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    1. Garg, S; Achenie, LEK
      Mathematical programming assisted drug design for nonclassical antifolates

      BIOTECHNOLOGY PROGRESS
    2. Gangjee, A; Adair, O; Queener, SF
      Synthesis of 2,4-diamino-6-(thioarylmethyl)pyrido [2,3-d]pyrimidines as dihydrofolate reductase inhibitors

      BIOORGANIC & MEDICINAL CHEMISTRY
    3. Camidge, R; Price, A
      Characterizing the phenomenon of radiation recall dermatitis

      RADIOTHERAPY AND ONCOLOGY
    4. Rosowsky, A; Chen, H
      A novel method of synthesis of 2,4-diamino-6-arylmethylquinazolines using palladium(0)-catalyzed organozinc chemistry

      JOURNAL OF ORGANIC CHEMISTRY
    5. Graffner-Nordberg, M; Kolmodin, K; Aqvist, J; Queener, SF; Hallberg, A
      Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystiscarinii

      JOURNAL OF MEDICINAL CHEMISTRY
    6. Smego, RA; Nagar, S; Maloba, B; Popara, M
      A meta-analysis of salvage therapy for Pneumocystis carinii pneumonia

      ARCHIVES OF INTERNAL MEDICINE
    7. Dabaja, MAK; Morgensztern, D; Markoe, AM; Bartlett-Pandite, L
      Radiation recall dermatitis induced by methotrexate in a patient with Hodgkin's disease

      AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
    8. Szelenyi, H; Hohenberger, P; Lochs, H; Haboubi, N; Berdel, WE; Thiel, E; Kreuser, ED
      Sequential trimetrexate, 5-fluorouracil and folinic acid are effective andwell tolerated in metastatic colorectal carcinoma

      ONCOLOGY
    9. Kobayashi, H; Takemura, Y; Kawai, Y; Miyachi, H; Kawabata, M; Matsumura, T; Yamashita, T; Mori, S; Furihata, K; Shimodaira, S; Motoyoshi, K; Hotta, T; Sekiguchi, S; Ando, Y; Watanabe, K
      Competitive reverse transcription-polymerase chain reaction assay for quantification of human multidrug resistance 1 (MDR1) gene expression in fresh leukemic cells

      JOURNAL OF LABORATORY AND CLINICAL MEDICINE
    10. Rosowsky, A; Fu, HN; Queener, SF
      Synthesis of 2,4-diaminopyrido[2,3-d]pyrimidines and 2,4-diaminoquinazolines with bulky dibenz[b,f]azepine and dibenzo[a,d]-cycloheptene substituentsat the 6-position as inhibitors of dihydrofolate reductases from Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium

      JOURNAL OF HETEROCYCLIC CHEMISTRY
    11. Gangjee, A; Dubash, NP; Queener, SF
      The synthesis of new 2,4-diaminofuro[2,3-d]pyrimidines with 5-biphenyl, phenoxyphenyl and tricyclic substitutions as dihydrofolate reductase inhibitors

      JOURNAL OF HETEROCYCLIC CHEMISTRY
    12. Trippett, TM; Bertino, JR
      Therapeutic strategies targeting proteins that regulate folate and reducedfolate transport

      JOURNAL OF CHEMOTHERAPY
    13. Guo, W; Healey, JH; Meyers, PA; Ladanyi, M; Huvos, AG; Bertino, JR; Gorlick, R
      Mechanisms of methotrexate resistance in osteosarcoma

      CLINICAL CANCER RESEARCH
    14. Polshakov, VI; Birdsall, B; Frenkiel, TA; Gargaro, AR; Feeney, J
      Structure and dynamics in solution of the complex of Lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate

      PROTEIN SCIENCE
    15. Costanza, ME; Weiss, RB; Henderson, IC; Norton, L; Berry, DA; Cirrincione, C; Winer, E; Wood, WC; Frei, E; McIntyre, OR; Schilsky, RL
      Safety and efficacy of using a single agent or a phase II agent before instituting standard combination chemotherapy in previously untreated metastatic breast cancer patients: Report of a randomized study - Cancer and leukemia group B 8642

      JOURNAL OF CLINICAL ONCOLOGY
    16. Gong, MK; Cowan, KH; Gudas, J; Moscow, JA
      Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene (RFC1)

      GENE
    17. Bowen, D; Johnson, DH; Southerland, WM; Hughes, DE; Hawkins, M
      Selectivity in human breast cancer and human bone marrow using trimetrexate in combination with 5-fluorouracil

      ANTICANCER RESEARCH
    18. Newell, DR
      Clinical pharmacokinetics of antitumor antifolates

      SEMINARS IN ONCOLOGY
    19. Jansen, G; Barr, H; Kathmann, I; Bunni, MA; Priest, DG; Noordhuis, P; Peters, GJ; Assaraf, YG
      Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: Role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration

      MOLECULAR PHARMACOLOGY
    20. Rosowsky, A; Papoulis, AT; Forsch, RA; Queener, SF
      Synthesis and antiparasitic and antitumor activity of 2,4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim

      JOURNAL OF MEDICINAL CHEMISTRY
    21. Rosowsky, A; Cody, V; Galitsky, N; Fu, HN; Papoulis, AT; Queener, SF
      Structure-based design of selective inhibitors of dihydrofolate reductase:Synthesis and antiparasitic activity of 2,4-diaminopteridine analogues with a bridged diarylamine side chain

      JOURNAL OF MEDICINAL CHEMISTRY
    22. Gangjee, A; Adair, O; Queener, SF
      Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: Synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl]pyrido[2,3-d]pyrimidines

      JOURNAL OF MEDICINAL CHEMISTRY
    23. Kobayashi, H; Takemura, Y; Wang, FS; Oka, T; Ohnuma, T
      Retrovirus-mediated transfer of anti-MDR1 hammerhead ribozymes into multidrug-resistant human leukemia cells: Screening for effective target sites

      INTERNATIONAL JOURNAL OF CANCER
    24. Wahid, F; Monneret, C; Dauzonne, D
      Synthesis and biological evaluation of 5-arylfuro[2,3-d]pyrimidines as novel dihydrofolate reductase inhibitors

      CHEMICAL & PHARMACEUTICAL BULLETIN
    25. Ramanathan, RK; Lipsitz, S; Asbury, RF; Qazi, R; Greenberg, BR; Haller, DG
      Phase II trial of trimetrexate for patients with advanced gastric carcinoma - An Eastern Cooperative Oncology Group Study (E1287)

      CANCER
    26. LONGO GSA; IZZO J; CHANG YM; TONG WP; ZIELINSKI Z; GORLICK R; CHOU TC; BERTINO JR
      PRETREATMENT OF COLON-CARCINOMA CELLS WITH TOMUDEX ENHANCES 5-FLUOROURACIL CYTOTOXICITY

      Clinical cancer research
    27. LONGO GSA; IZZO J; CHANG YM; TONG WP; ZIELINSKI Z; GORLICK R; CHOU TC; BERTINO JR
      PRETREATMENT OF COLON-CARCINOMA CELLS WITH TOMUDEX ENHANCES 5-FLUOROURACIL CYTOTOXICITY

      Clinical cancer research
    28. MAREYA SM; SORRENTINO BP; BLAKLEY RL
      PROTECTION OF CCRF-CEM HUMAN LYMPHOID-CELLS FROM ANTIFOLATES BY RETROVIRAL GENE-TRANSFER OF VARIANTS OF MURINE DIHYDROFOLATE-REDUCTASE

      Cancer gene therapy
    29. RATLIFF AF; WILSON J; HUM M; MARLINGCASON M; ROSE K; WINICK N; KAMEN BA
      PHASE-I AND PHARMACOKINETIC TRIAL OF AMINOPTERIN IN PATIENTS WITH REFRACTORY MALIGNANCIES

      Journal of clinical oncology
    30. KOBAYASHI H; TAKEMURA Y; MIYACHI H
      MOLECULAR CHARACTERIZATION OF HUMAN ACUTE-LEUKEMIA CELL-LINE RESISTANT TO ZD9331, A NON-POLYGLUTAMATABLE THYMIDYLATE SYNTHASE INHIBITOR

      Cancer chemotherapy and pharmacology
    31. PEREZ JE; LACAVA JA; DOMINGUEZ ME; RODRIGUEZ R; BARBIERI MR; ORTIZ EH; ACUNA LAR; LANGHI MJ; ACUNA JMR; VALLEJO CT; LEONE BA; MACHIAVELLI MR; ROMERO AO
      BIOCHEMICAL MODULATION OF 5-FLUOROURACIL BY METHOTREXATE IN PATIENTS WITH ADVANCED GASTRIC-CARCINOMA

      American journal of clinical oncology
    32. ROMERO AO; PEREZ JE; CUEVAS MA; LACAVA JA; SABATINI CL; DOMINGUEZ ME; RODRIGUEZ R; BARBIERI MR; ORTIZ EH; SALVADORI MA; ACUNA LAR; ACUNA JMR; LANGHI MJ; AMATO S; MACHIAVELLI MR; LEONE BA; VALLEJO CT; LORUSSO V; DELENA M
      DOUBLE-MODULATION OF 5-FLUOROURACIL BY METHOTREXATE AND HIGH-DOSE L-LEUCOVORIN IN ADVANCED COLORECTAL-CANCER

      American journal of clinical oncology
    33. CABALLERO E; MEDARDE M; DECLAIRAC RPL; SAHAGUN H; TOME F
      SYNTHESIS OF (+ -)-7-(3,4,5-TRIMETHOXYPHENYL)-7-DEOXYIDARUBICINONE - A NEW FAMILY OF ANTHRACYCLINE ANALOGS/

      Tetrahedron
    34. GANGJEE A; ELZEIN E; QUEENER SF; MCGUIRE JJ
      SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF TRICYCLIC CONFORMATIONALLY RESTRICTED TETRAHYDROPYRIDO ANNULATED FURO[2,3-D]PYRIMIDINES AS INHIBITORS OF DIHYDROFOLATE REDUCTASES

      Journal of medicinal chemistry
    35. ROSOWSKY A; PAPOULIS AT; QUEENER SF
      2,4-DIAMINO-6,7-DIHYDRO-5H-CYCLOPENTA[D]PYRIMIDINE ANALOGS OF TRIMETHOPRIM AS INHIBITORS OF PNEUMOCYSTIS-CARINII AND TOXOPLASMA-GONDII DIHYDROFOLATE-REDUCTASE

      Journal of medicinal chemistry
    36. GANGJEE A; ZHU YM; QUEENER SF
      6-SUBSTITUTED 2,4-DIAMINOPYRIDO[3,2-D]PYRIMIDINE ANALOGS OF PIRITREXIM AS INHIBITORS OF DIHYDROFOLATE-REDUCTASE FROM RAT-LIVER, PNEUMOCYSTIS-CARINII, AND TOXOPLASMA-GONDII AND AS ANTITUMOR AGENTS

      Journal of medicinal chemistry
    37. GIFFORD AJ; KAVALLARIS M; MADAFIGLIO J; MATHERLY LH; STEWART BW; HABER M; NORRIS MD
      P-GLYCOPROTEIN-MEDIATED METHOTREXATE RESISTANCE IN CCRF-CEM SUBLINES DEFICIENT IN METHOTREXATE ACCUMULATION DUE TO A POINT MUTATION IN THE REDUCED FOLATE CARRIER GENE

      International journal of cancer
    38. LORIGA M; VITALE G; PAGLIETTI G
      QUINOXALINE CHEMISTRY - PART 9 - QUINOXALINE ANALOGS OF TRIMETREXATE (TMQ) AND 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID (CB-3717) AND ITS PRECURSORS - SYNTHESIS AND EVALUATION OF IN-VITRO ANTICANCER ACTIVITY

      Il Farmaco
    39. VITALE G; CORONA P; LORIGA M; PAGLIETTI G
      QUINOXALINE CHEMISTRY - PART 10 - QUINOXALINE 10-OXA-ANALOGS OF TRIMETREXATE (TMQ) AND OF 5,8-DIDEAZAFOLIC ACID - SYNTHESIS AND EVALUATION OF IN-VITRO ANTICANCER ACTIVITY

      Il Farmaco
    40. FAESSEL HM; SLOCUM HK; JACKSON RC; BORITZKI TJ; RUSTUM YM; NAIR MG; GRECO WR
      SUPER IN-VITRO SYNERGY BETWEEN INHIBITORS OF DIHYDROFOLATE-REDUCTASE AND INHIBITORS OF OTHER FOLATE-REQUIRING ENZYMES - THE CRITICAL ROLE OF POLYGLUTAMYLATION

      Cancer research
    41. CHANG AY; KIM K; BOUCHER H; BONOMI P; STEWART JA; KARP DD; BLUM RH
      A RANDOMIZED PHASE-II TRIAL OF ECHINOMYCIN, TRIMETREXATE, AND CISPLATIN PLUS ETOPOSIDE IN PATIENTS WITH METASTATIC NONSMALL CELL LUNG-CARCINOMA - AN EASTERN-COOPERATIVE-ONCOLOGY-GROUP STUDY (E1587)

      Cancer
    42. ROBSON C; WRIGHT KA; TWENTYMAN PR; LAMBERT PA; GRIFFIN RJ
      CHEMICAL SYNTHESIS AND BIOLOGICAL PROPERTIES OF NOVEL FLUORESCENT ANTIFOLATES IN PGP-OVEREXPRESSING AND MRP-OVEREXPRESSING TUMOR-CELL LINES

      Biochemical pharmacology
    43. OBRIEN JG; DONG BJ; COLEMAN RL; GEE L; BALANO KB
      A 5-YEAR RETROSPECTIVE REVIEW OF ADVERSE DRUG-REACTIONS AND THEIR RISK-FACTORS IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PATIENTS WHO WERE RECEIVING INTRAVENOUS PENTAMIDINE THERAPY FOR PNEUMOCYSTIS-CARINII PNEUMONIA

      Clinical infectious diseases
    44. ACOSTA JC; CABALLERO E; GRAVALOS DG; MEDARDE M; SAHAGUN H; STOODLEY RJ; TOME F
      NEW 7-ARYL ANALOGS OF ANTHRACYCLINES - SYNTHESIS AND CYTOTOXIC ACTIVITY OF (+ )-7-(3,4,5-TRIMETHOXYPHENYL)-7-DEOXYIDARUBICINONE/

      Bioorganic & medicinal chemistry letters
    45. MIYACHI H; TAKEMURA Y; KOBAYASHI H; ANDO Y
      CYTOTOXICITY OF TRIMETREXATE AGAINST ANTIFOLATE-RESISTANT HUMAN T-CELL LEUKEMIA-CELL LINES DEVELOPED IN OXIDIZED OR REDUCED FOLATE

      Japanese journal of cancer research
    46. MATSUO K; KIURA K; UEOKA H; TABATA M; SHIBAYAMA T; MATSUMURA T; TAKIGAWA N; HIRAKI S; HARADA M
      GROWTH-INHIBITORY EFFECTS OF ANTIFOLATES AGAINST AN ADRIAMYCIN-RESISTANT HUMAN SMALL-CELL LUNG-CANCER CELL-LINE

      Acta medica Okayama
    47. JELLIFFE RW; GOMIS P; TAHANI B; RUSKIN J; SATTLER FR
      A POPULATION PHARMACOKINETIC MODEL OF TRIMETHOPRIM IN PATIENTS WITH PNEUMOCYSTIS PNEUMONIA, MADE WITH PARAMETRIC AND NONPARAMETRIC METHODS

      Therapeutic drug monitoring
    48. STUDENBERG SD; WOOLLEY JL; DEANGELIS DV; WARGIN WA
      THE PHARMACOKINETICS OF 1954U89, HYLPROPYL)-8-METHYL-7H-PYRROLO-(3,2-F)QUINAZOLINE, IN DOGS AND RATS AFTER INTRAVENOUS AND ORAL-ADMINISTRATION

      Biopharmaceutics & drug disposition
    49. TAPLIN SC; BLANKE CD; BAUGHMAN C
      NURSING-CARE STRATEGIES FOR THE MANAGEMENT OF SIDE-EFFECTS IN PATIENTS TREATED FOR COLORECTAL-CANCER

      Seminars in oncology
    50. ADEVA M; CABALLERO E; GARCIA F; MEDARDE M; SAHAGUN H; TOME F
      DIELS-ALDER REACTIVITY OF 1-ALKOXYPHENYL-3-TRIALKYLSILOXY-1,3-DIENES

      Tetrahedron letters
    51. ROSOWSKY A; PAPOULIS AT; QUEENER SF
      2,4-DIAMINOTHIENO [2,3-D]PYRIMIDINE LIPOPHILIC ANTIFOLATES AS INHIBITORS OF PNEUMOCYSTIS-CARINII AND TOXOPLASMA-GONDII DIHYDROFOLATE-REDUCTASE

      Journal of medicinal chemistry
    52. ROBSON C; MEEK MA; GRUNWALDT JD; LAMBERT PA; QUEENER SF; SCHMIDT D; GRIFFIN RJ
      NONCLASSICAL 2,4-DIAMINO-5-ARYL-6-ETHYLPYRIMIDINE ANTIFOLATES - ACTIVITY AS INHIBITORS OF DIHYDROFOLATE-REDUCTASE FROM PNEUMOCYSTIS-CARINIIAND TOXOPLASMA-GONDII AND AS ANTITUMOR AGENTS

      Journal of medicinal chemistry
    53. CHAN JH; HONG JS; KUYPER LF; JONES ML; BACCANARI DP; TANSIK RL; BOYTOS CM; RUDOLPH SK; BROWN AD
      SYNTHESIS OF MINO-7,8,9,10-TETRAHYDROPYRIDO[3,2-F]-QUINAZOLINES - INHIBITORS OF CANDIDA-ALBICANS DIHYDROFOLATE-REDUCTASE AS POTENTIAL ANTIFUNGAL AGENTS

      Journal of heterocyclic chemistry
    54. ASSARAF YG; GOLDMAN ID
      LOSS OF FOLIC-ACID EXPORTER FUNCTION WITH MARKEDLY AUGMENTED FOLATE ACCUMULATION IN LIPOPHILIC ANTIFOLATE-RESISTANT MAMMALIAN-CELLS

      The Journal of biological chemistry
    55. BALINSKA M; SZABLEWSKA I; JANISZEWSKA D; BARTUZI K; PAWELCZAK K
      THE EFFECTS OF COMBINED ANTIFOLATES ON INHIBITION OF GROWTH OF MURINELEUKEMIA-CELLS CULTURED IN-VITRO

      Acta Biochimica Polonica
    56. SMITH A; HUM M; WINICK NJ; KAMEN BA
      A CASE FOR THE USE OF AMINOPTERIN IN TREATMENT OF PATIENTS WITH LEUKEMIA BASED ON METABOLIC STUDIES OF BLASTS IN-VITRO

      Clinical cancer research
    57. BERTINO JR; GOKER E; GORLICK R; LI WW; BANERJEE D
      RESISTANCE MECHANISMS TO METHOTREXATE IN TUMORS

      Stem cells
    58. HANAUSKE AR
      THE DEVELOPMENT OF NEW CHEMOTHERAPEUTIC-AGENTS

      Anti-cancer drugs
    59. TAKEMURA Y; KOBAYASHI H; MIYACHI H; GIBSON W; KIMBELL R; JACKMAN AL
      BIOLOGICAL-ACTIVITY AND INTRACELLULAR METABOLISM OF ZD1694 IN HUMAN LEUKEMIA-CELL LINES WITH DIFFERENT RESISTANCE MECHANISMS TO ANTIFOLATE DRUGS

      Japanese journal of cancer research
    60. BLIJHAM G; WAGENER T; WILS J; DEGREVE J; BUSET M; BLEIBERG H; LACAVE A; DALMARK M; SELLESLAG J; COLLETTE L; SAHMOUD T
      MODULATION OF HIGH-DOSE INFUSIONAL FLUOROURACIL BY LOW-DOSE METHOTREXATE IN PATIENTS WITH ADVANCED OR METASTATIC COLORECTAL-CANCER - FINAL RESULTS OF A RANDOMIZED EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT OF-CANCER STUDY

      Journal of clinical oncology
    61. MORELAND LW
      INITIAL EXPERIENCE COMBINING METHOTREXATE WITH BIOLOGIC AGENTS FOR TREATING RHEUMATOID-ARTHRITIS

      Journal of rheumatology
    62. HUM MC; KAMEN BA
      FOLATE, ANTIFOLATES, AND FOLATE ANALOGS IN PEDIATRIC ONCOLOGY

      Investigational new drugs
    63. GORLICK R; GOKER E; TRIPPETT T; WALTHAM M; BANERJEE D; BERTINO JR
      INTRINSIC AND ACQUIRED-RESISTANCE TO METHOTREXATE IN ACUTE-LEUKEMIA

      The New England journal of medicine
    64. DEGRAAF D; SHARMA RC; MECHETNER EB; SCHIMKE RT; RONINSON IB
      P-GLYCOPROTEIN CONFERS METHOTREXATE RESISTANCE IN 3T6 CELLS WITH DEFICIENT CARRIER-MEDIATED METHOTREXATE UPTAKE

      Proceedings of the National Academy of Sciences of the United Statesof America
    65. GANGJEE A; ZHU YM; QUEENER SF; FRANCOM P; BROOM AD
      NONCLASSICAL 2,4-DIAMINO-8-DEAZAFOLATE ANALOGS AS INHIBITORS OF DIHYDROFOLATE REDUCTASES FROM RAT-LIVER, PNEUMOCYSTIS-CARINII, AND TOXOPLASMA-GONDII

      Journal of medicinal chemistry
    66. KUYPER LF; BACCANARI DP; JONES ML; HUNTER RN; TANSIK RL; JOYNER SS; BOYTOS CM; RUDOLPH SK; KNICK V; WILSON HR; CADDELL JM; FRIEDMAN HS; COMLEY JCW; STABLES JN
      HIGH-AFFINITY INHIBITORS OF DIHYDROFOLATE-REDUCTASE - ANTIMICROBIAL AND ANTICANCER ACTIVITIES OF 7,8-DIALKYL-1,3-DIAMINOPYRROLO[3,2-F]QUINAZOLINES WITH SMALL MOLECULAR-SIZE

      Journal of medicinal chemistry
    67. DONKOR IO; DEVRAJ R; QUEENER SF; BARROWS LR; GANGJEE A
      SYNTHESIS OF A SERIES OF DIAMINOBENZO[F]PYRIMIDO[4,5-B]QUINOLINES ANDDIAMINOBENZO[H]PYRIMIDO[4,5-B]QUINOLINES AS 5-DEAZA TETRACYCLIC NONCLASSICAL ANTIFOLATES

      Journal of heterocyclic chemistry
    68. NORRIS MD; DEGRAAF D; HABER M; KAVALLARIS M; MADAFIGLIO J; GILBERT J; KWAN E; STEWART BW; MECHETNER EB; GUDKOV AV; RONINSON IB
      INVOLVEMENT OF MDR1 P-GLYCOPROTEIN IN MULTIFACTORIAL RESISTANCE TO METHOTREXATE

      International journal of cancer
    69. STROMHAUG A; SLORDAL L; WARREN DJ
      DIFFERENTIAL-EFFECTS OF THE ANTIFOLATES METHOTREXATE, AMINOPTERIN ANDTRIMETREXATE ON MURINE HEMATOPOIETIC PROGENITOR CELLS

      British Journal of Haematology
    70. MARTINEZ A; ALLEGRA CJ; KOVACS JA
      EFFICACY OF EPIROPRIM (RO11-8958), A NEW DIHYDROFOLATE-REDUCTASE INHIBITOR, IN THE TREATMENT OF ACUTE TOXOPLASMA INFECTION IN MICE

      The American journal of tropical medicine and hygiene
    71. LI WW; TONG WP; BERTINO JR
      ANTITUMOR-ACTIVITY OF ANTIFOLATE INHIBITORS OF THYMIDYLATE AND PURINESYNTHESIS IN HUMAN SOFT-TISSUE SARCOMA CELL-LINES WITH INTRINSIC RESISTANCE TO METHOTREXATE

      Clinical cancer research
    72. BROWN TD; FLEMING TR; GOODMAN PJ; MACDONALD JS; PUGH RP; OROURKE T
      A RANDOMIZED TRIAL OF 2 SCHEDULES OF TRIMETREXATE VERSUS 5-FLUOROURACIL IN ADVANCED COLORECTAL-CANCER - A SOUTHWEST-ONCOLOGY-GROUP STUDY

      Anti-cancer drugs
    73. PEREZ EA; CAMPBELL DL; RYU JK
      RADIATION RECALL DERMATITIS INDUCED BY EDATREXATE IN A PATIENT WITH BREAST-CANCER

      Cancer investigation
    74. HOFFMAN VA; WELSH WJ
      CONFORMATIONAL-ANALYSIS OF THE LIPOPHILIC ANTIFOLATE TRIMETREXATE

      Cancer biochemistry biophysics
    75. MIYACHI H; TAKEMURA Y; KOBAYASHI H; ANDO Y
      EXPRESSION OF VARIANT DIHYDROFOLATE-REDUCTASE WITH DECREASED BINDING-AFFINITY TO ANTIFOLATES IN MOLT-3 HUMAN LEUKEMIA-CELL LINES RESISTANT TO TRIMETREXATE

      Cancer letters
    76. FLEMING TR; BROWN TD; ROSS SW; MACDONALD JS
      PHASE-II TRIAL OF TRIMETREXATE IN ADVANCED ESOPHAGEAL CANCER - A SOUTHWEST-ONCOLOGY-GROUP STUDY

      Investigational new drugs
    77. ROSOWSKY A; MOTA CE; QUEENER SF; WALTHAM M; ERCIKANABALI E; BERTINO JR
      2,4-DIAMINO-5-SUBSTITUTED-QUINAZOLINES AS INHIBITORS OF A HUMAN DIHYDROFOLATE-REDUCTASE WITH A SITE-DIRECTED MUTATION AT POSITION-22 AND OFTHE DIHYDROFOLATE REDUCTASES FROM PNEUMOCYSTIS-CARINII AND TOXOPLASMA-GONDII

      Journal of medicinal chemistry
    78. ROSOWSKY A; FORSCH RA; QUEENER SF
      2,4-DIAMINOPYRIDO[3,2-D]PYRIMIDINE INHIBITORS OF DIHYDROFOLATE-REDUCTASE FROM PNEUMOCYSTIS-CARINII AND TOXOPLASMA-GONDII

      Journal of medicinal chemistry
    79. DRORI S; EYTAN GD; ASSARAF YG
      POTENTIATION OF ANTICANCER-DRUG CYTOTOXICITY BY MULTIDRUG-RESISTANCE CHEMOSENSITIZERS INVOLVES ALTERATIONS IN MEMBRANE FLUIDITY LEADING TO INCREASED MEMBRANE-PERMEABILITY

      European journal of biochemistry
    80. OCONNOR BM; WEBBER S; JACKSON RC; GALIVAN J; RHEE MS
      BIOLOGICAL-ACTIVITY OF A NOVEL RATIONALLY DESIGNED LIPOPHILIC THYMIDYLATE SYNTHASE INHIBITOR

      Cancer chemotherapy and pharmacology
    81. BORKOWSKI JM; DUERR M; DONEHOWER RC; ROWINSKY EK; CHEN TL; ETTINGER DS; GROCHOW LB
      RELATION BETWEEN AGE AND CLEARANCE RATE OF 9 INVESTIGATIONAL ANTICANCER DRUGS FROM PHASE-I PHARMACOKINETIC DATA

      Cancer chemotherapy and pharmacology
    82. WITTE RS; YEAP BY; TRUMP DL
      TRIMETREXATE IN ADVANCED HORMONE-REFRACTORY PROSTATE-CANCER - AN ECOGPHASE-II TRIAL

      Investigational new drugs
    83. HANTEL A; TANGEN CM; MACDONALD JS; RICHMAN SP; PUGH RP; POLLOCK T
      PHASE-II TRIAL OF TRIMETREXATE IN UNTREATED ADVANCED GASTRIC-CARCINOMA - A SOUTHWEST-ONCOLOGY-GROUP STUDY

      Investigational new drugs
    84. SASSO SP; GILLI RM; SARI JC; RIMET OS; BRIAND CM
      THERMODYNAMIC STUDY OF DIHYDROFOLATE-REDUCTASE INHIBITOR SELECTIVITY

      Biochimica et biophysica acta. Protein structure and molecular enzymology
    85. EGORIN MJ; REYNO LM; CANETTA RM; JODRELL DI; SWENERTON KD; PATER JL; BURROUGHS JN; NOVAK MJ; SRIDHARA R
      MODELING TOXICITY AND RESPONSE IN CARBOPLATIN-BASED COMBINATION CHEMOTHERAPY

      Seminars in oncology
    86. WITTE RS; ELSON P; KHANDAKAR J; TRUMP DL
      AN EASTERN-COOPERATIVE-ONCOLOGY-GROUP PHASE-II TRIAL OF TRIMETREXATE IN THE TREATMENT OF ADVANCED UROTHELIAL CARCINOMA

      Cancer
    87. KOBAYASHI H; KIM N; HALATSCH ME; OHNUMA T
      SPECIFICITY OF RIBOZYME DESIGNED FOR MUTATED DHFR MESSENGER-RNA

      Biochemical pharmacology
    88. ASSARAF YG; BORGNIA MJ
      DIFFERENTIAL REVERSAL OF LIPOPHILIC ANTIFOLATE RESISTANCE IN MAMMALIAN-CELLS WITH MODULATORS OF THE MULTIDRUG-RESISTANCE PHENOTYPE

      Anti-cancer drugs
    89. SORENSEN JB
      TREATMENT OF NONSMALL CELL LUNG-CANCER - NEW CYTOSTATIC AGENTS

      Lung cancer
    90. HARVEY WH; FLEMING TR; GOODMAN PJ; HARVEY JH; RIVKIN SE; MACDONALD JS
      PHASE-II STUDY OF TRIMETREXATE IN PREVIOUSLY UNTREATED PATIENTS WITH HEPATOCELLULAR-CARCINOMA - SOUTHWEST-ONCOLOGY-GROUP STUDY 8712

      Investigational new drugs
    91. FLEISHER M
      ANTIFOLATE ANALOGS - MECHANISM OF ACTION, ANALYTICAL METHODOLOGY, ANDCLINICAL EFFICACY

      Therapeutic drug monitoring
    92. LI XK; KOBAYASHI H; HOLLAND JF; OHNUMA T
      EXPRESSION OF DIHYDROFOLATE-REDUCTASE AND MULTIDRUG-RESISTANCE GENES IN TRIMETREXATE-RESISTANT HUMAN LEUKEMIA-CELL LINES

      Leukemia research
    93. CHIO LC; QUEENER SF
      IDENTIFICATION OF HIGHLY POTENT AND SELECTIVE INHIBITORS OF TOXOPLASMA-GONDII DIHYDROFOLATE-REDUCTASE

      Antimicrobial agents and chemotherapy
    94. KOVACS JA; POWELL F; VOELLER D; ALLEGRA CJ
      INHIBITION OF PNEUMOCYSTIS-CARINII DIHYDROPTEROATE SYNTHETASE BY PARA-ACETAMIDOBENZOIC ACID - POSSIBLE MECHANISM OF ACTION OF ISOPRINOSINE IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION

      Antimicrobial agents and chemotherapy
    95. FANIN R; BANERJEE D; VOLKENANDT M; WALTHAM M; LI WW; DICKER AP; SCHWEITZER BI; BERTINO JR
      MUTATIONS LEADING TO ANTIFOLATE RESISTANCE IN CHINESE-HAMSTER OVARY CELLS AFTER EXPOSURE TO THE ALKYLATING AGENT ETHYLMETHANESULFONATE

      Molecular pharmacology
    96. GANGJEE A; SHI JF; QUEENER SF; BARROWS LR; KISLIUK RL
      SYNTHESIS OF 5-METHYL-5-DEAZA NONCLASSICAL ANTIFOLATES AS INHIBITORS OF DIHYDROFOLATE REDUCTASES AND AS POTENTIAL ANTIPNEUMOCYSTIS, ANTITOXOPLASMA, AND ANTITUMOR AGENTS

      Journal of medicinal chemistry
    97. TERZIS AJA; FISKERSTRAND T; REFSUM H; UELAND PM; ARNOLD H; BJERKVIG R
      PROLIFERATION, MIGRATION AND INVASION OF HUMAN GLIOMA-CELLS EXPOSED TO ANTIFOLATE DRUGS

      International journal of cancer
    98. RHEE MS; WANG Y; NAIR MG; GALIVAN J
      ACQUISITION OF RESISTANCE TO ANTIFOLATES CAUSED BY ENHANCED GAMMA-GLUTAMYL HYDROLASE ACTIVITY

      Cancer research
    99. GESME DH; JETT JR; SCHREFFLER DD; SU JQ; MAILLIARD JA; FOLEY JF; KROOK JE; MAKSYMIUK AW; HATFIELD AK; EBBERT LP; PFEIFLE DM; MORTON RF; TSCHETTER LK; SCHAEFER PL
      A RANDOMIZED PHASE-II TRIAL OF AMONAFIDE OR TRIMETREXATE IN PATIENTS WITH ADVANCED NONSMALL CELL LUNG-CANCER - A TRIAL OF THE NORTH-CENTRAL-CANCER-TREATMENT-GROUP

      Cancer
    100. WRIGHT JE; ROSOWSKY A; CUCCHI CA; FLATOW J; FREI E
      METHOTREXATE AND GAMMA-TERT-BUTYL METHOTREXATE TRANSPORT IN CEM AND CEM MTX HUMAN LEUKEMIC LYMPHOBLASTS

      Biochemical pharmacology


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/01/21 alle ore 19:20:32