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Intravenous bolus topotecan in patients with myelodysplastic syndrome
LEUKEMIA & LYMPHOMA
Chemotherapy with irinotecan (CPT-11), a topoisomerase-I inhibitor, for refractory and relapsed non-Hodgkin's lymphoma
LEUKEMIA & LYMPHOMA
Metabolism and biliary excretion of the novel anticancer agent 10-hydroxycamptothecin in the isolated perfused rat liver
INTERNATIONAL JOURNAL OF ONCOLOGY
Phase I study of irinotecan and cisplatin with concurrent split-course radiotherapy in unresectable and locally advanced non-small cell lung cancer
EUROPEAN JOURNAL OF CANCER
Active transepithelial transport of irinotecan (CPT-11) and its metabolites by human intestinal Caco-2 cells
ANTI-CANCER DRUGS
Modulation of camptothecin analogs in the treatment of cancer: a review
ANTI-CANCER DRUGS
The homocamptothecin BN 80915 is a highly potent orally active topoisomerase I poison
ANTI-CANCER DRUGS
Oral topotecan as single-agent second-line chemotherapy in patients with advanced ovarian cancer
JOURNAL OF CLINICAL ONCOLOGY
The association of topotecan and cytarabine in the treatment of secondary or relapsed acute myeloid leukemia
HAEMATOLOGICA
Natural camptothecins
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
Idarubicin, cytarabine, and topotecan in patients with refractory or relapsed acute myelogenous leukemia and high-risk myelodysplastic syndrome
AMERICAN JOURNAL OF HEMATOLOGY
Effect of hemodialysis on topotecan disposition in a patient with severe renal dysfunction
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Improved therapeutic index of lower dose topotecan chemotherapy in recurrent ovarian cancer
GYNECOLOGIC ONCOLOGY
Dose-escalating study of weekly bolus topotecan in previously treated ovarian cancer patients
GYNECOLOGIC ONCOLOGY
Growth and production of camptothecin by cell suspension cultures of Nothapodytes foetida
PLANTA MEDICA
Feasibility of oral topotecan in previously untreated patients with small-cell lung cancer ineligible for standard therapy
ONCOLOGY
Preliminary results of combined therapy with topotecan and carboplatin in advanced non-small-cell lung cancer
ONCOLOGY
Permeability of human HT-29/B6 colonic epithelium as a function of apoptosis
JOURNAL OF PHYSIOLOGY-LONDON
Murine models for experimental therapy of pediatric solid tumors with poorprognosis
INTERNATIONAL JOURNAL OF CANCER
Breast cancer resistance protein directly confers SN-38 resistance of lungcancer cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Liposomal lurtotecan (NX211): determination of total drug levels in human plasma and urine by reversed-phase high-performance liquid chromatography
JOURNAL OF CHROMATOGRAPHY B
Patent focus on antiparasitic agents: May-October 1999
EXPERT OPINION ON THERAPEUTIC PATENTS
Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan
CELL DEATH AND DIFFERENTIATION
Sensitive high performance liquid chromatographic fluorescence determination of topotecan in human plasma and parotid saliva
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
Antitumor efficacy, pharmacokinetics, and biodistribution of NX 211: A low-clearance liposomal formulation of lurtotecan
CLINICAL CANCER RESEARCH
Topotecan lacks third space sequestration
CLINICAL CANCER RESEARCH
An open label evaluation of topotecan in patients with relapsed or refractory epithelial ovarian cancer - single institution experience in a developing country
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
Cyclophosphamide, ara-C and topotecan (CAT) for patients with refractory or relapsed acute leukemia
LEUKEMIA & LYMPHOMA
Differential activity of topotecan, irinotecan and SN-38 in fresh human tumour cells but not in cell lines
EUROPEAN JOURNAL OF CANCER
Efficacy and toxicity profile of oral topotecan in a panel of human tumourxenografts
EUROPEAN JOURNAL OF CANCER
Modulation of oral bioavailability of anticancer drugs: from mouse to man
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Intensive chemotherapy for patients with high-risk myelodysplastic syndrome
INTERNATIONAL JOURNAL OF HEMATOLOGY
Camptothecin analogues with enhanced antitumor activity at acidic pH
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Cellular and clinical pharmacokinetic/pharmacodynamic basis for lack of efficacy of 21-day continuous topotecan in patients with untreated advanced adenocarcinoma of the pancreas
TUMORI
Treatment of squamous cell esophageal cancer with topotecan - An Eastern Cooperative Oncology Group study (E2293)
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
Activity of crude extract of Rubus crataegifolius roots as a potent apoptosis inducer and DNA topoisomesase I inhibitor
ARCHIVES OF PHARMACAL RESEARCH
New approaches to acute lymphoblastic leukemia in adults: Where do we go?
SEMINARS IN ONCOLOGY
Phase II study of irinotecan and cisplatin as first-line chemotherapy in advanced or recurrent cervical cancer
ONCOLOGY
New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer
INTERNATIONAL JOURNAL OF CANCER
High-dose chemotherapy in ovarian adenocarcinoma
BULLETIN DU CANCER
Measurement and pharmacokinetics of unbound 20(S)-camptothecin in rat blood and brain by microdialysis coupled to microbore liquid chromatography with fluorescence detection
JOURNAL OF CHROMATOGRAPHY A
A comparison of clinical pharmacodynamics of different administration schedules of oral topotecan (hycamtin)
CLINICAL CANCER RESEARCH
Characterisation of a synergistic interaction between a thymidylate synthase inhibitor, ZD1694, and a novel lipophilic topoisomerase I inhibitor karenitecin, BNP1100: Mechanisms and clinical implications
EUROPEAN JOURNAL OF CANCER
Inhibition of DNA topoisomerase I by dihydrotanshinone I, components of a medicinal herb Salvia miltiorrhiza bunge
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Topotecan and cytarabine is an active combination regimen in myelodysplastic syndromes and chronic myelomonocytic leukemia
JOURNAL OF CLINICAL ONCOLOGY
Interpatient variability in bioavailability of the intravenous formulationof topotecan given orally to children with recurrent solid tumors
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Clinical and preclinical pharmacology of Topotecan
TUMORI
Combination of topotecan with cytarabine or etoposide in patients with refractory or relapsed acute myeloid leukemia: Results of a randomized phase I/II study
INVESTIGATIONAL NEW DRUGS
Successful clinical response to irinotecan in desmoplastic round blue celltumor
MEDICAL AND PEDIATRIC ONCOLOGY
Results of topotecan-based combination therapy in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia
SEMINARS IN HEMATOLOGY
The evolving role of oral topotecan
SEMINARS IN HEMATOLOGY
Shikonin, an ingredient of Lithospermum erythrorhizon induced apoptosis inHL60 human premyelocytic leukemia cell line
PLANTA MEDICA
Topotecan - A review of its efficacy in small cell lung cancer
DRUGS
Clinical pharmacokinetics of encapsulated oral 9-aminocamptothecin in plasma and saliva
CLINICAL PHARMACOLOGY & THERAPEUTICS
Oral topotecan: bioavailability and effect of food co-administration
BRITISH JOURNAL OF CANCER
SIMULTANEOUS DETERMINATION OF THE LACTONE AND CARBOXYLATE FORMS OF THE CAMPTOTHECIN DERIVATIVE CPT-11 AND ITS METABOLITE SN-38 IN PLASMA BYHIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
Journal of chromatography B. Biomedical sciences and applications
Results of topotecan single-agent therapy in patients with myelodysplasticsyndromes and chronic myelomonocytic leukemia
LEUKEMIA & LYMPHOMA
HUMAN DNA-TOPOISOMERASE-I ACTIVITY IS AFFECTED BY BIS-NETROPSINS BINDING TO DNA MINOR-GROOVE
Biochemistry and molecular biology international
O-GLUCURONIDATION, A NEWLY IDENTIFIED METABOLIC PATHWAY FOR TOPOTECANAND N-DESMETHYL TOPOTECAN
Anti-cancer drugs
SYNERGISTIC CYTOTOXICITY OF TOPOISOMERASE-I INHIBITORS WITH ALKYLATING-AGENTS AND ETOPOSIDE IN HUMAN BRAIN-TUMOR CELL-LINES
Anti-cancer drugs
IN-VITRO ANTITUMOR-ACTIVITY OF THE NOVEL MARINE AGENT, ECTEINASCIDIN-743 (ET-743, NSC-648766) AGAINST HUMAN TUMORS EXPLANTED FROM PATIENTS
Annals of oncology
PRECLINICAL AND CLINICAL-RESULTS WITH IRINOTECAN - EXTENDING PRINCIPLES LEARNED IN MODEL SYSTEMS TO CLINICAL-TRIALS DESIGN
Oncology
IRINOTECAN IN LYMPHOMA, LEUKEMIA, AND BREAST, PANCREATIC, OVARIAN, AND SMALL-CELL LUNG CANCERS
Oncology
EVALUATION OF TOPOTECAN IN RESISTANT AND RELAPSING MULTIPLE-MYELOMA -A SOUTHWEST-ONCOLOGY-GROUP STUDY
Journal of clinical oncology
Importance of topotecan in the therapy of ovarian carcinoma, today and tomorrow
ONKOLOGIE
Hycamtin in the therapy of non-small-cell lung cancer
ONKOLOGIE
Penetration of topotecan into cerebrospinal fluid after intravenous injection
ONKOLOGIE
Topotecan in haematologic malignancies
ONKOLOGIE
CLINICAL-PHARMACOLOGY OF CAMPTOTHECINS
Cancer chemotherapy and pharmacology
ORAL VERSUS INTRAPERITONEAL ADMINISTRATION OF IRINOTECAN IN THE TREATMENT OF HUMAN NEUROBLASTOMA IN NUDE-MICE
Cancer letters
ADVANCED OVARIAN-CANCER - STATE-OF-THE-ART AND FUTURE OUTLOOK
Tumori
Topoisomerase I inhibitors from the Streptomyces sp. strain KM86-9B isolated from a marine sponge
ARCHIVES OF PHARMACAL RESEARCH
CLINICAL-APPLICATIONS OF THE CAMPTOTHECINS
Biochimica et biophysica acta, N. Gene structure and expression
STANDARD AND LOW-DOSE CHEMOTHERAPY FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES
Leukemia research
A RISK-BENEFIT ASSESSMENT OF IRINOTECAN IN SOLID TUMORS
Drug safety
INDUCTION OF APOPTOSIS BY TOPOTECAN - IMPLICATIONS FOR THE TREATMENT OF LEUKEMIA
Seminars in hematology
TOPOTECAN IN THE TREATMENT OF HEMATOLOGIC MALIGNANCIES
Seminars in hematology
POTENTIATION OF CD95L-INDUCED APOPTOSIS OF HUMAN-MALIGNANT GLIOMA-CELLS BY TOPOTECAN INVOLVES INHIBITION OF RNA-SYNTHESIS BUT NOT CHANGES IN CD95 OR CD95L PROTEIN EXPRESSION
The Journal of pharmacology and experimental therapeutics
SYNTHESES AND BIOLOGICAL EVALUATION OF INDOLOCARBAZOLES, ANALOGS OF REBECCAMYCIN, MODIFIED AT THE IMIDE HETEROCYCLE
Journal of medicinal chemistry
GENETIC PREDISPOSITION TO THE METABOLISM OF IRINOTECAN (CPT-11) - ROLE OF URIDINE-DIPHOSPHATE GLUCURONOSYLTRANSFERASE ISOFORM 1A1 IN THE GLUCURONIDATION OF ITS ACTIVE METABOLITE (SN-38) IN HUMAN LIVER-MICROSOMES
The Journal of clinical investigation
Topotecan - A new approach in the treatment of ovarian cancer
GEBURTSHILFE UND FRAUENHEILKUNDE
TOPOTECAN - A REVIEW OF ITS POTENTIAL IN ADVANCED OVARIAN-CANCER
Drugs
Irinotecan: drug schedule, research of combinations, and phase I experiences
BULLETIN DU CANCER
A PHASE-I CLINICAL AND PHARMACOKINETIC STUDY OF THE NEW TOPOISOMERASEINHIBITOR GI147211 GIVEN AS A 72-H CONTINUOUS-INFUSION
British Journal of Cancer
EFFICACY OF SYSTEMIC ADMINISTRATION OF IRINOTECAN AGAINST NEUROBLASTOMA XENOGRAFTS
Clinical cancer research
EFFECT OF INHIBITORS OF DNA-REPLICATION ON EARLY ZEBRAFISH EMBRYOS - EVIDENCE FOR COORDINATE ACTIVATION OF MULTIPLE INTRINSIC CELL-CYCLE CHECKPOINTS AT THE MID-BLASTULA TRANSITION
Zygote
TRYPTOPHAN DECARBOXYLASE IS ENCODED BY 2 AUTONOMOUSLY REGULATED GENESIN CAMPTOTHECA-ACUMINATA WHICH ARE DIFFERENTIALLY EXPRESSED DURING DEVELOPMENT AND STRESS
Plant journal
EFFICACY OF ORAL IRINOTECAN AGAINST NEUROBLASTOMA XENOGRAFTS
Anti-cancer drugs
P16(INK4) EXPRESSION IS ASSOCIATED WITH THE INCREASED SENSITIVITY OF HUMAN NONSMALL CELL LUNG-CANCER CELLS TO DNA TOPOISOMERASE-I INHIBITORS
Japanese journal of cancer research
RESULTS OF DECITABINE THERAPY IN THE ACCELERATED AND BLASTIC PHASES OF CHRONIC MYELOGENOUS LEUKEMIA
Leukemia
TOPOTECAN VERSUS PACLITAXEL FOR THE TREATMENT OF RECURRENT EPITHELIALOVARIAN-CANCER
Journal of clinical oncology
PHARMACODYNAMICS AND PHARMACOKINETICS OF A 72-HOUR INFUSION OF 9-AMINOCAMPTOTHECIN IN ADULT CANCER-PATIENTS
Journal of clinical oncology
THE PHARMACOKINETICS OF TOPOTECAN AND ITS CARBOXYLATE FORM FOLLOWING SEPARATE INTRAVENOUS ADMINISTRATION TO THE DOG
Pharmaceutical research
ISOLATION AND STRUCTURAL CONFIRMATION OF N-DESMETHYL TOPOTECAN, A METABOLITE OF TOPOTECAN
Cancer chemotherapy and pharmacology
DIFFERENTIAL TOXICITY OF CAMPTOTHECIN, TOPOTECAN AND 9-AMINOCAMPTOTHECIN TO HUMAN, CANINE, AND MURINE MYELOID PROGENITORS (CFU-GM) IN-VITRO
Cancer chemotherapy and pharmacology
TOPOTECAN, A NEW DRUG FOR THE TREATMENT O F OVARIAN-CANCER AND SMALL-CELL LUNG-CANCER - SATELLITE SYMPOSIUM OF OCTOBER 4, 1997 - 15TH NATIONAL MEETING ON EXPERIMENTAL AND CLINICAL ONCOLOGY - CHIA-DOMUS-DE-MARIA (CAGLIARI), OCTOBER 4-7, 1997 - INTRODUCTION
Tumori
TOPOTECAN, A NEW DRUG FOR THE TREATMENT O F EPITHELIAL OVARIAN-CANCER
Tumori
MOLECULAR CHARACTERIZATION OF 3 DIFFERENTIALLY EXPRESSED MEMBERS OF THE CAMPTOTHECA-ACUMINATA 3-HYDROXY-3-METHYLGLUTARYL COA-REDUCTASE (HMGR) GENE FAMILY
Plant molecular biology
SUSTAINED HARVEST OF CAMPTOTHECIN FROM THE LEAVES OF CAMPTOTHECA-ACUMINATA
Journal of natural products
PAPILLARY THYROID-CARCINOMA - DEMOGRAPHICS, TREATMENT, AND OUTCOME IN11 PEDIATRIC-PATIENTS TREATED AT A SINGLE INSTITUTION
Medical and pediatric oncology