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CCR5 and CXCR4 expression on memory and naive T cells in HIV-1 infection and response to highly active antiretroviral therapy
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Immunogenicity of recombinant envelope glycoproteins derived from T-cell line-adapted isolates or primary HIV isolates - A comparative study using multivalent vaccine approaches
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Delta 32 mutation of the chemokine-receptor 5 gene in inflammatory bowel disease
CLINICAL IMMUNOLOGY
Receptors and entry cofactors for retroviruses include single and multipletransmembrane-spanning proteins as well as newly described glycophosphatidylinositol-anchored and secreted proteins
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
Inhibition of HIV-1 infection by down-regulation of the CXCR4 co-receptor using an intracellular single chain variable fragment against CXCR4
GENE THERAPY
Synthesis and evaluation of bifunctional anti-HIV agents based on specificCXCR4 antagonists-AZT conjugation
BIOORGANIC & MEDICINAL CHEMISTRY
Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Loss of N-linked glycans in the V3-loop region of gp120 is correlated to an enhanced infectivity of HIV-1
GLYCOBIOLOGY
HIV type 1 molecular clones able to use the Bonzo/STRL-33 coreceptor for virus entry
AIDS RESEARCH AND HUMAN RETROVIRUSES
HIV type 1 chemokine receptor usage in mother-to-child transmission
AIDS RESEARCH AND HUMAN RETROVIRUSES
Monocytes/macrophages in HIV infection and tuberculosis
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
Chemokine/CD4 receptor density ratios correlate with HIV replication in lymph node and peripheral blood of HIV-infected individuals
AIDS
Protective effect of CCR5 Delta 32 heterozygosity is restricted by SDF-1 genotype in children with HIV-1 infection
AIDS
Considering genetic profiles in functional studies of immune responsiveness to HIV-1
IMMUNOLOGY LETTERS
The impact of chemokine receptor conformational heterogeneity on HIV infection
CELLULAR AND MOLECULAR BIOLOGY
Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIVactivity of the betulinic acid derivative IC9564
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Adaptation to blockade of human immunodeficiency virus type 1 entry imposed by the anti-CCR5 monoclonal antibody 2D7
VIROLOGY
The role of DC-SIGN and DC-SIGNR in HIV and SIV attachment, infection, andtransmission
VIROLOGY
Coreceptor choice and T cell depletion by R5, X4, and R5X4 HIV-1 variants in CCR5-deficient (CCR5 Delta 32) and normal human lymphoid tissue
VIROLOGY
Inhibition of R5X4 dualtropic HIV-1 primary isolates by single chemokine co-receptor ligands
VIROLOGY
Regulation of human immunodeficiency virus type 1 infection, beta-chemokine production, and CCR5 expression in CD40L-stimulated macrophages: Immune control of viral entry
JOURNAL OF VIROLOGY
The LD78 beta isoform of MIP-1 alpha is the most potent CC-chemokine in inhibiting CCR5-dependent human immunodeficiency virus type 1 replication in human macrophages
JOURNAL OF VIROLOGY
Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate
JOURNAL OF VIROLOGY
CCR5, CXCR4, and CD4 are clustered and closely apposed on microvilli of human macrophages and T cells
JOURNAL OF VIROLOGY
Ability of the v3 loop of simian immunodeficiency virus to serve as a target for antibody-mediated neutralization: Correlation of neutralization sensitivity, growth in macrophages, and decreased dependence on CD4
JOURNAL OF VIROLOGY
Naturally occurring deletional mutation in the C-terminal cytoplasmic tailof CCR5 affects surface trafficking of CCR5
JOURNAL OF VIROLOGY
Unique monoclonal antibody recognizing the third extracellular loop of CXCR4 induces lymphocyte agglutination and enhances human immunodeficiency virus type 1-mediated syncytium formation and productive infection
JOURNAL OF VIROLOGY
Donor- and ligand-dependent differences in C-C chemokine receptor 5 reexpression
JOURNAL OF VIROLOGY
Binding of recombinant feline immunodeficiency virus surface glycoprotein to feline cells: Role of CXCR4, cell-surface heparans, and an unidentified non-CXCR4 receptor
JOURNAL OF VIROLOGY
Determination of coreceptor usage of human immunodeficiency virus type 1 from patient plasma samples by using a recombinant phenotypic assay
JOURNAL OF VIROLOGY
Molecular anatomy of CCR5 engagement by physiologic and viral chemokines and HIV-1 envelope glycoproteins: Differences in primary structural requirements for RANTES, MIP-1 alpha, and vMIP-II binding
JOURNAL OF MOLECULAR BIOLOGY
Soluble CD16 inhibits CR3 (CD11b/CD18)-mediated infection of monocytes/macrophages by opsonized primary R5 HIV-1
JOURNAL OF IMMUNOLOGY
A membrane-proximal basic domain and cysteine cluster in the C-terminal tail of CCR5 constitute a bipartite motif critical for cell surface expression
JOURNAL OF BIOLOGICAL CHEMISTRY
Octamer transcription factors up-regulate the expression of CCR5, a coreceptor for HIV-1 entry
JOURNAL OF BIOLOGICAL CHEMISTRY
Inhibition of the human chemokine receptor CXCR4 by antisense phosphorothioate oligodeoxyribonucleotides
FEBS LETTERS
Allosteric regulation of CCR5 by guanine nucleotides and HIV-1 envelope
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Enhanced infection of an X4 strain of HIV-1 due to capping and colocalization of CD4 and CXCR4 induced by capsianoside G, a diterpene glycoside
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Host determinants in HIV infection and disease - Part 2: Genetic factors and implications for antiretroviral therapeutics
ANNALS OF INTERNAL MEDICINE
CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha(+) dendritic cells
NATURE IMMUNOLOGY
Antisense phosphorothioate oligonucleotides targeted to the human chemokine receptor CXCR4
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
New targets for inhibitors of HIV-1 replication
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Enhanced expression of the CXCR4 co-receptor in HIV-1-infected individualscorrelates with the emergence of syncytia-inducing strains
CYTOKINES CELLULAR & MOLECULAR THERAPY
In vitro inhibition of HIV-1 by Met-SDF-1 beta alone or in combination with antiretroviral drugs
ANTIVIRAL THERAPY
Downregulation of the CCRS beta-chemokine receptor and inhibition of HIV-1infection by stable VA1-ribozyme chimeric transcripts
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT
Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: A possible role for tumor progression
CLINICAL CANCER RESEARCH
Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads todevelopment of effective anti-HIV agents with very high selectivity indexes
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Roles of chemokines and chemokine receptors in HIV-1 infection
INTERNATIONAL JOURNAL OF HEMATOLOGY
Good or evil: CD26 and HIV infection
JOURNAL OF DERMATOLOGICAL SCIENCE
Chemokine/receptor dynamics in the regulation of hematopoiesis
INTERNAL MEDICINE
Productive human immunodeficiency virus-1 infection of epithelial cell lines of salivary gland origin
ORAL MICROBIOLOGY AND IMMUNOLOGY
Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection
AIDS RESEARCH AND HUMAN RETROVIRUSES
Natural variation in the amino acid sequence around the HIV type 1 glycoprotein 160 cleavage site and its effect on cleavability, subunit association, and membrane fusion
AIDS RESEARCH AND HUMAN RETROVIRUSES
Influenza virus upregulates CXCR4 expression in CD4(+) cells
AIDS RESEARCH AND HUMAN RETROVIRUSES
Mono Mac 1: a new in vitro model system to study HIV-1 infection in human cells of the mononuclear phagocyte series
JOURNAL OF LEUKOCYTE BIOLOGY
The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes
JOURNAL OF LEUKOCYTE BIOLOGY
How can human and simian immunodeficiency viruses utilize chemokine receptors as their coreceptors?
GENE
Selective HIV-1-induced downmodulation of CD4 and coreceptors
ARCHIVES OF VIROLOGY
The first report of CCR5 delta 32 mutant in Thai injecting drug users
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS
IMMUNOLOGICAL REVIEWS
Fluorescence-based quantitative methods for detecting human immunodeficiency virus type 1-induced syncytia
JOURNAL OF CLINICAL MICROBIOLOGY
Polygenic and multifactorial disease gene association in man: Lessons fromAIDS
ANNUAL REVIEW OF GENETICS
Soluble glycosaminoglycans do not potentiate RANTES antiviral activity on the infection of primary macrophages by human immunodeficiency virus type 1
VIROLOGY
Beyond receptor expression: The influence of receptor conformation, density, and affinity in HIV-1 infection
VIROLOGY
Inhibition of CCR5-dependent HIV-1 infection by hairpin ribozyme gene therapy against CC-chemokine receptor 5
VIROLOGY
Interaction between virion-bound host intercellular adhesion molecule-1 and the high-affinity state of lymphocyte function-associated antigen-1 on target cells renders R5 and X4 isolates of human immunodeficiency virus type 1 more refractory to neutralization
VIROLOGY
Susceptibility of in vitro stimulated PBMC to infection with NSIHIV-1 is associated with levels of CCR5 expression and beta-chemokine production
VIROLOGY
Selective CXCR4 antagonism by Tat: Implications for in vivo expansion of coreceptor use by HIV-1
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: Inhibition of human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry
MOLECULAR PHARMACOLOGY
Pathogenesis of primary R5 human immunodeficiency virus type 1 clones in SCID-hu mice
JOURNAL OF VIROLOGY
A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses
JOURNAL OF VIROLOGY
Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1
JOURNAL OF VIROLOGY
Simian immunodeficiency viruses of diverse origin can use CXCR4 as a coreceptor for entry into human cells
JOURNAL OF VIROLOGY
CD4(+) T cell surface CCR5 density as a determining factor of virus load in persons infected with human immunodeficiency virus type 1
JOURNAL OF INFECTIOUS DISEASES
Unexpected coreceptor usage of primary human immunodeficiency virus type 1isolates from viremic patients under highly active antiretroviral therapy
JOURNAL OF INFECTIOUS DISEASES
Linkage of the CCR5 Delta 32 mutation with a functional polymorphism of CD45RA
JOURNAL OF IMMUNOLOGY
CCR5-reactive antibodies in seronegative partners of HIV-seropositive individuals down-modulate surface CCR5 in vivo and neutralize the infectivity of R5 strains of HIV-1 in vitro
JOURNAL OF IMMUNOLOGY
Lipopolysaccharide inhibits HIV-1 infection of monocyte-derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5
JOURNAL OF IMMUNOLOGY
beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4
JOURNAL OF BIOLOGICAL CHEMISTRY
beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk
JOURNAL OF BIOLOGICAL CHEMISTRY
Apelin peptides block the entry of human immunodeficiency virus (HIV)
FEBS LETTERS
Monoclonal antibody screening of a phage-displayed random peptide library reveals mimotopes of chemokine receptor CCR5: implications for the tertiarystructure of the receptor and for an N-terminal binding site for HIV-1 gp120
EUROPEAN JOURNAL OF IMMUNOLOGY
Molecular modeling and site-directed mutagenesis of CCR5 reveal residues critical for chemokine binding and signal transduction
EUROPEAN JOURNAL OF IMMUNOLOGY
HIV-1 co-receptor expression on trophoblastic cells from early placentas and permissivity to infection by several HIV-1 primary isolates
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
The effects of the 32-bp CCR-5 deletion on HIV transmission and HIV disease progression in individuals with haemophilia
BRITISH JOURNAL OF HAEMATOLOGY
Interferon gamma and interleukin 6 modulate the susceptibility of macrophages to human immunodeficiency virus type 1 infection
BLOOD
Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4(+) T cells during human endotoxemia and after stimulation with (myco)bacterial antigens: the role of cytokines
BLOOD
Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4(+) T cells during human endotoxemia and after stimulation with (myco)bacterial antigens: the role of cytokines
BLOOD
Expression and functional characterization of mutant human CXCR4 in insectcells: Role of cysteinyl and negatively charged residues in ligand binding
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Role of beta-chemokines in HIV-1 infection of dendritic cells maturing from CD34(+) stem cells
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
Role of macrophage protection in the development of murine AIDS
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
Coreceptor usage and RANTES sensitivity of non-syncytium-inducing HIV-1 isolates obtained from patients with AIDS
JOURNAL OF HUMAN VIROLOGY
Effect of beta-chemokines on human immunodeficiency virus type 1 replication, binding, uncoating, and CCR5 receptor expression in human monocyte-derived macrophages
JOURNAL OF HUMAN VIROLOGY
CD4 receptor-dependent entry of human immunodeficiency virus type-1 env-pseudotypes into CCR5-, CCR3-, and CXCP4-Expressing human alveolar macrophages is preferentially mediated by the CCR5 coreceptor
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
Gene transfer and expression of a non-viral polycation-based vector in CD4(+) cells
GENE THERAPY
Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences
HUMAN MOLECULAR GENETICS
Human immunodeficiency virus type 1 entry and chemokine receptors: a new therapeutic target
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY
Role of the HIV type 1 glycoprotein 120 V3 loop in determining coreceptor usage
AIDS RESEARCH AND HUMAN RETROVIRUSES
Marked increase in anti-HIV activity, as well as inhibitory activity against HIV entry mediated by CXCR4, linked to enhancement of the binding ability of tachyplesin analogs to CXCR4
AIDS RESEARCH AND HUMAN RETROVIRUSES
T cell-derived suppressive activity: Evidence of autocrine noncytolytic control of HIV type 1 transcription and replication
AIDS RESEARCH AND HUMAN RETROVIRUSES
Chemokines as molecular targets for therapeutic intervention
JOURNAL OF CLINICAL IMMUNOLOGY