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Activation of caspases and mitochondria in FTY720-mediated apoptosis in human T cell line Jurkat
INTERNATIONAL IMMUNOPHARMACOLOGY
Orthotopic liver transplantation using low-dose tacrolimus and sirolimus
LIVER TRANSPLANTATION
mTOR inhibitors: An overview
LIVER TRANSPLANTATION
Trends in expenditures for medicare liver transplant recipients
LIVER TRANSPLANTATION
Origin and true nature of the starter unit for the rapamycin polyketide synthase
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
High trough levels of oral FK506 induced by loss of small intestine
PEDIATRIC TRANSPLANTATION
Non-adherence in pediatric transplantation: A review of the existing literature
PEDIATRIC TRANSPLANTATION
Stereoselective total synthesis of (+)-myriocin from D-mannose
CHEMICAL COMMUNICATIONS
Potassium channel modulators as anti-inflammatory agents
EXPERT OPINION ON THERAPEUTIC PATENTS
Tacrolimus monotherapy in adult cardiac transplant recipients: Intermediate-term results
JOURNAL OF HEART AND LUNG TRANSPLANTATION
Mammalian expression cloning of two human trophoblast suppressors of majorhistocompatibility complex genes
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Triptolide, a novel immunosuppressive and anti-inflammatory agent purifiedfrom a Chinese herb Tripterygium Wilfordii Hook F
LEUKEMIA & LYMPHOMA
Efficacy of SDZ RAD compared with CsA monotherapy and combined RAD/FTY720 treatment in a murine cardiac allotransplantation model
TRANSPLANT IMMUNOLOGY
Combined FTY720/cyclosporine A treatment promotes graft survival and lowers the peripheral lymphocyte count in DA to Lewis heart and skin transplantation models
TRANSPLANT IMMUNOLOGY
Prolongation of islet allograft survival in mice by combined treatment with pravastatin and low-dose cyclosporine
CELL TRANSPLANTATION
Contribution of heat shock proteins to cell protection from complement-mediated lysis
INTERNATIONAL IMMUNOLOGY
High-throughput semi-automated 96-well liquid/liquid extraction and liquidchromatography/mass spectrometric analysis of everolimus (RAD 001) and cyclosporin a (CsA) in whole blood
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Long-term outcomes of immunosuppressed renal transplant recipients with malignancies
SURGERY TODAY
Total synthesis of stevastelin B, a novel immunosuppressant
SYNLETT
Intragraft expression of p38 and activated p38 MAPK (mitogen-activated protein kinase) in rat small bowel transplantation
TRANSPLANT INTERNATIONAL
Increased tacrolimus levels during diarrhea
TRANSPLANT INTERNATIONAL
Effects of dexamethasone and FK506 on Helicobacter pylori-induced gastritis and bacterial viability in Mongolian gerbils
JOURNAL OF PHYSIOLOGY-PARIS
Effects of chronic, post-injury Cyclosporin A administration on motor and sensorimotor function following severe, experimental traumatic brain injury
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
A novel screening for inhibitors of a pleiotropic drug resistant pump, Pdr5, in Saccharomyces cerevisiae
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Pentalenolactone I and hygromycin A, immunosuppressants produced by Streptomyces filipinensis and Streptomyces hygroscopicus
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Impact of clinical pharmacy services on renal transplant patients' compliance with immuno suppressive medications
CLINICAL TRANSPLANTATION
Efficient electrostatic solvation model for protein-fragment docking
PROTEINS-STRUCTURE FUNCTION AND GENETICS
Evaluation of carboxymethylpullulan as a novel carrier for targeting immune tissues
PHARMACEUTICAL RESEARCH
Neuroimmunophilins: Novel neuroprotective and neuroregenerative targets
ANNALS OF NEUROLOGY
Clinical pharmacokinetics of sirolimus
CLINICAL PHARMACOKINETICS
Comparative clinical pharmacokinetics of tacrolimus in paediatric and adult patients
CLINICAL PHARMACOKINETICS
Tolerability profile of sodium mycophenolate (ERL080) and mycophenolate mofetil with and without cyclosporine (Neoral) in the rat
TOXICOLOGY
Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans
EMBO JOURNAL
The biological activities of the small peptide immunosuppressant
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
Role of T cells in development of chronic pancreatitis in male Wistar Bonn/Kobori rats: effects of tacrolimus
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Nonclinical and early clinical development of tacrolimus ointment for the treatment of atopic dermatitis
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Therapeutic monitoring of tacrolimus concentrations in blood: Semi-automated extraction and liquid chromatography-electrospray ionization mass spectrometry
THERAPEUTIC DRUG MONITORING
Effects of FK506 on nerve regeneration and reinnervation after graft or tube repair of long nerve gaps
MUSCLE & NERVE
A small dose of the immunosuppressive agent FK506 (tacrolimus) protects peripheral nerve from ischemic fiber degeneration
MUSCLE & NERVE
Neointima suppression in rat carotid allografts by FTY720 combined with a small fixed cyclosporine dose is related to a diminution of the peripheral lymphocyte count
TRANSPLANTATION PROCEEDINGS
FTY-720 is efficacious in monkey kidney transplantation
TRANSPLANTATION PROCEEDINGS
Pharmacokinetics of tacrolimus during the early phase after heart transplantation
TRANSPLANTATION PROCEEDINGS
FK 506 protects brain tissue in animal models of stroke
TRANSPLANTATION PROCEEDINGS
FTY 720 prevents ischemic reperfusion damage in ret kidneys
TRANSPLANTATION PROCEEDINGS
Rapamycin: Clinical results and future opportunities
TRANSPLANTATION
Fluvastatin in combination with rad significantly reduces graft vascular disease in rat cardiac allografts
TRANSPLANTATION
Combined FTY720/cyclosporine treatment promotes graft survival and lowers the peripheral lymphocyte count in a murine cardiac allotransplantation model
TRANSPLANTATION
Towards the synthesis of (+)-discodermolide
TETRAHEDRON LETTERS
Total synthesis of sphingofungin E
TETRAHEDRON LETTERS
Multimodular biocatalysts for natural product assembly
NATURWISSENSCHAFTEN
Microarrays of cells expressing defined cDNAs
NATURE
Cyclophosphamide attenuates the degenerative changes induced by CSF from patients with amyotrophic lateral sclerosis in the neonatal rat spinal cord
JOURNAL OF THE NEUROLOGICAL SCIENCES
Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40
JOURNAL OF MOLECULAR BIOLOGY
Identification of an IL-2 binding protein in the saliva of the lyme disease vector tick, Ixodes scapularis
JOURNAL OF IMMUNOLOGY
Inhibition of cell cycle progression by the novel cyclophilin ligand sanglifehrin A is mediated through the NF kappa B-dependent activation of p53
JOURNAL OF BIOLOGICAL CHEMISTRY
Heat shock and oxidative stress-induced exposure of hydrophobic protein domains as common signal in the induction of hsp68
JOURNAL OF BIOLOGICAL CHEMISTRY
Heat shock protein-chaperoned peptides but not free peptides introduced into the cytosol are presented efficiently by major histocompatibility complex I molecules
JOURNAL OF BIOLOGICAL CHEMISTRY
Identification of an inhibitor of hsc70-mediated protein translocation andATP hydrolysis
JOURNAL OF BIOLOGICAL CHEMISTRY
Characteristics of the interaction between Hsc70 and the transferrin receptor in exosomes released during reticulocyte maturation
JOURNAL OF BIOLOGICAL CHEMISTRY
Deletion of rapQNML from the rapamycin gene cluster of Streptomyces hygroscopicus gives production of the 16-O-desmethyl-27-desmethoxy analog
JOURNAL OF ANTIBIOTICS
FKBP12 associates tightly with the skeletal muscle type 1 ryanodine receptor, but not with other intracellular calcium release channels
FEBS LETTERS
Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cis-trans isomerase Pin1
FEBS LETTERS
Systemic administration of the immunophilin ligand GPI 1046 in MPTP-treated monkeys
EXPERIMENTAL NEUROLOGY
Failure of GPI compounds to display neurotrophic activity in vitro and in vivo
EUROPEAN JOURNAL OF PHARMACOLOGY
The pharmacokinetics and metabolic disposition of tacrolimus: A comparisonacross ethnic groups
CLINICAL PHARMACOLOGY & THERAPEUTICS
Induction of lymphocyte apoptosis in rat liver allograft with ongoing rejection by FTY720
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Determination of the effects of mycophenolic acid on the nucleotide pool of human peripheral blood mononuclear cells in vitro by high-performance liquid chromatography
CLINICA CHIMICA ACTA
Treatment of hippocampal neurons with cyclosporin A results in calcium overload and apoptosis which are independent on NMDA receptor activation
BRITISH JOURNAL OF PHARMACOLOGY
Sirolimus, but not the structurally related RAD (everolimus), enhances thenegative effects of cyclosporine on mitochondrial metabolism in the rat brain
BRITISH JOURNAL OF PHARMACOLOGY
FK506 ameliorates the discrimination learning impairment due to preventingthe rarefaction of white matter induced by chronic cerebral hypoperfusion in rats
BRAIN RESEARCH
Intravenously injected FK506 failed to inhibit hippocampal calcineurin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Role of FK506-binding protein 12 in development of the chick embryonic heart
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
The effects of FK506 on neurologic and histopathologic outcome after transient spinal cord ischemia induced by aortic cross-clamping in rats
ANESTHESIA AND ANALGESIA
Determination of mycophenolic acid and mycophenolate mofetil by high-performance liquid chromatography using postcolumn derivatization
ANALYTICAL CHEMISTRY
An FKBP12 binding assay based upon biotinylated FKBP12
ANALYTICAL BIOCHEMISTRY
Drug therapy for acute graft-versus-host disease prophylaxis
JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
The chemistry and biology of discodermolide
CHEMBIOCHEM
Total synthesis of the antimicrotubule agent (+)-discodermolide using boron-mediated aldol reactions of chiral ketones
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Evaluation of mitoxantrone for the treatment of multiple sclerosis
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Human T-cell Kv1.3 potassium channel blockers: new strategies for immunosuppression
EXPERT OPINION ON THERAPEUTIC PATENTS
Rotamase inhibitors for neurological diseases
EXPERT OPINION ON THERAPEUTIC PATENTS
Time-specific occurrence of alopecia in neonatal C57BL mice treated with N-methyl-N-nitrosourea and the therapeutic efficacy of tacrolimus hydrate
PATHOLOGY INTERNATIONAL
Treatment of vasculitic IgA nephropathy
JOURNAL OF NEPHROLOGY
Cardiac and vascular abnormalities in renal transplant patients: differential effects of cyclosporin and azathioprine
JOURNAL OF NEPHROLOGY
High-performance affinity beads for identifying drug receptors
NATURE BIOTECHNOLOGY
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase
CHEMISTRY & BIOLOGY
The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90
CHEMISTRY & BIOLOGY
alpha-ketoamides and alpha-ketocarbonyls: Conformational analysis and development of all-atom OPLS force field
BIOORGANIC & MEDICINAL CHEMISTRY
The peripheral lymphocyte count predicts graft survival in DA to Lewis heterotopic heart transplantation treated with FTY720 and SDZ RAD
TRANSPLANT IMMUNOLOGY
Ring-closing metathesis protocol for a diastereocontrolled preparation of the C-28-C-34 Segment of FK-506
TETRAHEDRON-ASYMMETRY
Tacrolimus in corticosteroid-resistant ulcerative colitis
JOURNAL OF GASTROENTEROLOGY
Neurotoxicity of calcineurin inhibitors: impact and clinical management
TRANSPLANT INTERNATIONAL
NMR detection of side chain-side chain hydrogen bonding interactions in C-13/N-15-labeled proteins
JOURNAL OF BIOMOLECULAR NMR
Sensitivity enhanced NMR spectroscopy by quenching scalar coupling mediated relaxation: Application to the direct observation of hydrogen bonds in C-13/N-15-labeled proteins
JOURNAL OF BIOMOLECULAR NMR
Stimulation of Schwann cell proliferation and axonal regeneration by FK 506
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
Chronic treatment with FK506 increases p70 s6 kinase activity associated with reduced nitric oxide synthase activity in rabbit hearts
CARDIOVASCULAR DRUGS AND THERAPY
Single nucleotide polymorphism to disclose severe side-effects or proper dosage for each patient
INTERNAL MEDICINE
A positive screening for drugs that specifically inhibit the Ca2+ - Signaling activity on the basis of the growth promoting effect on a yeast mutant with a peculiar phenotype
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Targeted neutralization of calcineurin, by expression of an inhibitor peptide under the control of a cholinergic specific promoter in PC12 cells, promotes neurite outgrowth in the presence of NGF
METABOLIC BRAIN DISEASE