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La ricerca find articoli where soggetti phrase all words 'human cells' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 13011 riferimenti
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    1. Steinbach, JP; Supra, P; Huang, HJS; Cavenee, WK; Weller, M
      CD95-mediated apoptosis of human glioma cells: Modulation by epidermal growth factor receptor activity

      BRAIN PATHOLOGY
    2. Halladay, DL; Miles, RR; Thirunavukkarasu, K; Chandrasekhar, S; Martin, TJ; Onyia, JE
      Identification of signal transduction pathways and promoter sequences thatmediate parathyroid hormone 1-38 inhibition of osteoprotegerin gene expression

      JOURNAL OF CELLULAR BIOCHEMISTRY
    3. Verrier, S; Pallu, S; Bareille, R; Jonczyk, A; Meyer, J; Dard, M; Amedee, J
      Function of linear and cyclic RGD-containing peptides in osteoprogenitor cells adhesion process

      BIOMATERIALS
    4. Tatebe, S; Unate, H; Sinicrope, FA; Sakatani, T; Sugamura, K; Makino, M; Ito, H; Savaraj, N; Kaibara, N; Kuo, MT
      Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal carcinoma

      INTERNATIONAL JOURNAL OF CANCER
    5. Martinez, P; Moreno, I; De Miguel, F; Vila, V; Esbrit, P; Martinez, ME
      Changes in osteocalcin response to 1,25-dihydroxyvitamin D-3 stimulation and basal vitamin D receptor expression in human osteoblastic cells according to donor age and skeletal origin

      BONE
    6. Dubin, RL; Hall, CM; Pileri, CL; Kudlacek, PE; Li, XY; Yee, JA; Johnson, ML; Anderson, RJ
      Thermostable (SULT1A1) and thermolabile (SULT1A3) phenol sulfotransferasesin human osteosarcoma and osteoblast cells

      BONE
    7. Sun, HB; Yokota, H
      Messenger-RNA expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases, and transcription factors in rheumatic synovial cellsunder mechanical stimuli

      BONE
    8. Dudek, SM; Garcia, JGN
      Cytoskeletal regulation of pulmonary vascular permeability

      JOURNAL OF APPLIED PHYSIOLOGY
    9. Berger, P; Perng, DW; Thabrew, H; Compton, SJ; Cairns, JA; McEuen, AR; Marthan, R; De Lara, JMT; Walls, AF
      Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells

      JOURNAL OF APPLIED PHYSIOLOGY
    10. Gerthoffer, WT; Gunst, SJ
      Signal Transduction in smooth muscle - Invited review: Focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle

      JOURNAL OF APPLIED PHYSIOLOGY
    11. Calvijo, LC; Carter, MB; Matheson, PJ; Wilson, MA; Wead, WB; Garrison, RN
      PAF increases vascular permeability without increasing pulmonary arterial pressure in the rat

      JOURNAL OF APPLIED PHYSIOLOGY
    12. Dua, K; Williams, TM; Beretta, L
      Translational control of the proteome: Relevance to cancer

      PROTEOMICS
    13. Suzuki, S; Chuang, LF; Doi, RH; Bidlack, JM; Chuang, RY
      Kappa-opioid receptors on lymphocytes of a human lymphocytic cell line: morphine-induced up-regulation as evidenced by competitive RT-PCR and indirect immunofluorescence

      INTERNATIONAL IMMUNOPHARMACOLOGY
    14. Kim, PKM; Zamora, R; Petrosko, P; Billiar, TR
      The regulatory role of nitric oxide in apoptosis

      INTERNATIONAL IMMUNOPHARMACOLOGY
    15. Cifone, MG; Ulisse, S; Santoni, A
      Natural killer cells and nitric oxide

      INTERNATIONAL IMMUNOPHARMACOLOGY
    16. Blanco, L; Puente, J; Carrasco, C; Miranda, D; Wolf, ME; Mosnaim, AD
      Effect of salmonella-infected human monocytes on natural killer cell cytotoxicity. In vitro studies

      INTERNATIONAL IMMUNOPHARMACOLOGY
    17. Hirano, T; Horigome, A; Takatani, M; Oka, K
      Cortisone counteracts apoptosis-inducing effect of cortisol in human peripheral-blood mononuclear cells

      INTERNATIONAL IMMUNOPHARMACOLOGY
    18. Asano, K; Kamakazu, K; Hisamitsu, T; Suzaki, H
      Modulation of Th2 type cytokine production from human peripheral blood leukocytes by a macrolide antibiotic, roxithromycin, in vitro

      INTERNATIONAL IMMUNOPHARMACOLOGY
    19. Osna, N; Elliott, K; Khan, MM
      Regulation of interleukin-10 secretion by histamine in TH2 cells and splenocytes

      INTERNATIONAL IMMUNOPHARMACOLOGY
    20. Terness, P; Navolan, D; Dufter, C; Kopp, B; Opelz, G
      The T-cell suppressive effect of bufadienolides: structural requirements for their immunoregulatory activity

      INTERNATIONAL IMMUNOPHARMACOLOGY
    21. Verhasselt, V; Goldman, M
      New concepts on the pathogenesis of autoimmune disease

      ISRAEL MEDICAL ASSOCIATION JOURNAL
    22. Haviv, YS; Blackwell, J
      Transcriptional regulation in cancer gene therapy

      ISRAEL MEDICAL ASSOCIATION JOURNAL
    23. Prasad, KN; Hovland, AR; Nahreini, P; Cole, WC; Hovland, P; Kumar, B; Prasad, KC
      Differentiation genes: Are they primary targets for human carcinogenesis?

      EXPERIMENTAL BIOLOGY AND MEDICINE
    24. Minguell, JJ; Erices, A; Conget, P
      Mesenchymal stem cells

      EXPERIMENTAL BIOLOGY AND MEDICINE
    25. Linder, B; Bostrom, M; Gerdin, B; Rask-Andersen, H
      In vitro growth of human endolymphatic sac cells: A transmission electron microscopic and immunohistochemical study in patients with vestibular schwannoma and Meniere's disease

      OTOLOGY & NEUROTOLOGY
    26. Miyazaki, T; Reed, JC
      A GTP-binding adaptor protein couples TRAIL receptors to apoptosis-inducing proteins

      NATURE IMMUNOLOGY
    27. Colonna, M
      Can we apply the T(H)1-T(H)2 paradigm to all lymphocytes?

      NATURE IMMUNOLOGY
    28. Loza, MJ; Perussia, B
      Final steps of natural killer cell maturation: a model for type 1 type 2 differentiation?

      NATURE IMMUNOLOGY
    29. Guenechea, G; Gan, OI; Dorrell, C; Dick, JE
      Distinct classes of human stem cells that differ in proliferative and self-renewal potential

      NATURE IMMUNOLOGY
    30. Pfeifer, A; Verma, IM
      Gene therapy: Promises and problems

      ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS
    31. Rao, CV
      An overview of the past, present, and future of nongonadal LH/hCG actions in reproductive biology and medicine

      SEMINARS IN REPRODUCTIVE MEDICINE
    32. Licht, P; Russu, V; Wildt, L
      On the role of human chorionic gonadotropin (hCC) in the embryo-endometrial microenvironment: Implications for differentiation and implantation

      SEMINARS IN REPRODUCTIVE MEDICINE
    33. Chiorean, EG; Miller, JS
      The biology of natural killer cells and implications for therapy of human disease

      JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
    34. Maki, G; Klingemann, HG; Martinson, JA; Tam, YK
      Factors regulating the cytotoxic activity of the human natural killer cellline, NK-92

      JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
    35. Gazitt, Y
      Recent developments in the regulation of peripheral blood stem cell mobilization and engraftment by cytokines, chemokines, and adhesion molecules

      JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
    36. Hegyi, L; Hardwick, SJ; Siow, RCM; Skepper, JN
      Macrophage death and the role of apoptosis in human atherosclerosis

      JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
    37. Steinwaerder, DS; Carlson, CA; Lieber, A
      Human papilloma virus E6 and E7 proteins support DNA replication of adenoviruses deleted for the E1A and E1B genes

      MOLECULAR THERAPY
    38. Stoll, SM; Sclimenti, CR; Baba, EJ; Meuse, L; Kay, MA; Calos, MP
      Epstein-Barr virus/human vector provides high-level, long-term expression of alpha(1)-antitrypsin in mice

      MOLECULAR THERAPY
    39. Stecher, H; Shayakhmetov, DM; Stamatoyannopoulos, G; Lieber, A
      A capsid-modified adenovirus vector devoid of all viral genes: Assessment of transduction and toxicity in human hematopoietic cells

      MOLECULAR THERAPY
    40. Grifman, M; Trepel, M; Speece, P; Gilbert, LB; Arap, W; Pasqualini, R; Weitzman, MD
      Incorporation of tumor-targeting peptides into recombinant adeno-associated virus capsids

      MOLECULAR THERAPY
    41. Wang, JL; Vos, JMH
      Development of a competitive PCR method for physical titration of recombinant EBV vector in a helper-dependent packaging system

      MOLECULAR THERAPY
    42. Sirven, A; Ravet, E; Charneau, P; Zennou, V; Coulombel, L; Guetard, D; Pflumio, F; Dubart-Kupperschmitt, A
      Enhanced transgene expression in cord blood CD34(+)-derived hematopoietic cells, including developing T cells and NOD/SCID mouse repopulating cells, following transduction with modified TRIP lentiviral vectors

      MOLECULAR THERAPY
    43. Inoue, N; Dong, R; Hirata, RK; Russell, DW
      Introduction of single base substitutions at homologous chromosomal sequences by adeno-associated virus vectors

      MOLECULAR THERAPY
    44. Zavorotinskaya, T; Albritton, LM
      Two point mutations increase targeted transduction and stabilize vector association of a modified retroviral envelope protein

      MOLECULAR THERAPY
    45. Garcia-Castro, J; Segovia, JC; Garcia-Sanchez, F; Lillo, R; Gomez-Navarro, J; Curiel, DT; Bueren, JA
      Selective transduction of murine myelomonocytic leukemia cells (WEHI-3B) with regular and RGD-adenoviral vectors

      MOLECULAR THERAPY
    46. Sakamoto, J; Teramukai, T; Watanabe, Y; Hayata, Y; Okayasu, T; Nakazato, N; Ohashi, Y
      Mete-analysis of adjuvant immunochemotherapy using OK-432 in patients withresected non-small-cell lung cancer

      JOURNAL OF IMMUNOTHERAPY
    47. Zandstra, PW; Nagy, A
      Stem cell bioengineering

      ANNUAL REVIEW OF BIOMEDICAL ENGINEERING
    48. Cerrato, JA; Yung, WKA; Liu, TJ
      Introduction of mutant p53 into a wild-type p53-expressing glioma cell line confers sensitivity to Ad-p53-induced apoptosis

      NEURO-ONCOLOGY
    49. Maliner-Stratton, MS; Klein, RD; Udayakumar, TS; Nagle, RB; Bowden, GT
      Interleukin-1 beta-induced promatrilysin expression is mediated by NF kappa B-regulated synthesis of interleukin-6 in the prostate carcinoma cell line, LNCaP

      NEOPLASIA
    50. Kim, SJ; Uehara, H; Karashima, T; Mccarty, M; Shih, N; Fidler, IJ
      Expression of interleukin-8 correlates with angiogenesis, tumorigenicity, and metastasis of human prostate cancer cells implanted orthotopically in nude mice

      NEOPLASIA
    51. Yang, YM; Pace, B
      Pharmacologic induction of fetal hemoglobin synthesis: Cellular and molecular mechanisms

      PEDIATRIC PATHOLOGY & MOLECULAR MEDICINE
    52. Stanley, MA
      Human papillomavirus and cervical carcinogenesis

      BEST PRACTICE & RESEARCH IN CLINICAL OBSTETRICS & GYNAECOLOGY
    53. de Wit, TR; van Mourik, JA
      Biosynthesis, processing and secretion of von Willebrand factor: biological implications

      BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
    54. Le, YY; Wetzel, MA; Shen, WP; Gong, WH; Rogers, TJ; Henderson, EE; Wang, JM
      Desensitization of chemokine receptor CCR5 in dendritic cells at the earlystage of differentiation by activation of formyl peptide receptors

      CLINICAL IMMUNOLOGY
    55. Burchiel, SW; Luster, MI
      Signaling by environmental polycyclic aromatic hydrocarbons in human lymphocytes

      CLINICAL IMMUNOLOGY
    56. Bhol, KC; Desai, A; Kumari, S; Colon, JE; Ahmed, AR
      Pemphigus vulgaris: The role of IL-1 and IL-1 receptor antagonist in pathogenesis and effects of intravenous immunoglobulin on their production

      CLINICAL IMMUNOLOGY
    57. Elholm, M; Hollas, H; Issalene, C; Barroso, JFV; Berge, RK; Flatmark, T
      Transient up-regulation of liver mitochondrial thymidine kinase activity in proliferating mitochondria

      IUBMB LIFE
    58. von Schacky, C
      Dietary omega-3 fatty acids and human growth factor and cytokine gene expression

      EUROPEAN HEART JOURNAL SUPPLEMENTS
    59. Hansson, GK
      The stabilized plaque: will the dream come true?

      EUROPEAN HEART JOURNAL SUPPLEMENTS
    60. Mantovani, A; Locati, M; Vecchi, A; Sozzani, S; Allavena, P
      Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines

      TRENDS IN IMMUNOLOGY
    61. Cooper, MA; Fehniger, TA; Caligiuri, MA
      The biology of human natural killer-cell subsets

      TRENDS IN IMMUNOLOGY
    62. Novelli, EM; Barranger, JA
      Gene therapy for lysosomal storage disorders

      EXPERT OPINION ON BIOLOGICAL THERAPY
    63. Bodey, B
      Genetically engineered antibodies for direct antineoplastic treatment and systematic delivery of various therapeutic agents to cancer cells

      EXPERT OPINION ON BIOLOGICAL THERAPY
    64. Pandya, S; Klimatcheva, E; Planelles, V
      Lentivirus and foamy virus vectors: novel gene therapy tools

      EXPERT OPINION ON BIOLOGICAL THERAPY
    65. Gruenberg, L
      The endocytic pathway: A mosaic of domains

      NATURE REVIEWS MOLECULAR CELL BIOLOGY
    66. Patel, JL; Keyes, PL
      Immune cells in the corpus luteum: friends or foes?

      REPRODUCTION
    67. McLean, M; Smith, R
      Corticotrophin-releasing hormone and human parturition

      REPRODUCTION
    68. Greenfeder, S; Umland, SP; Cuss, FM; Chapman, RW; Egan, RW
      Th2 cytokines and asthma - The role of interleukin-5 in allergic eosinophilic disease

      RESPIRATORY RESEARCH
    69. Brown, NS; Bicknell, R
      Hypoxia and oxidative stress in breast cancer - Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer

      BREAST CANCER RESEARCH
    70. Tissandier, O; Peres, G; Fiet, J; Piette, F
      Testosterone, dehydroepiandrosterone, insulin-like growth factor 1, and insulin in sedentary and physically trained aged men

      EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
    71. Grandjean, C; Angyalosi, G; Loing, E; Adriaenssens, E; Melnyk, O; Pancre, V; Auriault, C; Gras-Masse, H
      Novel hyperbranched glycomimetics recognized by the human mannose receptor: Quinic or shikimic acid derivatives as mannose bioisosteres

      CHEMBIOCHEM
    72. von Loewenich, FD; Wintermeyer, E; Dumig, M; Frosch, M
      Analysis of transcriptional control mechanisms of capsule expression in Neisseria meningitidis

      INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
    73. El Tahir, Y; Skurnik, M
      YadA, the multifaceted Yersinia adhesin

      INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
    74. Totzke, G; Metzner, C; Ulrich-Merzenich, G; Ko, Y; Sachinidis, A; Vetter, H
      Effect of vitamin E and vitamin C on the DNA synthesis of human umbilical arterial endothelial cells

      EUROPEAN JOURNAL OF NUTRITION
    75. Schlaf, G; Demberg, T; Koleva, M; Jungermann, K; Gotze, O
      Complement factor I is upregulated in rat hepatocytes by interleukin-6 butnot by interferon-gamma, interleukin-1 beta or tumor necrosis factor-alpha

      BIOLOGICAL CHEMISTRY
    76. Komba, S; Yamaguchi, M; Ishida, H; Kiso, M
      6-O-sulfo de-N-acetylsialyl Lewis X as a novel high-affinity ligand for human L-selectin: Total synthesis and structural characterization

      BIOLOGICAL CHEMISTRY
    77. Kwak, B; Mulhaupt, F; Veillard, N; Pelli, G; Mach, F
      The HMG-CoA reductase inhibitor simvastatin inhibits IFN-gamma induced MHCclass II expression in human vascular endothelial cells - Statins as a potential novel immunosuppressive agent

      SWISS MEDICAL WEEKLY
    78. Daigle, I; Simon, HU
      Alternative functions for TRAIL receptors in eosinophils and neutrophils

      SWISS MEDICAL WEEKLY
    79. Cooper, S; Shayman, JA
      Revisiting retinoblastoma protein phosphorylation during the mammalian cell cycle

      CELLULAR AND MOLECULAR LIFE SCIENCES
    80. Schonbeck, U; Libby, P
      The CD40/CD154 receptor/ligand dyad

      CELLULAR AND MOLECULAR LIFE SCIENCES
    81. Kitahara, M; Ichikawa, M; Kinoshita, T; Shiozawa, S; Shigematsu, H; Komiyama, A
      Prostacyclin inhibits the production of MMP-9 induced by phorbol ester through protein kinase A activation, but does not affect the production of MMP-2 in human cultured mesangial cells

      KIDNEY & BLOOD PRESSURE RESEARCH
    82. Assero, G; Lupo, G; Anfuso, CD; Ragusa, N; Alberghina, M
      High glucose and advanced glycation end products induce phospholipid hydrolysis and phospholipid enzyme inhibition in bovine retinal pericytes

      BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
    83. Igarashi, M; Miyazawa, T
      The growth inhibitory effect of conjugated linoleic acid on a human hepatoma cell line, HepG2, is induced by a change in fatty acid metabolism, but not the facilitation of lipid peroxidation in the cells

      BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
    84. Wall, DB; Parus, SJ; Lubman, DM
      Comparison of the capabilities of liquid isoelectric focusing-one-dimensional nonporous silica reversed-phase liquid chromatography-electrospray ionization time-of-flight mass spectrometry and liquid isoelectric focusing-one-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis massmapping for the analysis of intact protein molecular masses

      JOURNAL OF CHROMATOGRAPHY B
    85. Campbell, SM; Crowe, SM; Mak, J
      Lipid rafts and HIV-1: from viral entry to assembly of progeny virions

      JOURNAL OF CLINICAL VIROLOGY
    86. Shen, S; Cooley, DM; Glickman, LT; Glickman, N; Waters, DJ
      Reduction in DNA damage in brain and peripheral blood lymphocytes of elderly dogs after treatment with dehydroepiandrosterone (DHEA)

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    87. Vogt, BL; Rossman, TG
      Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts - a possible mechanism for arsenite's comutagenicity

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    88. Nakabeppu, Y
      Molecular genetics and structural biology of human MutT homolog, MTH1

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    89. Tsuzuki, T; Egashira, A; Kura, S
      Analysis of MTH1 gene function in mice with targeted mutagenesis

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    90. Thompson, LH; Schild, D
      Homologous recombinational repair of DNA ensures mammalian chromosome stability

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    91. de Oliveira, EM; Suzuki, MF; do Nascimento, PA; da Silva, MA; Okazaki, K
      Evaluation of the effect of Sr-90 beta-radiation on human blood cells by chromosome aberration and single cell gel electrophoresis (comet assay) analysis

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    92. Collins, AR
      Carotenoids and genomic stability

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    93. Claycombe, KJ; Meydani, SN
      Vitamin E and genome stability

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    94. Domon, OE; McGarrity, LJ; Bishop, M; Yoshioka, M; Chen, JJ; Morris, SM
      Evaluation of the genotoxicity of the phytoestrogen, coumestrol, in AHH-1 TK+/- human lymphoblastoid cells

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    95. Wijnhoven, SWP; Kool, HJM; van Teijlingen, CMM; van Zeeland, AA; Vrieling, H
      Loss of heterozygosity in somatic cells of the mouse - An important step in cancer initiation?

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    96. Branda, RF; O'Neill, JP; Brooks, EM; Trombley, LM; Nicklas, JA
      The effect of folate deficiency on the cytotoxic and mutagenic responses to ethyl methanesulfonate in human lymphoblastoid cell lines that differ in p53 status

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    97. Woodruff, NW; Durant, JL; Donhoffner, LL; Penman, BW; Crespi, CL
      Human cell mutagenicity of chlorinated and unchlorinated water and the disinfection byproduct 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)

      MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
    98. Yoshida, R; Ogawa, Y; Takayanagi, S
      In isolated DNA, formamidopyrimidine-DNA glycosylase-sensitive sites determined by electrophoresis correspond to the amount of 8-oxo-7, 8-dihydro-2 '-deoxyguanosine by HPLC-ECD

      MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
    99. Honma, M; Momose, M; Sakamoto, H; Sofuni, T; Hayashi, M
      Spindle poisons induce allelic loss in mouse lymphoma cells through mitotic non-disjunction

      MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
    100. Kassie, F; Laky, B; Nobis, E; Kundi, M; Knasmuller, S
      Genotoxic effects of methyl isothiocyanate

      MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS


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Documento generato il 01/06/20 alle ore 10:55:35