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Combinatorial chemistry in cancer drug development
CANCER JOURNAL
Generation of species cross-reactive aptamers using "toggle" SELEX
MOLECULAR THERAPY
Prolongation of repolarization in pre-clinical investigations and phase I/II clinical trials: what should be done?
EUROPEAN HEART JOURNAL SUPPLEMENTS
Focus on issues in measuring and interpreting changes in the QTc interval duration
EUROPEAN HEART JOURNAL SUPPLEMENTS
Dithranol and dimethylfumarate suppress the interferon-gamma-induced up-regulation of cytokeratin 17 as a putative psoriasis autoantigen in vitro
SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY
Chlorproguanil-dapsone (LAPDAP) for uncomplicated falciparum malaria
TROPICAL MEDICINE & INTERNATIONAL HEALTH
Experimental approaches and drugs in development for the treatment of dementia
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Resveratrol causes WAF-l/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells
CLINICAL CANCER RESEARCH
Pet in psychopharmacology
PHARMACOLOGICAL RESEARCH
Discovery and initial structure-activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
In vitro stability of alpha-helical peptide nucleic acids (alpha PNAs)
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Population pharmacokinetics and dynamics in phase II studies of the novel bioreductive alkylating cytotoxic indoloquinone EO9
ANTI-CANCER DRUGS
Regeneration in avian hair cell epithelia: identification of intracellularsignals required for S-phase entry
EUROPEAN JOURNAL OF NEUROSCIENCE
Anticonvulsant activities of the FS-1 subfraction isolated from roots of Delphinium denudatum
PHYTOTHERAPY RESEARCH
In vitro intestinal and alveolar epithelium cultures in drug research
ALTEX-ALTERNATIVEN ZU TIEREXPERIMENTEN
TOGA analysis of gene expression to accelerate target development
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Computer-assisted drug development (CADD): an emerging technology for designing first-time-in-man and proof-of-concept studies from preclinical experiments
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Role of modelling and simulation in Phase I drug development
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Progress report on new antiepileptic drugs: a summary of the Fifth Eilat Conference (EILAT V)
EPILEPSY RESEARCH
Comparison of the effects of ketamine and memantine on prolactin and cortisol release in men: A randomized, double-blind, placebo-controlled trial
NEUROPSYCHOPHARMACOLOGY
In vitro metabolism studies of the prodrug, 2 ',3 ',5 '-triacetyl-6-azauridine, utilizing an automated analytical system
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Workshop on bioanalytical methods validation for macromolecules: Summary report
PHARMACEUTICAL RESEARCH
Mass spectrometry innovations in drug discovery and development
PHARMACEUTICAL RESEARCH
Anticonvulsant activities of ethanolic extract and aqueous fraction isolated from Delphinium denudatum
JOURNAL OF ETHNOPHARMACOLOGY
Use of positron emission tomography in analysing receptor function in vivo
TOXICOLOGY LETTERS
Antitumor efficacy of 26-fluoroepothilone B against human prostate cancer xenografts
CANCER CHEMOTHERAPY AND PHARMACOLOGY
New strategies for cancer therapy in the 21st century
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Interpreting the International Normalized Ratio (INR) in individuals receiving argatroban and warfarin
THROMBOSIS AND HAEMOSTASIS
Growth and development of children to 4 years of age after repeated antenatal steroid administration
EUROPEAN JOURNAL OF PEDIATRICS
Concentration-controlled or effect-controlled trials - Useful alternativesto conventional dose-controlled trials?
CLINICAL PHARMACOKINETICS
Pharmacokinetic-pharmacodynamic model for perindoprilat regional haemodynamic effects in healthy volunteers and in congestive heart failure patients
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
In vivo activity of CHS 828 on hollow-fibre cultures of primary human tumour cells from patients
CANCER LETTERS
Multiparameter flow cytometry of bacteria: Implications for diagnostics and therapeutics
CYTOMETRY
Towards the scientific validation of traditional medicinal plants
PLANT GROWTH REGULATION
Pharmacokinetic and pharmacodynamic modeling of NN703, a growth hormone secretagogue, after a single po dose to human volunteers
JOURNAL OF CLINICAL PHARMACOLOGY
Chapter 26. PET ligands for assessing receptor occupancy in vivo
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 36
"Natural history" clinical trials: An enduring contribution to modern medical practice
ADVANCES IN PROTEIN CHEMISTRY, VOL 56
Do we need new clnical ethical models in medical research?
WIENER KLINISCHE WOCHENSCHRIFT
Pharmacological properties of some aminoalkanolic derivatives of xanthone
PHARMAZIE
Anticonvulsant and neurotoxicity evaluation of 5-(un)-substituted isatinimino derivatives
PHARMAZIE
What does the human genome project mean for medicine?
NEW ZEALAND MEDICAL JOURNAL
Anticonvulsant and sodium channel blocking activity of higher doses of clenbuterol
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Pharmacognosy in the 21st century
JOURNAL OF PHARMACY AND PHARMACOLOGY
Enantiomeric drug development: Issues, considerations, and regulatory requirements
JOURNAL OF PHARMACEUTICAL SCIENCES
Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor
JOURNAL OF MOLECULAR BIOLOGY
Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax
JOURNAL OF MOLECULAR BIOLOGY
Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors
JOURNAL OF MEDICINAL CHEMISTRY
Indolequinone antitumor agents: Correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H : quinone oxidoreductase. Part 2
JOURNAL OF MEDICINAL CHEMISTRY
A new generation of Melan-A/MART-1 peptides that fulfill both increased immunogenicity and high resistance to biodegradation: Implication for molecular anti-melanoma immunotherapy
JOURNAL OF IMMUNOLOGY
Population pharmacokinetic-pharmacodynamic modelling of S 15535, a 5-MT1A receptor agonist, using a behavioural model in rats
EUROPEAN JOURNAL OF PHARMACOLOGY
Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist
EUROPEAN JOURNAL OF PHARMACOLOGY
Comparative QSAR study of tyrosine kinase inhibitors
CHEMICAL REVIEWS
Pharmacokinetic-pharmacodynamic modelling in the early development phase of anti-psychotics: A comparison of the effects of clozapine, S 16924 and S 18327 in the EEG model in rats
BRITISH JOURNAL OF PHARMACOLOGY
A novel strategy for NQO1 (NAD(P)H : quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9
BRITISH JOURNAL OF CANCER
Translating the basic and clinical cognitive neuroscience of schizophreniato drug development and clinical trials of antipsychotic medications
BIOLOGICAL PSYCHIATRY
Gene expression microarray analysis in cancer biology, pharmacology, and drug development: progress and potential
BIOCHEMICAL PHARMACOLOGY
Genotyping of NAD(P)H : quinone oxidoreductase (NQO1) in a panel of human tumor xenografts: relationship between genotype status, NQO1 activity and the response of xenografts to Mitomycin C chemotherapy in vivo
BIOCHEMICAL PHARMACOLOGY
Relationship between NAD(P)H : quinone oxidoreductase 1 (NQO1) levels in aseries of stably transfected cell lines and susceptibility to antitumor quinones
BIOCHEMICAL PHARMACOLOGY
Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol
BIOCHEMICAL PHARMACOLOGY
From anatomy to the target: Contributions of magnetic resonance imaging topreclinical pharmaceutical research
ANATOMICAL RECORD
Replication of the hepatitis C virus
BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
The role of reductive enzymes in cancer cell resistance to mitomycin C
DRUG RESISTANCE UPDATES
New advances in pharmacogenomics
CURRENT OPINION IN CHEMICAL BIOLOGY
An assessment of rufinamide as an anti-epileptic in comparison with other drugs in clinical development
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Inhibition of CFU-E/BFU-E by 3 '-azido-3 '-deoxythymidine, chlorpropamide,and protoporphirin IX zinc (II): A comparison between direct exposure of progenitor cells and long-term exposure of bone marrow cultures
TOXICOLOGICAL SCIENCES
Pharmacology of antisense oligonucleotides
JOURNAL OF CLINICAL LIGAND ASSAY
A polyphenolic fraction from grape seeds causes irreversible growth inhibition of breast carcinoma MDA-MB468 cells by inhibiting mitogen-activated protein kinases activation and inducing G(1) arrest and differentiation
CLINICAL CANCER RESEARCH
Enhancing cancer clinical trial management: Recommendations from a qualitative study of trial participants' experiences
PSYCHO-ONCOLOGY
Financing new drug development in ophthalmology
JOURNAL OF GLAUCOMA
Genomics and proteomics - The new millennium of drug discovery and development
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
The assessment of potential for QT interval prolongation with new pharmaceuticals Impact on drug development
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
Monitoring response to treatment in the development of anticancer drugs using PET
NUCLEAR MEDICINE AND BIOLOGY
Use of PET and the radioligand [Carbonyl-C-11]WAY-100635 in psychotropic drug development
NUCLEAR MEDICINE AND BIOLOGY
In silico studies for the rational discovery of anticonvulsant compounds
BIOORGANIC & MEDICINAL CHEMISTRY
Insect peptides with improved protease-resistance protect mice against bacterial infection
PROTEIN SCIENCE
Differential activity of topotecan, irinotecan and SN-38 in fresh human tumour cells but not in cell lines
EUROPEAN JOURNAL OF CANCER
New therapies and delivery mechanisms for treatment of erectile dysfunction
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
Ethnobotany and its role in drug development
PHYTOTHERAPY RESEARCH
Development of inhibitors for protein tyrosine kinases
ONCOGENE
Cultural differences: implications on drug therapy and global drug development
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
East-West development: understanding the usability and acceptance of foreign data in Japan
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
Effect of food and gender on the pharmacokinetics of RP 73401, a phosphodiesterase IV inhibitor
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
Induction and drug development
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Harmonization of dementia drug guidelines (United States and Europe): A report of the International Working Group for the Harmonization for Dementia Drug Guidelines
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
Nitric oxide and postangioplasty restenosis: pathological correlates and therapeutic potential
FREE RADICAL BIOLOGY AND MEDICINE
Nitric oxide (NO)-related pharmaceuticals: Contemporary approaches to therapeutic NO modulation
FREE RADICAL BIOLOGY AND MEDICINE
Validation of immunoassays for bioanalysis: a pharmaceutical industry perspective
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Multiagent chemopreventive agent combinations
JOURNAL OF CELLULAR BIOCHEMISTRY
Career opportunities for physicians in the pharmaceutical industry
MEDIZINISCHE KLINIK
Tasks of clinical pharmacology in the early phase of drug development
MEDIZINISCHE KLINIK
Pharmacometrics: modelling and simulation tools to improve decision makingin clinical drug development
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
Biopharmaceutics and pharmacokinetics in drug research
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Simulation of clinical trials
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
Applications of pharmacogenetics to drug development: The Glaxo Wellcome experience
DRUG METABOLISM REVIEWS
Camptothecin analogues with enhanced antitumor activity at acidic pH
CANCER CHEMOTHERAPY AND PHARMACOLOGY
The application of Shannon entropy in the identification of putative drug targets
BIOSYSTEMS
Development of a melatonin-based formulation for the treatment of insomniain the elderly
DRUG DEVELOPMENT RESEARCH
Site-directed irreversible inhibitors of the erbB family of receptor tyrosine kinases as novel chemotherapeutic agents for cancer
ANTI-CANCER DRUG DESIGN
Synthesis and anticonvulsant activity of 4-bromophenyl substituted aryl semicarbazones
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Enantiomeric separation of alanyl and leucyl dipeptides by capillary electrophoresis with cyclodextrins as chiral selectors
ELECTROPHORESIS