Per ulteriori informazioni selezionare i riferimenti di interesse.
RING finger mutations that abolish C-Cbl-directed polyubiquitination and downregulation of the EGF receptor ave insufficient for cell transformation
MOLECULAR CELL
Regulation of STAT protein synthesis by c-Cbl
ONCOGENE
Dynamic expression of alternate splice forms of D-cbl during embryogenesis
MECHANISMS OF DEVELOPMENT
Suppression of apoptosis and granulocyte colony-stimulating factor-induceddifferentiation by an oncogenic form of Cbl
EXPERIMENTAL HEMATOLOGY
c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route
JOURNAL OF CELL SCIENCE
c-Cbl protein in human cancer tissues is frequently tyrosine phosphorylated in a tumor-specific manner
INTERNATIONAL JOURNAL OF ONCOLOGY
Adapting to multiple personalities: Cbl is also a RING finger ubiquitin ligase
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation
MOLECULAR AND CELLULAR BIOLOGY
Platelet alpha IIb-ss 3 integrin engagement induces the tyrosine phosphorylation of Cbl and its association with phosphoinositide 3-kinase and Syk
BIOCHEMICAL JOURNAL
Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma 2 activation by regulating B cell linker protein-PLC-gamma 2 binding
JOURNAL OF EXPERIMENTAL MEDICINE
c-Cbl localizes to actin lamellae and regulates lamellipodia formation andcell morphology
JOURNAL OF CELL SCIENCE
The evolutionarily conserved n-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor
JOURNAL OF BIOLOGICAL CHEMISTRY
Differential effects of Cbl and 70Z/3 Cbl on T cell receptor-induced phospholipase C gamma-1 activity
FEBS LETTERS
Nuclear localization of a new c-cbl related protein, CARP 90, during in vivo thymic apoptosis in mice
CELL DEATH AND DIFFERENTIATION
Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation
ONCOGENE
cbl-3: a new mammalian cbl family protein
ONCOGENE
The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases
ONCOGENE
cbl-b inhibits epidermal growth factor receptor signaling
ONCOGENE
Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase
NATURE
Enhancement of Fc gamma receptor-mediated phagocytosis by transforming mutants of Cbl
JOURNAL OF IMMUNOLOGY
Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins
JOURNAL OF IMMUNOLOGY
Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z
JOURNAL OF BIOLOGICAL CHEMISTRY
Activation of nuclear factor of activated T cells-(NFAT) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk(L) or p85 phosphatidylinositol S-kinase association
JOURNAL OF BIOLOGICAL CHEMISTRY
The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor
JOURNAL OF BIOLOGICAL CHEMISTRY
Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation - A critical role for Cbl tyrosine kinase-binding domain
JOURNAL OF BIOLOGICAL CHEMISTRY
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
GENES & DEVELOPMENT
INTERLEUKIN-2 STIMULATION INDUCES TYROSINE PHOSPHORYLATION OF P120-CBL AND CRKL AND FORMATION OF MULTIMOLECULAR SIGNALING COMPLEXES IN T-LYMPHOCYTES AND NATURAL-KILLER-CELLS
The Journal of biological chemistry
Cbl-mediated negative regulation of the Syk tyrosine kinase - A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323
JOURNAL OF BIOLOGICAL CHEMISTRY
SLP-76-CBL-GRB2-SHC INTERACTIONS IN FC-GAMMA-RI SIGNALING
Blood
SEQUENCES SURROUNDING THE SRC-HOMOLOGY-3 DOMAIN OF PHOSPHOLIPASE C-GAMMA-1 INCREASE THE DOMAINS ASSOCIATION WITH CBL
Biochemical and biophysical research communications (Print)
TYROSINE KINASE-ACTIVITY OF THE EGF RECEPTOR IS ENHANCED BY THE EXPRESSION OF ONCOGENIC 70Z-CBL
Oncogene
D-CBL, THE DROSOPHILA HOMOLOG OF THE C-CBL PROTOONCOGENE, INTERACTS WITH THE DROSOPHILA EGF RECEPTOR IN-VIVO, DESPITE LACKING C-TERMINAL ADAPTER BINDING-SITES
Oncogene
TYROSINE PHOSPHORYLATION OF P120(CBL) IN BCR ABL TRANSFORMED HEMATOPOIETIC-CELLS MEDIATES ENHANCED ASSOCIATION WITH PHOSPHATIDYLINOSITOL 3-KINASE/
Oncogene
PHOSPHORYLATION OF CBL AFTER STIMULATION OF NB2 CELLS WITH PROLACTIN AND ITS ASSOCIATION WITH PHOSPHATIDYLINOSITOL 3-KINASE
Molecular endocrinology
TYROSINE PHOSPHORYLATION OF THE PRODUCT OF THE C-CBL PROTOONCOGENESISINDUCED AFTER INTEGRIN STIMULATION
Experimental hematology
PHOSPHOTYROSINE BINDING DOMAIN-DEPENDENT UP-REGULATION OF THE PLATELET-DERIVED GROWTH-FACTOR RECEPTOR-ALPHA SIGNALING CASCADE BY TRANSFORMING MUTANTS OF CBL - IMPLICATIONS FOR CBL FUNCTION AND ONCOGENICITY
Molecular and cellular biology
INTERACTIONS OF DROSOPHILA CBL WITH EPIDERMAL GROWTH-FACTOR RECEPTORSAND ROLE OF CBL IN R7 PHOTORECEPTOR CELL-DEVELOPMENT
Molecular and cellular biology
INSULIN STIMULATES TYROSINE PHOSPHORYLATION OF THE PROTOONCOGENE PRODUCT OF C-CBL IN 3T3-L1 ADIPOCYTES
Biochemical journal
THE PRODUCT OF THE PROTOONCOGENE C-CBL - A NEGATIVE REGULATOR OF THE SYK TYROSINE KINASE
Science
3 DOMAINS OF SLP-76 ARE REQUIRED FOR ITS OPTIMAL FUNCTION IN A T-CELLLINE
The Journal of immunology
PROTO-ONCOPROTEIN VAV INTERACTS WITH C-CBL IN ACTIVATED THYMOCYTES AND PERIPHERAL T-CELLS
The Journal of immunology
DIFFERENTIAL SIGNALING AFTER BETA-1 INTEGRIN LIGATION IS MEDIATED THROUGH BINDING OF CRKL TO P120(CBL) AND P110(HEF1)
The Journal of biological chemistry
SERINE PHOSPHORYLATION OF CBL INDUCED BY PHORBOL ESTER ENHANCES ITS ASSOCIATION WITH 14-3-3-PROTEINS IN T-CELLS VIA A NOVEL SERINE-RICH 14-3-3-BINDING MOTIF
The Journal of biological chemistry
DIRECT T-CELL ACTIVATION BY CHIMERIC SINGLE-CHAIN FV-SYK PROMOTES SYK-CBL ASSOCIATION AND CBL PHOSPHORYLATION
The Journal of biological chemistry
ANTISENSE REPRESSION OF PROTOONCOGENE C-CBL ENHANCES ACTIVATION OF THE JAK-STAT PATHWAY BUT NOT THE RAS PATHWAY IN EPIDERMAL GROWTH-FACTOR RECEPTOR SIGNALING
The Journal of biological chemistry
A C-CBL YEAST 2 HYBRID SCREEN REVEALS INTERACTIONS WITH 14-3-3-ISOFORMS AND CYTOSKELETAL COMPONENTS
Biochemical and biophysical research communications
THE 2 MAJOR SITES OF CBL TYROSINE PHOSPHORYLATION IN ABL-TRANSFORMED CELLS SELECT THE CRKL SH2 DOMAIN
Oncogene
COUPLING OF THE C-CBL PROTOONCOGENE PRODUCT TO ERBB-1 EGF-RECEPTOR BUT NOT TO OTHER ERBB PROTEINS/
Oncogene
THE PROTOONCOGENE PRODUCT P120(CBL) AND THE ADAPTER PROTEINS CRKL ANDC-CRK LINK C-ABL, P190(BCR ABL) AND P210(BCR/ABL) TO THE PHOSPHATIDYLINOSITOL-3' KINASE PATHWAY/
Oncogene
NETWORKS OF INTERACTION OF P120(CBL) AND P130(CAS) WITH CRK AND GRB2 ADAPTER PROTEINS
Oncogene
P210(BCR ABL) INDUCES FORMATION OF COMPLEXES CONTAINING FOCAL ADHESION PROTEINS AND THE PROTOONCOGENE PRODUCT P120(C-CBL)/
Experimental hematology
CONTROL AND INTEGRATION OF CELL SIGNALING PATHWAYS DURING C-ELEGANS VULVAR DEVELOPMENT
BioEssays
ASSOCIATION BETWEEN PHOSPHATIDYLINOSITOL-3 KINASE, CBL AND OTHER TYROSINE-PHOSPHORYLATED PROTEINS IN COLONY-STIMULATING FACTOR-1-STIMULATEDMACROPHAGES
Biochemical journal
TYROSINE-PHOSPHORYLATED CBL BINDS TO CRK AFTER T-CELL ACTIVATION
The Journal of immunology
CHARACTERIZATION OF CBL TYROSINE PHOSPHORYLATION AND A CBL-SYK COMPLEX IN RBL-2H3 CELLS
The Journal of experimental medicine
PHYSICAL AND FUNCTIONAL ASSOCIATION OF THE CBL PROTOONCOGENE PRODUCT WITH AN SRC-FAMILY PROTEIN-TYROSINE KINASE, P53 56(LYN), IN THE B-CELLANTIGEN RECEPTOR-MEDIATED SIGNALING/
The Journal of experimental medicine
ASSOCIATION OF TYROSINE PROTEIN-KINASE ZAP-70 WITH THE PROTOONCOGENE PRODUCT P120(C-CBL) IN T-LYMPHOCYTES
The Journal of experimental medicine
P120(CBL) IS A MAJOR SUBSTRATE OF TYROSINE PHOSPHORYLATION UPON B-CELL ANTIGEN RECEPTOR STIMULATION AND INTERACTS IN-VIVO WITH FYN AND SYK TYROSINE KINASES, GRB2 AND SHC ADAPTERS, AND THE P85 SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE
The Journal of biological chemistry
SPECIFIC ASSOCIATION OF TYROSINE-PHOSPHORYLATED C-CBL WITH FYN TYROSINE KINASE IN T-CELLS
The Journal of biological chemistry
REGULATION OF THE ASSOCIATION OF P120(CBL) WITH GRB2 IN JURKAT T-CELLS
The Journal of biological chemistry
A NOVEL PHOSPHOTYROSINE-BINDING DOMAIN IN THE N-TERMINAL TRANSFORMINGREGION OF CBL INTERACTS DIRECTLY AND SELECTIVELY ZAP-70 IN T-CELLS
The Journal of biological chemistry
FORMATION OF C-CBL-CENTER-DOT-PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXESON LYMPHOCYTE MEMBRANES BY A P56(LCK)-INDEPENDENT MECHANISM
The Journal of biological chemistry
SOS, VAV, AND C3G PARTICIPATE IN B-CELL RECEPTOR-INDUCED SIGNALING PATHWAYS AND DIFFERENTIALLY ASSOCIATE WITH SHC-GRB2, CRK, AND CRK-L ADAPTERS
The Journal of biological chemistry
STIMULATION THROUGH THE T-CELL RECEPTOR INDUCES CBL ASSOCIATION WITH CRK PROTEINS AND THE GUANINE-NUCLEOTIDE EXCHANGE PROTEIN C3G
The Journal of biological chemistry
INTERACTIONS OF CBL WITH 2 ADAPTER PROTEINS, GRB2 AND CRK, UPON T-CELL ACTIVATION
The Journal of biological chemistry
C-CBL IS TRANSIENTLY TYROSINE-PHOSPHORYLATED, UBIQUITINATED, AND MEMBRANE-TARGETED FOLLOWING CSF-1 STIMULATION OF MACROPHAGES
The Journal of biological chemistry
P120(CBL) IS A CYTOSOLIC ADAPTER PROTEIN THAT ASSOCIATES WITH PHOSPHOINOSITIDE 3-KINASE IN RESPONSE TO EPIDERMAL GROWTH-FACTOR IN PC12 AND OTHER CELLS
The Journal of biological chemistry
THE PROTEIN PRODUCT OF THE PROTOONCOGENE C-CBL FORMS A COMPLEX WITH PHOSPHATIDYLINOSITOL 3-KINASE P85 AND CD19 IN ANTI-IGM-STIMULATED HUMANB-LYMPHOMA CELLS
Blood
P120(C-CBL) IS PRESENT IN HUMAN BLOOD-PLATELETS AND IS DIFFERENTIALLYINVOLVED IN SIGNALING BY THROMBOPOIETIN AND THROMBIN
Blood
CD38-MEDIATED GROWTH SUPPRESSION OF B-CELL PROGENITORS REQUIRES ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE AND INVOLVES ITS ASSOCIATION WITH THE PROTEIN PRODUCT OF THE C-CBL PROTOONCOGENE
Blood
PROTOONCOGENE PRODUCTS VAV AND C-CBL ARE INVOLVED IN THE SIGNAL-TRANSDUCTION THROUGH GRB2 ASH IN HEMATOPOIETIC-CELLS/
Acta haematologica
THE PROTEIN PRODUCT OF THE C-CBL ONCOGENE RAPIDLY COMPLEXES WITH THE EGF RECEPTOR AND IS TYROSINE-PHOSPHORYLATED FOLLOWING EGF STIMULATION
Oncogene
CLONING AND CHARACTERIZATION OF CBL-B - A SH3 BINDING-PROTEIN WITH HOMOLOGY TO THE C-CBL PROTOONCOGENE
Oncogene
INTERACTIONS OF CBL WITH GRB2 AND PHOSPHATIDYLINOSITOL 3'-KINASE IN ACTIVATED JURKAT CELLS
Molecular and cellular biology
SIMILARITY OF SLI-1, A REGULATOR OF VULVAR DEVELOPMENT IN C-ELEGANS, TO THE MAMMALIAN PROTOONCOGENE C-CBL
Science
THE PROTEIN PRODUCT OF THE C-CBL PROTOONCOGENE IS PHOSPHORYLATED AFTER B-CELL RECEPTOR STIMULATION AND BINDS THE SH3 DOMAIN OF BRUTONS TYROSINE KINASE
The Journal of experimental medicine
ASSOCIATION OF ACTIVATED PHOSPHATIDYLINOSITOL 3-KINASE WITH P120(CBL)IN ANTIGEN RECEPTOR-LIGATED B-CELLS
The Journal of biological chemistry
COUPLING OF THE PROTOONCOGENE PRODUCT C-CBL TO THE EPIDERMAL GROWTH-FACTOR RECEPTOR
The Journal of biological chemistry
TYROSINE PHOSPHORYLATION OF THE C-CBL PROTOONCOGENE PROTEIN PRODUCT AND ASSOCIATION WITH EPIDERMAL GROWTH-FACTOR (EGF) RECEPTOR UPON EGF STIMULATION
The Journal of biological chemistry
THE SH3 DOMAIN-BINDING T-CELL TYROSYL PHOSPHOPROTEIN P120 - DEMONSTRATION OF ITS IDENTITY WITH THE C-CBL PROTOONCOGENE PRODUCT AND IN-VIVO COMPLEXES WITH FYN, GRB2, AND PHOSPHATIDYLINOSITOL 3-KINASE
The Journal of biological chemistry
TYROSINE PHOSPHORYLATION AND TRANSLOCATION OF THE C-CBL PROTEIN AFTERACTIVATION OF TYROSINE KINASE SIGNALING PATHWAYS
The Journal of biological chemistry
THE PROTOONCOGENE PRODUCT C-CBL BECOMES TYROSINE-PHOSPHORYLATED BY STIMULATION WITH GM-CSF OR EPO AND CONSTITUTIVELY BINDS TO THE SH3 DOMAIN OF GRB2 ASH IN HUMAN HEMATOPOIETIC-CELLS/
The Journal of biological chemistry
THE CBL ONCOGENE - A NOVEL SUBSTRATE OF PROTEIN-TYROSINE KINASES
Australian and New Zealand Journal of Medicine
PHYSICAL LINKAGE OF THE FRAGILE SITE FRA11B AND A JACOBSEN SYNDROME CHROMOSOME DELETION BREAKPOINT IN 11Q23.3
Human molecular genetics
EXPRESSION OF C-CBL PROTOONCOGENE IS MODULATED DURING DIFFERENTIATIONBUT NOT DURING INDUCTION OF PROLIFERATION
Oncogene
TUMOR-INDUCTION BY ACTIVATED ABL INVOLVES TYROSINE PHOSPHORYLATION OFTHE PRODUCT OF THE CBL ONCOGENE
EMBO journal
THE PROTEIN PRODUCT OF THE C-CBL PROTOONCOGENE IS THE 120-KDA TYROSINE-PHOSPHORYLATED PROTEIN IN JURKAT CELLS ACTIVATED VIA THE T-CELL ANTIGEN RECEPTOR
The Journal of biological chemistry
PHYSICAL ASSOCIATION BETWEEN SRC HOMOLOGY-3 ELEMENTS AND THE PROTEIN PRODUCT OF THE C-CBL PROTOONCOGENE
The Journal of biological chemistry