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La ricerca find articoli where soggetti phrase all words 'TYROSINE KINASE INHIBITOR' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 243 riferimenti
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    1. Druker, BJ
      Current treatment approaches for chronic myelogenous leukemia

      CANCER JOURNAL
    2. Campbell, JDM; Cook, G; Holyoake, TL
      Evolution of bone marrow transplantation - the original immunotherapy

      TRENDS IN IMMUNOLOGY
    3. Szer, J; Lieschke, GJ
      Small molecule: large hopes

      INTERNAL MEDICINE JOURNAL
    4. Boussioutas, A; Taupin, D
      Towards a molecular approach to gastric cancer management

      INTERNAL MEDICINE JOURNAL
    5. Krystal, GW
      Mechanisms of resistance to imatinib (ST1571) and prospects for combination with conventional, chemotherapeutic agents

      DRUG RESISTANCE UPDATES
    6. Weisberg, E; Griffin, JD
      Mechanisms of resistance imatinib (ST1571) in preclinical models and in leukemia patients

      DRUG RESISTANCE UPDATES
    7. Fruh, K; Simmen, K; Luukkonen, BGM; Bell, YC; Ghazal, P
      Virogenomics: a novel approach to antiviral drug discovery

      DRUG DISCOVERY TODAY
    8. Roomans, GM
      Pharmacological treatment of the ion transport defect in cystic fibrosis

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    9. Nicholson, RI; Hutcheson, IR; Harper, ME; Knowlden, JM; Barrow, D; McClelland, RA; Jones, HE; Wakeling, AE; Gee, JMW
      Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer

      ENDOCRINE-RELATED CANCER
    10. Mendelsohn, J
      The epidermal growth factor receptor as a target for cancer therapy

      ENDOCRINE-RELATED CANCER
    11. Dinh, HKB; Zhao, BT; Schuschereba, ST; Merrill, G; Bowman, PD
      Gene expression profiling of the response to thermal injury in human cells

      PHYSIOLOGICAL GENOMICS
    12. Nimmanapalli, R; Porosnicu, M; Nguyen, D; Worthington, E; O'Bryan, E; Perkins, C; Bhalla, K
      Cotreatment with STI-571 enhances tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL or Apo-2L)-induced apoptosis of Bcr-Abl-positive human acute leukemia cells

      CLINICAL CANCER RESEARCH
    13. Howe, JR; Karnell, LH; Scott-Conner, C
      Small bowel sarcoma: Analysis of survival from the National Cancer Data Base

      ANNALS OF SURGICAL ONCOLOGY
    14. Harari, PM; Huang, SM
      Radiation response modification following molecular inhibition of epidermal growth factor receptor signaling

      SEMINARS IN RADIATION ONCOLOGY
    15. Tuveson, DA; Fletcher, JA
      Signal transduction pathways in sarcoma as targets for therapeutic intervention

      CURRENT OPINION IN ONCOLOGY
    16. Kuo, YC; Meng, HC; Tsai, WJ
      Regulation of cell proliferation, inflammatory cytokine production and calcium mobilization in primary human T lymphocytes by emodin from Polygonum hypoleucum Ohwi

      INFLAMMATION RESEARCH
    17. Yang, EB; Zhao, YN; Zhang, K; Mack, P
      Microsatellite alterations in human hepatocellular carcinoma infected withhepatitis B virus: Associated with the elevation of serum alpha-fetoprotein

      INTERNATIONAL JOURNAL OF ONCOLOGY
    18. Nadav, L; Katz, BZ
      The molecular effects of oncogenesis on cell-extracellular matrix adhesion(Review)

      INTERNATIONAL JOURNAL OF ONCOLOGY
    19. Brouard, MC; Prins, C; Mach-Pascual, S; Saurat, JH
      Acute generalized exanthematous pustulosis associated with STI571 in a patient with chronic myeloid leukemia

      DERMATOLOGY
    20. Watanabe, T; Pakala, R; Katagiri, T; Benedict, CR
      Monocyte chemotactic protein 1 amplifies serotonin-induced vascular smoothmuscle cell proliferation

      JOURNAL OF VASCULAR RESEARCH
    21. Hietala, EM; Salminen, US; Stahls, A; Valimaa, T; Maasilta, P; Tormala, P; Nieminen, MS; Harjula, ALJ
      Biodegradation of the copolymeric polylactide stent - Long-term follow-up in a rabbit aorta model

      JOURNAL OF VASCULAR RESEARCH
    22. del Olmo, E; Armas, MG; Lopez-Perez, JL; Munoz, V; Deharo, E; San Feliciano, A
      Leishmanicidal activity of some stilbenoids and related heterocyclic compounds

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    23. Verweij, J; Judson, I; van Oosterom, A
      STI571: a magic bullet?

      EUROPEAN JOURNAL OF CANCER
    24. O'Dwyer, ME; Druker, BJ
      Chronic myelogenous leukaemia - new therapeutic principles

      JOURNAL OF INTERNAL MEDICINE
    25. Brandt, R; Wong, AML; Hynes, NE
      Mammary glands reconstituted with Neu/ErbB2 transformed HC11 cells providea novel orthotopic tumor model for testing anti-cancer agents

      ONCOGENE
    26. Tuveson, DA; Willis, NA; Jacks, T; Griffin, JD; Singer, S; Fletcher, CDM; Fletcher, JA; Demetri, GD
      STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications

      ONCOGENE
    27. Berquin, IM; Dziubinski, ML; Nolan, GP; Ethier, SP
      A functional screen for genes inducing epidermal growth factor autonomy ofhuman mammary epithelial cells confirms the role of amphiregulin

      ONCOGENE
    28. Nakanishi, K; Sweeney, WE; Avner, ED; Murcia, NS
      Expression of the orpk disease gene during kidney development and maturation

      PEDIATRIC NEPHROLOGY
    29. Pedersen, MW; Meltorn, M; Damstrup, L; Poulsen, HS
      The type III epidermal growth factor receptor mutation - Biological significance and potential target for anti-cancer therapy

      ANNALS OF ONCOLOGY
    30. Spiekermann, K; Biethahn, S; Wilde, S; Hiddemann, W; Alves, F
      Constitutive activation of STAT transcription factors in acute myelogenousleukemia

      EUROPEAN JOURNAL OF HAEMATOLOGY
    31. Duhrsen, U; Martinez, T; Vohwinkel, G; Ergun, S; Sun, L; McMahon, G; Durig, J; Hossfeld, DK; Fielder, W
      Effects of vascular endothelial and platelet-derived growth factor receptor inhibitors on long-term cultures from normal human bone marrow

      GROWTH FACTORS

    32. Current clinical trials with ST1571

      ONCOLOGY-NEW YORK
    33. Obasaju, C; Hudes, GR
      Paclitaxel and docetaxel in prostate cancer

      HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
    34. Martin, TG; Gajewski, JL
      Allogeneic stem cell transplantation for acute lymphocytic leukemia in adults

      HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
    35. Garcia-Manero, G; Thomas, DA
      Salvage therapy for refractory or relapsed acute lymphocytic leukemia

      HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
    36. Pui, CH; Sailan, S; Relling, MV; Masera, G; Evans, WE
      International childhood Acute Lymphoblastic Leukemia workshop: Sausalito, CA, 30 November-1 December 2000

      LEUKEMIA
    37. Porosnicu, M; Nimmanapalli, R; Nguyen, D; Worthington, E; Perkins, C; Bhalla, KN
      Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Bcr-Abl-positive acute leukemia cells

      LEUKEMIA
    38. Miyamoto, N; Sugita, K; Goi, K; Inukai, T; Iijima, K; Tezuka, T; Kojika, S; Nakamura, M; Kagami, K; Nakazawa, S
      The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome

      LEUKEMIA
    39. Sirulink, A; Silver, RT; Najfeld, V
      Marked ploidy and BCR-ABL gene amplification in vivo in a patient treated with STI571

      LEUKEMIA
    40. Blagosklonny, MV; Fojo, T; Bhalla, KN; Kim, JS; Trepel, JB; Figg, WD; Rivera, Y; Neckers, LM
      The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressingleukemia cells to cytotoxic chemotherapy

      LEUKEMIA
    41. Kramer, A; Loffler, H; Bergmann, J; Hochhaus, A; Hehlmann, R
      Proliferating status of peripheral blood progenitor cells from patients with BCR/ABL-positive chronic myelogenous leukemia

      LEUKEMIA
    42. Desaulniers, P; Fernandes, M; Gilbert, C; Bourgoin, SG; Naccache, PH
      Crystal-induced neutrophil activation. VII. Involvement of Syk in the responses to monosodium urate crystals

      JOURNAL OF LEUKOCYTE BIOLOGY
    43. Arteaga, CL
      The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia

      JOURNAL OF CLINICAL ONCOLOGY
    44. Knowlton, AA; Sun, LM
      Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart

      AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
    45. Buchdunger, E; Matter, A; Druker, BJ
      Bcr-Abl inhibition as a modality of CML therapeutics

      BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
    46. Jahagirdar, BN; Miller, JS; Shet, A; Verfaillie, CM
      Novel therapies for chronic myelogenous leukemia

      EXPERIMENTAL HEMATOLOGY
    47. Delaney, B; Phillips, K; Buswell, D; Mowry, B; Nickels, D; Cox, D; Wang, HB; Manthey, J
      Immunotoxicity of a standardized citrus polymethoxylated flavone extract

      FOOD AND CHEMICAL TOXICOLOGY
    48. Jorgensen, HG; Holyoake, TL
      A comparison of normal and leukemic stem cell biology in chronic myeloid leukemia

      HEMATOLOGICAL ONCOLOGY
    49. Calvet, JP; Grantham, JJ
      The genetics and physiology of polycystic kidney disease

      SEMINARS IN NEPHROLOGY
    50. Mahon, FX
      Chronic myelogenous leukemic and tyrosine kinase inhibitors.

      REVUE DE MEDECINE INTERNE
    51. Marley, SB; Davidson, RJ; Lewis, JL; Nguyen, DX; Eades, A; Parker, S; Goldman, JM; Gordon, MY
      Progenitor cells from patients with advanced phase chronic myeloid leukaemia respond to STI571 in vitro and in vivo

      LEUKEMIA RESEARCH
    52. van Oosterom, AT; Judson, I; Verweij, J; Stroobants, S; di Paola, ED; Dimitrijevic, S; Martens, M; Webb, A; Sciot, R; Van Glabbeke, M; Silberman, S; Nielsen, OS
      Safety and efficacy of imatinib (ST1571) in metastatic gastrointestinal stromal tumours: a phase I study

      LANCET
    53. Wang, HW; Chen, TL; Yang, PC; Ueng, TH
      Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5

      DRUG METABOLISM AND DISPOSITION
    54. Dell, KM; Nemo, R; Sweeney, WE; Levin, JI; Frost, P; Avner, ED
      A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease

      KIDNEY INTERNATIONAL
    55. Qian, Q; Harris, PC; Torres, VE
      Treatment prospects for autosomal-dominant polycystic kidney disease

      KIDNEY INTERNATIONAL
    56. Gilbert, RE; Kelly, DJ; McKay, T; Chadban, S; Hill, PA; Cooper, ME; Atkins, RC; Nikolic-Paterson, DJ
      PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis

      KIDNEY INTERNATIONAL
    57. Ostman, A; Heldin, CH
      Involvement of platelet-derived growth factor in disease: Development of specific antagonists

      ADVANCES IN CANCER RESEARCH, VOL 80
    58. Kallio, EA; Koskinen, PK; Tikkanen, JM; Lemstrom, KB
      Obliterative bronchiolitis: Prevention

      TRANSPLANTATION PROCEEDINGS
    59. Witte, O
      The role of Bcr-Abl in chronic myeloid leukemia and stem cell biology

      SEMINARS IN HEMATOLOGY
    60. Druker, B
      Signal transduction inhibition: Results from phase I clinical trials in chronic myeloid leukemia

      SEMINARS IN HEMATOLOGY
    61. Jantova, S; Urbancikova, M; Maliar, T; Mikulasova, M; Rauko, P; Cipak, L; Kubikova, J; Stankovsky, S; Spirkova, K
      Biological activity of some 4-anilinoquinazolines: cytotoxic, genotoxic and antiprotease effects, induction of necrosis and changes of actin cytoskeleton

      NEOPLASMA
    62. Zhang, K; Chew, M; Yang, EB; Wong, KP; Mack, P
      Modulation of cisplatin cytotoxicity and cisplatin-induced DNA cross-linksin HepG2 cells by regulation of glutathione-related mechanisms

      MOLECULAR PHARMACOLOGY
    63. Kuo, SM; Lin, CP; Morehouse, HF
      Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells

      LIFE SCIENCES
    64. Kuo, YC; Tsai, WJ; Meng, HC; Chen, WP; Yang, LY; Lin, CY
      Immune responses in human mesangial cells regulated by emodin from Polygonum hypoleucum Ohwi

      LIFE SCIENCES
    65. Mendelsohn, J; Dinney, CPN
      The Willet F. Whitmore, Jr., lectureship: Blockade of epidermal growth factor receptors as anticancer therapy

      JOURNAL OF UROLOGY
    66. Yu, JC; Lokker, NA; Hollenbach, S; Apatira, M; Li, J; Betz, A; Sedlock, D; Oda, S; Nomoto, Y; Matsuno, K; Ide, SI; Tsukuda, E; Giese, NA
      Efficacy of the novel selective platelet-derived growth factor receptor antagonist CT52923 on cellular proliferation, migration, and suppression of neointima following vascular injury

      JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    67. Nagane, M; Narita, Y; Mishima, K; Levitzki, A; Burgess, AW; Cavenee, WK; Huang, HJS
      Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor

      JOURNAL OF NEUROSURGERY
    68. Miura, K; Lavens-Phillips, S; MacGlashan, DW
      Localizing a control region in the pathway to leukotriene C-4 secretion following stimulation of human basophils with anti-IgE antibody

      JOURNAL OF IMMUNOLOGY
    69. Brock, R; Jovin, TM
      Heterogeneity of signal transduction at the subcellular level: microsphere-based focal EGF receptor activation and stimulation of Shc translocation

      JOURNAL OF CELL SCIENCE
    70. Wu, X; Davis, GE; Meininger, GA; Wilson, E; Davis, MJ
      Regulation of the L-type calcium channel by alpha(5)beta(1) integrin requires signaling between focal adhesion proteins

      JOURNAL OF BIOLOGICAL CHEMISTRY
    71. Anderson, NG; Ahmad, T; Chan, K; Dobson, R; Bundred, NJ
      ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer celllines with or without erbB2 overexpression

      INTERNATIONAL JOURNAL OF CANCER
    72. Greco, A; Roccato, E; Miranda, C; Cleris, L; Formelli, F; Pierotti, MA
      Growth-inhibitory effect of STI571 on cells transformed by the COL1A1/PDGFB rearrangement

      INTERNATIONAL JOURNAL OF CANCER
    73. Lyseng-Williamson, K; Jarvis, B
      Imatinib

      DRUGS
    74. Nimmanapalli, R; O'Bryan, E; Bhalla, K
      Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts

      CANCER RESEARCH
    75. Sjoblom, T; Shimizu, A; O'Brien, KP; Pietras, K; Dal Cin, P; Buchdunger, E; Dumanski, JP; Ostman, A; Heldin, CH
      Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis

      CANCER RESEARCH
    76. Viloria-Petit, A; Crombet, T; Jothy, S; Hicklin, D; Bohlen, P; Schlaeppi, JM; Rak, J; Kerbel, RS
      Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis

      CANCER RESEARCH
    77. Blagosklonny, MV; Pardee, AB
      Exploiting cancer cell cycling for selective protection of normal cells

      CANCER RESEARCH
    78. Etienne, G; Mahon, FX
      Leukemogenesis and new therapy development: the example of chronic myelogenous leukemia

      BULLETIN DU CANCER
    79. Chan, KC; Knox, WF; Gandhi, A; Slamon, DJ; Potten, CS; Bundred, NJ
      Blockade of growth factor receptors in ductal carcinoma in situ inhibits epithelial proliferation

      BRITISH JOURNAL OF SURGERY
    80. Simakajornboon, N; Szerlip, NJ; Gozal, E; Anonetapipat, JW; Gozal, D
      In vivo PDGF beta receptor activation in the dorsocaudal brainstem of the rat prevents hypoxia-induced apoptosis via activation of Akt and BAD

      BRAIN RESEARCH
    81. Sternberg, DW; Tomasson, MH; Carroll, M; Curley, DP; Barker, G; Caprio, M; Wilbanks, A; Kazlauskas, A; Gilliland, DG
      The TEL/PDGF beta R fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways

      BLOOD
    82. Frey, RS; Li, JY; Singletary, KW
      Effects of genistein on cell proliferation and cell cycle arrest in nonneoplastic human mammary epithelial cells: involvement of Cdc2, p21(waf/cip1),p27(kip1), and Cdc25C expression

      BIOCHEMICAL PHARMACOLOGY
    83. Hamel, L; Kenney, M; Jayyosi, Z; Ardati, A; Clark, K; Spada, A; Zilberstein, A; Perrone, M; Kaplow, J; Merkel, L; Rojas, C
      Induction of heat shock protein 70 by herbimycin A and cyclopentenone prostaglandins in smooth muscle cells

      CELL STRESS & CHAPERONES
    84. Kath, JC
      Patent focus: inhibitors of tumour cell growth

      EXPERT OPINION ON THERAPEUTIC PATENTS
    85. Ebert, AD; Wechselberger, C; Martinez-Lacaci, I; Bianco, C; Weitzel, HK; Salomon, DS
      Expression and function of EGF-related peptides and their receptors in gynecological cancer - From basic science to therapy?

      JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH
    86. Okuyama, M; Yamaguchi, S; Yamaoka, M; Nitobe, J; Fujii, S; Yoshimura, T; Tomoike, H
      Nitric oxide enhances expression and shedding of tumor necrosis factor receptor I (p55) in endothelial cells

      ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
    87. Leppanen, O; Janjic, N; Carlsson, MA; Pietras, K; Levin, M; Vargeese, C; Green, LS; Bergqvist, D; Ostman, A; Heldin, CH
      Intimal hyperplasia recurs after removal of PDGF-AB and -BB inhibition in the rat carotid artery injury model

      ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
    88. Violette, SM; Shakespeare, WC; Bartlett, C; Guan, W; Smith, JA; Rickles, RJ; Bohacek, RS; Holt, DA; Baron, R; Sawyer, TK
      A Src SH2 selective binding compound inhibits osteoclast-mediated resorption

      CHEMISTRY & BIOLOGY
    89. Klein, SM; Wong, HR; Dayao, EK; Hauser, GJ
      Effect of tyrosine kinase inhibition on sepsis-induced vascular hyporesponsiveness, iNOS mRNA expression and NF-kappa B nuclear translocation in rats

      SHOCK
    90. Xu, L; Yoneda, J; Herrera, C; Wood, J; Killion, JJ; Fidler, IJ
      Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growthfactor receptor tyrosine kinases

      INTERNATIONAL JOURNAL OF ONCOLOGY
    91. Arnold, LD; Calderwood, DJ; Dixon, RW; Johnston, DN; Kamens, JS; Munschauer, R; Rafferty, P; Ratnofsky, SE
      Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    92. Mendelsohn, J; Baselga, J
      The EGF receptor family as targets for cancer therapy

      ONCOGENE
    93. Turkson, J; Jove, R
      STAT proteins: novel molecular targets for cancer drug discovery

      ONCOGENE
    94. Zhao, M; Kiyoi, H; Yamamoto, Y; Ito, M; Towatari, M; Omura, S; Kitamura, T; Ueda, R; Saito, H; Naoe, T
      In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor

      LEUKEMIA
    95. Chandrasekar, B; Tanguay, JF
      Platelets and restenosis

      JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
    96. White, LR; Petrovitch, H; Ross, GW; Masaki, K; Hardman, J; Nelson, J; Davis, D; Markesbery, W
      Brain aging and midlife tofu consumption

      JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
    97. Goddard, CA; Evans, MJ; Colledge, WH
      Genistein activates CFTR-mediated Cl- secretion in the murine trachea and colon

      AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
    98. Lim, JK; Negash, K; Hanrahan, SM; VanBrocklin, HF
      Synthesis of 4-(3 '-[I-125]iodoanilino)-6,7-dialkoxyquinazolines: Radiolabeled epidermal growth factor receptor tyrosine kinase inhibitors

      JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
    99. Vincent, PW; Bridges, AJ; Dykes, DJ; Fry, DW; Leopold, WR; Patmore, SJ; Roberts, BJ; Rose, S; Sherwood, V; Zhou, HR; Elliott, WL
      Anticancer efficacy of the irreversible EGFr tyrosine kinase inhibitor PD 0169414 against human tumor xenografts

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    100. Mathews, ST; Chellam, N; Srinivas, PR; Cintron, VJ; Leon, MA; Goustin, AS; Grunberger, G
      alpha(2)-HSG, a specific inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor

      MOLECULAR AND CELLULAR ENDOCRINOLOGY


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 15:02:43