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La ricerca find articoli where soggetti phrase all words 'TRAIL-INDUCED APOPTOSIS' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 86 riferimenti
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    1. Zisman, A; Ng, CP; Pantuck, AJ; Bonavida, B; Belldegrun, AS
      Actinomycin D and gemcitabine synergistically sensitize androgen-independent prostate cancer cells to Apo2L/TRAIL-mediated apoptosis

      JOURNAL OF IMMUNOTHERAPY
    2. Srivastava, RK
      TRAIL/Apo-2L: Mechanisms and clinical applications in cancer

      NEOPLASIA
    3. Sartorius, U; Schmitz, I; Krammer, PH
      Molecular mechanisms of death-receptor-mediated apoptosis

      CHEMBIOCHEM
    4. Mitsiades, N; Mitsiades, CS; Poulaki, V; Anderson, KC; Treon, SP
      Concepts in the use of TRAIL/Apo2L: an emerging biotherapy for myeloma andother neoplasias

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    5. Ichikawa, K; Liu, WM; Zhao, LM; Wang, Z; Liu, D; Ohtsuka, T; Zhang, HG; Mountz, JD; Koopman, WJ; Kimberly, RP; Zhou, T
      Tumoricidal activity of a novel anti-human DR5 monoclonal antibody withouthepatocyte cytotoxicity

      NATURE MEDICINE
    6. Pollack, IF; Erff, M; Ashkenazi, A
      Direct stimulation of apoptotic signaling by soluble Apo2L/tumor necrosis factor-related apoptosis-inducing ligand leads to selective killing of glioma cells

      CLINICAL CANCER RESEARCH
    7. Nguyen, T; Zhang, XD; Hersey, P
      Relative resistance of fresh isolates of melanoma to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis

      CLINICAL CANCER RESEARCH
    8. Nimmanapalli, R; Porosnicu, M; Nguyen, D; Worthington, E; O'Bryan, E; Perkins, C; Bhalla, K
      Cotreatment with STI-571 enhances tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL or Apo-2L)-induced apoptosis of Bcr-Abl-positive human acute leukemia cells

      CLINICAL CANCER RESEARCH
    9. Liu, WH; Bodle, E; Chen, JY; Gao, MX; Rosen, GD; Broaddus, VC
      Tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy cooperate to induce apoptosis in mesothelioma cell lines

      AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
    10. Oshima, K; Yanase, N; Ibukiyama, C; Yamashina, A; Kayagaki, N; Yagita, H; Mizuguchi, J
      Involvement of trail/trail-R interaction in IFN-alpha-induced apoptosis ofdaudi B lymphoma cells

      CYTOKINE
    11. Mitsiades, N; Poulaki, V; Mitsiades, CS; Koutras, DA; Chrousos, GR
      Apoptosis induced FasL and TRAIL/Apo2L in the pathogenesis of thyroid diseases

      TRENDS IN ENDOCRINOLOGY AND METABOLISM
    12. Mow, BMF; Blajeski, AL; Chandra, J; Kaufmann, SH
      Apoptosis and the response to anticancer therapy

      CURRENT OPINION IN ONCOLOGY
    13. Wei, XC; Wang, XJ; Chen, K; Zhang, L; Liang, Y; Lin, XL
      Killing effect of TNF-related apoptosis inducing ligand regulated by tetracycline on gastric cancer cell line NCI-N87

      WORLD JOURNAL OF GASTROENTEROLOGY
    14. Kasof, GM; Lu, JJ; Liu, DR; Speer, B; Mongan, KN; Gomes, BC; Lorenzi, MV
      Tumor necrosis factor-alpha induces the expression of DR6, a member of theTNF receptor family, through activation of NF-kappa B

      ONCOGENE
    15. Satoh, K; Kaneko, K; Hirota, M; Masamune, A; Satoh, A; Shimosegawa, T
      Tumor necrosis factor-related apoptosis-inducing ligand and its receptor expression and the pathway of apoptosis in human pancreatic cancer

      PANCREAS
    16. Liu, Q; El-Deiry, WS; Gazitt, Y
      Additive effect of Apo2L/TRAIL and Adeno-p53 in the induction of apoptosisin myeloma cell lines

      EXPERIMENTAL HEMATOLOGY
    17. Golby, SJC; Spencer, J
      Role of innate immunity in cancer

      CURRENT OPINION IN GASTROENTEROLOGY
    18. Guo, BC; Xu, YH
      Anti-human hepatocellular carcinoma effects of tumor necrosis factor-related apoptosis-inducing ligand in vivo and in vitro

      ACTA PHARMACOLOGICA SINICA
    19. Simon, AK; Williams, O; Mongkolsapaya, J; Jin, B; Xu, XN; Walczak, H; Screaton, GR
      Tumor necrosis factor-related apoptosis-inducing ligand in T cell development: Sensitivity of human thymocytes

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    20. Lum, JJ; Pilon, AA; Sanchez-Dardon, J; Phenix, BN; Kim, JE; Mihowich, J; Jamison, K; Hawley-Foss, N; Lynch, DH; Badley, AD
      Induction of cell death in human immunodeficiency virus-infected macrophages and resting memory CD4 T cells by TRAIL/Apo2L

      JOURNAL OF VIROLOGY
    21. Mizutani, Y; Nakao, M; Ogawa, O; Yoshida, O; Bonavida, B; Miki, T
      Enhanced sensitivity of bladder cancer cells to tumor necrosis factor related apoptosis inducing ligand mediated apoptosis by cisplatin and carboplatin

      JOURNAL OF UROLOGY
    22. Qin, JZ; Bacon, P; Chaturvedi, V; Nickoloff, BJ
      Role of NF-kappa B activity in apoptotic response of keratinocytes mediated by interferon-gamma, tumor necrosis factor-alpha, and tumor-necrosis-factor-related apoptosis-inducing ligand

      JOURNAL OF INVESTIGATIVE DERMATOLOGY
    23. Bullani, RR; Huard, B; Viard-Leveugle, I; Byers, HR; Irmler, M; Saurat, JH; Tschopp, J; French, LE
      Selective expression of FLIP in malignant melanocytic skin lesions

      JOURNAL OF INVESTIGATIVE DERMATOLOGY
    24. Vidalain, PO; Azocar, O; Yagita, H; Rabourdin-Combe, C; Servet-Delprat, C
      Cytotoxic activity of human dendritic cells is differentially regulated bydouble-stranded RNA and CD40 ligand

      JOURNAL OF IMMUNOLOGY
    25. Baetu, TM; Kwon, H; Sharma, S; Grandvaux, N; Hiscott, J
      Disruption of NF-kappa B signaling reveals a novel role for NF-kappa B in the regulation of TNF-related apoptosis-inducing ligand expression

      JOURNAL OF IMMUNOLOGY
    26. Franco, AV; Zhang, XD; Van Berkel, E; Sanders, JE; Zhang, XY; Thomas, WD; Nguyen, T; Hersey, P
      The role of NF-kappa B in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells

      JOURNAL OF IMMUNOLOGY
    27. Liu, SX; Yu, YZ; Zhang, MH; Wang, WY; Cao, XT
      The involvement of TNF-alpha-related apoptosis-inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cells

      JOURNAL OF IMMUNOLOGY
    28. Pettersen, RD; Bernard, G; Olafsen, MK; Pourtein, M; Lie, SO
      CD99 signals caspase-independent T cell death

      JOURNAL OF IMMUNOLOGY
    29. Kischkel, FC; Lawrence, DA; Tinel, A; LeBlanc, H; Virmani, A; Schow, P; Gazdar, A; Blenis, J; Arnott, D; Ashkenazi, A
      Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8.

      JOURNAL OF BIOLOGICAL CHEMISTRY
    30. Han, ZY; Pantazis, P; Wyche, JH; Kouttab, N; Kidd, VJ; Hendrickson, EA
      A Fas-associated Death Domain Protein-dependent mechanism mediates the apoptotic action of non-steroidal anti-inflammatory drugs in the human leukemic Jurkat cell line

      JOURNAL OF BIOLOGICAL CHEMISTRY
    31. Harper, N; Farrow, SN; Kaptein, A; Cohen, GM; MacFarlane, M
      Modulation of tumor necrosis factor apoptosis-inducing ligand-induced NF-kappa B activation by inhibition of apical caspases

      JOURNAL OF BIOLOGICAL CHEMISTRY
    32. Varela, N; Munoz-Pinedo, C; Ruiz-Ruiz, C; Robledo, G; Pedroso, M; Lopez-Rivas, A
      Interferon-gamma sensitizes human myeloid leukemia cells to death receptor-mediated apoptosis by a pleiotropic mechanism

      JOURNAL OF BIOLOGICAL CHEMISTRY
    33. McDonald, ER; Chui, PC; Martelli, PF; Dicker, DT; El-Deiry, WS
      Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling

      JOURNAL OF BIOLOGICAL CHEMISTRY
    34. Panka, DJ; Mano, T; Suhara, T; Walsh, K; Mier, JW
      Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells

      JOURNAL OF BIOLOGICAL CHEMISTRY
    35. Helmbach, H; Rossmann, E; Kern, MA; Schadendorf, D
      Drug-resistance in human melanoma

      INTERNATIONAL JOURNAL OF CANCER
    36. Shin, EC; Ahn, JM; Kim, CH; Choi, Y; Ahn, YS; Kim, H; Kim, SJ; Park, JH
      IFN-gamma induces cell death in human hepatoma cells through a trail/deathreceptor-mediated apoptotic pathway

      INTERNATIONAL JOURNAL OF CANCER
    37. Park, WS; Lee, JH; Shin, MS; Park, JY; Kim, HS; Kim, YS; Park, CH; Lee, SK; Lee, SH; Lee, SN; Kim, H; Yoo, NJ; Lee, JY
      Inactivating mutations of KILLER/DR5 gene in gastric cancers

      GASTROENTEROLOGY
    38. Yoshida, T; Maeda, A; Tani, N; Sakai, T
      Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL-R2 gene

      FEBS LETTERS
    39. Mitsiades, N; Poulaki, V; Mitsiades, C; Tsokos, M
      Ewing's sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5

      CANCER RESEARCH
    40. Eggert, A; Grotzer, MA; Zuzak, TJ; Wiewrodt, BR; Ho, R; Ikegaki, N; Brodeur, GM
      Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression

      CANCER RESEARCH
    41. Lacour, S; Hammann, A; Wotawa, A; Corcos, L; Solary, E; Dimanche-Boitrel, MT
      Anticancer agents sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand-mediated caspase-8 activation and apoptosis

      CANCER RESEARCH
    42. Nimmanapalli, R; Perkins, CL; Orlando, M; O'Bryan, E; Nguyen, D; Bhalla, KN
      Pretreatment with paclitaxel enhances Apo-2 ligand tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of prostate cancer cellsby inducing death receptors 4 and 5 protein levels

      CANCER RESEARCH
    43. Zhang, XD; Zhang, XY; Gray, CP; Nguyen, T; Hersey, P
      Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by Smac/DIABLO release from mitochondria

      CANCER RESEARCH
    44. Huang, Y; He, Q; Hillman, MJ; Rong, R; Sheikh, MS
      Sulindac sulfide-induced apoptosis involves death receptor 5 and the caspase 8-dependent pathway in human colon and prostate cancer cells

      CANCER RESEARCH
    45. Cuello, M; Ettenberg, SA; Clark, AS; Keane, MM; Posner, RH; Nau, MM; Dennis, PA; Lipkowitz, S
      Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhancestumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosisin breast and ovarian cancer cell lines that overexpress erbB-2

      CANCER RESEARCH
    46. Fiumara, P; Younes, A
      CD40 ligand (CD154) and tumour necrosis factor-related apoptosis inducing ligand (APO-2L) in haematological malignancies

      BRITISH JOURNAL OF HAEMATOLOGY
    47. Chen, Q; Gong, B; Mahmoud-Ahmed, AS; Zhou, A; Hsi, ED; Hussein, M; Almasan, A
      Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced in multiple myeloma

      BLOOD
    48. Secchiero, P; Gonelli, A; Celeghini, C; Mirandola, P; Guidotti, L; Visani, G; Capitani, S; Zauli, G
      Activation of the nitric oxide synthase pathway represents a key componentof tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity on hematologic malignancies

      BLOOD
    49. Zang, DY; Goodwin, RG; Loken, MR; Bryant, E; Deeg, HJ
      Expression of tumor necrosis factor-related apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: effects on in vitro hemopoiesis

      BLOOD
    50. Shinohara, H; Kayagaki, N; Yagita, H; Oyaizu, N; Ohba, M; Kuroki, T; Ikawa, Y
      A protective role of PKC epsilon against TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in glioma cells

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    51. Schmitz, I; Kirchhoff, S; Krammer, PH
      Regulation of death receptor-mediated apoptosis pathways

      INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
    52. Pasechnik, V
      Microbial pathogens and apoptotic anticancer therapy

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    53. Dejosez, M; Ramp, U; Mahotka, C; Krieg, A; Walczak, H; Gabbert, HE; Gerharz, CD
      Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan

      CELL DEATH AND DIFFERENTIATION
    54. Shiiki, K; Yoshikawa, H; Kinoshita, H; Takeda, M; Ueno, A; Nakajima, Y; Tasaka, K
      Potential mechanisms of resistance to TRAIL/Apo2L-induced apoptosis in human promyelocytic leukemia HL-60 cells during granulocytic differentiation

      CELL DEATH AND DIFFERENTIATION
    55. Kischkel, FC; Lawrence, DA; Chuntharapai, A; Schow, P; Kim, KJ; Ashkenazi, A
      Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5

      IMMUNITY
    56. Screaton, G; Xu, XN
      T cell life and death signalling via TNF-receptor family members

      CURRENT OPINION IN IMMUNOLOGY
    57. Wang, TTY; Jeng, JJ
      Coordinated regulation of two TRAIL-R2/KILLER/DR5 mRNA isoforms by DNA damaging agents, serum and 17 beta-estradiol in human breast cancer cells

      BREAST CANCER RESEARCH AND TREATMENT
    58. Wu, GS; Kim, K; El-Deiry, WS
      Killer/DR5, a novel DNA-damage inducible death receptor gene, links the p53-tumor suppressor to caspase activation and apoptotic death

      CANCER GENE THERAPY
    59. Murakami-Mori, K; Mori, S; Bonavida, B
      Molecular pathogenesis of AIDS-associated Kaposi's sarcoma: Growth and apoptosis

      ADVANCES IN CANCER RESEARCH, VOL 78
    60. Chinnaiyan, AM; Prasad, U; Shankar, S; Hamstra, DA; Shanaiah, M; Chenevert, TL; Ross, BD; Rehemtulla, A
      Combined effect of tumor necrosis factor-related apoptosis-inducing ligandand ionizing radiation in breast cancer therapy

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    61. Wehrli, P; Viard, I; Bullani, R; Tschopp, J; French, LE
      Death receptors in cutaneous biology and disease

      JOURNAL OF INVESTIGATIVE DERMATOLOGY
    62. Griffith, TS; Anderson, RD; Davidson, BL; Williams, RD; Ratliff, TL
      Adenoviral-mediated transfer of the TNF-related apoptosis-inducing ligand/apo-2 ligand gene induces tumor cell apoptosis

      JOURNAL OF IMMUNOLOGY
    63. Thomas, WD; Zhang, XD; Franco, AV; Nguyen, T; Hersey, P
      TNF-related apoptosis-inducing ligand-induced apoptosis of melanoma is associated with changes in mitochondrial membrane potential and perinuclear clustering of mitochondria

      JOURNAL OF IMMUNOLOGY
    64. Leverkus, M; Neumann, M; Mengling, T; Rauch, CT; Brocker, EB; Krammer, PH; Walczak, H
      Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes

      CANCER RESEARCH
    65. Ozoren, N; Kim, KH; Burns, TF; Dicker, DT; Moscioni, AD; El-Deiry, WS
      The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand

      CANCER RESEARCH
    66. Gong, BD; Almasan, A
      Apo2 ligand/TNF-related apoptosis-inducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells

      CANCER RESEARCH
    67. Hopkins-Donaldson, S; Bodmer, JL; Bourloud, KB; Brognara, CB; Tschopp, J; Gross, N
      Loss of caspase-8 expression in highly malignant human neuroblastoma cellscorrelates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis

      CANCER RESEARCH
    68. Mitsiades, N; Poulaki, V; Tseleni-Balafouta, S; Koutras, DA; Stamenkovic, I
      Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive to tumor necrosis factor-related apoptosis-inducing ligand

      CANCER RESEARCH
    69. Fulda, S; Meyer, E; Debatin, KM
      Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression

      CANCER RESEARCH
    70. Walczak, H; Bouchon, A; Stahl, H; Krammer, PH
      Tumor necrosis factor-related apoptosis-inducing ligand retains its apoptosis-inducing capacity on Bcl-2-or Bcl-x(L)-overexpressing chemotherapy-resistant tumor cells

      CANCER RESEARCH
    71. Leverkus, M; Walczak, H; McLellan, A; Fries, HW; Terbeck, G; Brocker, EB; Kampgen, E
      Maturation of dendritic cells leads to up-regulation of cellular FLICE-inhibitory protein and concomitant down-regulation of death ligand-mediated apoptosis

      BLOOD
    72. Wen, JH; Ramadevi, N; Nguyen, D; Perkins, C; Worthington, E; Bhalla, K
      Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells

      BLOOD
    73. Hymowitz, SG; O'Connell, MP; Ultsch, MH; Hurst, A; Totpal, K; Ashkenazi, A; de Vos, AM; Kelley, RF
      A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL

      BIOCHEMISTRY
    74. Roth, W; Weller, M
      Chemotherapy and immunotherapy of malignant glioma: molecular mechanisms and clinical perspectives

      CELLULAR AND MOLECULAR LIFE SCIENCES
    75. Hymowitz, SG; Christinger, HW; Fuh, G; Ultsch, M; O'Connell, M; Kelley, RF; Ashkenazi, A; de Vos, AM
      Triggering cell death: The crystal structure of Apo2L/TRAIL in a complex with death receptor 5

      MOLECULAR CELL
    76. Walczak, H; Miller, RE; Ariail, K; Gliniak, B; Griffith, TS; Kubin, M; Chin, W; Jones, J; Woodward, A; Le, T; Smith, C; Smolak, P; Goodwin, RG; Rauch, CT; Schuh, JCL; Lynch, DH
      Tumoricidal activity of tumor necrosis factor related apoptosis-inducing ligand in vivo

      NATURE MEDICINE
    77. Johnsen, AC; Haux, J; Steinkjer, B; Nonstad, U; Egeberg, K; Sundan, A; Ashkenazi, A; Espevik, T
      Regulation of Apo-2 ligand/trail expression in NK cells - Involvement in NK cell-mediated cytotoxicity

      CYTOKINE
    78. Mori, S; Murakami-Mori, K; Nakamura, S; Ashkenazi, A; Bonavida, B
      Sensitization of AIDS Kaposi's sarcoma cells to Apo-2 ligand-induced apoptosis by actinomycin D

      JOURNAL OF IMMUNOLOGY
    79. Ashkenazi, A; Pai, RC; Fong, S; Leung, S; Lawrence, DA; Masters, SA; Blackie, C; Chang, L; McMurtrey, AE; Hebert, A; DeForge, L; Koumenis, IL; Lewis, D; Harris, L; Bussiere, J; Koeppen, H; Shahrokh, Z; Schwall, RH
      Safety and antitumor activity of recombinant soluble Apo2 ligand

      JOURNAL OF CLINICAL INVESTIGATION
    80. Costanzo, A; Guiet, C; Vito, P
      c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappa B

      JOURNAL OF BIOLOGICAL CHEMISTRY
    81. Lee, SH; Shin, MS; Kim, HS; Lee, HK; Park, WS; Kim, SY; Lee, JH; Han, SY; Park, JY; Oh, RR; Jang, JJ; Han, JY; Lee, JY; Yoo, NJ
      Alterations of the DR5/TRAIL receptor 2 gene in non-small cell lung cancers

      CANCER RESEARCH
    82. Roth, W; Isenmann, S; Naumann, U; Kugler, S; Bahr, M; Dichgans, J; Ashkenazi, A; Weller, M
      Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    83. Darnay, BG; Aggarwal, BB
      Signal transduction by tumour necrosis factor and tumour necrosis factor related ligands and their receptors

      ANNALS OF THE RHEUMATIC DISEASES
    84. Rieger, J; Ohgaki, H; Kleihues, P; Weller, M
      Human astrocytic brain tumors express AP02L/TRAIL

      ACTA NEUROPATHOLOGICA
    85. ASHKENAZI A; DIXIT VM
      DEATH RECEPTORS - SIGNALING AND MODULATION

      Science
    86. KOTHNYWILKES G; KULMS D; POPPELMANN B; LUGER TA; KUBIN M; SCHWARZ T
      INTERLEUKIN-1 PROTECTS TRANSFORMED KERATINOCYTES FROM TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND

      The Journal of biological chemistry


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Documento generato il 16/01/21 alle ore 22:55:08