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1. Rodis, NP; Digenis, GA
   Synthesis and in-vitro evaluation of novel low molecular weight thiocarbamates as inhibitors of human leukocyte elastase
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2. Vicentini, CB; Guarneri, M; Andrisano, V; Guccione, S; Langer, T; Marschhofer, R; Chabin, R; Edison, AM; Huang, X; Knight, WB; Giori, P
   Potential of pyrazolooxadiazinone derivatives as serine protease inhibitors
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3. Walker, B; Lynas, JF
   Strategies for the inhibition of serine proteases
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4. Beardsell, M; Hinchliffe, PS; Wood, JM; Wilmouth, RC; Schofield, CJ; Page, MI
   beta-Sultams - A novel class of serine protease inhibitors
   CHEMICAL COMMUNICATIONS
   
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5. Lee, WL; Downey, GP
   Leukocyte elastase - Physiological functions and role in acute lung injury
   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
   
   W.L. Lee e G.P. Downey, "Leukocyte elastase - Physiological functions and role in acute lung injury", AM J R CRIT, 164(5), 2001, pp. 896-904
6. Yanagihara, K; Seki, M; Cheng, PW
   Lipopolysaccharide induces mucus cell metaplasia in mouse lung
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7. Kumar, S; Pearson, AL; Pratt, RF
   Design, synthesis, and evaluation of alpha-ketoheterocycles as class C beta-lactamase inhibitors
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8. Akahoshi, F; Ashimori, A; Yoshimura, T; Imada, T; Nakajima, M; Mitsutomi, N; Kuwahara, S; Ohtsuka, T; Fukaya, C; Miyazaki, M; Nakamura, N
   Non-peptidic inhibitors of human chymase. Synthesis, structure-activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones
   BIOORGANIC & MEDICINAL CHEMISTRY
   
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9. Tsukahara, K; Moriwaki, S; Fujimura, T; Takema, Y
   Inhibitory effect of an extract of Sanguisorba officinalis L. on Ultraviolet-B-induced photodamage of rat skin
   BIOLOGICAL & PHARMACEUTICAL BULLETIN
   
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10. Cavarra, E; Martorana, PA; Bartalesi, B; Fineschi, S; Gambelli, F; Lucattelli, M; Ortiz, L; Lungarella, G
    Genetic deficiency of alpha(1)-PI in mice influences lung responses to bleomycin
    EUROPEAN RESPIRATORY JOURNAL
    
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11. De Noncourt, P; Robledo, O; Alain, T; Kossakowska, AE; Urbanski, SJ; Potworowski, EF; St-Pierre, Y
    Leukocyte elastase in murine and human non-Hodgkin lymphomas
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12. Andreotti, R; Malavazi-Piza, KC; Sasaki, SD; Torquato, RJS; Gomes, A; Tanaka, AS
    Serine proteinase inhibitors from eggs and larvae of tick Boophilus microplus: Purification and biochemical characterization
    JOURNAL OF PROTEIN CHEMISTRY
    
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13. Gingras, D; Renaud, A; Mousseau, N; Beaulieu, E; Kachra, Z; Beliveau, R
    Matrix proteinase inhibition by AE-941, a multifunctional antiangiogenic compound
    ANTICANCER RESEARCH
    
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14. Balsamo, A; Cercignani, G; Gentili, D; Lapucci, A; Macchia, M; Orlandini, E; Rapposelli, S; Rossello, A
    Synthesis and inhibitory activity towards human leukocyte elastase of new 7 alpha-methoxy and 7 alpha-chloro (2-acyloxymethyl) cephem derivatives
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
    
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15. May, BCH; Abell, AD
    The synthesis and crystal structure of alpha-keto tetrazole-based dipeptide mimics
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16. Doris, E; Wagner, A; Mioskowski, C
    alpha-aminocyclopropanone hydrates: potential transition-state analogy inhibitors of serine proteases
    TETRAHEDRON LETTERS
    
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17. Akahoshi, F; Ashimori, A; Sakashita, H; Yoshimura, T; Imada, T; Nakajima, M; Mitsutomi, N; Kuwahara, S; Ohtsuka, T; Fukaya, C; Miyazaki, M; Nakamura, N
    Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase
    JOURNAL OF MEDICINAL CHEMISTRY
    
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18. Brill, A; Hershkoviz, R; Vaday, GG; Chowers, Y; Lider, O
    Augmentation of RANTES-induced extracellular signal-regulated kinase mediated signaling and T cell adhesion by elastase-treated fibronectin
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19. Scuri, M; Forteza, R; Lauredo, I; Sabater, JR; Botvinnikova, Y; Allegra, L; Abraham, WM
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20. Prakash, GKS; Mandal, M; Schweizer, S; Petasis, NA; Olah, GA
    A facile stereocontrolled synthesis of anti-alpha-(trifluoromethyl)-beta-amino alcohols
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21. Perrin, DM
    Nucleic acids for recognition and catalysis: Landmarks, limitations, and looking to the future
    COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
    
    D.M. Perrin, "Nucleic acids for recognition and catalysis: Landmarks, limitations, and looking to the future", COMB CHEM H, 3(3), 2000, pp. 243-269
22. Song, KS; Kim, HK; Kim, HS; Song, JW
    Plasma granulocyte elastase levels and its relation to D-dimer in liver cirrhosis
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23. Leckie, MJ; Bryan, SA; Hansel, TT; Barnes, PJ
    Novel therapy for COPD
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24. Kim, WM; Kang, K
    Enzymatic and molecular biochemical characterizations of human neutrophil elastases and a cathepsin G-like enzyme
    MOLECULES AND CELLS
    
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25. Dragovich, PS; Zhou, R; Webber, SE; Prins, TJ; Kwok, AK; Okano, K; Fuhrman, SA; Zalman, LS; Maldonado, FC; Brown, EL; Meador, JW; Patick, AK; Ford, CE; Brothers, MA; Binford, SL; Matthews, DA; Ferre, RA; Worland, ST
    Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    
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26. Hill, AT; Bayley, DL; Campbell, EJ; Hill, SL; Stockley, RA
    Airways inflammation in chronic bronchitis: the effects of smoking and alpha(1)-antitrypsin deficiency
    EUROPEAN RESPIRATORY JOURNAL
    
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27. Nikula, KJ; Green, FHY
    Animal models of chronic bronchitis and their relevance to studies of particle-induced disease
    INHALATION TOXICOLOGY
    
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28. Sethi, JM; Rochester, CL
    Smoking and chronic obstructive pulmonary disease
    CLINICS IN CHEST MEDICINE
    
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29. Felbor, U; Dreier, L; Bryant, RAR; Ploegh, HL; Olsen, BR; Mothes, W
    Secreted cathepsin L generates endostatin from collagen XVIII
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30. Lee, K; Im, JM
    A convenient procedure for oxidation of phosphorus ylides to their corresponding oxo-derivatives using m-CPBA under mild conditions
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY
    
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31. Macchia, B; Gentili, D; Macchia, M; Mamone, F; Martinelli, A; Orlandini, E; Rossello, A; Cercignani, G; Pierotti, R; Allegretti, M; Asti, C; Caselli, G
    Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
    
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32. Furlong, ST; Dutta, AS; Coath, MM; Gormley, JJ; Hubbs, SJ; Lloyd, D; Mauger, RC; Strimpler, AM; Sylvester, MA; Scott, CW; Edwards, PD
    C3 activation is inhibited by analogs of compstatin but not by serine protease inhibitors or peptidyl alpha-ketoheterocycles
    IMMUNOPHARMACOLOGY
    
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33. Hill, A; Gompertz, S; Stockley, R
    Factors influencing airway inflammation in chronic obstructive pulmonary disease
    THORAX
    
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34. Capriati, V; Florio, S; Luisi, R; Russo, V; Salomone, A
    Oxiranyllithium based synthesis of alpha-keto-2-oxazolines
    TETRAHEDRON LETTERS
    
    V. Capriati et al., "Oxiranyllithium based synthesis of alpha-keto-2-oxazolines", TETRAHEDR L, 41(45), 2000, pp. 8835-8838
35. Boger, DL; Sato, H; Lerner, AE; Hedrick, MP; Fecik, RA; Miyauchi, H; Wilkie, GD; Austin, BJ; Patricelli, MP; Cravatt, BF
    Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    
    D.L. Boger et al., "Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide", P NAS US, 97(10), 2000, pp. 5044-5049
36. Yamaguchi, Y; Ohshiro, H; Nagao, Y; Odawara, K; Okabe, K; Hidaka, H; Ishihara, K; Uchino, S; Furuhashi, T; Yamada, S; Mori, K; Ogawa, M
    Urinary trypsin inhibitor reduces C-X-C chemokine production in rat liver ischemia/reperfusion
    JOURNAL OF SURGICAL RESEARCH
    
    Y. Yamaguchi et al., "Urinary trypsin inhibitor reduces C-X-C chemokine production in rat liver ischemia/reperfusion", J SURG RES, 94(2), 2000, pp. 107-115
37. Leung, D; Abbenante, G; Fairlie, DP
    Protease inhibitors: Current status and future prospects
    JOURNAL OF MEDICINAL CHEMISTRY
    
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38. Cowan, KN; Jones, PL; Rabinovitch, M
    Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease
    JOURNAL OF CLINICAL INVESTIGATION
    
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39. Nakanishi, I; Kinoshita, T; Sato, A; Tada, T
    Structure of porcine pancreatic elastase complexed with FR901277, a novel macrocyclic inhibitor of elastases, at 1.6 angstrom resolution
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40. Doring, G
    Serine proteinase inhibitor therapy in alpha(1)-antitrypsin inhibitor deficiency and cystic fibrosis
    PEDIATRIC PULMONOLOGY
    
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41. Rapala-Kozik, M; Potempa, J; Nelson, D; Kozik, A; Travis, J
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42. Skiles, JW; Jeng, AY
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43. Cho, HY; Hotchkiss, JA; Harkema, JR
    Inflammatory and epithelial responses during the development of ozone-induced mucous cell metaplasia in the nasal epithelium of rats
    TOXICOLOGICAL SCIENCES
    
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44. Barnes, PJ
    Novel approaches and targets for treatment of chronic obstructive pulmonary disease
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
    
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45. Hill, AT; Bayley, D; Stockley, RA
    The interrelationship of sputum inflammatory markers in patients with chronic bronchitis
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
    
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46. Harkema, JR; Hotchkiss, JA; Barr, EB; Bennett, CB; Gallup, M; Lee, JK; Basbaum, C
    Long-lasting effects of chronic ozone exposure on rat nasal epithelium
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
    
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47. Buckmaster, MJ; Curci, JA; Murray, PR; Liao, S; Allen, BT; Sicard, GA; Thompson, RW
    Source of elastin-degrading enzymes in mycotic aortic aneurysms: bacteria or host inflammatory response?
    CARDIOVASCULAR SURGERY
    
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48. Tai, S; Kai, H; Isohama, Y; Moriuchi, H; Hagino, N; Miyata, T
    The effect of Maimendongtang on airway clearance and secretion
    PHYTOTHERAPY RESEARCH
    
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49. Ludolph-Hauser, D; Schubert, C; Wiedow, O
    Structural changes of human epidermis induced by human leukocyte-derived proteases
    EXPERIMENTAL DERMATOLOGY
    
    D. Ludolph-Hauser et al., "Structural changes of human epidermis induced by human leukocyte-derived proteases", EXP DERMATO, 8(1), 1999, pp. 46-52
50. Owen, CA; Campbell, EJ
    The cell biology of leukocyte-mediated proteolysis
    JOURNAL OF LEUKOCYTE BIOLOGY
    
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51. Dall'Acqua, W; Halin, C; Rodrigues, ML; Carter, P
    Elastase substrate specificity tailored through substrate-assisted catalysis and phage display
    PROTEIN ENGINEERING
    
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52. Famulok, M; Mayer, G
    Aptamers as tools in molecular biology and immunology
    COMBINATORIAL CHEMISTRY IN BIOLOGY
    
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53. Kurz, M; Breaker, RR
    In vitro selection of nucleic acid enzymes
    COMBINATORIAL CHEMISTRY IN BIOLOGY
    
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54. Cho, HY; Hotchkiss, JA; Bennett, CB; Harkema, JR
    Effects of pre-existing rhinitis on ozone-induced mucous cell metaplasia in rat nasal epithelium
    TOXICOLOGY AND APPLIED PHARMACOLOGY
    
    H.Y. Cho et al., "Effects of pre-existing rhinitis on ozone-induced mucous cell metaplasia in rat nasal epithelium", TOX APPL PH, 158(2), 1999, pp. 92-102
55. Boatman, PD; Ogbu, CO; Eguchi, M; Kim, HO; Nakanishi, H; Cao, BL; Shea, JP; Kahn, M
    Secondary structure peptide mimetics: Design, synthesis, and evaluation ofbeta-strand mimetic thrombin inhibitors
    JOURNAL OF MEDICINAL CHEMISTRY
    
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56. Gutschow, M; Kuerschner, L; Neumann, U; Pietsch, M; Loser, R; Koglin, N; Eger, K
    2-(diethylamino)thieno[1,3]oxazin-4-ones as stable inhibitors of human leukocyte elastase
    JOURNAL OF MEDICINAL CHEMISTRY
    
    M. Gutschow et al., "2-(diethylamino)thieno[1,3]oxazin-4-ones as stable inhibitors of human leukocyte elastase", J MED CHEM, 42(26), 1999, pp. 5437-5447
57. Britigan, BE; Railsback, MA; Cox, CD
    The Pseudomonas aeruginosa secretory product pyocyanin inactivates alpha(1) protease inhibitor: Implications for the pathogenesis of cystic fibrosis lung disease
    INFECTION AND IMMUNITY
    
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58. Reid, PT; Marsden, ME; Cunningham, GA; Haslett, C; Sallenave, JM
    Human neutrophil elastase regulates the expression and secretion of elafin(elastase-specific inhibitor) in type II alveolar epithelial cells
    FEBS LETTERS
    
    P.T. Reid et al., "Human neutrophil elastase regulates the expression and secretion of elafin(elastase-specific inhibitor) in type II alveolar epithelial cells", FEBS LETTER, 457(1), 1999, pp. 33-37
59. Simpson, AJ; Maxwell, AI; Govan, JRW; Haslett, C; Sallenave, JM
    Elafin (elastase-specific inhibitor) has anti-microbial activity against Gram-positive and Gram-negative respiratory pathogens
    FEBS LETTERS
    
    A.J. Simpson et al., "Elafin (elastase-specific inhibitor) has anti-microbial activity against Gram-positive and Gram-negative respiratory pathogens", FEBS LETTER, 452(3), 1999, pp. 309-313
60. Sadallah, S; Hess, C; Miot, S; Spertini, O; Lutz, H; Schifferli, JA
    Elastase and metalloproteinase activities regulate soluble complement receptor 1 release
    EUROPEAN JOURNAL OF IMMUNOLOGY
    
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61. McBride, JD; Freeman, HNM; Leatherbarrow, RJ
    Selection of human elastase inhibitors from a conformationally-constrainedcombinatorial peptide library
    EUROPEAN JOURNAL OF BIOCHEMISTRY
    
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62. Fujimoto, K; Kubo, K; Yamamoto, H; Yamaguchi, S; Matsuzawa, Y
    Eosinophilic inflammation in the airway is related to glucocorticoid reversibility in patients with pulmonary emphysema
    CHEST
    
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63. Jayasena, SD
    Aptamers: An emerging class of molecules that rival antibodies in diagnostics
    CLINICAL CHEMISTRY
    
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64. Mitsuhashi, H; Nonaka, T; Hamamura, I; Kishimoto, T; Muratani, E; Fujii, K
    Pharmacological activities of TEI-8362, a novel inhibitor of human neutrophil elastase
    BRITISH JOURNAL OF PHARMACOLOGY
    
    H. Mitsuhashi et al., "Pharmacological activities of TEI-8362, a novel inhibitor of human neutrophil elastase", BR J PHARM, 126(5), 1999, pp. 1147-1152
65. Simons, JWFA; Cox, RC; Egmond, MR; Verheij, HM
    Rational design of alpha-keto triglyceride analogues as inhibitors for Staphylococcus hyicus lipase
    BIOCHEMISTRY
    
    J.W.F.A. Simons et al., "Rational design of alpha-keto triglyceride analogues as inhibitors for Staphylococcus hyicus lipase", BIOCHEM, 38(19), 1999, pp. 6346-6351
66. Wieczorek, M; Gyorkos, A; Spruce, LW; Ettinger, A; Ross, SE; Kroona, HS; Burgos-Lepley, CE; Bratton, LD; Drennan, TS; Garnert, DL; Von Burg, G; Pilkington, CG; Cheronis, JC
    Biochemical characterization of alpha-ketooxadiazoie inhibitors of elastases
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
    
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67. LaPlante, SR; Bonneau, PR; Aubry, N; Cameron, DR; Deziel, R; Grand-Maitre, E; Plouffe, C; Tong, L; Kawai, SH
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