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La ricerca find articoli where soggetti phrase all words 'human lysozyme' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 149 riferimenti
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    1. Kerr, DE; Plaut, K; Bramley, AJ; Williamson, CM; Lax, AJ; Moore, K; Wells, KD; Wall, RJ
      Lysostaphin expression in mammary glands confers protection against staphylococcal infection in transgenic mice

      NATURE BIOTECHNOLOGY
    2. Dobson, CM
      The structural basis of protein folding and its links with human disease

      PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
    3. Pepys, MB
      Pathogenesis, diagnosis and treatment of systemic amyloidosis

      PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
    4. Loladze, VV; Ermolenko, DN; Makhatadze, GI
      Heat capacity changes upon burial of polar and nonpolar groups in proteins

      PROTEIN SCIENCE
    5. Harrison, PM; Chan, HS; Prusiner, SB; Cohen, FE
      Conformational propagation with prion-like characteristics in a simple model of protein folding

      PROTEIN SCIENCE
    6. Zavodszky, M; Chen, CW; Huang, JK; Zolkiewski, M; Wen, L; Krishnamoorthi, R
      Disulfide bond effects on protein stability: Designed variants of Cucurbita maxima trypsin inhibitor-V

      PROTEIN SCIENCE
    7. Gunasekaran, K; Eyles, SJ; Hagler, AT; Gierasch, LM
      Keeping it in the family: folding studies of related proteins

      CURRENT OPINION IN STRUCTURAL BIOLOGY
    8. Bellotti, V; Gallieni, M; Giorgetti, S; Brancaccio, D
      Dynamic of beta(2)-microglobulin fibril formation and reabsorption: The role of proteolysis

      SEMINARS IN DIALYSIS
    9. Takano, K; Yamagata, Y; Yutani, K
      Role of amino acid residues in left-handed helical conformation for the conformational stability of a protein

      PROTEINS-STRUCTURE FUNCTION AND GENETICS
    10. Joniau, M; Haezebrouck, P; Noyelle, K; Van Dael, H
      Structural basis for the appearance of a molten globule state in chimeric molecules derived from lysozyme and alpha-lactalbumin

      PROTEINS-STRUCTURE FUNCTION AND GENETICS
    11. Inaka, K; Kanaya, E; Kikuchi, M; Miki, K
      Crystal structure of a mutant human lysozyme with a substituted disulfide bond

      PROTEINS-STRUCTURE FUNCTION AND GENETICS
    12. Takano, K; Yutani, K
      A new scale for side-chain contribution to protein stability based on the empirical stability analysis of mutant proteins

      PROTEIN ENGINEERING
    13. Ota, M; Isogai, Y; Nishikawa, K
      Knowledge-based potential defined for a rotamer library to design protein sequences

      PROTEIN ENGINEERING
    14. Edde, L; Hipolito, RB; Hwang, FFY; Headon, DR; Shalwitz, RA; Sherman, MP
      Lactoferrin protects neonatal rats from gut-related systemic infection

      AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
    15. Higo, J; Sugimoto, Y; Wakabayashi, K; Nakamura, H
      Collective motions of myosin head derived from backbone molecular dynamicsand combination with X-ray solution scattering data

      JOURNAL OF COMPUTATIONAL CHEMISTRY
    16. Pace, CN; Horn, G; Hebert, EJ; Bechert, J; Shaw, K; Urbanikova, L; Scholtz, JM; Sevcik, J
      Tyrosine hydrogen bonds make a large contribution to protein stability

      JOURNAL OF MOLECULAR BIOLOGY
    17. Jimenez, JL; Tennent, G; Pepys, M; Saibil, HR
      Structural diversity of ex vivo amyloid fibrils studied by cryo-electron microscopy

      JOURNAL OF MOLECULAR BIOLOGY
    18. Zurdo, J; Guijarro, JI; Jimenez, JL; Saibil, HR; Dobson, CM
      Dependence on solution conditions of aggregation and amyloid formation by an SH3 domain

      JOURNAL OF MOLECULAR BIOLOGY
    19. Noyelle, K; Joniau, M; Van Dael, H
      The fast folding pathway in human lysozyme and its blockage by appropriatemutagenesis: A sequential stopped-flow fluorescence study

      JOURNAL OF MOLECULAR BIOLOGY
    20. Yamagata, Y; Ogasahara, K; Hioki, Y; Lee, SJ; Nakagawa, A; Nakamura, H; Ishida, M; Kuramitsu, S; Yutani, K
      Entropic stabilization of the tryptophan synthase alpha-subunit from a hyperthermophile, Pyrococcus furiosus - X-ray analysis and calorimetry

      JOURNAL OF BIOLOGICAL CHEMISTRY
    21. Tanaka, H; Chinami, M; Mizushima, T; Ogasahara, K; Ota, M; Tsukihara, T; Yutani, K
      X-ray crystalline structures of pyrrolidone carboxyl peptidase from a hyperthermophile, Pyrococcus furiosus, and its Cys-free mutant

      JOURNAL OF BIOCHEMISTRY
    22. Ura, H; Harata, K; Matsui, I; Kuramitsu, S
      Temperature dependence of the enzyme-substrate recognition mechanism

      JOURNAL OF BIOCHEMISTRY
    23. Takano, K; Funahashi, J; Yutani, K
      The stability and folding process of amyloidogenic mutant human lysozymes

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    24. Cao, ZW; Chen, YZ
      Hydrogen-bond disruption probability in proteins by a modified self-consistent harmonic approach

      BIOPOLYMERS
    25. Bolon, DN; Mayo, SL
      Polar residues in the protein core of Escherichia coli thioredoxin are important for fold specificity

      BIOCHEMISTRY
    26. De Vos, S; Backmann, J; Prevost, M; Steyaert, J; Loris, R
      Hydrophobic core manipulations in ribonuclease T1

      BIOCHEMISTRY
    27. Takano, K; Yamagata, Y; Yutani, K
      Contribution of polar groups in the interior of a protein to the conformational stability

      BIOCHEMISTRY
    28. Jeon, YJ; Shahidi, F; Kim, SK
      Preparation of chitin and chitosan oligomers amd their applications in physiological functional foods

      FOOD REVIEWS INTERNATIONAL
    29. Saito, M; Kono, H; Morii, H; Uedaira, H; Tahirov, TH; Ogata, K; Sarai, A
      Cavity-filling mutations enhance protein stability by lowering the free energy of native state

      JOURNAL OF PHYSICAL CHEMISTRY B
    30. Watanabe, K; Fujita, Y; Usami, M; Takimoto, A; Suzuki, Y
      Thermodynamic analysis of Bacillus cereus oligo-1,6-glucosidase and its cumulatively proline-introduced mutant proteins by differential scanning calorimetry

      JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
    31. Esposito, G; Michelutti, R; Verdone, G; Viglino, P; Hernandez, H; Robinson, CV; Amoresano, A; Dal Piaz, F; Monti, M; Pucci, P; Mangione, P; Stoppini, M; Merlini, G; Ferri, G; Bellotti, V
      Removal of the N-terminal hexapeptide from human beta 2-microglobulin facilitates protein aggregation and fibril formation

      PROTEIN SCIENCE
    32. Bouchard, M; Zurdo, J; Nettleton, EJ; Dobson, CM; Robinson, CV
      Formation of insulin amyloid fibrils followed by FTIR simultaneously with CD and electron microscopy

      PROTEIN SCIENCE
    33. Lee, JW; Kang, DO; Kim, BY; Oh, WK; Mheen, TI; Pyun, YR; Ahn, JS
      Mutagenesis of the glucoamylase signal peptide of Saccharomyces diastaticus and functional analysis in Saccharomyces cerevisiae

      FEMS MICROBIOLOGY LETTERS
    34. Santiago-Garcia, J; Delgado-Coello, B; Maas-Oliva, J
      Thermal analysis of the plasma membrane Ca2+-ATPase

      MOLECULAR AND CELLULAR BIOCHEMISTRY
    35. Goda, S; Takano, K; Yamagata, Y; Katakura, Y; Yutani, G
      Effect of extra N-terminal residues on the stability and folding of human lysozyme expressed in Pichia pastoris

      PROTEIN ENGINEERING
    36. Chiti, F; Taddei, N; Bucciantini, M; White, P; Ramponi, G; Dobson, CM
      Mutational analysis of the propensity for amyloid formation by a globular protein

      EMBO JOURNAL
    37. Tama, F; Miyashita, O; Kitao, A; Go, N
      Molecular dynamics simulation shows large volume fluctuations of proteins

      EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
    38. Takaichi, M; Oeda, K
      Transgenic carrots with enhanced resistance against two major pathogens, Erysiphe heraclei and Alternaria dauci

      PLANT SCIENCE
    39. Jing, J; Tang, JG
      Platelet aggregation inhibitory activity of mutant proinsulin with C-peptide replaced by CRGDSC sequence

      BIOTECHNOLOGY LETTERS
    40. Blanch, EW; Morozova-Roche, LA; Cochran, DAE; Doig, AJ; Hecht, L; Barron, LD
      Is polyproline II helix the killer conformation? A Raman optical activity study of the amyloidogenic prefibrillar intermediate of human lysozyme

      JOURNAL OF MOLECULAR BIOLOGY
    41. Serpell, LC; Sunde, M; Benson, MD; Tennent, GA; Pepys, MB; Fraser, PE
      The protofilament substructure of amyloid fibrils

      JOURNAL OF MOLECULAR BIOLOGY
    42. Coker, AR; Purvis, A; Baker, D; Pepys, MB; Wood, SP
      Molecular chaperone properties of serum amyloid P component

      FEBS LETTERS
    43. Chamberlain, AK; MacPhee, CE; Zurdo, J; Morozova-Roche, LA; Hill, HAO; Dobson, CM; Davis, JJ
      Ultrastructural organization of amyloid fibrils by atomic force microscopy

      BIOPHYSICAL JOURNAL
    44. Nettleton, EJ; Tito, P; Sunde, M; Bouchard, M; Dobson, CM; Robinson, CV
      Characterization of the oligomeric states of insulin in self-assembly and amyloid fibril formation by mass spectrometry

      BIOPHYSICAL JOURNAL
    45. Sundberg, EJ; Urrutia, M; Braden, BC; Isern, J; Tsuchiya, D; Fields, BA; Malchiodi, EL; Tormo, J; Schwarz, FP; Mariuzza, RA
      Estimation of the hydrophobic effect in an antigen-antibody protein-protein interface

      BIOCHEMISTRY
    46. Ratnaparkhi, GS; Varadarajan, R
      Thermodynamic and structural studies of cavity formation in proteins suggest that loss of packing interactions rather than the hydrophobic effect dominates the observed energetics

      BIOCHEMISTRY
    47. Takano, K; Tsuchimori, K; Yamagata, Y; Yutani, K
      Contribution of salt bridges near the surface of a protein to the conformational stability

      BIOCHEMISTRY
    48. Fukuda, H; Arai, M; Kuwajima, K
      Folding of green fluorescent protein and the cycle3 mutant

      BIOCHEMISTRY
    49. Thomas, ST; Makhatadze, GI
      Contribution of the 30/36 hydrophobic contact at the C-terminus of the alpha-helix to the stability of the ubiquitin molecule

      BIOCHEMISTRY
    50. Takano, K; Yamagata, Y; Katsuhide, Y
      Role of amino acid residues at turns in the conformational stability and folding of human lysozyme

      BIOCHEMISTRY
    51. Yutani, K; Takayama, C; Goda, S; Yamagata, Y; Maki, S; Namba, K; Tsunasawa, S; Ogasahara, K
      The process-of amyloid-like fibril formation by methionine aminopeptidase from a hyperthermophile, Pyrococcus furiosus

      BIOCHEMISTRY
    52. Vella, F; Hernandez, JF; Molla, A; Block, MR; Arlaud, GJ
      Grafting an RGD motif onto an epidermal growth factor-like module: chemical synthesis and functional characterization of the chimeric molecule

      JOURNAL OF PEPTIDE RESEARCH
    53. Kobashigawa, Y; Sakurai, M; Nitta, K
      Effect of hydrostatic pressure on unfolding of alpha-lactalbumin: Volumetric equivalence of the molten globule and unfolded state

      PROTEIN SCIENCE
    54. Watanabe, I; Koishi, R; Yao, Y; Tsuji, T; Serizawa, N
      Molecular cloning and expression of the gene encoding a phospholipase A(1)from Aspergillus oryzae

      BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
    55. Oka, C; Tanaka, M; Muraki, M; Harata, K; Suzuki, K; Jigami, Y
      Human lysozyme secretion increased by alpha-factor pro-sequence in Pichia pastoris

      BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
    56. Takano, K; Ota, M; Ogasahara, K; Yamagata, Y; Nishikawa, K; Yutani, K
      Experimental verification of the 'stability profile of mutant protein' (SPMP) data using mutant human lysozymes

      PROTEIN ENGINEERING
    57. Funahashi, J; Takano, K; Yamagata, Y; Yutani, K
      Contribution of amino acid substitutions at two different interior positions to the conformational stability of human lysozyme

      PROTEIN ENGINEERING
    58. Katakura, Y; Ametani, A; Totsuka, M; Nagafuchi, S; Kaminogawa, S
      Accelerated secretion of mutant beta-lactoglobulin in Saccharomyces cerevisiae resulting from a single amino acid substitution

      BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
    59. Abaturov, LV; Lebedev, YO; Nosova, NG; Shlyapnikov, SV
      Crystallographic temperature B factors and intramolecular mobility of RNase A

      MOLECULAR BIOLOGY
    60. Haezebrouck, P; Noyelle, K; Joniau, M; Van Dael, H
      Kinetic and equilibrium intermediate states are different in LYLA1, a chimera of lysozyme and alpha-lactalbumin

      JOURNAL OF MOLECULAR BIOLOGY
    61. Miller, DW; Agard, DA
      Enzyme specificity under dynamic control: A normal mode analysis of alpha-lytic protease

      JOURNAL OF MOLECULAR BIOLOGY
    62. Vlassi, M; Cesareni, G; Kokkinidis, M
      A correlation between the loss of hydrophobic core packing interactions and protein stability

      JOURNAL OF MOLECULAR BIOLOGY
    63. Dauber-Osguthorpe, P; Osguthorpe, DJ; Stern, PS; Moult, J
      Low frequency motion in proteins - Comparison of normal mode and moleculardynamics of streptomyces griseus protease A

      JOURNAL OF COMPUTATIONAL PHYSICS
    64. Schmidt, BZ; Fowler, NL; Hidvegi, T; Perlmutter, DH; Colten, HR
      Disruption of disulfide bonds is responsible for impaired secretion in human complement factor H deficiency

      JOURNAL OF BIOLOGICAL CHEMISTRY
    65. Takano, K; Tsuchimori, K; Yamagata, Y; Yutani, K
      Effect of foreign N-terminal residues on the conformational stability of human lysozyme

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    66. Schwerdtfeger, RM; Chiaraluce, R; Consalvi, V; Scandurra, R; Antranikian, G
      Stability, refolding and Ca2+ binding of pullulanase from the hyperthermophilic archaeon Pyrococcus woesei

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    67. Canet, D; Sunde, M; Last, AM; Miranker, A; Spencer, A; Robinson, CV; Dobson, CM
      Mechanistic studies of the folding of human lysozyme and the origin of amyloidogenic behavior in its disease-related variants

      BIOCHEMISTRY
    68. Otzen, DE; Kristensen, O; Proctor, M; Oliveberg, M
      Structural changes in the transition state of protein folding: Alternativeinterpretations of curved chevron plots

      BIOCHEMISTRY
    69. Kiselar, JG; Downard, KM
      Direct identification of protein epitopes by mass spectrometry without immobilization of antibody and isolation of antibody-peptide complexes

      ANALYTICAL CHEMISTRY
    70. Van Dael, H
      Chimeras of human lysozyme and alpha-lactalbumin: an interesting tool for studying partially folded states during protein folding

      CELLULAR AND MOLECULAR LIFE SCIENCES
    71. HANSSENS I; VANDERHEEREN G
      THERMODYNAMIC CHARACTERIZATION OF 2 NEARLY SIMULTANEOUS PROTEIN DENATURATIONS

      JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
    72. WATANABE K; SUZUKI Y
      PROTEIN THERMOSTABILIZATION BY PROLINE SUBSTITUTIONS

      Journal of molecular catalysis. B, Enzymatic
    73. SUGITA Y; KITAO A; GO N
      COMPUTATIONAL ANALYSIS OF THERMAL-STABILITY - EFFECT OF ILE-]VAL MUTATIONS IN HUMAN LYSOZYME

      Folding & design
    74. HELLINGA HW
      THE CONSTRUCTION OF METAL CENTERS IN PROTEINS BY RATIONAL DESIGN

      Folding & design
    75. Ogundele, MO
      A novel anti-inflammatory activity of lysozyme: modulation of serum complement activation

      MEDIATORS OF INFLAMMATION
    76. KELLY JW
      THE ALTERNATIVE CONFORMATIONS OF AMYLOIDOGENIC PROTEINS AND THEIR MULTISTEP ASSEMBLY PATHWAYS

      Current opinion in structural biology
    77. SUGITA Y; KITAO A
      IMPROVED PROTEIN-FREE ENERGY CALCULATION BY MORE ACCURATE TREATMENT OF NONBONDED ENERGY - APPLICATION TO CHYMOTRYPSIN INHIBITOR-2, V57A

      Proteins
    78. HARATA K; ABE Y; MURAKI M
      FULL-MATRIX LEAST-SQUARES REFINEMENT OF LYSOZYMES AND ANALYSIS OF ANISOTROPIC THERMAL MOTION

      Proteins
    79. Kitao, A; Hayward, S; Go, N
      Energy landscape of a native protein: Jumping-among-minima model

      PROTEINS-STRUCTURE FUNCTION AND GENETICS
    80. BENING U; CASTINO R; HARTH N; ISIDORO C; HASILIK A
      LYSOSOMAL SEGREGATION OF A MANNOSE-RICH GLYCOPROTEIN IMPARTED BY THE PROSEQUENCE OF MYELOPEROXIDASE

      Journal of cellular biochemistry
    81. BORDEN KLB
      STRUCTURE FUNCTION IN NEUROPROTECTION AND APOPTOSIS/

      Annals of neurology
    82. HIROSE M; HAYANO T; SHIRAI H; NAKAMURA H; KIKUCHI M
      ISOLATION OF ANTI-GLUTATHIONE ANTIBODIES FROM A PHAGE DISPLAY LIBRARY

      Protein engineering
    83. SUNDE M; BLAKE CCF
      FROM THE GLOBULAR TO THE FIBROUS STATE - PROTEIN-STRUCTURE AND STRUCTURAL CONVERSION IN AMYLOID FORMATION

      Quarterly Reviews of Biophysics
    84. TAKANO K; YAMAGATA Y; YUTANI K
      A GENERAL RULE FOR THE RELATIONSHIP BETWEEN HYDROPHOBIC EFFECT AND CONFORMATIONAL STABILITY OF A PROTEIN - STABILITY AND STRUCTURE OF A SERIES OF HYDROPHOBIC MUTANTS OF HUMAN LYSOZYME

      Journal of Molecular Biology
    85. WESTPHAL V; SPETZLER JC; MELDAL M; CHRISTENSEN U; WINTHER JR
      KINETIC-ANALYSIS OF THE MECHANISM AND SPECIFICITY OF PROTEIN-DISULFIDE ISOMERASE USING FLUORESCENCE-QUENCHED PEPTIDES

      The Journal of biological chemistry
    86. AIZAWA T; KOGANESAWA N; KAMAKURA A; MASAKI K; MATSUURA A; NAGADOME H; TERADA Y; KAWANO K; NITTA K
      ADSORPTION OF HUMAN LYSOZYME ONTO HYDROXYAPATITE - IDENTIFICATION OF ITS ADSORBING SITE USING SITE-DIRECTED MUTAGENESIS

      FEBS letters
    87. ARNOLD CE; PAREKH RN; YANG WL; WITTRUP KD
      LEADER PEPTIDE EFFICIENCY CORRELATES WITH SIGNAL RECOGNITION PARTICLEDEPENDENCE IN SACCHAROMYCES-CEREVISIAE

      Biotechnology and bioengineering
    88. KOWALSKI JM; PAREKH RN; WITTRUP KD
      SECRETION EFFICIENCY IN SACCHAROMYCES-CEREVISIAE OF BOVINE PANCREATICTRYPSIN-INHIBITOR MUTANTS LACKING DISULFIDE BONDS IS CORRELATED WITH THERMODYNAMIC STABILITY

      Biochemistry
    89. SERPELL LC; SUNDE M; BLAKE CCF
      THE MOLECULAR-BASIS OF AMYLOIDOSIS

      Cellular and molecular life sciences
    90. MURAKI M; GODA S; NAGAHORA H; HARATA K
      IMPORTANCE OF VAN-DER-WAALS CONTACT BETWEEN GLU-35 AND TRP-109 TO THECATALYTIC ACTION OF HUMAN LYSOZYME

      Protein science
    91. VITA C
      ENGINEERING NOVEL PROTEINS BY TRANSFER OF ACTIVE-SITES TO NATURAL SCAFFOLDS

      Current opinion in biotechnology
    92. LUBBERT M; MERTELSMANN R; HERRMANN F
      CYTOSINE METHYLATION CHANGES DURING NORMAL HEMATOPOIESIS AND IN ACUTEMYELOID-LEUKEMIA

      Leukemia
    93. NAKAJIMA H; MURANAKA T; ISHIGE F; AKUTSU K; OEDA K
      FUNGAL AND BACTERIAL DISEASE RESISTANCE IN TRANSGENIC PLANTS EXPRESSING HUMAN LYSOZYME

      Plant cell reports
    94. TAKANO K; FUNAHASHI J; YAMAGATA Y; FUJII S; YUTANI K
      CONTRIBUTION OF WATER-MOLECULES IN THE INTERIOR OF A PROTEIN TO THE CONFORMATIONAL STABILITY

      Journal of Molecular Biology
    95. WALLON G; KRYGER G; LOVETT ST; OSHIMA T; RINGE D; PETSKO GA
      CRYSTAL-STRUCTURES OF ESCHERICHIA-COLI AND SALMONELLA-TYPHIMURIUM 3-ISOPROPYLMALATE DEHYDROGENASE AND COMPARISON WITH THEIR THERMOPHILIC COUNTERPART FROM THERMUS-THERMOPHILUS

      Journal of Molecular Biology
    96. ITO Y; KWON OH; UEDA M; TANAKA A; IMANISHI Y
      BACTERICIDAL ACTIVITY OF HUMAN LYSOZYMES CARRYING VARIOUS LENGTHS OF POLYPROLINE CHAIN AT THE C-TERMINUS

      FEBS letters
    97. ANDERSON PJ; BROOKS CL; BERLINER LJ
      FUNCTIONAL IDENTIFICATION OF CALCIUM-BINDING RESIDUES IN BOVINE ALPHA-LACTALBUMIN

      Biochemistry
    98. VARALLYAY V; LENGYEL Z; GRAF L; SZILAGYI L
      THE ROLE OF DISULFIDE BOND C191-C220 IN TRYPSIN AND CHYMOTRYPSIN

      Biochemical and biophysical research communications
    99. HORNISCHER K; BLOCKER H
      GRAFTING OF DISCONTINUOUS SITES - A PROTEIN MODELING STRATEGY

      Protein engineering
    100. BURDETTE DS; VIEILLE C; ZEIKUS JG
      CLONING AND EXPRESSION OF THE GENE ENCODING THE THERMOANAEROBACTER-ETHANOLICUS 39E SECONDARY-ALCOHOL DEHYDROGENASE AND BIOCHEMICAL-CHARACTERIZATION OF THE ENZYME

      Biochemical journal


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Documento generato il 06/08/20 alle ore 12:34:02