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La ricerca find articoli where soggetti phrase all words 'compartmentalization' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 321 riferimenti
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    1. Miller, ML; Andringa, A; Dixon, K; Carty, MP
      Insights into UV-induced apoptosis: ultrastructure, trichrome stain and spectral imaging

      MICRON
    2. Hoheisel, G; Sack, U; Hui, DSC; Huse, K; Chan, KS; Chan, KK; Hartwig, K; Schuster, E; Scholz, GH; Schauer, J
      Occurrence of matrix metalloproteinases and tissue inhibitors of metalloproteinases in tuberculous pleuritis

      TUBERCULOSIS
    3. Rozdilsky, ID; Stone, L
      Complexity can enhance stability in competitive systems

      ECOLOGY LETTERS
    4. Martin, W; Hoffmeister, M; Rotte, C; Henze, K
      An overview of endosymbiotic models for the origins of eukaryotes, their ATP-producing organelles (mitochondria and hydrogenosomes), and their heterotrophic lifestyle

      BIOLOGICAL CHEMISTRY
    5. Rothardt, G; Beier, K
      Peroxisomes in the apocrine sweat glands of the human axilla and their putative role in pheromone production

      CELLULAR AND MOLECULAR LIFE SCIENCES
    6. Matute-Bello, G; Frevert, CW; Kajikawa, O; Skerrett, SJ; Goodman, RB; Park, DR; Martin, TR
      Septic shock and acute lung injury in rabbits with peritonitis - Failure of the neutrophil response to localized infection

      AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
    7. Mathiak, G; Neville, LF; Grass, G; Boehm, SA; Luebke, T; Herzmann, T; Kabir, K; Rosendahl, R; Schaefer, U; Mueller, C; Bohlen, H; Wassermann, K; Hoelscher, AH
      Chemokines and interleukin-18 are up-regulated in bronchoalveolar lavage fluid but not in serum of septic surgical ICU patients

      SHOCK
    8. Jertborn, M; Ahren, C; Svennerholm, AM
      Dose-dependent circulating immunoglobulin A antibody-secreting cell and serum antibody responses in Swedish volunteers to an oral inactivated enterotoxigenic Escherichia coli vaccine

      CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
    9. Pastor-Satorras, R; Sole, RV
      Field theory for a reaction-diffusion model of quasispecies dynamics - art. no. 051909

      PHYSICAL REVIEW E
    10. Bozza, PT; Weller, PF
      Arachidonyl trifluoromethyl ketone induces lipid body formation in leukocytes

      PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
    11. O'Keefe, DD; Thomas, JB
      Drosophila wing development in the absence of dorsal identity

      DEVELOPMENT
    12. Weihe, U; Milan, M; Cohen, SM
      Regulation of Apterous activity in Drosophila wing development

      DEVELOPMENT
    13. Milan, M; Weihe, U; Tiong, S; Bender, W; Cohen, SM
      msh specifies dorsal cell fate in the Drosophila wing

      DEVELOPMENT
    14. Houtsmuller, AB; Vermeulen, W
      Macromolecular dynamics in living cell nuclei revealed by fluorescence redistribution after photobleaching

      HISTOCHEMISTRY AND CELL BIOLOGY
    15. Fischer, MS
      Locomotory organs of mammals: New mechanics and feed-back pathways but conservative central control

      ZOOLOGY-ANALYSIS OF COMPLEX SYSTEMS
    16. Bulchand, S; Grove, EA; Porter, FD; Tole, S
      LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem

      MECHANISMS OF DEVELOPMENT
    17. Grant, SC; Buckley, DL; Gibb, S; Webb, AG; Blackband, SJ
      MR microscopy of multicomponent diffusion in single neurons

      MAGNETIC RESONANCE IN MEDICINE
    18. Terra, WR
      The origin and functions of the insect peritrophic membrane and peritrophic gel

      ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
    19. Vergani, L; Mascetti, G; Nicolini, C
      Changes of nuclear structure induced by increasing temperatures

      JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
    20. Thapa, GB
      Changing approaches to mountain watersheds management in mainland South and Southeast Asia

      ENVIRONMENTAL MANAGEMENT
    21. Van Emous, JG; Vleggeert-Lankamp, LAM; Nederhoff, MGJ; Ruigrok, TJC; Van Echteld, CJA
      Postischemic Na+-K+-ATPase reactivation is delayed in the absence of glycolytic ATP in isolated rat hearts

      AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
    22. Scarfo, LM; Weller, PF; Farber, HW
      Induction of endothelial cell cytoplasmic lipid bodies during hypoxia

      AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
    23. Trump, ME; Hanstock, CC; Allen, PS; Gheorghiu, D; Hochachka, PW
      An H-1-MRS evaluation of the phosphocreatine/creatine pool (tCr) in human muscle

      AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
    24. Snyder-Keller, A; Costantini, LC; Graber, DJ
      Development of striatal patch/matrix organization in organotypic co-cultures of perinatal striatum, cortex and substantia nigra

      NEUROSCIENCE
    25. Nishizawa, Y; Usukura, J; Singh, DP; Chylack, LT; Shinohara, T
      Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus

      CELL AND TISSUE RESEARCH
    26. Lyckman, AW; Jhaveri, S; Feldheim, DA; Vanderhaeghen, P; Flanagan, JG; Sur, M
      Enhanced plasticity of retinothalamic projections in an ephrin-A2/A5 double mutant

      JOURNAL OF NEUROSCIENCE
    27. Gauck, V; Thomann, M; Jaeger, D; Borst, A
      Spatial distribution of low- and high-voltage-activated calcium currents in neurons of the deep cerebellar nuclei

      JOURNAL OF NEUROSCIENCE
    28. Jones, K; Bray, PG; Khoo, SH; Davey, RA; Meaden, ER; Ward, SA; Back, DJ
      P-glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?

      AIDS
    29. Reymond, A; Meroni, G; Fantozzi, A; Merla, G; Cairo, S; Luzi, L; Riganelli, D; Zanaria, E; Messali, S; Cainarca, S; Guffanti, A; Minucci, S; Pelicci, PG; Ballabio, A
      The tripartite motif family identifies cell compartments

      EMBO JOURNAL
    30. Doulazmi, M; Frederic, F; Capone, F; Becker-Andre, M; Delhaye-Bouchaud, N; Mariani, J
      A comparative study of Purkinje cells in two ROR alpha gene mutant mice: staggerer and ROR alpha(-/-)

      DEVELOPMENTAL BRAIN RESEARCH
    31. Law, S; Maiti, D; Palit, A; Majumder, D; Basu, K; Chaudhuri, S; Chaudhuri, S
      Facilitation of functional compartmentalization of bone marrow cells in leukemic mice by biological response modifiers: an immunotherapeutic approach

      IMMUNOLOGY LETTERS
    32. Milan, M; Weihe, U; Perez, L; Cohen, SM
      The LRR proteins Capricious and Tartan mediate cell interactions during DVboundary formation in the Drosophila wing

      CELL
    33. Papageorgiou, S
      A physical force may expose Hox genes to express in a morphogenetic density gradient

      BULLETIN OF MATHEMATICAL BIOLOGY
    34. Matsumae, M; Kurita, D; Atsumi, H; Haida, M; Sato, O; Tsugane, R
      Sequential changes in MR water proton relaxation time detect the process of rat brain myelination during maturation

      MECHANISMS OF AGEING AND DEVELOPMENT
    35. Simard, M; Rioux, D; Laflamme, G
      Formation of Ligno-suberized tissues in jack pine resistant to the European race of Gremmeniella abietina

      PHYTOPATHOLOGY
    36. Negrutskii, BS; El'skaya, AV
      Functional compartmentalization of the translation apparatus and channeling of tRNA/aminoacyl-tRNA in cells of higher eukaryotes

      MOLECULAR BIOLOGY
    37. Cohn, MA; Frankel, SS; Rugpao, S; Young, MA; Willett, G; Tovanabutra, S; Khamboonruang, C; VanCott, T; Bhoopat, L; Barrick, S; Fox, C; Quinn, TC; Vahey, M; Nelson, KE; Weissman, D
      Chronic inflammation with increased human immunodeficiency virus (HIV) RNAexpression in the vaginal epithelium of HIV-infected Thai women

      JOURNAL OF INFECTIOUS DISEASES
    38. Pullium, JK; Adams, DR; Jackson, E; Kim, CN; Smith, DK; Janssen, R; Gould, K; Folks, TM; Butera, S; Otten, RA
      Pig-tailed macaques infected with human immunodeficiency virus (HIV) type 2(GB122) or simian/HIV89.6p express virus in semen during primary infection: New model for genital tract shedding and transmission

      JOURNAL OF INFECTIOUS DISEASES
    39. Schwarz, C; Mock, M
      Spatial arrangement of cerebro-pontine terminals

      JOURNAL OF COMPARATIVE NEUROLOGY
    40. Watson, RT; Shigematsu, S; Chiang, SH; Mora, S; Kanzaki, M; Macara, IG; Saltiel, AR; Pessin, JE
      Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation

      JOURNAL OF CELL BIOLOGY
    41. Jacobs, AR; LeRoith, D; Taylor, SI
      Insulin receptor substrate-1 pleckstrin homology and phosphotyrosine-binding domains are both involved in plasma membrane targeting

      JOURNAL OF BIOLOGICAL CHEMISTRY
    42. Bandeira-Melo, C; Phoofolo, M; Weller, PF
      Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C-4 production in eosinophils and basophils

      JOURNAL OF BIOLOGICAL CHEMISTRY
    43. Santini, CL; Bernadac, A; Zhang, M; Chanal, A; Ize, B; Blanco, C; Wu, LF
      Translocation of jellyfish green fluorescent protein via the Tat system ofEscherichia coli and change of its periplasmic localization in response toosmotic up-shock

      JOURNAL OF BIOLOGICAL CHEMISTRY
    44. Kilhamn, J; Brevinge, H; Quiding-Jarbrink, M; Svennerholm, AM; Jertborn, M
      Induction and distribution of intestinal immune responses after administration of recombinant cholera toxin B subunit in the ileal pouches of colectomized patients

      INFECTION AND IMMUNITY
    45. Peters-Golden, M; Brock, TG
      Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets

      FEBS LETTERS
    46. Watson, RT; Pessin, JE
      Subcellular compartmentalization and trafficking of the insulin-responsiveglucose transporter, GLUT4

      EXPERIMENTAL CELL RESEARCH
    47. Scholle, HC; Schumann, NP; Biedermann, F; Stegeman, DF; Grassme, R; Roeleveld, K; Schilling, N; Fischer, MS
      Spatiotemporal surface EMG characteristics from rat triceps brachii muscleduring treadmill locomotion indicate selective recruitment of functionallydistinct muscle regions

      EXPERIMENTAL BRAIN RESEARCH
    48. Ghielmi, A; Storti, G; Morbidelli, M
      Role of active chain segregation in emulsion polymerization

      CHEMICAL ENGINEERING SCIENCE
    49. Palecek, J; Hasek, J; Ruis, H
      Rpg1p/Tif32p, a subunit of translation initiation factor 3, interacts withactin-associated protein Sla2p

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    50. Pesco, J; Salmon, JM; Vigo, J; Viallet, P
      Mag-indo1 affinity for Ca2+, compartmentalization and binding to proteins:The challenge of measuring Mg2+ concentrations in living cells

      ANALYTICAL BIOCHEMISTRY
    51. Kreth, G; Edelmann, P; Cremer, C
      Towards a dynamical approach for the simulation of large scale, cancer correlated chromatin structures

      ADVANCES IN MICROANATOMY OF CELLS AND TISSUES, BIOPHYSICAL AND BIOCHEMICALCORRELATES
    52. Cormery, B; Pons, F; Marini, JF; Gardiner, PF
      Myosin heavy chains in fibers of TTX-paralyzed rat soleus and medial gastrocnemius muscles

      JOURNAL OF APPLIED PHYSIOLOGY
    53. Kaoser, S; Barrington, S; Elektorowicz, N
      Compartments for the management of municipal solid waste

      SOIL & SEDIMENT CONTAMINATION
    54. Collins, KR; Mayanja-Kizza, H; Sullivan, BA; Quinones-Mateu, ME; Toossi, Z; Arts, EJ
      Greater diversity of HIV-1 quasispecies in HIV-infected individuals with active tuberculosis

      JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
    55. Monier, K; Armas, JCG; Etteldorf, S; Ghazal, P; Sullivan, KF
      Annexation of the interchromosomal space during viral infection

      NATURE CELL BIOLOGY
    56. Reumann, S
      The structural properties of plant peroxisomes and their metabolic significance

      BIOLOGICAL CHEMISTRY
    57. Hiltunen, JK; Qin, YM
      beta-Oxidation - strategies for the metabolism of a wide variety of acyl-CoA esters

      BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
    58. Moreno-Fierros, L; Garcia, N; Gutierrez, R; Lopez-Revilla, R; Vazquez-Padron, RI
      Intranasal, rectal and intraperitoneal immunization with protoxin Cry1Ac from Bacillus thuringiensis induces compartmentalized serum, intestinal, vaginal and pulmonary immune responses in Balb/c mice

      MICROBES AND INFECTION
    59. Crapo, JD; Harmsen, AG; Sherman, MP; Musson, RA
      Pulmonary immunobiology and inflammation in pulmonary diseases

      AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
    60. Munnelly, HM; Brady, CJ; Hagen, GM; Wade, WF; Roess, DA; Barisas, BG
      Rotational and lateral dynamics of I-A(k) molecules expressing cytoplasmictruncations

      INTERNATIONAL IMMUNOLOGY
    61. van Meyel, DJ; O'Keefe, DD; Thor, S; Jurata, LW; Gill, GN; Thomas, JB
      Chip is an essential cofactor for Apterous in the regulation of axon guidance in Drosophila

      DEVELOPMENT
    62. Cavodeassi, F; Modolell, J; Campuzano, S
      The Iroquois homeobox genes function as dorsal selectors in the Drosophilahead

      DEVELOPMENT
    63. Ghazi, A; Anant, S; VijayRaghavan, K
      Apterous mediates development of direct flight muscles autonomously and indirect flight muscles through epidermal cues

      DEVELOPMENT
    64. Calleja, M; Herranz, H; Estella, C; Casal, J; Lawrence, P; Simpson, P; Morata, G
      Generation of medial and lateral dorsal body domains by the pannier gene of Drosophila

      DEVELOPMENT
    65. Gartner, BL; Baker, DC; Spicer, R
      Distribution and vitality of xylem rays in relation to tree leaf area in Douglas-fir

      IAWA JOURNAL
    66. Jackson, DA; Pombo, A; Iborra, F
      The balance sheet for transcription: an analysis of nuclear RNA metabolismin mammalian cells

      FASEB JOURNAL
    67. Copin, JC; Gasche, Y; Chan, PH
      Overexpression of copper/zinc superoxide dismutase does not prevent neonatal lethality in mutant mice that lack manganese superoxide dismutase

      FREE RADICAL BIOLOGY AND MEDICINE
    68. Schubeler, D; Francastel, C; Cimbora, DM; Reik, A; Martin, DIK; Groudine, M
      Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus

      GENES & DEVELOPMENT
    69. Wang, SH; Simcox, A; Campbell, G
      Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development

      GENES & DEVELOPMENT
    70. Huang, P; Trotter, K; Boucher, RC; Milgram, SL; Stutts, MJ
      PKA holoenzyme is functionally coupled to CFTR by AKAPs

      AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
    71. Haitsma, JJ; Uhlig, S; Goggel, R; Verbrugge, SJ; Lachmann, U; Lachmann, B
      Ventilator-induced lung injury leads to loss of alveolar and systemic compartmentalization of tumor necrosis factor-alpha

      INTENSIVE CARE MEDICINE
    72. Christ, B; Huang, RJ; Wilting, J
      The development of the avian vertebral column

      ANATOMY AND EMBRYOLOGY
    73. Trutko, SM; Akimenko, VK; Suzina, NE; Anisimova, LA; Shlyapnikov, MG; Baskunov, BP; Duda, VI; Boronin, AM
      Involvement of the respiratory chain of gram-negative bacteria in the reduction of tellurite

      ARCHIVES OF MICROBIOLOGY
    74. Ponomarev, AL; Brenner, D; Hlatky, LR; Sachs, RK
      A polymer, random walk model for the size-distribution of large DNA fragments after high linear energy transfer radiation

      RADIATION AND ENVIRONMENTAL BIOPHYSICS
    75. Marquette, CA; Degiuli, A; Blum, LJ
      Fiberoptic biosensors based on chemiluminescent reactions

      APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
    76. Rossi, SG; Vazquez, AE; Rotundo, RL
      Local control of acetylcholinesterase gene expression in multinucleated skeletal muscle fibers: Individual nuclei respond to signals from the overlying plasma membrane

      JOURNAL OF NEUROSCIENCE
    77. Marchand, S; Bignami, F; Stetzkowski-Marden, F; Cartaud, J
      The myristoylated protein rapsyn is cotargeted with the nicotinic acetylcholine receptor to the postsynaptic membrane via the exocytic pathway

      JOURNAL OF NEUROSCIENCE
    78. Wang, YM; Dyer, WB; Workman, C; Wang, B; Sullivan, JS; Saksena, NK
      Molecular evidence for drug-induced compartmentalization of HIV-1 quasispecies in a patient with periodic changes to HAART

      AIDS
    79. Haddad, DN; Birch, C; Middleton, T; Dwyer, DE; Cunningham, AL; Saksena, NK
      Evidence for late stage compartmentalization of HIV-1 resistance mutationsbetween lymph node and peripheral blood mononuclear cells

      AIDS
    80. Reichelderfer, PS; Coombs, RW; Wright, DJ; Cohn, J; Burns, DN; Cu-Uvin, S; Baron, PA; Cohen, MH; Landay, AL; Beckner, SK; Lewis, SR; Kovacs, AA
      Effect of menstrual cycle on HIV-1 levels in the peripheral blood and genital tract

      AIDS
    81. Lewis, PJ; Thaker, SD; Errington, J
      Compartmentalization of transcription and translation in Bacillus subtilis

      EMBO JOURNAL
    82. Bravo, A; Illana, B; Salas, M
      Compartmentalization of phage phi 29 DNA replication: interaction between the primer terminal protein and the membrane-associated protein p1

      EMBO JOURNAL
    83. Moreno-Fierros, L; Martinez-Hurtado, A; Lopez-Revilla, R; Resendiz-Albor, AA
      Compartmentalization of the intestinal antiamebic immune response in Balb/c mice: Effect of cholera toxin coadministration

      ARCHIVES OF MEDICAL RESEARCH
    84. Roy, RL; Kim, JA; Grossman, EJ; Bekmezian, A; Talmadge, RJ; Zhong, H; Edgerton, VR
      Persistence of myosin heavy chain-based fiber types in innervated but silenced rat fast muscle

      MUSCLE & NERVE
    85. Martineau, L; Shek, PN
      Peritoneal cytokine concentrations and survival outcome in an experimentalbacterial infusion model of peritonitis

      CRITICAL CARE MEDICINE
    86. Hafez, AA; Kopel, HM; Cox, CF
      Pulpotomy reconsidered: Application of an adhesive system to pulpotomized permanent primate pulps

      QUINTESSENCE INTERNATIONAL
    87. Ping, LH; Cohen, MS; Hoffman, I; Vernazza, P; Seillier-Moiseiwitsch, F; Chakraborty, H; Kazembe, P; Zimba, D; Maida, M; Fiscus, SA; Eron, JJ; Swanstrom, R; Nelson, JAE
      Effects of genital tract inflammation on human immunodeficiency virus type1 V3 populations in blood and semen

      JOURNAL OF VIROLOGY
    88. Wachsmuth, M; Waldeck, W; Langowski, J
      Anomalous diffusion of fluorescent probes inside living cell nuclei investigated by spatially-resolved fluorescence correlation spectroscopy

      JOURNAL OF MOLECULAR BIOLOGY
    89. Gonzalez-Melendi, P; Beven, A; Boudonck, K; Abranches, R; Wells, B; Dolan, L; Shaw, P
      The nucleus: a highly organized but dynamic structure

      JOURNAL OF MICROSCOPY-OXFORD
    90. Bobbitt, KR; Justement, LB
      Regulation of MHC class II signal transduction by the B cell coreceptors CD19 and CD22

      JOURNAL OF IMMUNOLOGY
    91. Volpi, EV; Chevret, E; Jones, T; Vatcheva, R; Williamson, J; Beck, S; Campbell, RD; Goldsworthy, M; Powis, SH; Ragoussis, J; Trowsdale, J; Sheer, D
      Large-scale chromatin organization of the major histocompatibility complexand other regions of human chromosome 6 and its response to interferon in interphase nuclei

      JOURNAL OF CELL SCIENCE
    92. Nogami, M; Kohda, A; Taguchi, H; Nakao, M; Ikemura, T; Okumura, K
      Relative locations of the centromere and imprinted SNRPN gene within chromosome 15 territories during the cell cycle in HL60 cells

      JOURNAL OF CELL SCIENCE
    93. Mills, JW; Pedersen, SF; Walmod, PS; Hoffmann, EK
      Effect of cytochalasins on F-actin and morphology of Ehrlich ascites tumorcells

      EXPERIMENTAL CELL RESEARCH
    94. Remmers, AE; Clark, MJ; Alt, A; Medzihradsky, F; Woods, JH; Traynor, JR
      Activation of G protein by opioid receptors: role of receptor number and G-protein concentration

      EUROPEAN JOURNAL OF PHARMACOLOGY
    95. Wagner, J; Schmidt, C; Nikowits, W; Christ, B
      Compartmentalization of the somite and myogenesis in chick embryos are influenced by Wnt expression

      DEVELOPMENTAL BIOLOGY
    96. Milan, M; Cohen, SM
      Subdividing cell populations in the developing limbs of Drosophila: Do wing veins and leg segments define units of growth control?

      DEVELOPMENTAL BIOLOGY
    97. Kovaleva, IE; Grivennikov, SI; Luzikov, VN
      On the effect of cholesterol on the fate of CYP11A1 imported into yeast mitochondria in vivo

      BIOCHEMISTRY-MOSCOW
    98. Doucas, V
      The promyelocytic (PML) nuclear compartment and transcription control

      BIOCHEMICAL PHARMACOLOGY
    99. Oldenhof, H; Willemse, MTM
      Functional compartments during sporangium development in the pteridophyte Cyrtomium falcatum (L. f.) Presl as expressed in tapetum function

      PLANT BIOLOGY
    100. Murray, GM; Phanachet, I; Klineberg, IJ
      Electromyographic evidence for functional heterogeneity in the inferior head of the human lateral pterygoid muscle: a preliminary multi-unit study

      CLINICAL NEUROPHYSIOLOGY


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Documento generato il 28/10/20 alle ore 12:24:24