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La ricerca find articoli where soggetti phrase all words 'TERBUTALINE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 713 riferimenti
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    1. Biarent, D
      Therapeutic strategies in near fatal asthma in children

      PEDIATRIC PULMONOLOGY
    2. Norlin, A; Lu, LN; Guggino, SE; Matthay, MA; Folkesson, HG
      Contribution of amiloride-insensitive pathways to alveolar fluid clearancein adult rats

      JOURNAL OF APPLIED PHYSIOLOGY
    3. Brieva, J; Wanner, A
      Adrenergic airway vascular smooth muscle responsiveness in healthy and asthmatic subjects

      JOURNAL OF APPLIED PHYSIOLOGY
    4. Sakuma, T; Tuchihara, C; Ishigaki, M; Osanai, K; Nambu, Y; Toga, H; Takahashi, K; Ohya, N; Kurihara, T; Matthay, MA
      Denopamine, a beta(1)-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs

      JOURNAL OF APPLIED PHYSIOLOGY
    5. Kim, KH; Kim, HJ; Kim, JH; Shin, SD
      Determination of terbutaline enantiomers in human urine by coupled achiral-chiral high-performance liquid chromatography with fluorescence detection

      JOURNAL OF CHROMATOGRAPHY B
    6. Henze, MK; Opfermann, G; Spahn-Langguth, H; Schanzer, W
      Screening of beta-2 agonists and confirmation of fenoterol, orciprenaline,reproterol and terbutaline with gas chromatography-mass spectrometry as tetrahydroisoquinoline derivatives

      JOURNAL OF CHROMATOGRAPHY B
    7. Sharma, P; Hamsa, V
      Formulation and evaluation of buccal mucoadhesive patches of terbutaline sulphate

      STP PHARMA SCIENCES
    8. Fishwick, D; Bradshaw, L; MacDonald, C; Beasley, R; Gash, D; Bengtsson, T; Bondesson, E; Borgstrom, L
      Cumulative and single-dose design to assess the bronchodilator effects of beta(2)-agonists in individuals with asthma

      AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
    9. Bramuglia, GF; Rubio, MC
      Effects of optical isomers of clenbuterol on the relaxant response in rat uterus

      PHARMACOLOGICAL RESEARCH
    10. Ram, FSF; Wright, J; Brocklebank, D; White, JES
      Systematic review of clinical effectiveness of pressurised metered dose inhalers versus other hand held inhaler devices for delivering beta(2) agonist bronchodilators in asthma

      BRITISH MEDICAL JOURNAL
    11. Hirst, PH; Bacon, RE; Pitcairn, GR; Silvasti, M; Newman, SP
      A comparison of the lung deposition of budesonide from Easyhaler (R), Turbuhaler (R) and pMDI plus spacer in asthmatic patients

      RESPIRATORY MEDICINE
    12. Berggren, F; Ekstrom, T
      A cost-effectiveness study comparing the as-needed use of formoterol (Oxis(R)) and terbutaline (Bricanyl (R)) in patients with moderate to severe asthma

      RESPIRATORY MEDICINE
    13. Eiser, NM; Phillips, C; Wooler, PA
      Does the mode of inhalation affect the bronchodilator response in patientswith severe COPD?

      RESPIRATORY MEDICINE
    14. Arvidsson, P; Palmqvist, M; Lotvall, J
      Response to Prof. Borgstrom re: paper by Arvidsson et al. (Respir Med 2000; 94 : 574-577)

      RESPIRATORY MEDICINE
    15. Cazzola, M; Di Perna, F; D'Amato, M; Califano, C; Matera, MG; D'Amato, G
      Formoterol Turbuhaler (R) for as-needed therapy in patients with mild acute exacerbations of COPD

      RESPIRATORY MEDICINE
    16. Borgstrom, L
      The importance of the device in asthma therapy

      RESPIRATORY MEDICINE
    17. Pauwels, R
      Formoterol - where does it fit in the current guidelines?

      RESPIRATORY MEDICINE
    18. Vela, J; Yanes, EG; Stalcup, AM
      Quantitative determination of clenbuterol, salbutamol and tulobuterol enantiomers by capillary electrophoresis

      FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY
    19. Knox, AJ; Zhu, YM; Pang, L
      Do long-acting beta(2)-adrenoceptor agonists enhance the anti-inflammatoryeffect of glucocorticoids in asthma?

      EUROPEAN RESPIRATORY JOURNAL
    20. Borgstrom, L
      On the use of dry powder inhalers in situations perceived as constrained

      JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
    21. Newman, SP; Pitcairn, GR; Hirst, PH
      A brief history of gamma scintigraphy

      JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
    22. Lee, ZH; Berridge, MS; Nelson, AD; Heald, DL
      The effect of scatter and attenuation on aerosol deposition as determined by gamma scintigraphy

      JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
    23. Walker, PS; Conway, JH; Fleming, JS; Bondesson, E; Borgstrom, L
      Pulmonary clearance rate of two chemically different forms of inhaled pertechnetate

      JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
    24. Walker, PS; Petterson, GL; Bondesson, E; Conway, JH
      An advanced and detailed in vitro validation procedure for the radiolabeling of carrier-free terbutaline sulphate dry powder

      JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
    25. Pritchard, JN
      The influence of lung deposition on clinical response

      JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
    26. Lotvall, J
      Inhalation therapy of the future - How will it change the way we treat asthma?

      JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
    27. Au, DH; Curtis, JR; Psaty, BM
      Risk of myocardial ischaemia and beta-adrenoceptor agonists

      ANNALS OF MEDICINE
    28. Kim, KH; Kim, HJ; Kim, JH; Lee, JH; Lee, SC
      Determination of the optical purity of (R)-terbutaline by H-1-NMR and RP-LC using chiral derivatizing agent, (S)-(-)-alpha-methylbenzyl isocyanate

      JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
    29. Auman, JT; Seidler, FJ; Tate, CA; Slotkin, TA
      beta-Adrenoceptor-mediated cell signaling in the neonatal heart and liver:responses to terbutaline

      AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
    30. Marion-Latard, F; De Glisezinski, E; Crampes, F; Berlan, M; Galitzky, J; Suljkovicova, H; Riviere, D; Stich, V
      A single bout of exercise induces beta-adrenergic desensitization in humanadipose tissue

      AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
    31. Ryden, M; Hoffstedt, J; Eriksson, P; Bringman, S; Arner, P
      The Arg 389 Gly beta(1)-adrenergic receptor gene polymorphism and human fat cell lipolysis

      INTERNATIONAL JOURNAL OF OBESITY
    32. Newman, SP
      Lung distribution of inhaled drugs

      BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    33. Chrystyn, H
      Lung distribution of inhaled drugs - Reply

      BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    34. Chrystyn, H
      Methods to identify drug deposition in the lungs following inhalation

      BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    35. Werner, C; Werdan, K; Ponicke, K; Brodde, OE
      Impaired beta-adrenergic control of immune function in patients with chronic heart failure: reversal by beta(1)-blocker treatment

      BASIC RESEARCH IN CARDIOLOGY
    36. Schafers, MA; Wichter, T; Schafers, KP; Rahman, S; Rhodes, CG; Lammertsma, AA; Lerch, H; Knickmeier, M; Hermansen, F; Schober, O; Camici, PG; Breithardt, G
      Pulmonary beta adrenoceptor density in arrhythmogenic right ventricular cardiomyopathy and idiopathic tachycardia

      BASIC RESEARCH IN CARDIOLOGY
    37. Anstead, MI; Hunt, TA; McConnell, JW; Burki, NK
      Effects of therapeutic doses of albuterol on beta(2)-adrenergic receptor density and metabolic changes

      JOURNAL OF ASTHMA
    38. Garcia-Ruiz, C; Marina, ML
      Fast enantiomeric separation of basis drugs by electrokinetic chromatography. Application to the quantitation of terbutaline in a pharmaceutical preparation

      ELECTROPHORESIS
    39. Slotkin, TA; Tate, CA; Cousins, MM; Seidler, FJ
      beta-adrenoceptor signaling in the developing brain: sensitization or desensitization in response to terbutaline

      DEVELOPMENTAL BRAIN RESEARCH
    40. Maxwell, CV; Amankwah, KS
      Alternative approaches to preterm labor

      SEMINARS IN PERINATOLOGY
    41. Caughey, AB; Parer, JT
      Tocolysis with beta-adrenergic receptor agonists

      SEMINARS IN PERINATOLOGY
    42. Barnewolt, BA; Walter, FG; Bey, TA
      Metabolic effects of metaproterenol overdose: Hypokalemia, hyperglycemia and hyperlactatemia

      VETERINARY AND HUMAN TOXICOLOGY
    43. Pautler, SE; Brock, GB
      Priapism - From Priapus to the present time

      UROLOGIC CLINICS OF NORTH AMERICA
    44. Partridge, MR
      The profile of respiratory conditions: why government action is necessary

      THORAX
    45. Haahtela, T; Klaukka, T; Koskela, K; Erhola, M; Laitinen, LA
      Asthma programme in Finland: a community problem needs community solutions

      THORAX
    46. Loew, TH; Tritt, K; Siegfried, W; Bohmann, H; Martus, P; Hahn, EG
      Efficacy of 'functional relaxation' in comparison to terbutaline and a 'placebo relaxation' method in patients with acute asthma - A randomized, prospective, placebo-controlled, crossover experimental investigation

      PSYCHOTHERAPY AND PSYCHOSOMATICS
    47. Laurie, S; Khan, D
      Inhaled corticosteroids as first-line therapy for asthma - Why they work-and what the guidelines and evidence suggest

      POSTGRADUATE MEDICINE
    48. Rizk, MS; Abdel-Ghani, NT; El Nashar, RM
      Construction and performance characteristics of terbutaline plastic membrane electrode in batch and FIA conditions

      MICROCHEMICAL JOURNAL
    49. Elliott, JP; Bergauer, NK; Jacques, DL; Coleman, SK; Stanziano, GJ
      Pregnancy prolongation in triplet pregnancies - Oral vs. continuous subcutaneous terbutaline

      JOURNAL OF REPRODUCTIVE MEDICINE
    50. Kitano, Y; Kanai, M; Davies, P; von Allmen, D; Yang, EY; Radu, A; Kitano, Y; Adzick, NS; Flake, AW
      Lung growth induced by prenatal tracheal occlusion and its modifying factors: A study in the rat model of congenital diaphragmatic hernia

      JOURNAL OF PEDIATRIC SURGERY
    51. Jiang, X; Ingbar, DH; O'Grady, SM
      Adrenergic regulation of ion transport across adult alveolar epithelial cells: Effects on Cl- channel activation and transport function in cultures with an apical air interface

      JOURNAL OF MEMBRANE BIOLOGY
    52. Marunaka, Y; Niisato, N
      The essential role of cytosolic Cl- in Ca2+ regulation of an amiloride-sensitive channel in fetal rat pneumocyte

      JOURNAL OF MEMBRANE BIOLOGY
    53. Sakuma, T; Hida, M; Nambu, Y; Osanai, K; Toga, H; Takahashi, K; Ohya, N; Inoue, M; Watanabe, Y
      Beta(1)-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs

      JAPANESE JOURNAL OF PHARMACOLOGY
    54. de Vries, B; Roffel, AF; Zaagsma, J; Meurs, H
      Effect of fenoterol-induced constitutive beta(2)-adrenoceptor activity on contractile receptor function in airway smooth muscle

      EUROPEAN JOURNAL OF PHARMACOLOGY
    55. Epstein, S; Maidenberg, A; Hallett, D; Khan, K; Chapman, KR
      Patient handling of a dry-powder inhaler in clinical practice

      CHEST
    56. Assaly, R; Olson, D; Hammersley, J; Fan, PS; Liu, J; Shapiro, JI; Kahaleh, MB
      Initial evidence of endothelial cell apoptosis as a mechanism of systemic capillary leak syndrome

      CHEST
    57. Brodde, OE; Buscher, R; Tellkamp, R; Radke, J; Dhein, S; Insel, PA
      Blunted cardiac responses to receptor activation in subjects with Thr164Ile beta(2)-adrenoceptors

      CIRCULATION
    58. Kim, KH; Kim, HJ; Kim, JH; Lee, JH; Lee, SC
      High-performance liquid chromatographic and capillary electrophoretic methods for the quantitation of the (S)-terbutaline in (R)-terbutaline

      CHROMATOGRAPHIA
    59. Hoffstedt, J; Iliadou, A; Pedersen, NL; Schalling, M; Arner, P
      The effect of the beta(2) adrenoceptor gene Thr164Ile polymorphism on human adipose tissue lipolytic function

      BRITISH JOURNAL OF PHARMACOLOGY
    60. Amann, R; Peskar, BA; Schuligoi, R
      Effects of terbutaline on NGF formation in allergic inflammation of the rat

      BRITISH JOURNAL OF PHARMACOLOGY
    61. Johnsson, H; Eriksson, L; Sedin, G
      Antenatal terbutaline administration decreases the lung hyaluronan concentration in preterm rabbit pups

      BIOLOGY OF THE NEONATE
    62. Gratz, SR; Schneiderman, E; Mertens, TR; Stalcup, AM
      Use of dyes to investigate migration of the chiral selector in CFFE and the impact on the chiral separations

      ANALYTICAL CHEMISTRY
    63. Agatonovic-Kustrin, S; Alany, R
      Application of diffuse reflectance infrared Fourier transform spectroscopycombined with artificial neural networks in analysing enantiomeric purity of terbutaline sulphate bulk drug

      ANALYTICA CHIMICA ACTA
    64. Fisk, NM; Calder, AA; Cameron, AD; Elder, MG; Fusi, L; Greer, IA; Lamont, RF; Mason, GC; Owen, E; Steer, PJ; Tuffnell, DJ; Walker, J; Marsal, K; Ekman-Ordeberg, G; Gudmundsson, S; Ingemarsson, I; Lyrenas, S; Mattsson, LA; Molin, A; Thomassen, P; Wennergren, M; Weber, T; Andersen, LF; Lyndrup, J; Presl, J; Bouda, J; Cech, E; Koliba, P; Kucera, P; Kudela, M; Pilka, L; Unzeitig, V; Zivny, J
      The oxytocin antagonist atosiban versus the beta-agonist terbutaline in the treatment of preterm labor - A randomized, double-blind, controlled study

      ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
    65. Zarkovic, JP; Marenk, M; Valovirta, E; Kuusela, AL; Sandahl, G; Persson, B; Olsson, H
      One-year safety study with bambuterol once daily and terbutaline three times daily in 2-12-year-old children with asthma

      PEDIATRIC PULMONOLOGY
    66. Kuusela, AL; Marenk, M; Sandahl, G; Sanderud, J; Nikolajev, K; Persson, B; Olsson, H
      Comparative study using oral solutions of bambuterol once daily or terbutaline three times daily in 2-5-year-old children with asthma

      PEDIATRIC PULMONOLOGY
    67. Khazaeinia, T; Ramsey, AA; Tam, YK
      The effects of exercise on the pharmacokinetics of drugs

      JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
    68. Herring, VL; Johnson, JA
      Simple method for determination of terbutaline plasma concentration by high-performance liquid chromatography

      JOURNAL OF CHROMATOGRAPHY B
    69. Au, DH; Lemaitre, RN; Curtis, JR; Smith, NL; Psaty, BM
      The risk of myocardial infarction associated with inhaled beta-adrenoceptor agonists

      AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
    70. Lazrak, A; Nielsen, VG; Matalon, S
      Mechanisms of increased Na+ transport in ATII cells by cAMP: we agree to disagree and do more experiments

      AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
    71. O'Grady, SM; Jiang, XP; Ingbar, DH
      Cl-channel activation is necessary for stimulation of Na transport in adult alveolar epithelial cells

      AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
    72. Airaghi, L; Montori, D; Santambrogio, L; Miadonna, A; Tedeschi, A
      Chronic systemic capillary leak syndrome. Report of a case and review of the literature

      JOURNAL OF INTERNAL MEDICINE
    73. Hancox, RJ; Cowan, JO; Flannery, EM; Herbison, GP; McLachlan, CR; Taylor, DR
      Bronchodilator tolerance and rebound bronchoconstriction during regular inhaled beta-agonist treatment

      RESPIRATORY MEDICINE
    74. Arvidsson, P; Mellen, A; Palmqvist, M; Lotvall, J
      Equivalent therapeutic ratio of salbutamol given by Turbuhaler (R) and Diskus (TM)

      RESPIRATORY MEDICINE
    75. Seberova, E; Andersson, A
      Oxis (R) (formoterol given by Turbuhaler (R)) showed as rapid an onset of action as salbutamol given by a pMDI

      RESPIRATORY MEDICINE
    76. Hawksworth, GM; James, L; Chrystyn, H
      Characterization of the inspiratory manoeuvre when asthmatics inhale through a Turbohaler pre- and post-counselling in a community pharmacy

      RESPIRATORY MEDICINE
    77. Koskela, T; Malmstrom, K; Sairanen, U; Peltola, S; Keski-Karhu, J; Silvasti, M
      Efficacy of salbutamol via Easyhaler (R) unaffected by low inspiratory flow

      RESPIRATORY MEDICINE
    78. Chege, JK; Chrystyn, H
      The relative bioavailability of salbutamol to the lung using urinary excretion following inhalation from a novel dry powder inhaler: the effect of inhalation rate and formulation

      RESPIRATORY MEDICINE
    79. Jonasson, G; Carlsen, KH; Hultquist, C
      Low-dose budesonide improves exercise-induced bronchospasm in schoolchildren

      PEDIATRIC ALLERGY AND IMMUNOLOGY
    80. Newman, SP; Pitcairn, GR; Hirst, PH; Bacon, RE; O'Keefe, E; Reiners, M; Hermann, R
      Scintigraphic comparison of budesonide deposition from two dry powder inhalers

      EUROPEAN RESPIRATORY JOURNAL
    81. Gershman, NH; Wong, HH; Liu, JT; Fahy, JV
      Low- and high-dose fluticasone propionate in asthma; effects during and after treatment

      EUROPEAN RESPIRATORY JOURNAL
    82. Packham, S
      Difficult asthma

      EUROPEAN RESPIRATORY JOURNAL
    83. Pitcairn, GR; Lankinen, T; Seppala, OP; Newman, SP
      Pulmonary drug delivery from the Taifun dry powder inhaler is relatively independent of the patient's inspiratory effort

      JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
    84. Balzano, G; Battiloro, R; Biraghi, M; Stefanelli, F; Fuschillo, S; Gaudiosi, C; De Angelis, E
      Effectiveness and acceptability of a domiciliary multidrug inhalation treatment in elderly patients with chronic airflow obstruction: Metered dose inhaler versus jet nebulizer

      JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
    85. Ramon, M; Juan, G; Ciscar, MA; Marti-Bonmati, E; Morcillo, EJ; Marin, J
      Influence of low temperature on bronchodilatation induced by terbutaline administered by metered dose or dry powder inhalers in asthmatics

      FUNDAMENTAL & CLINICAL PHARMACOLOGY
    86. Majeed, S; Schor, JA; Jacobson, S; Jagoda, A; Mahadeo, R
      Refractory priapism of unknown etiology in a pediatric patient

      PEDIATRIC EMERGENCY CARE
    87. Belal, F; Al-Malaq, HA; Al-Majed, AA
      Voltammetric determination of isoxsuprine and fenoterol in dosage forms and biological fluids through nitrosation

      JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
    88. Wollmer, P; Backstrom, K; Zhao, H; Nilsson, PG; Jonson, B
      Surface active agents as enhancers of alveolar absorption

      PHARMACEUTICAL RESEARCH
    89. Cuna, M; Jato, JLV; Torres, D
      Controlled-release liquid suspensions based on ion-exchange particles entrapped within acrylic microcapsules

      INTERNATIONAL JOURNAL OF PHARMACEUTICS
    90. Borgstrom, L; Bengtsson, T; Derom, E; Pauwels, R
      Variability in lung deposition of inhaled drug, within and between asthmatic patients, with a pMDI and a dry powder inhaler, Turbuhaler (R)

      INTERNATIONAL JOURNAL OF PHARMACEUTICS
    91. Aboul-Enein, HY; Surmeian, M
      Analysis of salbutamol and related impurities by derivative spectrometry

      ARCHIV DER PHARMAZIE
    92. Fischer, R; Peters, A; Klein, M; Leschke, M; Schneider, M
      Systemic capillary leak syndrome - unusual cause of myalgia and elevated creatinkinase

      ZEITSCHRIFT FUR RHEUMATOLOGIE
    93. Chrystyn, H
      Methods to determine lung distribution of inhaled drugs - could gamma scintigraphy be the gold standard?

      BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    94. Newman, SP
      Can lung deposition data act as a surrogate for the clinical response to inhaled asthma drugs?

      BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    95. Rosenborg, J; Larsson, P; Nyberg, L
      Pharmacokinetics of bambuterol during oral administration of plain tabletsand solution to healthy adults

      BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    96. Zhang, M; Fawcett, JP; Kennedy, JM; Shaw, JP
      Stereoselective glucuronidation of formoterol by human liver microsomes

      BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    97. Mittendorf, R; Pryde, PG
      An overview of the possible relationship between antenatal pharmacologic magnesium and cerebral palsy

      JOURNAL OF PERINATAL MEDICINE
    98. Langford, NJ; Kendall, MJ
      Pulmonary heart disease - the need for evidence-based management

      JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
    99. Kim, KH; Kim, HJ; Hong, SP; Shin, SD
      Determination of terbutaline enantiomers in human plasma by coupled achiral-chiral high performance liquid chromatogaphy

      ARCHIVES OF PHARMACAL RESEARCH
    100. Kim, KH; Kim, DS; Hong, SP; Keon, OS
      Reversed-phase high performance liquid chromatographic separation of the enantiomers of terbutaline by derivatization with 2,3,4,6-tetra-D-acetyl-beta-D-glucopyranosyl isothiocyanate

      ARCHIVES OF PHARMACAL RESEARCH


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Documento generato il 15/01/21 alle ore 21:43:54