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Analytical approaches for traditional Chinese medicines exhibiting antineoplastic activity
JOURNAL OF CHROMATOGRAPHY B
Antitumor drugs possessing topoisomerase I inhibition: applicable separation methods
JOURNAL OF CHROMATOGRAPHY B
Quantitation of camptothecin and related compounds
JOURNAL OF CHROMATOGRAPHY B
Separation methods for camptothecin and related compounds
JOURNAL OF CHROMATOGRAPHY B
Cellular, pharmacokinetic, and pharmacodynamic aspects of response to camptothecins: can we improve it?
DRUG RESISTANCE UPDATES
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
CLINICAL CANCER RESEARCH
Why drugs fail: Of mice and men revisited
CLINICAL CANCER RESEARCH
Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts
CLINICAL CANCER RESEARCH
Phase I and pharmacological study of a new camptothecin derivative, exatecan mesylate (DX-8951f), infused over 30 minutes every three weeks
CLINICAL CANCER RESEARCH
Identification and activities of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug
BIOCONJUGATE CHEMISTRY
Chemotherapy with irinotecan (CPT-11), a topoisomerase-I inhibitor, for refractory and relapsed non-Hodgkin's lymphoma
LEUKEMIA & LYMPHOMA
Internet pharmaco-economic studies in metastatic colorectal cancer
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Metabolism and biliary excretion of the novel anticancer agent 10-hydroxycamptothecin in the isolated perfused rat liver
INTERNATIONAL JOURNAL OF ONCOLOGY
High-dose intensity oxaliplatin added to the simplified bimonthly leucovorin and 5-fluorouracil regimen as second-line therapy for metastatic colorectal cancer (FOLFOX 7)
EUROPEAN JOURNAL OF CANCER
Integrating the oral fluoropyrimidines into the management of advanced colorectal cancer
EUROPEAN JOURNAL OF CANCER
Phase I trial of weekly irinotecan combined with UFT as second-line treatment for advanced colorectal cancer
EUROPEAN JOURNAL OF CANCER
Risk factors of treatment-related death in chemotherapy and thoracic radiotherapy for lung cancer
EUROPEAN JOURNAL OF CANCER
Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo
ANTI-CANCER DRUGS
Toxicity of irinotecan (CPT-11) and hepato-renal dysfunction
ANTI-CANCER DRUGS
Active transepithelial transport of irinotecan (CPT-11) and its metabolites by human intestinal Caco-2 cells
ANTI-CANCER DRUGS
Modulation of camptothecin analogs in the treatment of cancer: a review
ANTI-CANCER DRUGS
The homocamptothecin BN 80915 is a highly potent orally active topoisomerase I poison
ANTI-CANCER DRUGS
The current status of docetaxel for advanced non-small cell lung cancer
ANTI-CANCER DRUGS
Control of irinotecan-induced diarrhea by octreotide after loperamide failure
SUPPORTIVE CARE IN CANCER
Randomized phase III trial of bleomycin, vindesine, mitomycin-C, and cisplatin (BEMP) versus cisplatin (P) in disseminated squamous-cell carcinoma ofthe uterine cervix: An EORTC Gynecological Cancer Cooperative Group study
ANNALS OF ONCOLOGY
Phase I trial of gemcitabine and CPT-11 given weekly for four weeks every six weeks
ANNALS OF ONCOLOGY
Second-line treatment with oxaliplatin plus raltitrexed in patients with advanced colorectal cancer failing fluoropyrimidine/leucovorin-based chemotherapy
ANNALS OF ONCOLOGY
A phase II trial of irinotecan (CPT-11) for unresectable biliary tree carcinoma
ANNALS OF ONCOLOGY
Safe administration of irinotecan, oxaliplatin and raltitrexed in a DPD-deficient patient with metastatic colon cancer
ANNALS OF ONCOLOGY
The role of mitomycin C in the treatment of patients with advanced colorectal cancer resistant to 5-fluorouracil-folinic acid chemotherapy
ANNALS OF ONCOLOGY
Use of the ratio of time to progression following first- and second-line therapy to document the activity of the combination of oxaliplatin with 5-fluorouracil in the treatment of colorectal carcinoma
ANNALS OF ONCOLOGY
A phase I study of sequential intravenous topotecan and etoposide in lung cancer patients
ANNALS OF ONCOLOGY
A phase II study of irinotecan with 5-fluorouracil and leucovorin in patients with previously untreated gastric adenocarcinoma
ANNALS OF ONCOLOGY
Phase I dose-finding and pharmacokinetic trial of irinotecan (CPT-11) administered every two weeks
ANNALS OF ONCOLOGY
High-performance liquid chromatographic analysis of lactone and hydroxy acid of new antitumor drug, DX-8951 (Exatecan), in mouse plasma
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Bacillus cereus brain abscesses occurring in a severely neutropenic patient: Successful treatment with antimicrobial agents, granulocyte colony-stimulating factor and surgical drainage
INTERNAL MEDICINE
CPT-11 alters the circadian rhythm of dihydropyrimidine dehydrogenase mRNAin mouse liver
JAPANESE JOURNAL OF CANCER RESEARCH
Update on chemotherapy for advanced colorectal cancer
ONCOLOGY-NEW YORK
Camptothecin schedule and timing of administration with irradiation
ONCOLOGY-NEW YORK
New drugs and combinations in the palliative treatment of colon and rectalcancer
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study
JOURNAL OF CLINICAL ONCOLOGY
Phase I and pharmacokinetic study of ecteinaseidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors
JOURNAL OF CLINICAL ONCOLOGY
Irinotecan in the treatment of colorectal cancer: Clinical overview
JOURNAL OF CLINICAL ONCOLOGY
Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large phase III study
JOURNAL OF CLINICAL ONCOLOGY
Body-surface area-based dosing does not increase accuracy of predicting cisplatin exposure
JOURNAL OF CLINICAL ONCOLOGY
Excretion into gastrointestinal tract of irinotecan lactone and carboxylate forms and their pharmacodynamics in rodents
PHARMACEUTICAL RESEARCH
New aspects in the palliative treatment of metastatic colorectal carcinoma
MEDIZINISCHE KLINIK
New therapeutic options in the chemotherapy of advanced colorectal cancer
MEDIZINISCHE KLINIK
New chemotherapies for colorectal cancer treatment
GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE
Malignant mixed mesodermal tumor of the ovary treated with a cisplatin-irinotecan combination: case report
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
Chemotherapy in colorectal cancer - Which therapy is justified in elderly patients?
ONKOLOGIE
Clinical effect of irinotecan in advanced and metastatic breast cancer patients previously treated with doxorubicin- and docetaxel-containing regimens
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
Effective pelvic symptom control using initial chemoradiation without colostomy in metastatic rectal cancer
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Limited sampling models for CPT-11, SN-38, and SN-38 glucuronide
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Therapeutic activity of the topoisomerase I inhibitor J-107088 [6-N-(1-hydroxymethyla-2-hydroxy) ethylamino-12,13-dihydro-13-(beta-D-gluco pyranosyl)5H-indolo[2,3-a]-pyrrolo[3,4-c]-carbazole-5,7(6H)-dione] against pediatric and adult central nervous system tumor xenografts
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Dose escalation study of irinotecan combined with carboplatin for advancednon-small-cell lung cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Therapeutic activity of 7-[(2-trimethylsilyl)ethyl)]-20 (S)-camptothecin against central nervous system tumor-derived xenografts in athymic mice
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Preliminary study of fortnightly irinotecan hydrochloride plus cisplatin therapy in patients with advanced gastric and colorectal cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Human plasma carboxylesterase and butyrylcholinesterase enzyme activity: correlations with SN-38 pharmacokinetics during a prolonged infusion of irinotecan
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Development, characterization and therapy of a disseminated model of childhood neuroblastoma in SCID mice
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Effect of bile acids on the uptake of irinotecan and its active metabolite, SN-38, by intestinal cells
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Response of metastatic epidermoid anal cancer to single agent irinotecan: A case report
TUMORI
Phase I clinical trial of weekly combined topotecan and irinotecan
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
Phase I-II study of irinotecan in combination with mitomycin C in patientswith advanced gastrointestinal cancer
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
Phase II study of liposomal doxorubicin in patients with advanced colorectal cancer
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
Prospective phase II trial of irinotecan, 5-fluorouracil, and leucovorin in combination as salvage therapy for advanced colorectal cancer
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
DNA topoisomerases as targets for anticancer drugs
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
High-performance liquid chromatographic assay for glucuronidation activityof 7-ethyl-10-hydroxycamptothecin (SN-38), the active metabolite of irinotecan (CPT-11), in human liver microsomes
BIOMEDICAL CHROMATOGRAPHY
Streptococcal preparation OK-432 enhances the antitumor activity of CPT-11by increasing Th1-cytokine production in mice
ANTICANCER RESEARCH
A phase II trial of 9-aminocaptothecin (9-AC) as a 120-h infusion in patients with non-small cell lung cancer
INVESTIGATIONAL NEW DRUGS
Therapeutic response to octreotide in patients with refractory CPT-11 induced diarrhea
INVESTIGATIONAL NEW DRUGS
Factors affecting the pharmacokinetics of CPT-11: The body mass index, ageand sex are independent predictors of pharmacokinetic parameters of CPT-11
INVESTIGATIONAL NEW DRUGS
A theoretical study on camptothecin-AM1 treatment
JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
Irinotecan and oxaliplatin: an overview of the novel chemotherapeutic options for the treatment of advanced colorectal cancer
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
Temozolomide in combination with other cytotoxic agents
SEMINARS IN ONCOLOGY
North Central Cancer Treatment Group-Mayo Clinic trials in colon cancer
SEMINARS IN ONCOLOGY
A new metabolite of irinotecan in which formation is mediated by human hepatic cytochrome P-450 3A4
DRUG METABOLISM AND DISPOSITION
Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin
XENOBIOTICA
Irinotecan and mitomycin C in 5-fluorouracil-refractory colorectal cancer patients - A phase I/II study of the Southern Italy Cooperative Oncology Group
ONCOLOGY
Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases
MOLECULAR PHARMACOLOGY
Hepatic extraction, metabolism, and biliary excretion of irinotecan in theisolated perfused rat liver
JOURNAL OF PHARMACEUTICAL SCIENCES
Prevention of irinotecan (CPT-11)-induced diarrhea by oral alkalization combined with control of defecation in cancer patients
INTERNATIONAL JOURNAL OF CANCER
Combination chemotherapy in patients with malignant pleural effusions fromnon-small cell lung cancer - Cisplatin, ifosfamide, and irinotecan with recombinant human granulocyte colony-stimulating factor support
CHEST
Use of a modified ornithine decarboxylase promoter to achieve efficient c-MYC- or N-MYC-regulated protein expression
CANCER RESEARCH
Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor
CANCER RESEARCH
Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase
CANCER RESEARCH
A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11
CANCER RESEARCH
Phase II study of irinotecan as first-line chemotherapy for patients with advanced colorectal carcinoma
CANCER
Irinotecan and chronomodulated infusion of 5-fluorouracil and folinic acidin the treatment of patients with advanced colorectal carcinoma - A phase I study
CANCER
A Phase II study of irinotecan in patients with advanced hepatocellular carcinoma
CANCER CYTOPATHOLOGY
A Phase II study of irinotecan in patients with advanced hepatocellular carcinoma
CANCER
Oxaliplatin in combination with non fluoropyrimidine drugs in colorectal cancer
BULLETIN DU CANCER
Comment on a published paper
BRITISH JOURNAL OF PHARMACOLOGY
Characterization of a novel mechanism accounting for the adverse cholinergic effects of the anticancer drug irinotecan
BRITISH JOURNAL OF PHARMACOLOGY
Oxaliplatin and protracted venous infusion of 5-fluorouracil in patients with advanced or relapsed 5-fluorouracil pretreated colorectal cancer
BRITISH JOURNAL OF CANCER
Liver metastases from colorectal cancer: regional intra-arterial treatmentfollowing failure of systemic chemotherapy
BRITISH JOURNAL OF CANCER
Factors predicting efficacy of oxaliplatin in combination with 5-fluorouracil (5-FU) +/- folinic acid in a compassionate-use cohort of 481 5-FU-resistant advanced colorectal cancer patients
BRITISH JOURNAL OF CANCER
Fractionated administration of irinotecan and cisplatin for treatment of non-small-cell lung cancer: a phase II study of Okayama Lung Cancer Study Group
BRITISH JOURNAL OF CANCER
5-fluorouracil modulated by leucovorin, methotrexate and mitomycin: highlyeffective, low cost chemotherapy for advanced colorectal cancer
BRITISH JOURNAL OF CANCER
Ternary combination of irinotecan, fluorouracil-folinic acid and oxaliplatin: results on human colon cancer cell lines
BRITISH JOURNAL OF CANCER