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Analysis of tauopathies with transgenic mice
TRENDS IN MOLECULAR MEDICINE
Reduced expression of amyloid precursor protein, presenilin-1 and rab3a incortical brain regions in Alzheimer's disease
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Constructional apraxia in Alzheimer's disease: Association with occipital lobe pathology and accelerated cognitive decline
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Elevated serum total and LDL cholesterol in very old patients with Alzheimer's disease
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Mild amyloid pathology in the primary visual system of nonagenarians and centenarians
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Neurotoxic traffic: Uncovering the mechanics of amyloid production in Alzheimer's disease
TRAFFIC
AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs?
BIOGERONTOLOGY
Immunohistochemical investigation of the brain of aged dogs. I. Detection of neurofibrillary tangles and of 4-hydroxynonenal protein, an oxidative damage product, in senile plaques
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
Assembly of Alzheimer's amyloid-beta fibrils and approaches for therapeutic intervention
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
Senile plaques in an aged Western lowland gorilla
EXPERIMENTAL ANIMALS
Phosphorylated map kinase (ERK1, ERK2) expression is associated with earlytau deposition in neurones and glial cells, but not with increased nuclearDNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration
BRAIN PATHOLOGY
Lysosomal membrane damage in soluble A beta-mediated cell death in Alzheimer's disease
NEUROBIOLOGY OF DISEASE
Coexpression of human cdk5 and its activator p35 with human protein tau inneurons in brain of triple transgenic mice
NEUROBIOLOGY OF DISEASE
Neurofilament-immunoreactive neurons are not selectively vulnerable in Alzheimer's disease
NEUROBIOLOGY OF DISEASE
Compartmentalized tau hyperphosphorylation and increased levels of kinasesin transgenic mice
NEUROREPORT
Diffuse neurofibrillary tangles with calcification (a form of dementia): X-ray spectrometric evidence of lead accumulation in calcified regions
NEUROREPORT
Paradoxical phosphorylation of the serine 199 on tau proteins from young individuals
NEUROREPORT
Oligodendroglial tau filament formation in transgenic mice expressing G272V tau
EUROPEAN JOURNAL OF NEUROSCIENCE
Therapeutic targets in the biology of Alzheimer's disease
CURRENT OPINION IN PSYCHIATRY
Pathologic correlates of nondemented aging, mild cognitive impairment, andearly-stage Alzheimer's disease
JOURNAL OF MOLECULAR NEUROSCIENCE
Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease
JOURNAL OF MOLECULAR NEUROSCIENCE
Lewy body pathology in Alzheimer's disease
JOURNAL OF MOLECULAR NEUROSCIENCE
Activation mechanism of brain microglia in patients with diffuse neurofibrillary tangles with calcification: A comparison with Alzheimer disease
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer's disease
JOURNAL OF CHEMICAL NEUROANATOMY
Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8)
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
Ultrastructural study of rat hippocampus after chronic administration of aluminum L-glutamate: an acceleration of the aging process
EXPERIMENTAL GERONTOLOGY
Pick's disease associated with the novel Tau gene mutation K369I
ANNALS OF NEUROLOGY
The selective vulnerability of brainstem nuclei to Alzheimer's disease
ANNALS OF NEUROLOGY
Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy
JOURNAL OF NEUROSCIENCE RESEARCH
Use of cDNA microarray in the search for molecular markers involved in theonset of Alzheimer's disease dementia
JOURNAL OF NEUROSCIENCE RESEARCH
Altered apolipoprotein D expression in the brain of patients with Alzheimer disease
JOURNAL OF NEUROSCIENCE RESEARCH
Mutated tau binds less avidly to microtubules than wildtype tau in living cells
JOURNAL OF NEUROSCIENCE RESEARCH
Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease
HISTOPATHOLOGY
Does an inhibition of the uhiquitin/26S proteasome pathway of protein degradation underlie the pathogenesis of non-familial Alzheimer's disease?
MEDICAL HYPOTHESES
Activation of mitogen-activated protein kinase cascade and phosphorylationof cytoskeletal proteins after neurone-specific activation of p21ras. II. Cytoskeletal proteins and dendritic morphology
NEUROSCIENCE
Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease
NEUROSCIENCE
Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments
NEUROSCIENCE
The relationship between alpha B-crystallin and neurofibrillary tangles inAlzheimer's disease
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
Tau-associated neuropathology in ganglion cell tumours increases with patient age but appears unrelated to ApoE genotype
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
The microtubule associated protein Tau gene and Alzheimer's disease - an association study and meta-analysis
NEUROSCIENCE LETTERS
Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain
NEUROSCIENCE LETTERS
Complement activation by neurofibrillary tangles in Alzheimer's disease
NEUROSCIENCE LETTERS
Tau, beta-amyloid and beta-amyloid precursor protein distribution in the entorhinal-hippocampal alvear and perforant pathways in the Alzheimer's brain
NEUROSCIENCE LETTERS
A beta amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice
NEUROSCIENCE LETTERS
The extended haplotype of the microtubule associated protein tau gene is not associated with Pick's disease
NEUROSCIENCE LETTERS
Mechanisms of amyloid beta protein-induced modification in ion transport systems: Implications for neurodegenerative diseases
CELLULAR AND MOLECULAR NEUROBIOLOGY
Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: Role of the intracellular adapter protein Fe65
JOURNAL OF NEUROSCIENCE
Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments
JOURNAL OF NEUROSCIENCE
Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3 beta conditional transgenic mice
EMBO JOURNAL
MRI of human entorhinal cortex: a reliable protocol for volumetric measurement
NEUROBIOLOGY OF AGING
Synaptic loss and pathological change in older adults - aging versus disease?
NEUROBIOLOGY OF AGING
Apolipoprotein E epsilon 4 positive individuals demonstrate delayed olfactory event-related potentials
NEUROBIOLOGY OF AGING
The prevalence of the neuropathological lesions of Alzheimer's disease is independent of race and gender
NEUROBIOLOGY OF AGING
Neuropathological epidemiology of cerebral aging: a study of two genetic polymorphisms
NEUROBIOLOGY OF AGING
Hyperphosphorylated protein tau is restricted to neurons devoid of perineuronal nets in the cortex of aged bison
NEUROBIOLOGY OF AGING
PHF and PHF-like fibrils - cause or consequence?
NEUROBIOLOGY OF AGING
Interleukin-1 promotion of MAPK-p38 overexpression in experimental animalsand in Alzheimer's disease: potential significance for tau protein phosphorylation
NEUROCHEMISTRY INTERNATIONAL
Viral-based gene transfer to the mammalian CNS for functional genomic studies
TRENDS IN NEUROSCIENCES
A novel fluorescent method for direct visualization of neurofibrillary pathology in Alzheimer's disease
JOURNAL OF NEUROSCIENCE METHODS
Senile plaques exert no mass lesion effect on surrounding neurons
JOURNAL OF NEUROSCIENCE METHODS
Aluminium and neuronal cell injury: inter-relationships between neurofilamentous arrays and apoptosis
JOURNAL OF INORGANIC BIOCHEMISTRY
Immunohistochemical presence of apolipoprotein D in senile plaques
JOURNAL OF HISTOTECHNOLOGY
Joint effect of the APOE gene and midlife systolic blood pressure on late-life cognitive impairment - The Honolulu-Asia aging study
STROKE
Alzheimer's disease: Genes, proteins, and therapy
PHYSIOLOGICAL REVIEWS
Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based study
NEUROLOGY
Neuropathology of Pick's disease
NEUROLOGY
Transgenic mouse models of tauopathies: Prospects for animal models of Pick's disease
NEUROLOGY
Tauopathies - a new class of neurodegenerative diseases
NERVENARZT
Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Brain t-complex polypeptide 1 (TCP-1) related to its natural substrate beta 1 tubulin is decreased in Alzheimer's disease
LIFE SCIENCES
Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain
LIFE SCIENCES
Corticobasal degeneration presenting with nonfluent primary progressive aphasia: a clinicopathological study
JOURNAL OF THE NEUROLOGICAL SCIENCES
Caspases, apoptosis, and Alzheimer disease: Causation, correlation, and confusion
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Selective deposition of mutant tau in the FTDP-17 brain affected by the P301L mutation.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Cortical synapse loss in progressive supranuclear palsy
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Substantia nigra in progressive supranuclear palsy, corticobasal degeneration, and Parkinsonism-dementia complex of Guam: Specific pathological features
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Hyperphosphorylation of RNA polymerase II and reduced neuronal RNA levels precede neurofibrillary tangles in Alzheimer disease
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Alzheimer disease therapeutics
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Clinical validity of a beta-protein deposition staging in brain aging and Alzheimer disease
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Inclusion-body myositis: Newest concepts of pathogenesis and relation to aging and Alzheimer disease
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Tau-66: evidence for a novel tau conformation in Alzheimer's disease
JOURNAL OF NEUROCHEMISTRY
Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry
JOURNAL OF NEUROCHEMISTRY
Cholesterol-dependent modulation of tau phosphorylation in cultured neurons
JOURNAL OF NEUROCHEMISTRY
Utilizing the peptidyl-prolyl cis-trans isomerase Pin1 as a probe of its phosphorylated target proteins: Examples of binding to nuclear proteins in ahuman kidney cell line and to tau in Alzheimer's diseased brain
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
A 7-kDa prion protein (PrP) fragment, an integral component of the PrP region required for infectivity, is the major amyloid protein in Gerstmann-Straussler-Scheinker disease A117V
JOURNAL OF BIOLOGICAL CHEMISTRY
Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein
JOURNAL OF BIOLOGICAL CHEMISTRY
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
JOURNAL OF BIOLOGICAL CHEMISTRY
Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice
JOURNAL OF BIOLOGICAL CHEMISTRY
Brain donation in normal aging: Procedures, motivations, and donor characteristics from the biologically resilient adults in neurological studies (BRAiNS) project
GERONTOLOGIST
Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells
FEBS LETTERS
Neurodegeneration in Niemann-Pick type C disease mice
EXPERIMENTAL BRAIN RESEARCH
Tau and A beta 42 in cerebrospinal fluid from healthy adults 21-93 years of age: Establishment of reference values
CLINICAL CHEMISTRY
Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology
BRAIN RESEARCH
Apolipoprotein E deposition and astrogliosis are associated with maturation of beta-amyloid plaques in beta APPswe transgenic mouse: Implications forthe pathogenesis of Alzheimer's disease
BRAIN RESEARCH
Metabolic activity of the human ventromedial nucleus neurons in relation to sex and ageing
BRAIN RESEARCH
alpha-Synuclein-positive structures in cases with sporadic Alzheimer's disease: morphology and its relationship to tau aggregation
BRAIN RESEARCH
Progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17 and familial tauopathies
BRAIN
A clinical and pathological study of motor neurone disease on Guam
BRAIN
In vitro assembly of tau protein: Mapping the regions involved in filamentformation
BIOCHEMISTRY
Cyclooxygenase-2 stimulates production of amyloid beta-peptide in neuroblastoma x glioma hybrid NG108-15 cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS