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La ricerca find articoli where soggetti phrase all words 'THYMINE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 1148 riferimenti
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    1. Kim, SR; Matsui, K; Yamada, M; Gruz, P; Nohmi, T
      Roles of chromosomal and episomal dinB genes encoding DNA pol IV in targeted and untargeted mutagenesis in Escherichia coli

      MOLECULAR GENETICS AND GENOMICS
    2. Gellon, L; Barbey, R; van der Kemp, PA; Thomas, D; Boiteux, S
      Synergism between base excision repair, mediated by the DNA glycosylases Ntg1 and Ntg2, and nucleotide excision repair in the removal of oxidatively damaged DNA bases in Saccharomyces cerevisiae

      MOLECULAR GENETICS AND GENOMICS
    3. Falero, A; Llanes, N; Perez, C; Fonseca, M; Aguila, B; Borrego, S; Lightbourne, E; Gonzalez, VL
      Quantitative RP high-performance liquid chromatography of thymine and thymidine

      JOURNAL OF SEPARATION SCIENCE
    4. Yekeler, H; Ozbakir, D
      Concerning the solvent effect in the tautomerism of uracil, 5-fluorouracil, and thymine by density-functional theory and ab initio calculations

      JOURNAL OF MOLECULAR MODELING
    5. Saffarian, HM; Srinivasan, R; Chu, D; Gilman, S
      Effect of adsorbed uracil and its derivatives on the rate of oxygen reduction on platinum in acid electrolytes

      JOURNAL OF ELECTROANALYTICAL CHEMISTRY
    6. Zeng, XM; Winter, DB; Kasmer, C; Kraemer, KH; Lehmann, AR; Gearhart, PJ
      DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

      NATURE IMMUNOLOGY
    7. Li, Y; Jin, T; Liu, KL
      Synthesis and binding affinity of a chiral PNA analogue

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    8. Dubey, I; Pratviel, G; Robert, A; Meunier, B
      Convenient method for the preparation of 2 '-deoxyribosylurea by thymidineoxidation and NMR study of both anomers

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    9. Falkiewicz, B; Wisniowski, W; Kolodziejczyk, AS; Wisniewski, K
      Synthesis of new chiral peptide nucleic acid (PNA) monomers

      NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
    10. Zhou, RH; Friesner, RA; Ghosh, A; Rizzo, RC; Jorgensen, WL; Levy, RM
      New linear interaction method for binding affinity calculations using a continuum solvent model

      JOURNAL OF PHYSICAL CHEMISTRY B
    11. Ravn, J; Thorup, N; Nielsen, P
      A conformationally locked tricyclic nucleoside. Synthesis, crystal structure and incorporation into oligonucleotides

      JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
    12. Pedersen, DS; Boesen, T; Eldrup, AB; Kiaer, B; Madsen, C; Henriksen, U; Dahl, O
      The first example of a new type of acyclic, achiral nucleoside analogue: 1-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]thymine

      JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
    13. Sommerfeld, T
      Electron-induced chemistry of 5-chlorouracil

      CHEMPHYSCHEM
    14. Demidov, VV; Broude, NE; Lavrentieva-Smolina, IV; Kuhn, H; Frank-Kamenetskii, MD
      An artificial primosome: Design, function, and applications

      CHEMBIOCHEM
    15. Inouye, M; Takase, M
      Specific binding and separation of dinucleotides by ferrocene-modified artificial receptors

      ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    16. Pavlov, YI; Nguyen, D; Kunkel, TA
      Mutator effects of overproducing DNA polymerase eta (Rad30) and its catalytically inactive variant in yeast

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    17. Jackson, AL; Loeb, LA
      The contribution of endogenous sources of DNA damage to the multiple mutations in cancer

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    18. Li, C; Huang, JG; Liang, YQ
      Spectroscopic studies on molecular recognition capabilities of a nucleolipid bearing thymine headgroup to adenosine

      SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
    19. Gambari, R
      Peptide-nucleic acids (PNAs): A tool for the development of gene expression modifiers

      CURRENT PHARMACEUTICAL DESIGN
    20. Kajiwara, K; O-Wang, JY; Sakurai, T; Yamashita, S; Tanaka, M; Sato, M; Tagawa, M; Sugaya, E; Nakamura, K; Nakao, K; Katsuki, M; Kimura, M
      Sez4 gene encoding an elongation subunit of DNA polymerase zeta is required for normal embryogenesis

      GENES TO CELLS
    21. Clarke, NRA; Kelion, AD; Nixon, J; Hilton-Jones, D; Forfar, JC
      Does cytosine-thymine-guanine (CTG) expansion size predict cardiac events and electrocardiographic progression in myotonic dystrophy?

      HEART
    22. Haracska, L; Kondratick, CM; Unk, I; Prakash, S; Prakash, L
      Interaction with PCNA is essential for yeast DNA polymerase eta function

      MOLECULAR CELL
    23. Trincao, J; Johnson, RE; Escalante, CR; Prakash, S; Prakash, L; Aggarwal, AK
      Structure of the catalytic core of S-cerevisiae DNA polymerase eta: Implications for translesion DNA synthesis

      MOLECULAR CELL
    24. Kryachko, ES; Nguyen, MT; Zeegers-Huyskens, T
      Theoretical study of tautomeric forms of uracil. 1. Relative order of stabilities and their relation to proton affinities and deprotonation enthalpies

      JOURNAL OF PHYSICAL CHEMISTRY A
    25. Colacino, E; Giorgi, G; Liguori, A; Napoli, A; Romeo, R; Salvini, L; Siciliano, C; Sindona, G
      Structural characterization of isoxazolidinyl nucleosides by fast atom bombardment tandem mass spectrometry

      JOURNAL OF MASS SPECTROMETRY
    26. Kofoed, T; Hansen, HF; Orum, H; Koch, T
      PNA synthesis using a novel Boc/acyl protecting group strategy

      JOURNAL OF PEPTIDE SCIENCE
    27. Zan, H; Komori, A; Li, ZD; Cerutti, A; Schaffer, A; Flajnik, MF; Diaz, M; Casali, P
      The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation

      IMMUNITY
    28. Demidov, VV; Frank-Kamenetskii, MD
      Sequence-specific targeting of duplex DNA by peptide nucleic acids via triplex strand invasion

      METHODS
    29. Flora, JW; Muddiman, DC
      Complete sequencing of mono-deprotonated peptide nucleic acids by sustained off-resonance irradiation collision-induced dissociation

      JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
    30. El-Emam, AA; Nasr, MNA; Pedersen, EB; Fouad, T; Nielsen, C
      Synthesis of certain 6-(arylthio)uracils as potential antiviral agents

      PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
    31. Wu, SG; Zheng, LZ; Rui, L; Lin, XQ
      Electrochemical studies on the oxidation of thymine at beta-cyclodextrin modified electrode

      ELECTROANALYSIS
    32. Bai, JQ; Li, Y; Liu, KL
      Design and synthesis of novel peptide nucleic acid monomers

      CHINESE JOURNAL OF CHEMISTRY
    33. Beard, WA; Wilson, SH
      DNA lesion bypass polymerases open up

      STRUCTURE
    34. Balasundaram, G; Takahashi, T; Ueno, A; Mihara, H
      Construction of peptide conjugates with peptide nucleic acids containing an anthracene probe and their interactions with DNA

      BIOORGANIC & MEDICINAL CHEMISTRY
    35. Obika, S; Uneda, T; Sugimoto, T; Nanbu, D; Minami, T; Doi, T; Imanishi, T
      2 '-O,4 '-C-methylene bridged nucleic acid (2 ',4 '-BNA): Synthesis and triplex-forming properties

      BIOORGANIC & MEDICINAL CHEMISTRY
    36. Kimura, E; Aoki, S
      Chemistry of zinc(II) fluorophore sensors

      BIOMETALS
    37. Lawrence, CW; Maher, VM
      Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1p

      PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
    38. McDonald, JP; Tissier, A; Frank, EG; Iwai, S; Hanaoka, F; Woodgate, R
      DNA polymerase iota and related Rad30-like enzymes

      PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
    39. Hakansson, AE; Wengel, J
      The adenine derivative of alpha-L-LNA (alpha-L-ribo configured locked nucleic acid): Synthesis and high-affinity hybridization towards DNA, RNA, LNA and alpha-L-LNA complementary sequences

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    40. Shiels, JC; Jerkovic, B; Baranger, AM; Bolton, PH
      RNA-DNA hybrids containing damaged DNA are substrates for RNase H

      BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    41. Liu, ZR; Hall, JD; Mount, DW
      Arabidopsis UVH3 gene is a homolog of the Saccharomyces cerevisiae RAD2 and human XPG DNA repair genes

      PLANT JOURNAL
    42. Miyabe, I; Zhang, QM; Sugiyama, H; Kino, K; Yonei, S
      Mutagenic effects of 5-formyluracil on a plasmid vector during replicationin Escherichia coli

      INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
    43. Freisinger, E; Schimanski, A; Lippert, B
      Thymine-metal ion interactions: relevance for thymine quartet structures

      JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
    44. Nielsen, PE
      Targeting double stranded DNA with peptide nucleic acid (PNA)

      CURRENT MEDICINAL CHEMISTRY
    45. Chou, SH; Chin, KH; Chen, CW
      Enhanced loop DNA folding induced by thymine-CH3 group contact and perpendicular guanine-thymine interaction

      JOURNAL OF BIOMOLECULAR NMR
    46. Chabita, K; Mandal, PC; Mahal, HS; Mukherjee, T
      Reactions of the OH adducts of cytosine and its derivatives with TEMPO andTEMPOL: A steady state gamma-radiolysis and pulse radiolysis study

      RESEARCH ON CHEMICAL INTERMEDIATES
    47. Joshi, R; Adhikari, S; Mukherjee, T
      Redox reactions of 3 '-azido-3 '-deoxythymidine (AZT) and interaction of its OH-derived radical with bilirubin and riboflavin: A pulse radiolysis study

      RESEARCH ON CHEMICAL INTERMEDIATES
    48. Broomfield, S; Hryciw, T; Xiao, W
      DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae

      MUTATION RESEARCH-DNA REPAIR
    49. Wang, ZG
      Translesion synthesis by the UmuC family of DNA polymerases

      MUTATION RESEARCH-DNA REPAIR
    50. Bill, CA; Taghian, DG; Duran, WA; Nickoloff, JA
      Repair bias of large loop mismatches during recombination in mammalian cells depends on loop length and structure

      MUTATION RESEARCH-DNA REPAIR
    51. Woodgate, R
      Evolution of the two-step model for UV-mutagenesis

      MUTATION RESEARCH-DNA REPAIR
    52. Gupta, S; Singh, M; Madan, AK
      Predicting anti-HIV activity: computational approach using a novel topological descriptor

      JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
    53. Mizushina, Y; Sugiyama, Y; Yoshida, H; Hanashima, S; Yamazaki, T; Kamisuki, S; Ohta, K; Takemura, M; Yamaguchi, T; Matsukage, A; Yoshida, S; Saneyoshi, M; Sugawara, F; Sakagauchi, K
      Galactosyldiacylglycerol, a mammalian DNA polymerase alpha-specific inhibitor from a sea alga, Petalonia bingbamiae

      BIOLOGICAL & PHARMACEUTICAL BULLETIN
    54. Whitmore, SE; Potten, CS; Chadwick, CA; Strickland, PT; Morison, WL
      Effect of photoreactivating fight on UV radiation-induced alterations in human skin

      PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
    55. Setlow, P
      Resistance of spores of Bacillus species to ultraviolet light

      ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
    56. Friedberg, EC
      Why do cells have multiple error-prone DNA polymerases?

      ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
    57. Yao, JQ; Dixon, K; Carty, MP
      A single (6-4) photoproduct inhibits plasmid DNA replication in xeroderma pigmentosum variant cell extracts

      ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
    58. Kobayashi, N; Katsumi, S; Imoto, K; Nakagawa, A; Miyagawa, S; Furumura, M; Mori, T
      Quantitation and visualization of ultraviolet-induced DNA damage using specific antibodies: Application to pigment cell biology

      PIGMENT CELL RESEARCH
    59. Haracska, L; Unk, I; Johnson, RE; Johansson, E; Burgers, PMJ; Prakash, S; Prakash, L
      Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass ofabasic sites

      GENES & DEVELOPMENT
    60. Kannouche, P; Broughton, BC; Volker, M; Hanaoka, F; Mullenders, LHF; Lehmann, AR
      Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells

      GENES & DEVELOPMENT
    61. Danilov, VI; Les, A; Alderfer, JL
      A theoretical study of the cis-syn pyrimidine dimers in the gas phase and water cluster and a tautomer-bypass mechanism for the origin of UV-induced mutations

      JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
    62. Wu, Y; Xu, JC
      Synthesis of chiral phosphono-peptide nucleic acid monomers

      ACTA CHIMICA SINICA
    63. Heinkele, G; Hofmann, U; Opitz, J; Murdter, TE
      Syntheses of H-2-labelled dihydropyrimidinediones and their metabolites

      JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
    64. Klecker, RW; Collins, JM
      Thymidine phosphorylase as a target for imaging and therapy with thymine analogs

      CANCER CHEMOTHERAPY AND PHARMACOLOGY
    65. Zhang, YB; Yuan, FH; Wu, XH; Taylor, JS; Wang, ZG
      Response of human DNA polymerase iota to DNA lesions

      NUCLEIC ACIDS RESEARCH
    66. Boudsocq, F; Iwai, S; Hanaoka, F; Woodgate, R
      Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-likeDNA polymerase with lesion-bypass properties akin to eukaryotic pol eta

      NUCLEIC ACIDS RESEARCH
    67. Ulrich, HD
      The srs2 suppressor of UV sensitivity acts specifically on the RAD5- and MMS2-dependent branch of the RAD6 pathway

      NUCLEIC ACIDS RESEARCH
    68. Wu, XH; Guo, DY; Yuan, FH; Wang, ZG
      Accessibility of DNA polymerases to repair synthesis during nucleotide excision repair in yeast cell-free extracts

      NUCLEIC ACIDS RESEARCH
    69. Guo, DY; Wu, XH; Rajpal, DK; Taylor, JS; Wang, ZG
      Translesion synthesis by yeast DNA polymerase zeta from templates containing lesions of ultraviolet radiation and acetylaminofluorene

      NUCLEIC ACIDS RESEARCH
    70. Piuzzi, F; Mons, M; Dimicoli, I; Tardivel, B; Zhao, Q
      Ultraviolet spectroscopy and tautomerism of the DNA base guanine and its hydrate formed in a supersonic jet

      CHEMICAL PHYSICS
    71. Pas, E; Einav, M; Woldringh, CL; Zaritsky, A
      Perpendicular planes of FtsZ arcs in spheroidal Escherichia coli cells

      BIOCHIMIE
    72. Tissier, A; Frank, EG; McDonald, JP; Vaisman, A; de Henestrosa, ARF; Boudsocq, F; McLenigan, MP; Woodgate, R
      Biochemical characterization of human DNA polymerase iota provides clues to its biological function

      BIOCHEMICAL SOCIETY TRANSACTIONS
    73. Kondratick, CM; Washington, MT; Prakash, S; Prakash, L
      Acidic residues critical for the activity and biological function of yeastDNA polymerase eta

      MOLECULAR AND CELLULAR BIOLOGY
    74. Haracska, L; Johnson, RE; Unk, I; Phillips, B; Hurwitz, J; Prakash, L; Prakash, S
      Physical and functional interactions of human DNA polymerase eta with PCNA

      MOLECULAR AND CELLULAR BIOLOGY
    75. Johnson, RE; Haracska, L; Prakash, S; Prakash, L
      Role of DNA polymerase eta in the bypass of a (6-4) TT photoproduct

      MOLECULAR AND CELLULAR BIOLOGY
    76. Allinson, SL; Dianova, II; Dianov, GL
      DNA polymerase beta is the major dRP lyase involved in repair of oxidativebase lesions in DNA by mammalian cell extracts

      EMBO JOURNAL
    77. Frank, EG; Tissier, A; McDonald, JP; Rapic-Otrin, V; Zeng, XM; Gearhart, PJ; Woodgate, R
      Altered nucleotide misinsertion fidelity associated with pol iota-dependent replication at the end of a DNA template

      EMBO JOURNAL
    78. Yoo, DJ; Hyun, SH; Shim, SC
      Intramolecular ring-ring stacking interactions between 8-methoxypsoralen and adenine induced by polymethylene bridges

      BULLETIN OF THE KOREAN CHEMICAL SOCIETY
    79. Mishra, L; Pathak, B; Mandal, RK
      XRD and optical microscopic studies of Co(III) complexes containing 5-cyano-6-(4-pyridyl)-2-thiouracil, thymine and adenine bases

      BULLETIN OF MATERIALS SCIENCE
    80. Pinak, M
      Molecular dynamics simulation of thymine glycol-lesioned DNA reveals specific hydration at the lesion

      JOURNAL OF COMPUTATIONAL CHEMISTRY
    81. Whitmore, SE; Morison, WL; Potten, CS; Chadwick, C
      Tanning salon exposure and molecular alterations

      JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
    82. Helbling, EW; Buma, AGJ; de Boer, MK; Villafane, VE
      In situ impact of solar ultraviolet radiation on photosynthesis and DNA intemperate marine phytoplankton

      MARINE ECOLOGY-PROGRESS SERIES
    83. Norberg, J; Vihinen, M
      Molecular dynamics simulation of the effects of cytosine methylation on structure of oligonucleotides

      JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
    84. Brasun, J; Oldziej, S; Taddei, M; Kozlowski, H
      Impact of Cu(II) and Ni(II) on a structure of chiral peptide nucleic acidshaving four, six and eight thymines in a peptide side chain

      JOURNAL OF INORGANIC BIOCHEMISTRY
    85. Gutfilen, B; Rodrigues, E; Soraggi, R; Da Fonseca, LHB
      Preliminary observation of Tc-99m-thymine imaging in breast neoplasms

      NUCLEAR MEDICINE COMMUNICATIONS
    86. Hemminki, K; Xu, GG; Angelini, S; Snellman, E; Jansen, CT; Lambert, B; Hou, SM
      XPD exon 10 and 23 polymorphisms and DNA repair in human skin in situ

      CARCINOGENESIS
    87. Bullock, SK; Kaufmann, WK; Cordeiro-Stone, M
      Enhanced S phase delay and inhibition of replication of an undamaged shuttle vector in UVC-irradiated xeroderma pigmentosum variant

      CARCINOGENESIS
    88. Komiyama, M; Uchihashi, T; Sugawara, Y; Morita, S
      Molecular orbital interpretation of thymine/graphite nc-AFM images

      SURFACE AND INTERFACE ANALYSIS
    89. Danilov, VI; Les, A; Alderfer, JL
      A theoretical study of the cis-syn cytosine-containing pyrimidine dimers in the gase phase and a water cluster and a tautomer-bypass mechanism for the origin of UV-incduced mutations

      POLISH JOURNAL OF CHEMISTRY
    90. Cunha, FGC; Nart, FC
      In situ scanning tunneling microscopy study of 5,6-dimethyl uracil on Au (111)

      JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
    91. Rice, JK; Ewell, M
      Examination of peak power dependence in the UV inactivation of bacterial spores

      APPLIED AND ENVIRONMENTAL MICROBIOLOGY
    92. Zielenkiewicz, A; Golankiewicz, B; Zielenkiewicz, W
      Partial molar volumes and heat capacities of some analogs of acyclovir

      JOURNAL OF SOLUTION CHEMISTRY
    93. Hannongbua, S; Nivesanond, K; Lawtrakul, L; Pungpo, P; Wolschann, P
      3D-quantitative structure-activity relationships of HEPT derivatives as HIV-1 reverse transcriptase inhibitors, based on ab initio calculations

      JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
    94. Ling, H; Boudsocq, F; Woodgate, R; Yang, W
      Crystal structure of a Y-family DNA polymerase in action: A mechanism for error-prone and lesion-bypass replication

      CELL
    95. Sanderson, RJ; Bennett, SE; Sung, JS; Mosbaugh, DW
      Uracil-initiated base excision DNA repair synthesis fidelity in human colon adenocarcinoma LoVo and Escherichia coli cell extracts

      PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 68
    96. Ide, H
      DNA substrates containing defined oxidative base lesions and their application to study substrate specificities of base excision repair enzymes

      PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 68
    97. Dianov, GL; Souza-Pinto, N; Nyaga, SG; Thybo, T; Stevnsner, T; Bohr, VA
      Base excision repair in nuclear and mitochondrial DNA

      PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 68
    98. Toulme, JJ; Di Primo, C; Moreau, S
      Modulation of RNA function by oligonucleotides recognizing RNA structure

      PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 69
    99. Buckheit, RW; Watson, K; Fliakas-Boltz, V; Russell, J; Loftus, TL; Osterling, MC; Turpin, JA; Pallansch, LA; White, EL; Lee, JW; Lee, SH; Oh, JW; Kwon, HS; Chung, SG; Cho, EH
      SJ-3366, a unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) that also inhibits HIV-2

      ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    100. Sinha, RP; Dautz, M; Hader, DP
      A simple and efficient method for the quantitative analysis of thymine dimers in cyanobacteria, phytoplankton and macroalgae

      ACTA PROTOZOOLOGICA


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Documento generato il 07/08/20 alle ore 03:55:00