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La ricerca find articoli where soggetti phrase all words 'UCN-01' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 77 riferimenti
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    1. Luo, Y; Rockow-Magnone, SK; Kroeger, PE; Frost, L; Chen, ZH; Han, EKH; Ng, SC; Simmer, RL; Giranda, VL
      Blocking CHK1 expression induces apoptosis and abrogates the G2 checkpointmechanism

      NEOPLASIA
    2. Smith, JA; Cortes, J; Newman, RA; Madden, TL
      Development of a simplified, sensitive high-performance liquid chromatographic method using fluorescence detection to determine the concentration of UCN-01 in human plasma

      JOURNAL OF CHROMATOGRAPHY B
    3. Wang, CG; Fu, MF; Mani, S; Wadler, S; Senderowicz, AM; Pestell, RG
      Histone acetylation and the cell-cycle in cancer

      FRONTIERS IN BIOSCIENCE
    4. Sausville, EA
      Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: Sequenceand tumor biology matters - Commentary re: P. Munster et al., modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. Clin. Cancer Res., 7: 2228-2236, 2001.

      CLINICAL CANCER RESEARCH
    5. Bhoumik, A; Ivanov, V; Ronai, Z
      Activating transcription factor 2-derived peptides alter resistance of human tumor cell lines to ultraviolet irradiation and chemical treatment

      CLINICAL CANCER RESEARCH
    6. Wang, SH; Phelps, E; Utsugi, S; Baker, JR
      Susceptibility of thyroid cancer cells to 7-hydroxystaurosporine-induced apoptosis correlates with Bcl-2 protein level

      THYROID
    7. Sampath, D; Plunkett, W
      Design of new anticancer therapies targeting cell cycle checkpoint pathways

      CURRENT OPINION IN ONCOLOGY
    8. Blagosklonny, MV; Dixon, SC; Robey, R; Figg, WD
      Resistance to growth inhibitory and apoptotic effects of phorbol ester andUCN-01 in aggressive cancer cell lines

      INTERNATIONAL JOURNAL OF ONCOLOGY
    9. Graves, PR; Lovly, CM; Uy, GL; Piwnica-Worms, H
      Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding

      ONCOGENE
    10. Abe, S; Kubota, T; Otani, Y; Furukawa, T; Watanabe, M; Kumai, K; Akiyama, T; Akinaga, S; Kitajima, M
      UCN-01 (7-hydoxystaurosporine) inhibits in vivo growth of human cancer cells through selective perturbation of G1 phase checkpoint machinery

      JAPANESE JOURNAL OF CANCER RESEARCH
    11. Senderowicz, AM
      Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies

      LEUKEMIA
    12. Sausville, EA; Arbuck, SG; Messmann, R; Headlee, D; Bauer, KS; Lush, RM; Murgo, A; Figg, WD; Lahusen, T; Jaken, S; Jing, XX; Roberge, M; Fuse, E; Kuwabara, T; Senderowicz, AM
      Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms

      JOURNAL OF CLINICAL ONCOLOGY
    13. Cholody, WM; Kosakowska-Cholody, T; Michejda, CJ
      Bisimidazoacridones induce a potent cytostatic effect in colon tumor cellsthat sensitizes them to killing by UCN-01

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    14. Yasoshima, K; Kuwabara, T; Fuse, E; Kuramitu, T; Kurata, N; Nishiie, H; Oishi, T; Kobayashi, H; Kobayashi, S
      Pharmacokinetics, distribution, metabolism and excretion of [H-3]UCN-01 inrats and dogs after intravenous administration

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    15. Schupp, P; Steube, K; Meyer, C; Proksch, P
      Anti-proliferative effects of new staurosporine derivatives isolated from a marine ascidian and its predatory flatworm

      CANCER LETTERS
    16. Hu, BC; Zhou, XY; Wang, X; Zeng, ZC; Iliakis, G; Wang, Y
      The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway

      JOURNAL OF BIOLOGICAL CHEMISTRY
    17. Hirose, Y; Berger, MS; Pieper, RO
      p53 effects both the duration of G(2)/M arrest and the fate of temozolomide-treated human glioblastoma cells

      CANCER RESEARCH
    18. Hirose, Y; Berger, MS; Pieper, RO
      Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells

      CANCER RESEARCH
    19. Dai, Y; Yu, CR; Singh, V; Tang, L; Wang, ZL; McInistry, R; Dent, P; Grant, S
      Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells

      CANCER RESEARCH
    20. Kaubisch, A; Schwartz, GK
      Cyclin-dependent kinase and protein kinase C inhibitors: A novel class of antineoplastic agents in clinical development

      CANCER JOURNAL
    21. Mani, S; Wang, CG; Wu, KM; Francis, R; Pestell, R
      Cyclin-dependent kinase inhibitors: novel anticancer agents

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    22. Wilson, WH; Sorbara, L; Figg, WD; Mont, EK; Sausville, E; Warren, KE; Balis, FM; Bauer, K; Raffeld, M; Senderowicz, AM; Monks, A
      Modulation of clinical drug resistance in a B cell lymphoma patient by theprotein kinase inhibitor 7-hydroxystaurosporine: Presentation of a novel therapeutic paradigm

      CLINICAL CANCER RESEARCH
    23. Gescher, A
      Staurosporine analogues - pharmacological toys or useful antitumour agents?

      CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
    24. Jones, CB; Clements, MK; Redkar, A; Daoud, SS
      UCN-01 and camptothecin induce DNA double-strand breaks in p53 mutant tumor cells, but not in normal or p53 negative epithelial cells

      INTERNATIONAL JOURNAL OF ONCOLOGY
    25. Somerville, L; Cory, JG
      Altered sensitivity of deoxyadenosine-resistant mouse leukemia L1210 cellsto apoptosis induced by 7-hydroxystaurosporine

      INTERNATIONAL JOURNAL OF ONCOLOGY
    26. Senderowicz, AM
      Small molecule modulators of cyclin-dependent kinases for cancer therapy

      ONCOGENE
    27. Kurata, N; Matsushita, S; Nishi, K; Watanabe, H; Kobayashi, S; Suenaga, A; Otagiri, M
      Characterization of a binding site of UCN-01, a novel anticancer drug on alpha(1)-acid glycoprotein

      BIOLOGICAL & PHARMACEUTICAL BULLETIN
    28. Kuh, HJ; Nakagawa, S; Usuda, J; Yamaoka, K; Saijo, N; Nishio, K
      A computational model for quantitative analysis of cell cycle arrest and its contribution to overall growth inhibition by anticancer agents

      JAPANESE JOURNAL OF CANCER RESEARCH
    29. Abe, S; Kubota, T; Otani, Y; Furukawa, T; Watanabe, M; Kumai, K; Kitajima, M
      UCN-01 (7-hydroxystaurosporine) enhances 5-fluorouracil cytotoxicity through down-regulation of thymidylate synthetase messenger RNA

      JAPANESE JOURNAL OF CANCER RESEARCH
    30. Damiens, E; Meijer, L
      Chemical inhibitors of cyclin-dependent kinases: preclinical and clinical studies.

      PATHOLOGIE BIOLOGIE
    31. Jones, CB; Clements, MK; Wasi, S; Daoud, SS
      Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G(2) arrest

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    32. Akinaga, S; Sugiyama, K; Akiyama, T
      UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a newgeneration of anti-cancer agents for the new century?

      ANTI-CANCER DRUG DESIGN
    33. Yokoyama, Y; Shinohara, A; Takahashi, Y; Wan, X; Takahashi, S; Niwa, K; Tamaya, T
      Synergistic effects of danazol and mifepristone on the cytotoxicity of UCN-01 in hormone-responsive breast cancer cells

      ANTICANCER RESEARCH
    34. Monks, A; Harris, ED; Vaigro-Wolff, A; Hose, CD; Connelly, JW; Sausville, EA
      UCN-01 enhances the in vitro toxicity of clinical agents in human tumor cell lines

      INVESTIGATIONAL NEW DRUGS
    35. Li, HG; Forstermann, U
      Structure-activity relationship of staurosporine analogs in regulating expression of endothelial nitric-oxide synthase gene

      MOLECULAR PHARMACOLOGY
    36. Fukuoka, K; Yamagishi, T; Ichihara, T; Nakaike, S; Iguchi, K; Yamada, Y; Fukumoto, H; Yoneda, T; Samata, K; Ikeya, H; Nanaumi, K; Hirayama, N; Narita, N; Saijo, N; Nishio, K
      Mechanism of action of aragusterol A (YTA0040), a potent anti-tumor marinesteroid targeting the G(1) phase of the cell cycle

      INTERNATIONAL JOURNAL OF CANCER
    37. Usuda, J; Saijo, N; Fukuoka, K; Fukumoto, H; Kuh, HJ; Nakamura, T; Koh, Y; Suzuki, T; Koizumi, F; Tamura, T; Kato, H; Nishio, K
      Molecular determinants of UCN-01-induced growth inhibition in human lung cancer cells

      INTERNATIONAL JOURNAL OF CANCER
    38. Jackson, JR; Gilmartin, A; Imburgia, C; Winkler, JD; Marshall, LA; Roshak, A
      An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage

      CANCER RESEARCH
    39. Tang, L; Boise, LH; Dent, P; Grant, S
      Potentiation of 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing Bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01)

      BIOCHEMICAL PHARMACOLOGY
    40. Akiyama, T; Shimizu, M; Okabe, W; Tamaoki, T; Akinaga, S
      Differential effects of UCN-01, staurosporine and CGP 41 251 on cell cycleprogression and CDC2 cyclin B-1 regulation in A431 cells synchronized at Mphase by nocodazole

      ANTI-CANCER DRUGS
    41. Chen, XM; Lowe, M; Keyomarsi, K
      UCN-01-mediated G1 arrest in normal but not tumor breast cells is pRb-dependent and p53-independent

      ONCOGENE
    42. Akiyama, T; Sugiyama, K; Shimizu, M; Tamaoki, T; Akinaga, S
      G1-checkpoint function including a cyclin-dependent kinase 2 regulatory pathway as potential determinant of 7-hydroxystaurosporine (UCN-01)-induced apoptosis and G1-phase accumulation

      JAPANESE JOURNAL OF CANCER RESEARCH
    43. Kurata, N; Kuwabara, T; Tanii, H; Fuse, E; Akiyama, T; Akinaga, S; Kobayashi, H; Yamaguchi, K; Kobayashi, S
      Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor,UCN-01

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    44. Fukumoto, H; Tamura, T; Kamiya, Y; Usuda, J; Suzuki, T; Kanzawa, F; Kuh, HJ; Ohe, Y; Saijo, N; Nishio, K
      Activation-induced apoptosis of peripheral lymphocytes treated with 7-hydroxystaurosporine, UCN-01

      INVESTIGATIONAL NEW DRUGS
    45. Jarvis, WD; Grant, S
      Protein kinase C targeting in antineoplastic treatment strategies

      INVESTIGATIONAL NEW DRUGS
    46. Bredel, M; Pollack, IF; Freund, JM; Rusnak, J; Lazo, JS
      Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion

      JOURNAL OF NEURO-ONCOLOGY
    47. Eastman, A; Rigas, JR
      Modulation of apoptosis signaling pathways and cell cycle regulation

      SEMINARS IN ONCOLOGY
    48. Mahboobi, S; Dove, S; Kuhr, S; Pongratz, H
      Synthesis of arcyriarubine regioisomers by Pd(0)-catalysis or via lithiated indole derivatives - conformational analysis by semiempirical and X-ray methods

      PHARMAZIE
    49. Shapiro, GI; Harper, JW
      Anticancer drug targets: cell cycle and checkpoint control

      JOURNAL OF CLINICAL INVESTIGATION
    50. Jiang, H; Yang, LY
      Cell cycle checkpoint abrogator UCN-01 inhibits DNA repair: Association with attenuation of the interaction of XPA and ERCC1 nucleotide excision repair proteins

      CANCER RESEARCH
    51. Lee, SI; Brown, MK; Eastman, A
      Comparison of the efficacy of 7-hydroxystaurosporine (UCN-01) and other staurosporine analogs to abrogate cisplatin-induced cell cycle arrest in human breast cancer cell lines

      BIOCHEMICAL PHARMACOLOGY
    52. KURATA N; KURAMITSU T; TANII H; FUSE E; KUWABARA T; KOBAYASHI H; KOBAYASHI S
      DEVELOPMENT OF A HIGHLY SENSITIVE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR MEASURING AN ANTICANCER DRUG, UCN-01, IN HUMAN PLASMA OR URINE

      Journal of chromatography B. Biomedical sciences and applications
    53. GREVER M
      NEW THERAPEUTIC AGENTS OF POTENTIAL USE IN ACUTE MYELOID-LEUKEMIA

      Leukemia & lymphoma (Print)
    54. GESCHER A
      ANALOGS OF STAUROSPORINE - POTENTIAL ANTICANCER DRUGS

      General pharmacology
    55. HARKIN ST; COHEN GM; GESCHER A
      MODULATION OF APOPTOSIS IN RAT THYMOCYTES BY ANALOGS OF STAUROSPORINE- LACK OF DIRECT ASSOCIATION WITH INHIBITION OF PROTEIN-KINASE-C

      Molecular pharmacology
    56. HARRIS W; WILKINSON SE; NIXON JS
      RECENT DEVELOPMENTS IN PROTEIN-KINASE-C INHIBITORS

      Expert opinion on therapeutic patents
    57. TSUCHIDA E; URANO M
      THE EFFECT OF UCN-01 (7-HYDROXYSTAUROSPORINE), A POTENT INHIBITOR OF PROTEIN-KINASE-C, ON FRACTIONATED RADIOTHERAPY OR DAILY CHEMOTHERAPY OF A MURINE FIBROSARCOMA

      International journal of radiation oncology, biology, physics
    58. YOSHIDA S; SHIMIZU E; OGURA T; TAKADA M; SONE S
      STIMULATORY EFFECT OF RECONSTITUTED BASEMENT-MEMBRANE COMPONENTS (MATRIGEL) ON THE COLONY FORMATION OF A PANEL OF HUMAN LUNG-CANCER CELL-LINES IN SOFT AGAR

      Journal of cancer research and clinical oncology
    59. YANG SW; CORDELL GA
      DEUTERIUM LABELING AND MASS FRAGMENTATION STUDIES OF STAUROSPORINE

      Journal of natural products
    60. SHAO RG; CAO CX; POMMIER Y
      ACTIVATION OF PKC-ALPHA DOWNSTREAM FROM CASPASES DURING APOPTOSIS INDUCED BY 7-HYDROXYSTAUROSPORINE OR THE TOPOISOMERASE INHIBITORS, CAMPTOTHECIN AND ETOPOSIDE, IN HUMAN MYELOID-LEUKEMIA HL60 CELLS

      The Journal of biological chemistry
    61. JONES T; COURAGE C; HUBBARD A; GESCHER A
      CELLULAR RELOCALISATION OF PROTEIN-KINASE C-THETA CAUSED BY STAUROSPORINE AND SOME OF ITS ANALOGS

      Biochemical pharmacology
    62. BREDEL M; POLLACK IF
      THE ROLE OF PROTEIN-KINASE-C (PKC) IN THE EVOLUTION AND PROLIFERATIONOF MALIGNANT GLIOMAS, AND THE APPLICATION OF PKC INHIBITION AS A NOVEL-APPROACH TO ANTIGLIOMA THERAPY

      Acta neurochirurgica
    63. SASAKI T; ISHII SI; SENDA M; AKINAGA S; MURAKATA C
      SYNTHESIS OF [7-BETA-METHOXY C-11]METHOXY STAUROSPORINE FOR IMAGING PROTEIN-KINASE-C LOCALIZATION IN THE BRAIN

      Applied radiation and isotopes
    64. VEERANNA; SHETTY KT; AMIN N; GRANT P; ALBERS RW; PANT HC
      INHIBITION OF NEURONAL CYCLIN-DEPENDENT KINASE-5 BY STAUROSPORINE ANDPURINE ANALOGS IS INDEPENDENT OF ACTIVATION BY MUNC-18

      Neurochemical research
    65. SHIMIZU E; ZHAO MR; NAKANISHI H; YAMAMOTO A; YOSHIDA S; TAKADA M; OGURA T; SONE S
      DIFFERING EFFECTS OF STAUROSPORINE AND UCN-01 ON RB PROTEIN-PHOSPHORYLATION AND EXPRESSION OF LUNG-CANCER CELL-LINES

      Oncology
    66. COURAGE C; SNOWDEN R; GESCHER A
      DIFFERENTIAL-EFFECTS OF STAUROSPORINE ANALOGS ON CELL-CYCLE, GROWTH AND VIABILITY IN A549 CELLS

      British Journal of Cancer
    67. WANG QZ; WORLAND PJ; CLARK JL; CARLSON BA; SAUSVILLE EA
      APOPTOSIS IN 7-HYDROXYSTAUROSPURINE-TREATED T-LYMPHOBLASTS CORRELATESWITH ACTIVATION OF CYCLIN-DEPENDENT KINASE-1 AND KINASE-2

      Cell growth & differentiation
    68. GOEKE K; HOEHN P; GHISALBA O
      PRODUCTION OF THE STAUROSPORINE AGLYCON K-252C WITH A BLOCKED MUTANT OF THE STAUROSPORINE PRODUCER STRAIN STREPTOMYCES-LONGISPOROFLAVUS ANDBY BIOTRANSFORMATION OF STAUROSPORINE WITH STREPTOMYCES-MEDIOCIDICUS ATCC-13279

      Journal of antibiotics
    69. BUDWORTH J; GESCHER A
      DIFFERENTIAL INHIBITION OF CYTOSOLIC AND MEMBRANE-DERIVED PROTEIN-KINASE-C ACTIVITY BY STAUROSPORINE AND OTHER KINASE INHIBITORS

      FEBS letters
    70. MIZUNO K; NODA K; UEDA Y; HANAKI H; SAIDO TC; IKUTA T; KUROKI T; TAMAOKI T; HIRAI S; OSADA S; OHNO S
      UCN-01, AN ANTITUMOR DRUG, IS A SELECTIVE INHIBITOR OF THE CONVENTIONAL PKC SUBFAMILY

      FEBS letters
    71. CARAVATTI G; MEYER T; FREDENHAGEN A; TRINKS U; METT H; FABBRO D
      INHIBITORY ACTIVITY AND SELECTIVITY OF STAUROSPORINE DERIVATIVES TOWARDS PROTEIN-KINASE-C

      Bioorganic & medicinal chemistry letters
    72. VICE SF; BISHOP WR; MCCOMBIE SW; DAO H; FRANK E; GANGULY AK
      INDOLOCARBAZOLE NITROGENS LINKED BY 3-ATOM BRIDGES - A POTENT NEW CLASS OF PKC INHIBITORS

      Bioorganic & medicinal chemistry letters
    73. HILL DL; TILLERY KF; ROSE LM; POSEY CF
      DISPOSITION IN MICE OF 7-HYDROXYSTAUROSPORINE, A PROTEIN-KINASE INHIBITOR WITH ANTITUMOR-ACTIVITY

      Cancer chemotherapy and pharmacology
    74. MCCOMBIE SW; BISHOP RW; CARR D; DOBEK E; KIRKUP MP; KIRSCHMEIER P; LIN SI; PETRIN J; ROSINSKI K; SHANKAR BB; WILSON O
      INDOLOCARBAZOLES .1. TOTAL SYNTHESIS AND PROTEIN-KINASE INHIBITING CHARACTERISTICS OF COMPOUNDS RELATED TO K-252C

      Bioorganic & medicinal chemistry letters
    75. KLEINSCHROTH J; HARTENSTEIN J; RUDOLPH C; SCHACHTELE C
      NON-GLYCOSIDIC NON-AMINOALKYL-SUBSTITUTED INDOLOCARBAZOLES AS INHIBITORS OF PROTEIN-KINASE-C/

      Bioorganic & medicinal chemistry letters
    76. AKINAGA S; NOMURA K; GOMI K; OKABE M
      DIVERSE EFFECTS OF INDOLOCARBAZOLE COMPOUNDS ON THE CELL-CYCLE PROGRESSION OF RAS-TRANSFORMED RAT FIBROBLAST CELLS

      Journal of antibiotics
    77. KULANTHAIVEL P; HALLOCK YF; BOROS C; HAMILTON SM; JANZEN WP; BALLAS LM; LOOMIS CR; JIANG JB; KATZ B; STEINER JR; CLARDY J
      BALANOL - A NOVEL AND POTENT INHIBITOR OF PROTEIN-KINASE-C FROM THE FUNGUS VERTICILLIUM-BALANOIDES

      Journal of the American Chemical Society


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Documento generato il 26/10/20 alle ore 11:58:27