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La ricerca find articoli where soggetti phrase all words 'drug discovery' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 871 riferimenti
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    1. Guyon, I; Weston, J; Barnhill, S; Vapnik, V
      Gene selection for cancer classification using support vector machines

      MACHINE LEARNING
    2. Xue, L; Godden, JW; Stahura, FL; Bajorath, J
      A dual fingerprint-based metric for the design of focused compound libraries and analogs

      JOURNAL OF MOLECULAR MODELING
    3. Triche, TJ; Schofield, D; Buckley, J
      DNA microarrays in pediatric cancer

      CANCER JOURNAL
    4. Herrmann, JL; Rastelli, L; Burgess, CE; Fernandez, EE; Rothberg, BEG; Rothberg, JM; Shimkets, RA
      Implications of oncogenomics for cancer research and clinical oncology

      CANCER JOURNAL
    5. Weiss, GA
      Training future chemical biologists

      CHEMICAL INNOVATION
    6. Tice, CM
      Selecting the right compounds for screening: does Lipinski's Rule of 5 forpharmaceuticals apply to agrochemicals?

      PEST MANAGEMENT SCIENCE
    7. Harrison, BA; Verdine, GL
      The synthesis of an exhaustively stereodiversified library of cis-1,5 enediols by silyl-tethered ring-closing metathesis

      ORGANIC LETTERS
    8. Brady, SF; Chao, CJ; Handelsman, J; Clardy, J
      Cloning and heterologous expression of a natural product biosynthetic genecluster from eDNA

      ORGANIC LETTERS
    9. Martin, YC; Willett, P; Lajiness, M; Johnson, M; Maggiora, G; Martin, E; Bures, MG; Gasteiger, J; Cramer, RD; Pearlman, RS; Mason, JS
      Diverse viewpoints on computational aspects of molecular diversity

      JOURNAL OF COMBINATORIAL CHEMISTRY
    10. Albericio, F; Bryman, LM; Garcia, J; Michelotti, EL; Nicolas, E; Tice, CM
      Synthesis of a sulfahydantoin library

      JOURNAL OF COMBINATORIAL CHEMISTRY
    11. Acharya, AN; Nefzi, A; Ostresh, JM; Houghten, RA
      Tethered libraries: Solid-phase synthesis of substituted urea-linked bicyclic guanidines

      JOURNAL OF COMBINATORIAL CHEMISTRY
    12. Topiol, S; Davies, J; Vijayakuma, S; Wareing, JR
      Computer aided analysis of split and mix combinatorial libraries

      JOURNAL OF COMBINATORIAL CHEMISTRY
    13. Versele, M; Lemaire, K; Thevelein, JM
      Sex and sugar in yeast: two distinct GPCR systems

      EMBO REPORTS
    14. Craig, AG; DeBoard, R; Kirby, D; Jiang, GC; Koerber, SC; Rivier, JE
      Characterization of betidamino acid-containing somatostatin and gonadotropin-releasing hormone analogs with electrospray mass spectrometry and tandemmass spectrometry

      EUROPEAN JOURNAL OF MASS SPECTROMETRY
    15. Cooper, CS
      Applications of microarray technology in breast cancer research

      BREAST CANCER RESEARCH
    16. McConnell, JD
      The development of urology in the 21st century

      BJU INTERNATIONAL
    17. Takenaka, T
      Classical vs reverse pharmacology in drug discovery

      BJU INTERNATIONAL
    18. Bunyapaiboonsri, T; Ramstrom, O; Lohmann, S; Lehn, JM; Peng, L; Goeldner, M
      Dynamic deconvolution of a pre-equilibrated dynamic combinatorial library of acetylcholinesterase inhibitors

      CHEMBIOCHEM
    19. Ruijtenbeek, R; Kruijtzer, JAW; van de Wiel, W; Fischer, MJE; Fluck, M; Redegeld, FAM; Liskamp, RMJ; Nijkamp, FP
      Peptoid-peptide hybrids that bind Syk SH2 domains involved in signal transduction

      CHEMBIOCHEM
    20. Schlosser, M
      The organometallic approach to molecular diversity - Halogens as helpers

      EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
    21. Li, GY; Fagan, PJ; Watson, PL
      Versatile approaches to the polymer-supported synthesis of bidentate phosphorus-containing ligands

      ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    22. Atrash, B; Bradley, M; Kobylecki, R; Cowell, D; Reader, J
      Revolutionizing resin handling for combinatorial synthesis

      ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    23. Wess, G; Urmann, M; Sickenberger, B
      Medicinal chemistry: Challenges and opportunities

      ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    24. Nuttall, ME
      Drug discovery and target validation

      CELLS TISSUES ORGANS
    25. Leena, S; Kumar, KS
      Syntheses, characterization and application of crosslinked polystyrene-ethyleneglycol acrylate resin (CLPSER) as a novel polymer support for polypeptide syntheses

      JOURNAL OF PEPTIDE RESEARCH
    26. Henlin, JM; Boutin, JA; Kucharczyk, N; Desmet-Beaufort, C; Loynel, A; Bertrand, M; Genton, A; Tucker, GC; Atassi, G; Fauchere, JL
      From peptide libraries to optimized nonpeptide ligands in the search for S-farnesyltransferase inhibitors

      JOURNAL OF PEPTIDE RESEARCH
    27. Burgess, K; Han, I; Zhang, A; Zheng, WH; Shanmugam, K; Featherstone, MS; Saragovi, HU
      DiSSiMiL: Diverse Small Size Mini-Libraries applied to simple and rapid epitope mapping of a monoclonal antibody

      JOURNAL OF PEPTIDE RESEARCH
    28. Weber, WW
      The legacy of pharmacogenetics and potential applications

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    29. Xu, MC; Ou, ZZ; Shi, ZQ; Xu, MC; Li, HT; Yu, SX; He, BL
      Combinatorial synthesis and screening of polystyrene-supported quaternary ammonium salt phase transfer catalysts

      REACTIVE & FUNCTIONAL POLYMERS
    30. Budde, RJA; Ramdas, L; Sun, GQ
      Cloning, expression, purification and characterization of the alternate splice Src variants for drug discovery

      JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
    31. Hughes, I; Hunter, D
      Techniques for analysis and purification in high-throughput chemistry

      CURRENT OPINION IN CHEMICAL BIOLOGY
    32. Lowe, CR
      Combinatorial approaches to affinity chromatography

      CURRENT OPINION IN CHEMICAL BIOLOGY
    33. Arya, P; Baek, MG
      Natural-product-like chiral derivatives by solid-phase synthesis

      CURRENT OPINION IN CHEMICAL BIOLOGY
    34. Ripka, WC; Barker, G; Krakover, J
      High-throughput purification of compound libraries

      DRUG DISCOVERY TODAY
    35. Sanseau, P
      Impact of human genome sequencing for in silico target discovery

      DRUG DISCOVERY TODAY
    36. Beno, BR; Mason, JS
      The design of combinatorial libraries using properties and 3D pharmacophore fingerprints

      DRUG DISCOVERY TODAY
    37. Lepre, CA
      Library design for NMR-based screening

      DRUG DISCOVERY TODAY
    38. Manly, CJ; Louise-May, S; Hammer, JD
      The impact of informatics and computational chemistry on synthesis and screening

      DRUG DISCOVERY TODAY
    39. Everett, J; Gardner, M; Pullen, F; Smith, GF; Snarey, M; Terrett, N
      The application of non-combinatorial chemistry to lead discovery

      DRUG DISCOVERY TODAY
    40. Crouch, SPM; Slater, KJ
      High-throughput cytotoxicity screening: hit and miss

      DRUG DISCOVERY TODAY
    41. Wolcke, J; Ullmann, D
      Miniaturized HTS technologies - uHTS

      DRUG DISCOVERY TODAY
    42. Ross, A; Senn, H
      Automation of measurements and data evaluation in biomolecular NMR screening

      DRUG DISCOVERY TODAY
    43. Sawyer, T; Boyce, B; Dalgarno, D; Iuliucci, J
      Src inhibitors: genomics to therapeutics

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    44. Treadway, JL; Mendys, P; Hoover, DJ
      Glycogen phosphorylase inhibitors for treatment of type 2 diabetes mellitus

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    45. Neamati, N
      Structure-based HIV-1 integrase inhibitor design: a future perspective

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    46. Trust, TJ; Alm, RA; Pappo, J
      Helicobacter pylori: Today's treatment, and possible future treatment

      EUROPEAN JOURNAL OF SURGERY
    47. Fielden, MR; Zacharewski, TR
      Challenges and limitations of gene expression profiling in mechanistic andpredictive toxicology

      TOXICOLOGICAL SCIENCES
    48. Pessi, A
      A personal account of the role sf peptide research in drug discovery: the case of hepatitis C

      JOURNAL OF PEPTIDE SCIENCE
    49. Wienkers, LC
      Problems associated with in vitro assessment of drug inhibition of CYP3A4 and other P-450 enzymes and its impact on drug discovery

      JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
    50. Youssef, KM; Al-Abdullah, E; El-Khamees, H
      Synthesis of certain diarylsulfonylureas as antitumor agents

      MEDICINAL CHEMISTRY RESEARCH
    51. Kurella, M; Hsiao, LL; Yoshida, T; Randall, JD; Chow, G; Sarang, SS; Jensen, RV; Gullans, SR
      DNA microarray analysis of complex biologic processes

      JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
    52. Falsey, JR; Renil, M; Park, S; Li, SJ; Lam, KS
      Peptide and small molecule microarray for high throughput cell adhesion and functional assays

      BIOCONJUGATE CHEMISTRY
    53. Evans, B; Pipe, A; Clark, L; Banks, M
      Identification of a potent and selective oxytocin antagonist, from screening a fully encoded differential release combinatorial chemical library

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    54. Scheller, FW; Wollenberger, U; Warsinke, A; Scheller, FW
      Research and development in biosensors

      CURRENT OPINION IN BIOTECHNOLOGY
    55. Nakamura, C; Inuyama, Y; Shirai, K; Sugimoto, N; Miyake, J
      Detection of porphyrin using a short peptide immobilized on a surface plasmon resonance sensor chip

      BIOSENSORS & BIOELECTRONICS
    56. Baird, CL; Myszka, DG
      Current and emerging commercial optical biosensors

      JOURNAL OF MOLECULAR RECOGNITION
    57. He, H; Kramp, R; Ramos, L; Bakhtiar, R
      A preliminary study on the feasibility of an automated blood-sampling system in conjunction with liquid chromatography/mass spectrometry

      RAPID COMMUNICATIONS IN MASS SPECTROMETRY
    58. Wang, PG; Snavley, DF; Freitas, MA; Pei, DH
      Screening combinatorial libraries for optimal enzyme substrates by mass spectrometry

      RAPID COMMUNICATIONS IN MASS SPECTROMETRY
    59. Cordell, GA; Quinn-Beattie, ML; Farnsworth, NR
      The potential of alkaloids in drug discovery

      PHYTOTHERAPY RESEARCH
    60. Barkley, A; Arya, P
      Combinatorial chemistry toward understanding the function(s) of carbohydrates and carbohydrate conjugates

      CHEMISTRY-A EUROPEAN JOURNAL
    61. Shuker, SB; Esterbrook, J; Gonzalez, J
      Solid-phase synthesis of a novel peptide substituted calix[4]arene

      SYNLETT
    62. Delhaes, L; Abessolo, H; Biot, C; Berry, L; Delcourt, P; Maciejewski, L; Brocard, J; Camus, D; Dive, D
      In vitro and in vivo antimalarial activity of ferrochloroquine, a ferrocenyl analogue of chloroquine against chloroquine-resistant malaria parasites

      PARASITOLOGY RESEARCH
    63. Baba, Y
      Development of novel biomedicine based on genome science

      EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
    64. Thomson, S; Hoffmann, C; Ruthe, S; Schmidt, HW; Schuth, F
      The development of a high throughput reactor for the catalytic screening of three phase reactions

      APPLIED CATALYSIS A-GENERAL
    65. Scahill, TA; Kloosterman, DA; Cialdella, JI; Deibel, MR; Marshall, VP; Yem, AW
      Backbone (H-1, N-15, C-13) resonance assignments of a 21 kDa construct of S-aureus peptide deformylase

      JOURNAL OF BIOMOLECULAR NMR
    66. Hurko, O
      Genetics and genomics in neuropsychopharmacology: the impact on drug discovery and development

      EUROPEAN NEUROPSYCHOPHARMACOLOGY
    67. De Clercq, E
      Hamao Umezawa Memorial Award lecture 'an odyssey in the viral chemotherapyfield'

      INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
    68. Bertelli, M; El-Bastawissy, E; Knaggs, MH; Barrett, MP; Hanau, S; Gilbert, IH
      Selective inhibition of 6-phosphogluconate dehydrogenase from Trypanosoma brucei

      JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
    69. Leach, AR; Green, DVS
      Computational chemistry in lead identification, library design and lead optimisation

      MOLECULAR SIMULATION
    70. Lamb, ML; Burdick, KW; Toba, S; Young, MM; Skillman, KG; Zou, XQ; Arnold, JR; Kuntz, ID
      Design, docking, and evaluation of multiple libraries against multiple targets

      PROTEINS-STRUCTURE FUNCTION AND GENETICS
    71. Andersson, PM; Sjostrom, M; Wold, S; Lundstedt, T
      Strategies for subset selection of parts of an in-house chemical library

      JOURNAL OF CHEMOMETRICS
    72. Pinder, RM
      On the feasibility of designing new antidepressants

      HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
    73. Jung, DR; Kapur, R; Adams, T; Giuliano, KA; Mrksich, M; Craighead, HG; Taylor, DL
      Topographical and physicochemical modification of material surface to enable patterning of living cells

      CRITICAL REVIEWS IN BIOTECHNOLOGY
    74. Stepp, JR; Moerman, DE
      The importance of weeds in ethnopharmacology

      JOURNAL OF ETHNOPHARMACOLOGY
    75. Tolstrup, AB; Duch, M; Dalum, I; Pedersen, FS; Mouritsen, S
      Functional screening of a retroviral peptide library for MHC class I presentation

      GENE
    76. Bhattacharyya, S
      Polymer-assisted solution-phase organic synthesis: Advances in multi-step synthetic applications

      INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
    77. Gittins, JC; Harper, G
      Bounds on the performance of a greedy algorithm for probabilities

      MATHEMATICS OF OPERATIONS RESEARCH
    78. LeProust, E; Zhang, H; Yu, PL; Zhou, XC; Gao, XL
      Characterization of oligodeoxyribonucleotide synthesis on glass plates

      NUCLEIC ACIDS RESEARCH
    79. Watve, MG; Tickoo, R; Jog, MM; Bhole, BD
      How many antibiotics are produced by the genus Streptomyces?

      ARCHIVES OF MICROBIOLOGY
    80. Gong, YD; Yoo, SE
      Solid-phase synthesis of benzopyran derivatives via highly efficient epoxidation using two-phase solvents

      BULLETIN OF THE KOREAN CHEMICAL SOCIETY
    81. Jang, GR; Harris, RZ; Lau, DT
      Pharmacokinetics and its role in small molecule drug discovery research

      MEDICINAL RESEARCH REVIEWS
    82. Kumar, GN; Surapaneni, S
      Role of drug metabolism in drug discovery and development

      MEDICINAL RESEARCH REVIEWS
    83. Shacham, S; Topf, M; Avisar, N; Glaser, F; Marantz, Y; Bar-Haim, S; Noiman, S; Naor, Z; Becker, OM
      Modeling the 3D structure of GPCRs from sequence

      MEDICINAL RESEARCH REVIEWS
    84. Watterson, DM; Mirzoeva, S; Guo, L; Whyte, A; Bourguignon, JJ; Hilbert, M; Haiech, J; Van Eldik, LJ
      Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II

      NEUROCHEMISTRY INTERNATIONAL
    85. Kuckuck, FW; Edwards, BS; Sklar, LA
      High throughput flow cytometry

      CYTOMETRY
    86. Thormann, M; Pons, M
      Massive docking of flexible ligands using environmental niches in parallelized genetic algorithms

      JOURNAL OF COMPUTATIONAL CHEMISTRY
    87. Agrafiotis, DK; Lobanov, VS
      Multidimensional scaling of combinatorial libraries without explicit enumeration

      JOURNAL OF COMPUTATIONAL CHEMISTRY
    88. Blackshear, PE
      Genetically engineered rodent models of mammary gland carcinogenesis: An overview

      TOXICOLOGIC PATHOLOGY
    89. Lothgren, A; McCartney, M; Thuresson, ER; James, SR
      A model of activation of the protein tyrosine phosphatase SHP-2 by the human leptin receptor

      BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
    90. Pilowsky, LS
      Probing targets for antipsychotic drug action with PET and SPET receptor imaging

      NUCLEAR MEDICINE COMMUNICATIONS
    91. Kim, JJ
      Using viral genomics to develop viral gene products as a novel class of drugs to treat human ailments

      BIOTECHNOLOGY LETTERS
    92. Zahn, JA; Higgs, RE; Hilton, MD
      Use of direct-infusion electrospray mass spectrometry to guide empirical development of improved conditions for expression of secondary metabolites from actinomycetes

      APPLIED AND ENVIRONMENTAL MICROBIOLOGY
    93. Cassell, GH; Mekalanos, J
      Development of antimicrobial agents in the era of new and reemerging infectious diseases and increasing antibiotic resistance

      JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
    94. Reynolds, CH; Tropsha, A; Pfahler, LB; Druker, R; Chakravorty, S; Ethiraj, G; Zheng, WF
      Diversity and coverage of structural sublibraries selected using the SAGE and SCA algorithms

      JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
    95. Graham, ET; Jacober, SP; Cardozo, MG
      A novel frequency distribution selection method for efficient plate layoutof a diverse combinatorial library

      JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
    96. Ravi, M; Hopfinger, AJ; Hormann, RE; Dinan, L
      4D-QSAR analysis of a set of ecdysteroids and a comparison to CoMFA modeling

      JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
    97. Chen, LG; Deem, MW
      Monte carlo methods for small molecule high-throughput experimentation

      JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
    98. Olender, R; Rosenfeld, R
      A fast algorithm for searching for molecules containing a pharmacophore invery large virtual combinatorial libraries

      JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
    99. MacCuish, J; Nicolaou, C; MacCuish, NE
      Ties in proximity and clustering compounds

      JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
    100. Fabricant, DS; Farnsworth, NR
      The value of plants used in traditional medicine for drug discovery

      ENVIRONMENTAL HEALTH PERSPECTIVES


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 07:19:32