE MECHANISMS OF INTERACTION
The Journal of neuroscience
MOLECULAR ANALYSIS OF THE RET AND GDNF GENES IN A FAMILY WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE 2A AND HIRSCHSPRUNG-DISEASE
The Journal of clinical endocrinology and metabolism
MOLECULAR-CLONING, EXPRESSION AND TISSUE DISTRIBUTION OF GLIAL-CELL-LINE-DERIVED NEUROTROPHIC FACTOR FAMILY RECEPTOR ALPHA-3 (GFR-ALPHA-3)
European journal of biochemistry
EXPRESSION OF GLIAL-CELL LINE-DERIVED NEUROTROPHIC FACTOR AND GDNFR-ALPHA MESSENGER-RNAS IN HUMAN PERIPHERAL NEUROPATHIES
Brain research
NEURTURIN AND GLIAL-CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTOR-BETA (GDNFR-BETA), NOVEL PROTEINS RELATED TO GDNF AND GDNFR-ALPHA WITH SPECIFIC CELLULAR-PATTERNS OF EXPRESSION SUGGESTING ROLES IN THE DEVELOPING AND ADULT NERVOUS-SYSTEM AND IN PERIPHERAL ORGANS
The Journal of neuroscience