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La ricerca find articoli where soggetti phrase all words 'TATA-BINDING PROTEIN' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 918 riferimenti
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    1. Bruce, JW; Wilcox, KW
      Identification of a motif in the C terminus of herpes simplex virus regulatory protein ICP4 that contributes to activation of transcription

      JOURNAL OF VIROLOGY
    2. Marmorstein, R
      Protein modules that manipulate histone tails for chromatin regulation

      NATURE REVIEWS MOLECULAR CELL BIOLOGY
    3. Muhlhausser, P; Muller, EC; Otto, A; Kutay, U
      Multiple pathways contribute to nuclear import of core histones

      EMBO REPORTS
    4. Thiel, G; Lietz, M; Bach, K; Guethlein, L; Cibelli, G
      Biological activity of mammalian transcriptional repressors

      BIOLOGICAL CHEMISTRY
    5. Matsuda, T; Fujikawa, R; Haruki, M; Tang, XF; Ezaki, S; Imanaka, T; Morikawa, M; Kanaya, S
      Interaction of TIP26 from a hyperthermophilic archaeon with TFB/TBP/DNA ternary complex

      EXTREMOPHILES
    6. Kartalou, M; Essigmann, JM
      Recognition of cisplatin adducts by cellular proteins

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    7. Fisher, DE
      The p53 tumor suppressor: Critical regulator of life & death in cancer

      APOPTOSIS
    8. Hara, K; Shiota, M; Kido, H; Ohtsu, Y; Kashiwagi, T; Iwahashi, J; Hamada, N; Mizoue, K; Tsumura, N; Kato, H; Toyoda, T
      Influenza virus RNA polymerase PA subunit is a novel serine protease with Ser624 at the active site

      GENES TO CELLS
    9. Kayukawa, K; Kitajima, Y; Tamura, T
      TBP-interacting protein TIP120A is a new global transcription activator with bipartite functional domains

      GENES TO CELLS
    10. Gregor, D; Pfeifer, F
      Use of a halobacterial bgaH reporter gene to analyse the regulation of gene expression in halophilic archaea

      MICROBIOLOGY-SGM
    11. Li, QQ; Bever, CT
      Comparison of RANTES chemokine induction by Th1 cytokines in human astroglial cell lines

      INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
    12. Shou, WY; Sakamoto, KM; Keener, J; Morimoto, KW; Traverso, EE; Azzam, R; Hoppe, GJ; Feldman, RMR; DeModena, J; Moazed, D; Charbonneau, H; Nomura, M; Deshaies, RJ
      Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit

      MOLECULAR CELL
    13. Martianov, I; Fimia, GM; Dierich, A; Parvinen, M; Sassone-Corsi, P; Davidson, I
      Late arrest of spermiogenesis and germ cell apoptosis in mice lacking the TBP-like TLF/TRF2 gene

      MOLECULAR CELL
    14. Liu, J; Grogan, L; Nau, MM; Allegra, CJ; Chu, E; Wright, JJ
      Physical interaction between p53 and primary response gene Egr-1

      INTERNATIONAL JOURNAL OF ONCOLOGY
    15. Deb, D; Lanyi, A; Scian, M; Keiger, J; Brown, DR; Le Roith, D; Deb, SP; Deb, S
      Differential modulation of cellular and viral promoters by p73 and p53

      INTERNATIONAL JOURNAL OF ONCOLOGY
    16. Zuhlke, C; Hellenbroich, Y; Dalski, A; Kononowa, N; Hagenah, J; Vieregge, P; Riess, O; Klein, C; Schwinger, E
      Different types of repeat expansion in the TATA-binding protein gene are associated with a new form of inherited ataxia

      EUROPEAN JOURNAL OF HUMAN GENETICS
    17. Huang, BQ; Zeng, QH; Bi, XH; Wang, YH; Li, YX
      Roles of histones and nucleosomes in gene transcription

      CHINESE SCIENCE BULLETIN
    18. Gangloff, YG; Romier, C; Thuault, S; Werten, S; Davidson, I
      The histone fold is a key structural motif of transcription factor TFIID

      TRENDS IN BIOCHEMICAL SCIENCES
    19. Veenstra, GJC; Wolffe, AP
      Gene-selective developmental roles of general transcription factors

      TRENDS IN BIOCHEMICAL SCIENCES
    20. Breyer, WA; Matthews, BW
      A structural basis for processivity

      PROTEIN SCIENCE
    21. Muller, F; Lakatos, L; Dantonel, JC; Strahle, U; Tora, L
      TBP is not universally required for zygotic RNA polymerase II transcription in zebrafish

      CURRENT BIOLOGY
    22. Virbasius, CMA; Holstege, FC; Young, RA; Green, MR
      Promoter-specific activation defects by a novel yeast TBP mutant compromised for TFIIB interaction

      CURRENT BIOLOGY
    23. Rachez, C; Freedman, LP
      Mediator complexes and transcription

      CURRENT OPINION IN CELL BIOLOGY
    24. Offer, H; Milyavsky, M; Erez, N; Matas, D; Zurer, I; Harris, CC; Rotter, V
      Structural and functional involvement of p53 in BER in vitro and in vivo

      ONCOGENE
    25. Jung, MS; Yun, J; Chae, HD; Kim, JM; Kim, SC; Choi, TS; Shin, DY
      p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor

      ONCOGENE
    26. Purrello, M; Di Pietro, C; Rapisarda, A; Amico, V; Giunta, V; Engel, H; Stevens, S; Hsieh, YJ; Teichman, M; Wang, ZX; Sichel, G; Roeder, R; Grzeschik, KH
      Genes for human general transcription initiation factors TFIIIB, TFIIIB-associated proteins, TFIIIC2 and PTF/SNAPC: functional and positional candidates for tumour predisposition or inherited genetic diseases?

      ONCOGENE
    27. Wu, YL; Mehew, JW; Heckman, CA; Arcinas, M; Boxer, LM
      Negative regulation of bcl-2 expression by p53 in hematopoietic cells

      ONCOGENE
    28. Koch, KA; Allard, S; Santoro, N; Cote, J; Thiele, DJ
      The Candida glabrata Amt1 copper-sensing transcription factor requires Swi/Snf and Gcn5 at a critical step in copper detoxification

      MOLECULAR MICROBIOLOGY
    29. Guha, M; Mackman, N
      LPS induction of gene expression in human monocytes

      CELLULAR SIGNALLING
    30. Hiller, MA; Lin, TY; Wood, C; Fuller, MT
      Developmental regulation of transcription by a tissue-specific TAF homolog

      GENES & DEVELOPMENT
    31. Howe, L; Auston, D; Grant, P; John, S; Cook, RG; Workman, JL; Pillus, L
      Histone H3 specific acetyltransferases are essential for cell cycle progression

      GENES & DEVELOPMENT
    32. Bhaumik, SR; Green, MR
      SAGA is an essential in vivo target of the yeast acidic activator Gal4p

      GENES & DEVELOPMENT
    33. Larschan, E; Winston, F
      The S-cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4

      GENES & DEVELOPMENT
    34. Stargell, LA; Ogg, RC; Adkins, JN; Robinson, MM; Lumb, KJ
      Transcriptional activity of the TFIIA four-helix bundle in vivo

      PROTEINS-STRUCTURE FUNCTION AND GENETICS
    35. Yang, XH; Taylor, L; Polgar, P
      p53 down-regulates human bradykinin B1 receptor gene expression

      JOURNAL OF CELLULAR BIOCHEMISTRY
    36. Sampson, ER; Yeh, SY; Chang, HC; Tsai, MY; Wang, X; Ting, HJ; Chang, C
      Identification and characterization of androgen receptor associated coregulators in prostate cancer cells

      JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
    37. Gilinger, G; Bellofatto, V
      Trypanosome spliced leader RNA genes contain the first identified RNA polymerase II gene promoter in these organisms

      NUCLEIC ACIDS RESEARCH
    38. Huang, Y; Maraia, RJ
      Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human

      NUCLEIC ACIDS RESEARCH
    39. Kojima, K; Hayakawa, T; Asano, S; Bando, H
      Tandem repetition of baculovirus ie1 promoter results in upregulation of transcription - Brief report

      ARCHIVES OF VIROLOGY
    40. Qiao, L; Leach, K; McKinstry, R; Gilfor, D; Yacoub, A; Park, JS; Grant, S; Hylemon, PB; Fisher, PB; Dent, P
      Hepatitis B virus X protein increases expression of p(21Cip-1/WAF1/MDA6) and p(27Kip-1) in primary mouse hepatocytes, leading to reduced cell cycle progression

      HEPATOLOGY
    41. Panov, KI; Friedrich, JK; Zomerdijk, JCBM
      A step subsequent to preinitiation complex assembly at the ribosomal RNA gene promoter is rate limiting for human RNA polymerase I-dependent transcription

      MOLECULAR AND CELLULAR BIOLOGY
    42. Geisberg, JV; Holstege, FC; Young, RA; Struhl, K
      Yeast NC2 associates with the RNA polymerase II preinitiation complex and selectively affects transcription in vivo

      MOLECULAR AND CELLULAR BIOLOGY
    43. Park, JM; Gim, BS; Kim, JM; Yoon, JH; Kim, HS; Kang, JG; Kim, YJ
      Drosophila mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters

      MOLECULAR AND CELLULAR BIOLOGY
    44. Mencia, M; Struhl, K
      Region of yeast TAF 130 required for TFIID to associate with promoters

      MOLECULAR AND CELLULAR BIOLOGY
    45. Seigneurin-Berny, D; Verdel, A; Curtet, S; Lemercier, C; Garin, J; Rousseaux, S; Khochbin, S
      Identification of components of the murine histone deacetylase 6 complex: Link between acetylation and ubiquitination signaling pathways

      MOLECULAR AND CELLULAR BIOLOGY
    46. Waris, G; Huh, KW; Siddiqui, A
      Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress

      MOLECULAR AND CELLULAR BIOLOGY
    47. Durso, RJ; Fisher, AK; Albright-Frey, TJ; Reese, JC
      Analysis of TAF90 mutants displaying allele-specific and broad defects in transcription

      MOLECULAR AND CELLULAR BIOLOGY
    48. Guermah, M; Tao, Y; Roeder, RG
      Positive and negative TAF(II) functions that suggest a dynamic TFIID structure and elicit synergy with TRAPs in activator-induced transcription

      MOLECULAR AND CELLULAR BIOLOGY
    49. Shen, CH; Leblanc, BP; Alfieri, JA; Clark, DJ
      Remodeling of yeast CUP1 chromatin involves activator-dependent repositioning of nucleosomes over the entire gene and flanking sequences

      MOLECULAR AND CELLULAR BIOLOGY
    50. Hernandez-Hernandez, A; Ferrus, A
      Prodos is a conserved transcriptional regulator that interacts with dTAF(II)16 in Drosophila melanogaster

      MOLECULAR AND CELLULAR BIOLOGY
    51. Martin, MP; Gerlach, VL; Brow, DA
      A novel upstream RNA polymerase III promoter element becomes essential when the chromatin structure of the yeast U6 RNA gene is altered

      MOLECULAR AND CELLULAR BIOLOGY
    52. Shirra, MK; Patton-Vogt, J; Ulrich, A; Liuta-Tehlivets, O; Kohlwein, SD; Henry, SA; Arndt, KM
      Inhibition of acetyl coenzyme a carboxylase activity restores expression of the INO1 gene in a snf1 mutant strain of Saccharomyces cerevisiae

      MOLECULAR AND CELLULAR BIOLOGY
    53. Sullivan, EK; Weirich, CS; Guyon, JR; Sif, S; Kingston, RE
      Transcriptional activation domains of human heat shock factor 1 recruit human SWI/SNF

      MOLECULAR AND CELLULAR BIOLOGY
    54. Aprikian, P; Moorefield, B; Reeder, RH
      New model for the yeast RNA polymerase I transcription cycle

      MOLECULAR AND CELLULAR BIOLOGY
    55. Gangloff, YG; Pointud, JC; Thuault, S; Carre, L; Romier, C; Muratoglu, S; Brand, M; Tora, L; Couderc, JL; Davidson, I
      The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) arenovel metazoan homologues of yeast TAF(II)47 containing a histone fold anda PHD finger

      MOLECULAR AND CELLULAR BIOLOGY
    56. Faitar, SL; Brodie, SA; Ponticelli, AS
      Promoter-specific shifts in transcription initiation conferred by yeast TFIIB mutations are determined by the sequence in the immediate vicinity of the start sites

      MOLECULAR AND CELLULAR BIOLOGY
    57. Stafford, GA; Morse, RH
      GCN5 dependence of chromatin remodeling and transcriptional activation by the GAL4 and VP16 activation domains in budding yeast

      MOLECULAR AND CELLULAR BIOLOGY
    58. Murray, S; Udupa, R; Yao, S; Hartzog, G; Prelich, G
      Phosphorylation of the RNA polymerase II carboxy-terminal domain by the Bur1 cyclin-dependent kinase

      MOLECULAR AND CELLULAR BIOLOGY
    59. Yamamoto, S; Watanabe, Y; van der Spek, PJ; Watanabe, T; Fujimoto, H; Hanaoka, F; Ohkuma, Y
      Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation

      MOLECULAR AND CELLULAR BIOLOGY
    60. Mehra-Chaudhary, R; Matsui, H; Raghow, R
      Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter

      BIOCHEMICAL JOURNAL
    61. Darst, RP; Wang, DY; Auble, DT
      MOT1-catalyzed TBP-DNA disruption: uncoupling DNA conformational change and role of upstream DNA

      EMBO JOURNAL
    62. Miller, G; Panov, KI; Friedrich, JK; Trinkle-Mulcahy, L; Lamond, AI; Zomerdijk, JCBM
      hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters

      EMBO JOURNAL
    63. Brand, M; Moggs, JG; Oulad-Abdelghani, M; Lejeune, F; Dilworth, FJ; Stevenin, J; Almouzni, G; Tora, L
      UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation

      EMBO JOURNAL
    64. Kassavetis, GA; Letts, GA; Geiduschek, EP
      The RNA polymerase III transcription initiation factor TFIIIB participatesin two steps of promoter opening

      EMBO JOURNAL
    65. Sullivan, GJ; Bridger, JM; Cuthbert, AP; Newbold, RF; Bickmore, WA; McStay, B
      Human acrocentric chromosomes with transcriptionally silent nucleolar organizer regions associate with nucleoli

      EMBO JOURNAL
    66. Purcell, NH; Yu, CF; He, DY; Xiang, JL; Paran, N; DiDonato, JA; Yamaoka, S; Shaul, Y; Lin, AN
      Activation of NF-kappa B by hepatitis B virus X protein through an I kappaB kinase-independent mechanism

      AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
    67. Forsberg, H; Ljungdahl, PO
      Sensors of extracellular nutrients in Saccharomyces cerevisiae

      CURRENT GENETICS
    68. Kamada, K; Shu, F; Chen, H; Malik, S; Stelzer, G; Roeder, RG; Meisterernst, M; Burley, SK
      Crystal structure of Negative Cofactor 2 recognizing the TBP-DNA transcription complex

      CELL
    69. Cohen, SM; Lippard, SJ
      Cisplatin: From DNA damage to cancer chemotherapy

      PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 67
    70. Roth, SY; Denu, JM; Allis, CD
      Histone acetyltransferases

      ANNUAL REVIEW OF BIOCHEMISTRY
    71. Naar, AM; Lemon, BD; Tjian, R
      Transcriptional coactivator complexes

      ANNUAL REVIEW OF BIOCHEMISTRY
    72. Soppa, J
      Basal and regulated transcription in Archaea

      ARCHAEA: ANCIENT MICROBES, EXTREME ENVIRONOMENTS, AND THE ORIGIN OF LIFE
    73. Bini, E; Blum, P
      Archaeal catabolite repression: A gene regulatory paradigm

      ARCHAEA: ANCIENT MICROBES, EXTREME ENVIRONOMENTS, AND THE ORIGIN OF LIFE
    74. Zhang, D; Penttila, TL; Morris, PL; Teichmann, M; Roeder, RG
      Spermiogenesis deficiency in mice lacking the Trf2 gene

      SCIENCE
    75. Mazzanti, M; Bustamante, JO; Oberleithner, H
      Electrical dimension of the nuclear envelope

      PHYSIOLOGICAL REVIEWS
    76. Lecerf, JM; Shirley, TL; Zhu, Q; Kazantsev, A; Amersdorfer, P; Housman, DE; Messer, A; Huston, JS
      Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    77. Fath, S; Milkereit, P; Peyroche, G; Riva, M; Carles, C; Tschochner, H
      Differential roles of phosphorylation in the formation of transcriptional active RNA polymerase I

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    78. Cloutier, TE; Librizzi, MD; Mollah, AKMM; Brenowitz, M; Willis, IM
      Kinetic trapping of DNA by transcription factor IIIB

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    79. Hirst, M; Ho, C; Sabourin, L; Rudnicki, M; Penn, L; Sadowski, I
      A two-hybrid system for transactivator bait proteins

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    80. Bouchard, M; Giannakopoulos, S; Wang, EH; Tanese, N; Schneider, RJ
      Hepatitis B virus HBx protein activation of cyclin A-cyclin-dependent kinase 2 complexes and G(1) transit via a Src kinase pathway

      JOURNAL OF VIROLOGY
    81. Vance, KW; Campo, MS; Morgan, IM
      A novel silencer element in the bovine papillomavirus type 4 promoter represses the transcriptional response to papillomavirus E2 protein

      JOURNAL OF VIROLOGY
    82. Su, F; Theodosis, CN; Schneider, RJ
      Role of NF-kappa B and Myc proteins in apoptosis induced by hepatitis B virus HBx protein

      JOURNAL OF VIROLOGY
    83. Geiduschek, EP; Kassavetis, GA
      The RNA polymerase III transcription apparatus

      JOURNAL OF MOLECULAR BIOLOGY
    84. Thomsen, J; De Biase, A; Kaczanowski, S; Macario, AJL; Thomm, M; Zielenkiewicz, P; MacColl, R; de Macario, EC
      The basal transcription factors TBP and TFB from the mesophilic archaeon Methanosarcina mazeii: Structure and conformational changes upon interactionwith stress-gene promoters

      JOURNAL OF MOLECULAR BIOLOGY
    85. Vautier, D; Chesne, P; Cunha, C; Calado, A; Renard, JP; Carmo-Fonseca, M
      Transcription-dependent nucleocytoplasmic distribution of hnRNP A1 proteinin early mouse embryos

      JOURNAL OF CELL SCIENCE
    86. Wassarman, DA; Sauer, F
      TAF(II)250: a transcription toolbox

      JOURNAL OF CELL SCIENCE
    87. Shenk, JL; Fisher, CJ; Chen, SY; Zhou, XF; Tillman, K; Shemshedini, L
      p53 represses androgen-induced transactivation of prostate-specific antigen by disrupting hAR amino- to carboxyl-terminal interaction

      JOURNAL OF BIOLOGICAL CHEMISTRY
    88. Langelier, MF; Forget, D; Rojas, A; Porlier, Y; Burton, ZF; Coulombe, B
      Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II

      JOURNAL OF BIOLOGICAL CHEMISTRY
    89. Sampath, J; Sun, DX; Kidd, VJ; Grenet, J; Gandhi, A; Shapiro, LH; Wang, QJ; Zambetti, GP; Schuetz, JD
      Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 notMRP1

      JOURNAL OF BIOLOGICAL CHEMISTRY
    90. Guiral, M; Bess, K; Goodwin, G; Jayaraman, PS
      PRH represses transcription in hematopoietic cells by at least two independent mechanisms

      JOURNAL OF BIOLOGICAL CHEMISTRY
    91. Gomez-Gonzalo, M; Carretero, M; Rullas, J; Lara-Pezzi, E; Aramburu, J; Berkhout, B; Alcami, J; Lopez-Cabrera, M
      The hepatitis B virus X protein induces HIV-1 replication and transcription in synergy with T-cell activation signals - Functional roles of NF-kappa B/NF-AT and SP1-binding sites in the HIV-1 long terminal repeat promoter

      JOURNAL OF BIOLOGICAL CHEMISTRY
    92. Carter, AB; Tephly, LA; Hunninghake, GW
      The absence of activator protein 1-dependent gene expression in THP-1 macrophages stimulated with phorbol esters is due to lack of p38 mitogen-activated protein kinase activation

      JOURNAL OF BIOLOGICAL CHEMISTRY
    93. Lang, SE; McMahon, SB; Cole, MD; Hearing, P
      E2F transcriptional activation requires TRRAP and GCN5 cofactors

      JOURNAL OF BIOLOGICAL CHEMISTRY
    94. Chen, BS; Sun, ZW; Hampsey, M
      A Ga14-sigma(54) hybrid protein that functions as a potent activator of RNA polymerase II transcription in yeast

      JOURNAL OF BIOLOGICAL CHEMISTRY
    95. Forgues, M; Marrogi, AJ; Spillare, EA; Wu, CG; Yang , Q; Yoshida, M; Wang, XW
      Interaction of the hepatitis B virus X protein with the Crm1-dependent nuclear export pathway

      JOURNAL OF BIOLOGICAL CHEMISTRY
    96. Eichhorn, K; Jackson, SP
      A role for TAF3B2 in the repression of human RNA polymerase III transcription in nonproliferating cells

      JOURNAL OF BIOLOGICAL CHEMISTRY
    97. Scott, PH; Cairns, CA; Sutcliffe, JE; Alzuherri, HM; McLees, A; Winter, AG; White, RJ
      Regulation of RNA polymerase III transcription during cell cycle entry

      JOURNAL OF BIOLOGICAL CHEMISTRY
    98. Hong, TM; Chen, JJW; Peck, K; Yang, PC; Wu, CW
      p53 amino acids 339-346 represent the minimal p53 repression domain

      JOURNAL OF BIOLOGICAL CHEMISTRY
    99. Martin, AG; San-Antonio, B; Fresno, M
      Regulation of nuclear factor kappa B transactivation - Implication of phosphatidylinositol 3-kinase and protein kinase C xi IN c-Rel activation by tumor necrosis factor alpha

      JOURNAL OF BIOLOGICAL CHEMISTRY
    100. Uranishi, H; Tetsuka, T; Yamashita, M; Asamitsu, K; Shimizu, M; Itoh, M; Okamoto, T
      Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator

      JOURNAL OF BIOLOGICAL CHEMISTRY


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Documento generato il 22/10/20 alle ore 12:22:01