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    1. Michailidis, GD; Spencer, K; Economides, DL
      The use of nuchal translucency measurement and second trimester biochemical markers in screening for Down's Syndrome

      BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
    2. Bilardo, CM; Muller, MA; Pajkrt, E
      Outcome of fetuses with increased nuchal translucency

      CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
    3. Niemimaa, M; Suonpaa, M; Perheentupa, A; Seppala, M; Heinonen, S; Laitinen, P; Ruokonen, A; Ryynanen, M
      Evaluation of first trimester maternal serum and ultrasound screening for Down's syndrome in Eastern and Northern Finland

      EUROPEAN JOURNAL OF HUMAN GENETICS
    4. Mangione, R; Guyon, F; Taine, L; Wen, ZQ; Roux, D; Vergnaud, A; Maugey-Laulom, B; Horovitz, J; Saura, R
      Pregnancy outcome and prognosis in fetuses with increased first-trimester nuchal translucency

      FETAL DIAGNOSIS AND THERAPY
    5. Eiben, B; Hammans, W; Keuter, S; Goebel, R; Louwen, F; Epplen, J
      A clinical study on the practicability of trisomy 21 - risk analysis in the first trimester of pregnancy

      ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
    6. Hafner, E; Schuchter, K; Metzenbauer, M; Hofinger, D; Stangl, G; Philipp, K
      The combined test for Down Syndrome in the first pregnancy trimenon in 3316 non-selected pregnant women

      ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
    7. Souter, VL; Nyberg, DA
      Sonographic screening for fetal aneuploidy - First trimester

      JOURNAL OF ULTRASOUND IN MEDICINE
    8. Maymon, R; Jauniaux, E; Holmes, A; Wiener, YM; Dreazen, E; Herman, A
      Nuchal translucency measurement and pregnancy outcome after assisted conception versus spontaneously conceived twins

      HUMAN REPRODUCTION
    9. Liao, AW; Heath, V; Kametas, N; Spencer, K; Nicolaides, KH
      First-trimester screening for trisomy 21 in singleton pregnancies achievedby assisted reproduction

      HUMAN REPRODUCTION
    10. Spencer, K
      Screening for trisomy 21 in twin pregnancies in the first trimester: does chorionicity impact on maternal serum free beta-hCG or PAPP-A levels?

      PRENATAL DIAGNOSIS
    11. Spencer, K; Liao, AW; Ong, CYT; Geerts, L; Nicolaides, KH
      First trimester maternal serum placenta growth factor (PIGF) concentrations in pregnancies with fetal trisomy 21 or trisomy 18

      PRENATAL DIAGNOSIS
    12. Ochshorn, Y; Kupferminc, MJ; Wolman, L; Orr-Urtreger, A; Jaffa, AJ; Yaron, Y
      First trimester PAPP-A in the detection of non-Down syndrome aneuploidy

      PRENATAL DIAGNOSIS
    13. Wojdemann, KR; Larsen, SO; Shalmi, A; Sundberg, K; Christiansen, M; Tabor, A
      First trimester screening for Down syndrome and assisted reproduction: no basis for concern

      PRENATAL DIAGNOSIS
    14. Spencer, K; Liao, AW; Ong, CYT; Flack, NJ; Nicolaides, KH
      Maternal serum activin A and inhibin A in trisomy 18 pregnancies at 10-14 weeks

      PRENATAL DIAGNOSIS
    15. Spencer, K; Liao, AW; Ong, CYT; Geerts, L; Nicolaides, KH
      Maternal serum levels of dimeric inhibin A in pregnancies affected by trisomy 21 in the first trimester

      PRENATAL DIAGNOSIS
    16. Spencer, K
      Between pregnancy biological variability of first trimester markers of Down syndrome: implications for screening in subsequent pregnancies

      PRENATAL DIAGNOSIS
    17. Spencer, K; Liao, AW; Skentou, H; Ong, CYT; Nicolaides, KH
      Maternal serum levels of total activin-A in first-trimester trisomy 21 pregnancies

      PRENATAL DIAGNOSIS
    18. Yaron, Y; Mashiach, R
      First-trimester biochemical screening for Down syndrome

      CLINICS IN PERINATOLOGY
    19. Nicolaides, KH; Cicero, S; Liao, AW
      One-stop clinic for assessment of risk of chromosomal defects at 12 weeks of gestation

      PRENATAL AND NEONATAL MEDICINE
    20. Lambert-Messerlian, GM; Silver, HM; Petraglia, F; Luisi, S; Pezzani, I; Maybruck, WM; Hogge, WA; Hanley-Yanez, K; Roberts, JM; Neveux, LM; Canick, JA
      Second-trimester levels of maternal serum human chorionic gonadotropin andinhibin A as predictors of preeclampsia in the third trimester of pregnancy

      JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
    21. Richardson, BE; Peck, JD; Wormuth, JK
      Mean arterial pressure, pregnancy-induced hypertension, and preeclampsia: Evaluation as independent risk factors and as surrogates for high maternal serum alpha-fetoprotein in estimating breast cancer risk

      CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
    22. Spencer, K; Heath, V; Flack, N; Ong, C; Nicolaides, KH
      First trimester maternal serum AFP and total hCG in aneuploidies other than trisomy 21

      PRENATAL DIAGNOSIS
    23. Spencer, K
      The influence of fetal sex in screening for Down syndrome in the second trimester using AFP and free beta-hCG

      PRENATAL DIAGNOSIS
    24. Spencer, K
      Second-trimester prenatal screening for Down syndrome and the relationshipof maternal serum biochemical markers to pregnancy complications with adverse outcome

      PRENATAL DIAGNOSIS
    25. Spencer, K; Ong, CYT; Liao, AWJ; Papademetriou, D; Nicolaides, KH
      The influence of fetal sex in screening for trisomy 21 by fetal nuchal translucency, maternal serum free beta-hCG and PAPP-A at 10-14 weeks of gestation

      PRENATAL DIAGNOSIS
    26. Spencer, K; Ong, CYT; Liao, AWJ; Nicolaides, KH
      The influence of ethnic origin on first trimester biochemical markers of chromosomal abnormalities

      PRENATAL DIAGNOSIS
    27. Spencer, K; Liao, AWJ; Skentou, H; Cicero, S; Nicolaides, KH
      Screening for triploidy by fetal nuchal translucency and maternal serum free beta-hCG and PAPP-A at 10-14 weeks of gestation

      PRENATAL DIAGNOSIS
    28. Spencer, K; Ong, C; Skentou, H; Liao, AW; Nicolaides, KH
      Screening for trisomy 13 by fetal nuchal translucency and maternal serum free beta-hCG and PAPP-A at 10-14 weeks of gestation

      PRENATAL DIAGNOSIS
    29. Spencer, K; Berry, E; Crossley, JA; Aitken, DA; Nicolaides, KH
      Is maternal serum total hCG a marker of trisomy 21 in the first trimester of pregnancy?

      PRENATAL DIAGNOSIS
    30. de Graaf, IM; Cuckle, HS; Pajkrt, E; Leschot, NJ; Bleker, OP; van Lith, JMM
      Co-variables in first trimester maternal serum screening

      PRENATAL DIAGNOSIS
    31. Spencer, K
      Screening for trisomy 21 in twin pregnancies in the first trimester using free beta-hCG and PAPP-A, combined with fetal nuchal translucency thickness

      PRENATAL DIAGNOSIS
    32. Hallahan, T; Krantz, D; Orlandi, F; Rossi, C; Curcio, P; Macri, S; Larsen, J; Buchanan, P; Macri, J
      First trimester biochemical screening for Down syndrome: free beta hCG versus intact hCG

      PRENATAL DIAGNOSIS
    33. Spencer, K; Ong, CYT; Liao, AWJ; Nicolaides, KH
      The influence of parity and gravidity on first trimester markers of chromosomal abnormality

      PRENATAL DIAGNOSIS
    34. Spencer, K; Ong, CYT; Liao, AWJ; Papademetriou, D; Nicolaides, KH
      First trimester markers of trisomy 21 and the influence of maternal cigarette smoking status

      PRENATAL DIAGNOSIS
    35. Krantz, DA; Hallahan, TW; Orlandi, F; Buchanan, P; Larsen, JW; Macri, JN
      First-trimester Down syndrome screening using dried blood biochemistry andnuchal translucency

      OBSTETRICS AND GYNECOLOGY
    36. Reynolds, TM
      Down's syndrome screening: a controversial test, with more controversy to come!

      JOURNAL OF CLINICAL PATHOLOGY

    37. First-trimester screening for fetal anomalies with nuchal translucency

      INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
    38. Butler, SA; Ikram, MS; Mathieu, S; Iles, RK
      The increase in bladder carcinoma cell population induced by the free betasubunit of human chorionic gonadotrophin is a result of an anti-apoptosis effect and not cell proliferation

      BRITISH JOURNAL OF CANCER
    39. Eiben, B; Goebel, R; von Kaisenberg, C; Hammans, W; Epplen, JT
      A neu test for risk evaluation of chromosomal trisomia in the first trimester of pregnancy

      DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
    40. Bersinger, NA; Meisser, A; Bessou, T; Seguin, P; Birkhauser, MH; Bischof, P
      Production and characterization of monoclonal antibodies against pregnancy-associated plasma protein A

      MOLECULAR HUMAN REPRODUCTION
    41. Benattar, C; Audibert, F; Taieb, J; Ville, Y; Roberto, A; Lindenbaum, A; Frydman, R
      Efficiency of ultrasound and biochemical markers for Down's syndrome risk screening - A prospective study

      FETAL DIAGNOSIS AND THERAPY
    42. Spencer, K; Souter, V; Tul, N; Snijders, R; Nicolaides, KH
      A screening program for trisomy 21 at 10-14 weeks using fetal nuchal translucency, maternal serum free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A

      ULTRASOUND IN OBSTETRICS & GYNECOLOGY
    43. Sherer, DM; Manning, FA
      First-trimester nuchal translucency screening for fetal aneuploidy

      AMERICAN JOURNAL OF PERINATOLOGY
    44. Aitken, DA; Ireland, M; Berry, E; Crossley, JA; Macri, JN; Burn, J; Connor, JM
      Second-trimester pregnancy associated plasma protein-A levels are reduced in Cornelia de Lange syndrome pregnancies

      PRENATAL DIAGNOSIS
    45. Cuckle, HS; van Lith, JMM
      Appropriate biochemical parameters in first-trimester screening for Down syndrome

      PRENATAL DIAGNOSIS
    46. de Graaf, IM; Pajkrt, E; Bilardo, CM; Leschot, NJ; Cuckle, HS; van Lith, JMM
      Early pregnancy screening for fetal aneuploidy with serum markers and nuchal translucency

      PRENATAL DIAGNOSIS
    47. De Biasio, P; Siccardi, M; Volpe, G; Famularo, L; Santi, F; Canini, S
      First-trimester screening for Down syndrome using nuchal translucency measurement with free beta-hCG and PAPP-A between 10 and 13 weeks of pregnancy - the combined test

      PRENATAL DIAGNOSIS
    48. Raty, R; Koskinen, P; Alanen, A; Irjala, K; Matinlauri, I; Ekblad, U
      Prediction of pre-eclampsia with maternal mid-trimester total renin, inhibin A, AFP and free beta-hCG levels

      PRENATAL DIAGNOSIS
    49. Hsu, JJ; Spencer, K; Aitken, DA; Crossley, J; Choi, T; Ozaki, M; Tazawa, H
      Urinary free beta hCG, beta core fragment and total oestriol as markers ofDown syndrome in the second trimester of pregnancy

      PRENATAL DIAGNOSIS
    50. Spencer, K; Crossley, JA; Green, K; Worthington, DJ; Brownbill, K; Aitken, DA
      Second trimester levels of pregnancy associated plasma protein-A in cases of trisomy 18

      PRENATAL DIAGNOSIS
    51. Tul, N; Spencer, K; Noble, P; Chan, C; Nicolaides, K
      Screening for trisomy 18 by fetal nuchal translucency and maternal serum free beta-hCG and PAPP-A at 10-14 weeks of gestation

      PRENATAL DIAGNOSIS
    52. Spencer, K
      The influence of smoking on maternal serum PAPP-A and free beta hCG levelsin the first trimester of pregnancy

      PRENATAL DIAGNOSIS
    53. Christiansen, M; Oxvig, C; Wagner, JM; Qin, QP; Nguyen, TH; Overgaard, MT; Larsen, SO; Sottrup-Jensen, L; Gleich, GJ; Norgaard-Pedersen, B
      The preform of eosinophil major basic protein: A new maternal serum markerfor Down syndrome

      PRENATAL DIAGNOSIS

    54. First-trimester screening for fetal anomalies with nuchal translucency

      OBSTETRICS AND GYNECOLOGY
    55. Spencer, K
      Accuracy of Down's syndrome risks produced in a prenatal screening program

      ANNALS OF CLINICAL BIOCHEMISTRY
    56. Chao, AS; Chung, CL; Wu, CD; Chang, SD; Cheng, PJ; Lin, YT; Soong, YK
      Second trimester maternal serum screening using alpha fetoprotein, free beta human chorionic gonadotropin and maternal age specific risk: Result of chromosomal abnormalities detected in screen positive for Down syndrome in an Asian population

      ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
    57. Ogle, RF; Chitty, LS
      Prenatal screening for Down syndrome

      HOSPITAL MEDICINE
    58. CUCKLE H
      DOWNS-SYNDROME SCREENING IN TWINS

      Journal of medical screening
    59. SEBIRE NJ; NICOLAIDES KH
      SCREENING FOR FETAL ABNORMALITIES IN MULTIPLE PREGNANCIES

      Bailliere's clinical obstetrics and gynaecology
    60. EXTERMANN P; BISCHOF P; MARGUERAT P; MERMILLOD B
      2ND-TRIMESTER MATERNAL SERUM SCREENING FOR DOWNS-SYNDROME - FREE BETA-HUMAN CHORIONIC-GONADOTROPIN (HCG) AND ALPHA-FETOPROTEIN, WITH OR WITHOUT UNCONJUGATED ESTRIOL, COMPARED WITH TOTAL HCG, ALPHA-FETOPROTEIN AND UNCONJUGATED ESTRIOL

      Human reproduction
    61. HALLAHAN TW; KRANTZ DA; TULUI L; ALBERTI E; BUCHANAN PD; ORLANDI F; KLEIN V; LARSEN JW; MACRI JN
      COMPARISON OF URINARY FREE BETA(HCG) AND BETA-CORE (HCG) IN PRENATAL SCREENING FOR CHROMOSOMAL-ABNORMALITIES

      Prenatal diagnosis
    62. SHEU BC; SHYU MK; LEE CN; KUO BJ; TSENG YY; HSIEH FJ
      MATERNAL AGE-SPECIFIC RISK OF DOWN-SYNDROME IN AN ASIAN POPULATION - A REPORT OF THE TAIWAN DOWN-SYNDROME SCREENING GROUP

      Prenatal diagnosis
    63. LAM YH; GHOSH A; TANG MHY; TANG LCH; LEE CP; SIN SY; HO PKH
      2ND-TRIMESTER MATERNAL SERUM ALPHA-FETOPROTEIN AND HUMAN CHORIONIC-GONADOTROPIN SCREENING FOR DOWNS-SYNDROME IN HONG-KONG

      Prenatal diagnosis
    64. SPENCER K
      THE INFLUENCE OF SMOKING ON MATERNAL SERUM AFP AND FREE BETA-HCG LEVELS AND THE IMPACT ON SCREENING FOR DOWN-SYNDROME

      Prenatal diagnosis
    65. WALD NJ; WATT HC; HADDOW JE; KNIGHT GJ
      SCREENING FOR DOWN-SYNDROME AT 14 WEEKS OF PREGNANCY

      Prenatal diagnosis
    66. MORSSINK LP; KORNMAN LH; HALLAHAN TW; KLOOSTERMAN MD; BEEKHUIS JR; DEWOLF BTHM; MANTINGH A
      MATERNAL SERUM LEVELS OF FREE BETA-HCG AND PAPP-A IN THE FIRST-TRIMESTER OF PREGNANCY ARE NOT ASSOCIATED WITH SUBSEQUENT FETAL GROWTH-RETARDATION OR PRETERM DELIVERY

      Prenatal diagnosis
    67. SPENCER K; CARPENTER P
      IS PROSTATE-SPECIFIC ANTIGEN A MARKER FOR PREGNANCIES AFFECTED BY DOWN-SYNDROME

      Clinical chemistry
    68. ORLANDI F; DAMIANI G; HALLAHAN TW; KRANTZ DA; MACRI JN
      FIRST-TRIMESTER SCREENING FOR FETAL ANEUPLOIDY - BIOCHEMISTRY AND NUCHAL TRANSLUCENCY

      Ultrasound in obstetrics & gynecology
    69. BERRY E; AITKEN DA; CROSSLEY JA; MACRI JN; CONNOR JM
      SCREENING FOR DOWNS-SYNDROME - CHANGES IN MARKER LEVELS AND DETECTIONRATES BETWEEN FIRST AND 2ND TRIMESTERS

      British journal of obstetrics and gynaecology
    70. HSU JJ; HSIEH TT; SOONG YK; SPENCER K
      COMPARISON OF DOWNS-SYNDROME SCREENING STRATEGIES IN ASIANS COMBININGSERUM-FREE BETA-HCG AND ALPHA-FETOPROTEIN WITH MATERNAL AGE

      Prenatal diagnosis
    71. SPENCER K; NOBLE P; SNIJDERS RJM; NICOLAIDES KH
      FIRST-TRIMESTER URINE FREE BETA-HCG, BETA-CORE, AND TOTAL ESTRIOL IN PREGNANCIES AFFECTED BY DOWNS-SYNDROME - IMPLICATIONS FOR FIRST-TRIMESTER SCREENING WITH NUCHAL TRANSLUCENCY AND SERUM-FREE BETA-HCG

      Prenatal diagnosis
    72. SPENCER K; MULLER F; AITKEN DA
      BIOCHEMICAL MARKERS OF TRISOMY-21 IN AMNIOTIC-FLUID

      Prenatal diagnosis
    73. QIN QP; CHRISTIANSEN M; OXVIG C; PETTERSSON K; SOTTRUPJENSEN L; KOCH C; NORGAARDPEDERSEN B
      DOUBLE-MONOCLONAL IMMUNOFLUOROMETRIC ASSAYS FOR PREGNANCY-ASSOCIATED PLASMA-PROTEIN-A PROEOSINOPHIL MAJOR BASIC-PROTEIN (PAPP-A PROMBP) COMPLEX IN FIRST-TRIMESTER MATERNAL SERUM SCREENING FOR DOWN-SYNDROME/

      Clinical chemistry
    74. MASSE J; FOREST JC; MOUTQUIN JM; DEGRANDPRE P
      EFFECT OF REPEATED FREEZE-THAW CYCLES ON MATERNAL SERUM BIOLOGICAL MARKERS FOR THE DETECTION OF FETAL TRISOMIES

      Clinical biochemistry
    75. POWELL KJ; GRUDZINSKAS JG
      SCREENING FOR DOWN-SYNDROME IN THE FIRST TRIMESTER

      Reproduction, fertility and development
    76. VANLITH JMM
      MARKERS FOR DOWNS-SYNDROME IN EARLY-PREGNANCY

      Early human development
    77. ZIMMERMANN R; HUCHA A; SAVOLDELLI G; BINKERT F; ACHERMANN J; GRUDZINSKAS JG
      SERUM PARAMETERS AND NUCHAL TRANSLUCENCY IN FIRST TRIMESTER SCREENINGFOR FETAL CHROMOSOMAL-ABNORMALITIES

      British journal of obstetrics and gynaecology
    78. ALSEBAI MAH; DIVER M; HIPKIN LJ
      THE ROLE OF A SINGLE FREE BETA-HUMAN CHORIONIC-GONADOTROPIN MEASUREMENT IN THE DIAGNOSIS OF EARLY-PREGNANCY FAILURE AND THE PROGNOSIS OF FETAL VIABILITY

      Human reproduction
    79. LAUNDON CH; SPENCER K; MACRI JN; ANDERSON RW; BUCHANAN PD
      FREE BETA-HCG SCREENING OF HYDROPIC AND NON-HYDROPIC TURNER SYNDROME PREGNANCIES

      Prenatal diagnosis
    80. SPENCER K; AITKEN DA; MACRI JN; BUCHANAN PD
      URINE FREE BETA-HCG AND BETA-CORE IN PREGNANCIES AFFECTED BY DOWNS-SYNDROME

      Prenatal diagnosis
    81. NOBLE PL; ABRAHA HD; SNIJDERS RJM; SHERWOOD R; NICOLAIDES KH
      SCREENING FOR FETAL TRISOMY-21 IN THE FIRST TRIMESTER OF PREGNANCY - MATERNAL SERUM-FREE BETA-HCG AND FETAL NUCHAL TRANSLUCENCY THICKNESS

      Ultrasound in obstetrics & gynecology
    82. BRIZOT ML; SNIJDERS RJM; BUTLER J; BERSINGER NA; NICOLAIDES KH
      MATERNAL SERUM HCG AND FETAL NUCHAL TRANSLUCENCY THICKNESS FOR THE PREDICTION OF FETAL TRISOMIES IN THE FIRST TRIMESTER OF PREGNANCY

      British journal of obstetrics and gynaecology
    83. CHARD T; MACINTOSH MCM
      SCREENING FOR DOWNS-SYNDROME

      Journal of perinatal medicine
    84. SANCKEN U; BAHNER D
      THE EFFECT OF THERMAL-INSTABILITY OF INTACT HUMAN CHORIONIC-GONADOTROPIN (IHCG) ON THE APPLICATION OF ITS FREE BETA-SUBUNIT (FREE BETA-HCG)AS A SERUM MARKER IN DOWN-SYNDROME SCREENING

      Prenatal diagnosis
    85. WALD NJ; KENNARD A; HACKSHAW AK
      FIRST TRIMESTER SERUM SCREENING FOR DOWNS-SYNDROME

      Prenatal diagnosis
    86. BARNABEI VM; KRANTZ DA; MACRI JN; LARSEN JW
      ENHANCED TWIN PREGNANCY DETECTION WITHIN AN OPEN NEURAL-TUBE DEFECT AND DOWN-SYNDROME SCREENING PROTOCOL USING FREE-BETA HCG AND AFP

      Prenatal diagnosis
    87. FOREST JC; MASSE J; ROUSSEAU F; MOUTQUIN JM; BRIDEAU NA; BELANGER M
      SCREENING FOR DOWN-SYNDROME DURING THE FIRST AND 2ND TRIMESTERS - IMPACT OF RISK-ESTIMATION PARAMETERS

      Clinical biochemistry
    88. WALD NJ; KENNARD A; SMITH D
      FIRST TRIMESTER BIOCHEMICAL SCREENING FOR DOWNS-SYNDROME

      Annals of medicine
    89. WALD NJ; DENSEM JW; CHENG R; COLLISHAW S
      MATERNAL SERUM-FREE ALPHA-HUMAN AND FREE BETA-HUMAN CHORIONIC-GONADOTROPIN IN PREGNANCIES WITH INSULIN-DEPENDENT DIABETES-MELLITUS - IMPLICATIONS FOR SCREENING FOR DOWNS-SYNDROME

      Prenatal diagnosis
    90. WALD NJ; DENSEM JW; SMITH D; KLEE GG
      4-MARKER SERUM SCREENING FOR DOWNS-SYNDROME

      Prenatal diagnosis
    91. SPENCER K; SALONEN R; MULLER F
      DOWNS-SYNDROME SCREENING IN MULTIPLE PREGNANCIES USING ALPHA-FETOPROTEIN AND FREE BETA-HCG

      Prenatal diagnosis
    92. GOODWIN TM; HERSHMAN JM; COLE L
      INCREASED CONCENTRATION OF THE FREE BETA-SUBUNIT OF HUMAN CHORIONIC-GONADOTROPIN IN HYPEREMESIS GRAVIDARUM

      Acta obstetricia et gynecologica Scandinavica
    93. DEDEYSTERE O
      DOWNS-SYNDROME - IMPROVED SCREENING THROU GH FREE BETA-HCG

      Pathologie et biologie


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Documento generato il 26/10/20 alle ore 06:34:35