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    1. Tosal, L; Comendador, MA; Sierra, LM
      In vivo repair of ENU-induced oxygen alkylation damage by the nucleotide excision repair mechanism in Drosophila melanogaster

      MOLECULAR GENETICS AND GENOMICS
    2. Reese, JS; Qin, XS; Ballas, CB; Sekiguchi, M; Gerson, SL
      MGMT expression in murine bone marrow is a major determinant of animal survival after alkylating agent exposure

      JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
    3. Sawai, N; Zhou, S; Vanin, EF; Houghton, P; Brent, TP; Sorrentino, BP
      Protection and in vivo selection of hematopoietic stem cells using temozolomide, O-6-benzylguanine, and an alkyltransferase-expressing retroviral vector

      MOLECULAR THERAPY
    4. Gururangan, S; Cokgor, I; Rich, JN; Edwards, S; Affronti, ML; Quinn, JA; Herndon, JE; Provenzale, JM; McLendon, RE; Tourt-Uhlig, S; Sampson, JH; Stafford-Fox, V; Zaknoen, S; Early, M; Friedman, AH; Friedman, HS
      Phase I study of Gliadel (TM) wafers plus temozolomide in adults with recurrent supratentorial high-grade gliomas

      NEURO-ONCOLOGY
    5. Damoiseaux, R; Keppler, A; Johnsson, K
      Synthesis and applications of chemical probes for human O-6-alkylguanine-DNA alkyltransferase

      CHEMBIOCHEM
    6. Abril, N; Luque-Romero, FL; Yamada, M; Nohmi, T; Pueyo, C
      The effectiveness of the O-6-alkylguanine-DNA alkyltransferase encoded by the ogt(ST) gene from S. typhimurium in protection against alkylating drugs, resistance to O-6-benzylguanine and sensitisation to dibromoalkane genotoxicity

      MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
    7. Povey, AC; Hall, CN; Badawi, AF; Cooper, DP; Guppy, MJ; Jackson, PE; O'Connor, PJ; Margison, GP
      Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue: O-6-methylguanine levels are associated with GSTT1 genotype and O-6-alkylguanine-DNA alkyltransferase activity with CYP2D6 genotype

      MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
    8. Walter, RB; Sung, HM; Intano, GW; Walter, CA
      Characterization of O-6-methylguanine-DNA-methyltransferase (O-6-MGMT) activity in Xiphophorus fishes

      MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
    9. Brandes, AA; Basso, U; Pasetto, LM; Ermani, M
      New strategy developments in brain tumor therapy

      CURRENT PHARMACEUTICAL DESIGN
    10. Koskinen, M; Vodicka, P; Vodickova, L; Hemminki, K
      P-32-postlabelling/HPLC analysis of various styrene-induced DNA adducts inmice

      BIOMARKERS
    11. Liu, L; Spiro, TP; Qin, XS; Majka, S; Haaga, J; Schupp, J; Willson, JKV; Gerson, SL
      Differential degradation rates of inactivated alkyltransferase in blood mononuclear cells and tumors of patients after treatment with O-6-benzylguanine

      CLINICAL CANCER RESEARCH
    12. Srivenugopal, KS; Shou, J; Mullapudi, SRS; Lang, FF; Rao, JS; Ali-Osman, F
      Enforced expression of wild-type p53 curtails the transcription of the O-6-methylguanine-DNA methyltransferase gene in human tumor cells and enhancestheir sensitivity to alkylating agents

      CLINICAL CANCER RESEARCH
    13. Bobola, MS; Berger, MS; Ellenbogen, RG; Roberts, TS; Geyer, JR; Silber, JR
      O-6-methylguanine-DNA methyltransferase in pediatric primary brain tumors:Relation to patient and tumor characteristics

      CLINICAL CANCER RESEARCH
    14. Dowlati, A; Haaga, J; Remick, SC; Spiro, TP; Gerson, SL; Liu, LL; Berger, SJ; Berger, NA; Willson, JKV
      Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation

      CLINICAL CANCER RESEARCH
    15. Wu, M; Kelley, MR; Hansen, WK; Martin, WJ
      Reduction of BCNU toxicity to lung cells by high-level expression of O-6-methylguanine-DNA methyltransferase

      AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
    16. Beenken, K; Cai, ZH; Fix, D
      Overexpression of Ogt reduces MNU and ENU induced transition, but not transversion, mutations in E-coli

      MUTATION RESEARCH-DNA REPAIR
    17. Lips, J; Kaina, B
      Repair of O-6-methylguanine is not affected by thymine base pairing and the presence of MMR proteins

      MUTATION RESEARCH-DNA REPAIR
    18. Jansen, M; Bardenheuer, W; Sorg, UR; Seeber, S; Flasshove, M; Moritz, T
      Protection of hematopoietic cells from O-6-alkylation damage by O-6-methylguanine DNA methyltransferase gene transfer: studies with different O-6-alkylating agents and retroviral backbones

      EUROPEAN JOURNAL OF HAEMATOLOGY
    19. Kanugula, S; Pegg, AE
      Novel DNA repair alkyltransferase from Caenorhabditis elegans

      ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
    20. Tretyakova, N; Matter, B; Ogdie, A; Wishnok, JS; Tannenbaum, SR
      Locating nucleobase lesions within DNA sequences by MALDI-TOF mass spectral analysis of exonuclease ladders

      CHEMICAL RESEARCH IN TOXICOLOGY
    21. Navasumrit, P; Margison, GP; O'Connor, PJ
      Ethanol modulates rat hepatic DNA repair functions

      ALCOHOL AND ALCOHOLISM
    22. Del Bufalo, D; Trisciuoglio, D; Biroccio, A; Marcocci, L; Buglioni, S; Candiloro, A; Scarsella, M; Leonetti, C; Zupi, G
      Bcl-2 overexpression decreases BCNU sensitivity of a human glioblastoma line through enhancement of catalase activity

      JOURNAL OF CELLULAR BIOCHEMISTRY
    23. Peterson, LA; Spratt, TE; Shan, WF; Wang, LJ; Subotkowski, W; Roth, R
      An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)1-butanone

      JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
    24. Tentori, L; Portarena, I; Vernole, P; De Fabritiis, P; Madaio, R; Balduzzi, A; Roy, R; Bonmassar, E; Graziani, G
      Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    25. Perez-Cadenas, A; Godino-Salido, L; Lopez-Garzon, R; Arranz-Mascaros, P; Gutierrez-Valero, D; Cuesta-Martos, R
      The reactivity of N-2-(4-amino-1,6-dihydro-1-methyl-5-nitroso-6-oxopyrimidinyl)-L-histidine towards copper(II) ions

      TRANSITION METAL CHEMISTRY
    26. Lee, CH; Sidik, K; Chin, KV
      Role of cAMP-dependent protein kinase in the regulation of DNA repair

      CANCER LETTERS
    27. Westerhof, GR; Down, JD; Blokland, I; Wood, M; Boudewijn, A; Watson, AJ; McGown, AT; Ploemacher, RE; Margison, GP
      O-6-benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells

      EXPERIMENTAL HEMATOLOGY
    28. Boiardi, A; Silvani, A; Ciusani, E; Watson, A; Margison, G; Berger, E; Lucas, C; Giroux, B
      Fotemustine combined with procarbazine in recurrent malignant gliomas: A phase I study with evaluation of lymphocyte O-6-alkylguanine-DNA alkyltransferase activity

      JOURNAL OF NEURO-ONCOLOGY
    29. Chen, ZP; Pan, J; Huang, Q; Sun, ZF; Zhou, LY; Wang, AD
      Antitumor efficacy of SarCNU in a human glioma xenograft model expressing both MGMT and extraneuronal monoamine transporter

      JOURNAL OF NEURO-ONCOLOGY
    30. Hosfield, DJ; Daniels, DS; Mol, CD; Putnam, CD; Parikh, SS; Tainer, JA
      DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes

      PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 68
    31. Davis, BM; Encell, LP; Zielske, SP; Christians, FC; Liu, LL; Friebert, SE; Loeb, LA; Gerson, SL
      Applied molecular evolution of O-6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    32. Zhang, QW; Ohannesian, DW; Kreklau, EL; Erickson, LC
      Modulation of 1,3-bis-(2-chloroethyl)-1-nitrosourea resistance in human tumor cells using hammerhead ribozymes designed to degrade O-6-methylguanine DNA methyltransferase mRNA

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    33. Kreklau, EL; Liu, NL; Li, ZH; Cornetta, K; Erickson, LC
      Comparison of single- versus double-bolus treatments of O-6-benzylguanine for depletion of O-6-methylguanine DNA methyltransferase (MGMT) activity invivo: Development of a novel fluorometric oligonucleotide assay for measurement of MGMT activity

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    34. Reinhard, J; Hull, WE; von der Lieth, CW; Eichhorn, U; Kliem, HC; Kaina, B; Wiessler, M
      Monosaccharide-linked inhibitors of O-6-methylguanine-DNA methyltransferase (MGMT): Synthesis, molecular modeling, and structure-activity relationships

      JOURNAL OF MEDICINAL CHEMISTRY
    35. Oue, N; Shigeishi, H; Kuniyasu, H; Yokozaki, H; Kuraoka, K; Ito, R; Yasui, W
      Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma

      INTERNATIONAL JOURNAL OF CANCER
    36. Reinard, J; Eichhorn, U; Wiessler, M; Kaina, B
      Inactivation of O-6-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors

      INTERNATIONAL JOURNAL OF CANCER
    37. Christmann, M; Pick, M; Lage, H; Schadendorf, D; Kaina, B
      Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT

      INTERNATIONAL JOURNAL OF CANCER
    38. Marchenay, C; Cellarier, E; Levi, F; Rolhion, C; Kwiatkowski, F; Claustrat, B; Madelmont, JC; Chollet, P
      Circadian variation in O-6-alkylguanine-DNA alkyltransferase activity in circulating blood mononuclear cells of healthy human subjects

      INTERNATIONAL JOURNAL OF CANCER
    39. Eder, E; Kutt, W; Deininger, C
      On the role of alkylating mechanisms, O-alkylation and DNA-repair in genotoxicity and mutagenicity of alkylating methanesulfonates of widely varying structures in bacterial systems

      CHEMICO-BIOLOGICAL INTERACTIONS
    40. Wolf, P; Hu, YC; Doffek, K; Sidransky, D; Ahrendt, SA
      O-6-methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer

      CANCER RESEARCH
    41. Peterson, LA; Thomson, NM; Crankshaw, DL; Donaldson, EE; Kenney, PJ
      Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: Implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis

      CANCER RESEARCH
    42. Kokkinakis, DM; Hoffman, RM; Frenkel, EP; Wick, JB; Han, QH; Xu, MX; Tan, YY; Schold, SC
      Synergy between methionine stress and chemotherapy in the treatment of brain tumor xenografts in athymic mice

      CANCER RESEARCH
    43. Pourquier, P; Waltman, JL; Urasaki, Y; Loktionova, NA; Pegg, AE; Nitiss, JL; Pommier, Y
      Topoisomerase I-mediated cytotoxicity of N-methyl-N '-nitro-N-nitrosoguanidine: Trapping of topoisomerase I by the O-6-methylguanine

      CANCER RESEARCH
    44. Park, TJ; Han, SU; Cho, YK; Paik, WK; Kim, YB; Lim, IK
      Methylation of O-6-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma

      CANCER
    45. Delaney, JC; Essigmann, JM
      Effect of sequence context on O-6-methylguanine repair and replication in vivo

      BIOCHEMISTRY
    46. Long, L; Moschel, RC; Dolan, ME
      Debenzylation of O-6-benzyl-8-oxoguanine in human liver: implications for O-6-benzylguanine metabolism

      BIOCHEMICAL PHARMACOLOGY
    47. Colussi, C; Fiumicino, S; Giuliani, A; Rosini, S; Musiani, P; Macri, C; Potten, CS; Crescenzi, M; Bignami, M
      1,2-dimethylhydrazine-induced colon carcinoma and lymphoma in msh2(-/-) mice

      JOURNAL OF THE NATIONAL CANCER INSTITUTE
    48. Levin, VA; Lamborn, K; Wara, W; Davis, R; Edwards, M; Rabbitt, J; Malec, M; Prados, MD
      Phase II study of 6-thioguanine, procarbazine, dibromodulcitol, lomustine,and vincristine chemotherapy with radiotherapy for treating malignant glioma in children

      NEURO-ONCOLOGY
    49. Liu, H; Xu-Welliver, M; Pegg, AE
      The role of human O-6-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    50. Engelbergs, J; Thomale, J; Rajewsky, MF
      Role of DNA repair in carcinogen-induced ras mutation

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    51. Psaroudi, MC; Kyrtopoulos, SA
      Toxicity, mutation frequency and mutation spectrum induced by dacarbazine in CHO cells expressing different levels of O-6-methylguanine-DNA methyltransferase

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    52. Rajewsky, MF; Engelbergs, J; Thomale, J; Schweer, T
      DNA repair: counteragent in mutagenesis and carcinogenesis - accomplice incancer therapy resistance

      MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
    53. Roth, RB; Samson, LD
      Gene transfer to suppress bone marrow alkylation sensitivity

      MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
    54. Shima, N; Swiger, RR; Heddle, JA
      Dietary restriction during murine development provides protection against MNU-induced mutations

      MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
    55. Long, L; Berg, SL; Roy, SK; McCully, CL; Song-Yoo, HW; Moschel, RC; Balis, FM; Dolan, ME
      Plasma and cerebrospinal fluid pharmacokinetics of O-6-benzylguanine and analogues in nonhuman primates

      CLINICAL CANCER RESEARCH
    56. Schilsky, RL; Dolan, ME; Bertucci, D; Ewesuedo, RB; Vogelzang, NJ; Mani, S; Wilson, LR; Ratain, MJ
      Phase I clinical and pharmacological study of O-6-benzylguanine followed by carmustine in patients with advanced cancer

      CLINICAL CANCER RESEARCH
    57. Friedman, HS; Kerby, T; Calvert, H
      Temozolomide and treatment of malignant glioma

      CLINICAL CANCER RESEARCH
    58. Kaur, TB; Travaline, JM; Gaughan, JP; Richie, JP; Stellman, SD; Lazarus, P
      Role of polymorphisms in codons 143 and 160 of the O-6-alkylguanine DNA alkyltransferase gene in lung cancer risk

      CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
    59. Inoue, R; Abe, M; Nakabeppu, Y; Sekiguchi, M; Mori, T; Suzuki, T
      Characterization of human polymorphic DNA repair methyltransferase

      PHARMACOGENETICS
    60. Mariani, L; Citti, L; Nevischi, S; Eckstein, F; Rainaldi, G
      Ribozyme and free alkylated base: a dual approach for sensitizing Mex(+) cells to the alkylating antineoplastic drug

      CANCER GENE THERAPY
    61. Fairbairn, LJ; Chinnasamy, N; Lashford, LS; Chinnasamy, D; Rafferty, JA
      Enhancing hemopoietic drug resistance: A rationale for reconsidering the clinical use of mitozolomide

      CANCER GENE THERAPY
    62. Daniels, DS; Tainer, JA
      Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O-6-alkylguanine-DNA alkyltransferase

      MUTATION RESEARCH-DNA REPAIR
    63. Brown, LR; Deng, J; Clarke, ND
      Dominant sensitization variants of human O-6-methylguanine-DNA-methyltransferase obtained by a mutational screen of surface residues

      MUTATION RESEARCH-DNA REPAIR
    64. Shioyama, Y; Gondo, Y; Nakao, K; Katsuki, M
      Different mutation frequencies and spectra among organs by N-methyl-N-nitrosourea in rpsL (strA) transgenic mice

      JAPANESE JOURNAL OF CANCER RESEARCH
    65. Qin, XS; Zhang, SM; Matsukuma, S; Zarkovic, M; Shimizu, S; Ishikawa, T; Nakatsuru, Y
      Protection against malignant progression of spontaneously developing livertumors in transgenic mice expressing O-6-methylguanine-DNA methyltransferase

      JAPANESE JOURNAL OF CANCER RESEARCH
    66. Limp-Foster, M; Kelley, MR
      DNA repair and gene therapy: Implications for translational uses

      ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
    67. Farkasova, E; Chovanec, M; Vlasakova, D; Vlckova, V; Margison, GP; Brozmanova, J
      Effect of stable integration of the Escherichia coli ada gene on the sensitivity of Saccharomyces cerevisiae to the toxic and mutagenic effects of alkylating agents

      ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
    68. Tentori, L; Vernole, P; Lacal, PM; Madaio, R; Portarena, I; Levati, L; Balduzzi, A; Turriziani, M; Dande, P; Gold, B; Bonmassar, E; Graziani, G
      Cytotoxic and clastogenic effects of a DNA minor groove binding methyl sulfonate ester in mismatch repair deficient leukemic cells

      LEUKEMIA
    69. Friedman, HS; Pluda, J; Quinn, JA; Ewesuedo, RB; Long, L; Friedman, AH; Cokgor, I; Colvin, OM; Haglund, MM; Ashley, DM; Rich, JN; Sampson, J; Pegg, AE; Moschel, RC; McLendon, RE; Provenzale, JM; Stewart, ES; Tourt-Uhlig, S; Garcia-Turner, AM; Herndon, JE; Bigner, DD; Dolan, ME
      Phase I trial of carmustine plus O-6-benzylguanine for patients with recurrent or progressive malignant glioma

      JOURNAL OF CLINICAL ONCOLOGY
    70. Jackson, PE; Cooper, DP; Meyer, TA; Wood, M; Povey, AC; Margison, GP
      Formation and persistence of O-6-methylguanine in the mouse colon following treatment with 1, 2-dimethylhydrazine as measured by an O-6-alkylguanine-DNA alkyltransferase inactivation assay

      TOXICOLOGY LETTERS
    71. van Rijn, J; Heimans, JJ; van den Berg, J; van der Valk, P; Slotman, BJ
      Survival of human glioma cells treated with various combination of temozolomide and X-rays

      INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
    72. Ewesuedo, RB; Dolan, ME
      Pharmacokinetics of oral O-6-benzylguanine and evidence of interaction with oral ketoconazole in the rat

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    73. Keir, ST; Dolan, ME; Pegg, AE; Lawless, A; Moschel, RC; Bigner, DD; Friedman, HS
      O-6-benzylguanine-mediated enhancement of nitrosourea activity in Mer(-) central nervous system tumor xenografts - implications for clinical trials

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    74. Middleton, MR; Kelly, J; Goodger, S; Thatcher, N; Margison, GP
      Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    75. Kokkinakis, DM; Moschel, RC; Pegg, AE; Schold, SC
      Potentiation of BCNU antitumor efficacy by 9-substituted O-6-benzylguanines. Effect of metabolism

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    76. Smith, SA; Engelward, BP
      In vivo repair of methylation damage in Aag 3-methyladenine DNA glycosylase null mouse cells

      NUCLEIC ACIDS RESEARCH
    77. Takahashi, M; Mineura, K; Watanabe, K; Kohda, K
      O-6-(fluorobenzyl)guanine and chloroethylnitrosourea in xenografted rat brain tumor in vivo

      ACTA ONCOLOGICA
    78. Baum, C; Peinert, S; Carpinteiro, A; Eckert, HG; Fairbairn, LJ
      Genetic modification of haematopoietic cells for combined resistance to podophyllotoxins, other agents covered by MDR1-mediated efflux activity and nitrosoureas

      BONE MARROW TRANSPLANTATION
    79. Williams, DA; Maze, R; Kurpad, C; Pegg, A; Erickson, LC
      Protection of hematopoietic cells against combined O-6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O-6-methylguanine DNA methyltransferase

      BONE MARROW TRANSPLANTATION
    80. Fairbairn, LJ; Rafferty, JA; Lashford, LS
      Engineering drug resistance in human cells

      BONE MARROW TRANSPLANTATION
    81. Xu-Welliver, M; Pegg, AE
      Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O-6-alkylguanine-DNA alkyltransferase insensitive to O-6-benzylguanine

      BIOCHEMICAL JOURNAL
    82. Xu-Welliver, M; Kanugula, S; Loktionova, NA; Crone, TM; Pegg, AE
      Conserved residue lysine(165) is essential for the ability of O-6-alkylguanine-DNA alkyltransferase to react with O-6-benzylguanine

      BIOCHEMICAL JOURNAL
    83. Daniels, DS; Mol, CD; Arvai, AS; Kanugula, S; Pegg, AE; Tainer, JA
      Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding

      EMBO JOURNAL
    84. Bodell, WJ
      Measurement of sister chromatid exchange induction in intracerebral brain tumors as a method for evaluation of therapeutic drug combinations

      ANTICANCER RESEARCH
    85. O'Connor, PJ; Manning, FCR; Gordon, AT; Billett, MA; Cooper, DP; Elder, RH; Margison, GP
      DNA repair: Kinetics and thresholds

      TOXICOLOGIC PATHOLOGY
    86. Encell, LP; Loeb, LA
      Enhanced in vivo repair of O-4-methylthymine by a mutant human DNA alkyltransferase

      CARCINOGENESIS
    87. Toft, NJ; Sanson, OJ; Brookes, RA; Arends, MJ; Wood, M; Margison, GP; Winton, DJ; Clarke, AR
      In vivo administration of O-6-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but doesinhibit P450-dependent activation of dacarbazine

      CARCINOGENESIS
    88. Prados, MD; Levin, V
      Biology and treatment of malignant glioma

      SEMINARS IN ONCOLOGY
    89. Xu, YZ
      Synthesis and characterization of DNA containing O-6-carboxymethylguanine

      TETRAHEDRON
    90. Thompson, MJ; Abdul-Rahman, S; Baker, TG; Rafferty, JA; Margison, GP; Bibby, MC
      Role of O-6-alkylguanine-DNA alkyltransferase in the resistance of mouse spermatogenic cells to O-6-alkylating agents

      JOURNAL OF REPRODUCTION AND FERTILITY
    91. D'Atri, S; Graziani, G; Lacal, PM; Nistico, V; Gilberti, S; Faraoni, I; Watson, AJ; Bonmassar, E; Margison, GP
      Attenuation of O-6-methylguanine-DNA methyltransferase activity and mRNA levels by cisplatin and temozolomide in Jurkat cells

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    92. Griffin, RJ; Arris, CE; Bleasdale, C; Boyle, FT; Calvert, AH; Curtin, NJ; Dalby, C; Kanugula, S; Lembicz, NK; Newell, DR; Pegg, AE; Golding, BT
      Resistance-modifying agents. 8. Inhibition of O-6-alkylguanine-DNA alkyltransferase by O-6-alkenyl-, O-6-cycloalkenyl-, and O-6-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O-6-(1-cyclopentenylmethyl)guanine

      JOURNAL OF MEDICINAL CHEMISTRY
    93. Middleton, MR; Lee, SM; Arance, A; Wood, M; Thatcher, N; Margison, GP
      O-6-methylguanine formation, repair protein depletion and clinical outcomewith a 4 hr schedule of temozolomide in the treatment of advanced melanoma: Results of phase II study

      INTERNATIONAL JOURNAL OF CANCER
    94. Middleton, MR; Kelly, J; Thatcher, N; Donnelly, DJ; McElhinney, RS; McMurry, TBH; McCormick, JE; Margison, GP
      O-6-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts

      INTERNATIONAL JOURNAL OF CANCER
    95. Frosina, G
      Overexpression of enzymes that repair endogenous damage to DNA

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    96. Koskinen, M; Vodicka, P; Hemminki, K
      Adenine N3 is a main alkylation site of styrene oxide in double-stranded DNA

      CHEMICO-BIOLOGICAL INTERACTIONS
    97. Rhines, LD; Sampath, P; Dolan, ME; Tyler, BM; Brem, H; Weingart, J
      O-6-Benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma

      CANCER RESEARCH
    98. Ragg, S; Xu-Welliver, M; Bailey, J; D'Souza, M; Cooper, R; Chandra, S; Seshadri, R; Pegg, AE; Williams, DA
      Direct reversal of DNA damage by mutant methyltransferase protein protectsmice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells

      CANCER RESEARCH
    99. Boley, SE; McManus, TP; Maher, VM; McCormick, JJ
      Malignant transformation of human fibroblast cell strain MSU-1.1 by N-methyl-N-nitrosourea: Evidence of elimination of p53 by homologous recombination

      CANCER RESEARCH
    100. Davis, BM; Koc, ON; Gerson, SL
      Limiting numbers of G156A O-6-methylguanine-DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection

      BLOOD


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Documento generato il 16/01/21 alle ore 08:19:17