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    1. Barril, X; Gelpi, JL; Lopez, JM; Orozco, M; Luque, FJ
      How accurate can molecular dynamics/linear response and Poisson-Boltzmann/solvent accessible surface calculations be for predicting relative binding affinities? Acetylcholinesterase huprine inhibitors as a test case

      THEORETICAL CHEMISTRY ACCOUNTS
    2. Doody, RS; Dunn, JK; Clark, CM; Farlow, M; Foster, NL; Liao, T; Gonzales, N; Lai, E; Massman, P
      Chronic donepezil treatment is associated with slowed cognitive decline inAlzheimer's disease

      DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
    3. Almkvist, O; Jelic, V; Amberla, K; Hellstrom-Lindahl, E; Meurling, L; Nordberg, A
      Responder characteristics to a single oral dose of cholinesterase inhibitor: A double-blind placebo-controlled study with tacrine in Alzheimer patients

      DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
    4. Broadley, KJ; Kelly, DR
      Muscarinic receptor agonists and antagonists

      MOLECULES
    5. Sramek, JJ; Veroff, AE; Cutler, NR
      The status of ongoing trials for mild cognitive impairment

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    6. Winblad, B; Bonura, ML; Rossini, BM; Battaglia, A
      Nicergoline in the treatment of mild-to-moderate Alzheimer's disease - A European multicentre trial

      CLINICAL DRUG INVESTIGATION
    7. Landi, F; Onder, G; Zuccala, G; Russo, A; Lattanzio, F; Cesari, M; Bernabei, R
      Non-scientific drug prescription in demented older people living in the community - An Italian perspective

      CLINICAL DRUG INVESTIGATION
    8. Giacobini, E
      Do cholinesterase inhibitors have disease-modifying effects in Alzheimer'sdisease?

      CNS DRUGS
    9. McDonnell, J; Redekop, WK; van der Roer, N; Goes, E; Ruitenberg, A; Busschbach, JJV; Breteler, MMB; Rutten, FFH
      The cost of treatment of Alzheimer's disease in the Netherlands - A regression-based simulation model

      PHARMACOECONOMICS
    10. Zhu, H; Rockhold, RW; Baker, RC; Kramer, RE; Ho, IK
      Effects of single or repeated dermal exposure to methyl parathion on behavior and blood cholinesterase activity in rats

      JOURNAL OF BIOMEDICAL SCIENCE
    11. Tabarrini, O; Cecchetti, V; Temperini, A; Filipponi, E; Lamperti, MG; Fravolini, A
      Velnacrine thiaanalogues as potential agents for treating Alzheimer's disease

      BIOORGANIC & MEDICINAL CHEMISTRY
    12. Wang, R; Xiao, XQ; Tang, XC
      Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells

      NEUROREPORT
    13. Owen, GS; Halliwell, JV
      Electrophysiological characterization of laminar synaptic inputs to the olfactory tubercle of the rat studied in vitro: modulation of glutamatergic transmission by cholinergic agents is pathway-specific

      EUROPEAN JOURNAL OF NEUROSCIENCE
    14. Mega, MS; Cummings, JL; O'Connor, SM; Dinov, ID; Reback, E; Felix, J; Masterman, DL; Phelps, MF; Small, GW; Toga, AW
      Cognitive and metabolic responses to metrifonate therapy in Alzheimer disease

      NEUROPSYCHIATRY NEUROPSYCHOLOGY AND BEHAVIORAL NEUROLOGY
    15. DeKosky, ST; Ferris, SH
      Cornerstones in the management of Alzheimer's disease - CME accredited symposium at World Alzheimer Congress (WAC) 2000 Meeting - 9-18 July 2000 - Washington DC, USA - Introduction

      ALZHEIMER DISEASE & ASSOCIATED DISORDERS
    16. Schneider, LS
      Assessing outcomes in Alzheimer disease

      ALZHEIMER DISEASE & ASSOCIATED DISORDERS
    17. Tariot, PN
      Maintaining cognitive function in Alzheimer disease: How effective are current treatments?

      ALZHEIMER DISEASE & ASSOCIATED DISORDERS
    18. Cummings, JL; Nadel, A; Masterman, D; Cyrus, PA
      Efficacy of metrifonate in improving the psychiatric and behavioral disturbances of patients with Alzheimer's disease

      JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
    19. Hake, AM
      Use of cholinesterase inhibitors for treatment of Alzheimer disease

      CLEVELAND CLINIC JOURNAL OF MEDICINE
    20. Wilkinson, D; Murray, J
      Galantamine: a randomized, double-blind, dose comparison in patients with Alzheimer's disease

      INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
    21. Schneider, LS
      Treatment of Alzheimer's disease with cholinesterase inhibitors

      CLINICS IN GERIATRIC MEDICINE
    22. Rivas-Vazquez, RA
      Cholinesterase inhibitors: Current pharmacological treatments for Alzheimer's disease

      PROFESSIONAL PSYCHOLOGY-RESEARCH AND PRACTICE
    23. Wainwright, M
      Acridine - a neglected antibacterial chromophore

      Journal of antimicrobial chemotherapy
    24. Beach, TG; Kuo, YM; Schwab, C; Walker, DG; Roher, AE
      Reduction of cortical amyloid beta levels in guinea pig brain after systemic administration of physostigmine

      NEUROSCIENCE LETTERS
    25. Sjogren, M; Hesse, C; Basun, H; Kol, G; Thostrup, H; Kilander, L; Marcusson, J; Edman, A; Wallin, A; Karlsson, I; Troell, M; Wachtmaister, G; Ekdahl, A; Olofsson, H; Sandstrom, A; Andreasen, N; Minthon, L; Blennow, K
      Tacrine and rate of progression in Alzheimer's disease - relation to ApoE allele genotype

      JOURNAL OF NEURAL TRANSMISSION
    26. Werber, EA; Rabey, JM
      The beneficial effect of cholinesterase inhibitors on patients suffering from Parkinson's disease and dementia

      JOURNAL OF NEURAL TRANSMISSION
    27. Rainer, M; Mucke, HAM; Kruger-Rainer, C; Kraxberger, E; Haushofer, M; Jellinger, KA
      Cognitive relapse after discontinuation of drug therapy in Alzheimer's disease: cholinesterase inhibitors versus nootropics

      JOURNAL OF NEURAL TRANSMISSION
    28. Gauthier, S
      Alzheimer's disease: Current and future therapeutic perspectives

      PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
    29. Higgins, JPT; Whitehead, A; Turner, RM; Omar, RZ; Thompson, SG
      Meta-analysis of continuous outcome data from individual patients

      STATISTICS IN MEDICINE
    30. Chen, Z; Chen, JQ; Kamei, C
      Effect of H-1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats

      ACTA PHARMACOLOGICA SINICA
    31. Pakaski, M; Rakonczay, Z; Kasa, P
      Reversible and irreversible acetylcholinesterase inhibitors cause changes in neuronal amyloid precursor protein processing and protein kinase C levelin vitro

      NEUROCHEMISTRY INTERNATIONAL
    32. Hsieh, BH; Deng, JF; Ger, J; Tsai, WJ
      Acetylcholinesterase inhibition and the extrapyramidal syndrome: A review of the neurotoxicity of organophosphate

      NEUROTOXICOLOGY
    33. Schultz, RR; Siviero, MO; Bertolucci, PHF
      The cognitive subscale of the "Alzheimer's Disease Assessment Scale" in a Brazilian sample

      BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
    34. Pinsky, LE; Burke, W; Bird, TD
      Why should primary care physicians know about the genetics of dementia?

      WESTERN JOURNAL OF MEDICINE
    35. Parnetti, L; Amici, S; Lanari, A; Gallai, V
      Pharmacological treatment of non-cognitive disturbances in dementia disorders

      MECHANISMS OF AGEING AND DEVELOPMENT
    36. Savci, V; Cavun, S; Gurun, MS; Ulus, IH
      Reversal of haemorrhagic shock in rats by tetrahydroaminoacridine

      PHARMACOLOGY
    37. Keltner, NL; Zielinski, AL; Hardin, MS
      Drugs used for cognitive symptoms of Alzheimer's disease

      PERSPECTIVES IN PSYCHIATRIC CARE
    38. Winblad, B; Engedal, K; Soininen, H; Verhey, F; Waldemar, G; Wimo, A; Wetterholm, AL; Zhang, R; Haglund, A; Subbiah, P
      A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD

      NEUROLOGY
    39. Salamone, JD; Correa, M; Carlson, BB; Wisniecki, A; Mayorga, AJ; Nisenbaum, E; Nisenbaum, L; Felder, C
      Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents - Implications for cholinergic involvement in Parkinsonism

      LIFE SCIENCES
    40. Ros, E; Aleu, J; De Aranda, IG; Canti, C; Pang, YP; Marsal, J; Solsona, C
      Effects of bis(7)-tacrine on spontaneous synaptic activity and on the nicotinic ACh receptor of Torpedo electric organ

      JOURNAL OF NEUROPHYSIOLOGY
    41. Kim, WG; Song, NK; Yoo, ID
      Quinolactacins A1 and A2, new acetylcholinesterase inhibitors from Penicillium citrinum

      JOURNAL OF ANTIBIOTICS
    42. Ros, E; Aleu, J; de Aranda, IG; Munoz-Torrero, D; Camps, P; Badia, A; Marsal, J; Solsona, C
      The pharmacology of novel acetylcholinesterase inhibitors, (+/-)-huprines Y and X, on the Torpedo electric organ

      EUROPEAN JOURNAL OF PHARMACOLOGY
    43. Grutzendler, J; Morris, JC
      Cholinesterase inhibitors for Alzheimer's disease

      DRUGS
    44. Volkow, ND; Ding, YS; Fowler, JS; Gatley, SJ
      Imaging brain cholinergic activity with positron emission tomography: Its role in the evaluation of cholinergic treatments in Alzheimer's dementia

      BIOLOGICAL PSYCHIATRY
    45. Coyle, J; Kershaw, P
      Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: Effects on the course of Alzheimer's disease

      BIOLOGICAL PSYCHIATRY
    46. Farlow, MR; Hake, A; Messina, J; Hartman, R; Veach, J; Anand, R
      Response of patients with Alzheimer disease to rivastigmine treatment is predicted by the rate of disease progression

      ARCHIVES OF NEUROLOGY
    47. Pirmohamed, M; Park, BK
      Genetic susceptibility to adverse drug reactions

      TRENDS IN PHARMACOLOGICAL SCIENCES
    48. Pickar, D; Rubinow, K
      Pharmacogenomics of psychiatric disorders

      TRENDS IN PHARMACOLOGICAL SCIENCES
    49. Nordberg, A; Jelic, V; Arnaiz, E; Langstrom, B; Almkvist, O
      Brain functional imaging in early and preclinical Alzheimer's disease

      ALZHEIMER'S DISEASE
    50. Pesti, JA; Chorvat, RJ; Huhn, GF
      A better drug for Alzheimer's?

      CHEMICAL INNOVATION
    51. Oddoze, C; Michel, BF; Lucotte, G
      Apolipoprotein E epsilon 4 allele predicts a better response to donepezil therapy in Alzheimer's disease

      ALZHEIMERS REPORTS
    52. Homma, A; Takeda, M; Imai, Y; Udaka, F; Hasegawa, K; Kameyama, M; Nishimura, T
      Clinical efficacy and safety of donepezil on cognitive and global functionin patients with Alzheimer's disease - A 24-week, multicenter, double-blind, placebo-controlled study in Japan

      DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
    53. Querfurth, HW; Allam, GJ; Geffroy, MA; Schiff, HB; Kaplan, RF
      Acetylcholinesterase inhibition in dementia with Lewy bodies: Results of aprospective pilot trial

      DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
    54. Farlow, MR; Cyrus, PA
      Metrifonate therapy in Alzheimer's disease: A pooled analysis of four randomized, double-blind, placebo-controlled trials

      DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
    55. Sramek, JJ; Frackiewicz, EJ; Cutler, NR
      Review of the acetylcholinesterase inhibitor galanthamine

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    56. Rigaud, AS; Traykov, L; Caputo, L; Guelfi, MC; Latour, F; Couderc, R; Moulin, F; de Rotrou, J; Forette, F; Boller, F
      The apolipoprotein E epsilon 4 allele and the response to tacrine therapy in Alzheimer's disease

      EUROPEAN JOURNAL OF NEUROLOGY
    57. Becker, R; Markwell, S
      Problems arising from the generalising of treatment efficacy from clinicaltrials in Alzheimer's disease - Mistaking statistical significance as clinical significance

      CLINICAL DRUG INVESTIGATION
    58. Cummings, JL; Askin-Edgar, S
      Evidence for psychotropic effects of acetylcholinesterase inhibitors

      CNS DRUGS
    59. Hauber, AB; Gnanasakthy, A; Snyder, EH; Bala, MV; Richter, A; Mauskopf, JA
      Potential savings in the cost of caring for Alzheimer's disease - Treatment with rivastigmine

      PHARMACOECONOMICS
    60. Dooley, M; Lamb, HM
      Donepezil - A review of its use in Alzheimer's disease

      DRUGS & AGING
    61. Delfini, M; Gianferri, R; Dubbini, V; Manetti, C; Gaggelli, E; Valensin, G
      H-1 NMR relaxation investigation of inhibitors interacting with Torpedo californica acetylcholinesterase

      JOURNAL OF MAGNETIC RESONANCE
    62. Pepping, J
      Huperzine A

      AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
    63. Schildein, S; Huston, JP; Schwarting, RKW
      Injections of tacrine and scopolamine into the nucleus accumbens: Opposingeffects of immediate vs delayed posttrial treatment on memory of an open field

      NEUROBIOLOGY OF LEARNING AND MEMORY
    64. Cummings, JL; Donohue, JA; Brooks, RL
      The relationship between donepezil and behavioral disturbances in patientswith Alzheimer's disease

      AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
    65. Braida, D; Virag, W; Ottonello, F; Sala, M
      Excitatory and inhibitory effects of second-generation cholinesterase inhibitors on rat gastrointestinal transit

      PHARMACOLOGICAL RESEARCH
    66. Bollo, S; Munoz, L; Nunez-Vergara, LJ; Squella, JA
      Electrochemical characterization of tacrine, an antialzheimer's disease drug, and its determination in pharmaceuticals

      ELECTROANALYSIS
    67. Rampa, A; Bisi, A; Belluti, F; Gobbi, S; Valenti, P; Andrisano, V; Cavrini, V; Cavalli, A; Recanatini, M
      Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: Molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives

      BIOORGANIC & MEDICINAL CHEMISTRY
    68. Plate, R; Plaum, MJM; Van der Hulst, RGA; de Boer, T
      Synthesis and in vitro muscarinic activities of a series of 3-(pyrazol-3-yl)-1-azabicyclo[2.2.2]octanes

      BIOORGANIC & MEDICINAL CHEMISTRY
    69. Jeyarasasingam, G; Yeluashvili, M; Quik, M
      Tacrine, a reversible acetylcholinesterase inhibitor, induces myopathy

      NEUROREPORT
    70. Kaufer, DI; Cummings, JL; Ketchel, P; Smith, V; MacMillan, A; Shelley, T; Lopez, OL; DeKosky, ST
      Validation of the NPI-Q, a brief clinical form of the neuropsychiatric inventory

      JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
    71. Bachynsky, J; McCracken, P; Lier, D; Alloul, K; Jacobs, P
      Propentofylline treatment for Alzheimer disease and vascular dementia: An economic evaluation based on functional abilities

      ALZHEIMER DISEASE & ASSOCIATED DISORDERS
    72. Blass, JP; Cyrus, PA; Bieber, F; Gulanski, B
      Randomized, double-blind, placebo-controlled, multicenter study to evaluate the safety and tolerability of metrifonate in patients with probable Alzheimer disease

      ALZHEIMER DISEASE & ASSOCIATED DISORDERS
    73. Homma, A
      Current status of clinical trials for Alzheimer-type dementia in Japan: Strategies to facilitate the development of antidementia drugs

      ALZHEIMER DISEASE & ASSOCIATED DISORDERS
    74. Liu, WF
      Effects of cholinesterase inhibitors on a two-component chained schedule performance in rats

      NEUROTOXICOLOGY AND TERATOLOGY
    75. Samuel, W; Caligiuri, M; Galasko, D; Lacro, J; Marini, M; McClure, FS; Warren, K; Jeste, DV
      Better cognitive and psychopathologic response to donepezil in patients prospectively diagnosed as dementia with Lewy bodies: A preliminary study

      INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
    76. McKeith, IG; Grace, JB; Walker, Z; Byrne, EJ; Wilkinson, D; Stevens, T; Perry, EK
      Rivastigmine in the treatment of dementia with Lewy bodies: Preliminary findings from an open trial

      INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
    77. Lanctot, KL; Herrmann, N
      Donepezil for behavioural disorders associated with Lewy bodies: A case series

      INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
    78. Grossberg, GT; Stahelin, HB; Messina, JC; Anand, R; Veach, J
      Lack of adverse pharmacodynamic drug interactions with rivastigmine and twenty-two classes of medications

      INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
    79. Carcenac, D; Martin-Hunyadi, C; Kiesmann, M; Demuynck-Roegel, C; Alt, M; Kuntzmann, F
      Extra-pyramidal syndrome in three Alzheimer patients given donepezil

      PRESSE MEDICALE
    80. Issa, AM; Keyserlingk, EW
      Apolipoprotein E genotyping for pharmacogenetic purposes in Alzheimer's disease: Emerging ethical issues

      CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
    81. Ogura, H; Kosasa, T; Kuriya, Y; Yamanishi, Y
      Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro

      METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
    82. Ogura, H; Kosasa, T; Kuriya, Y; Yamanishi, Y
      Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats

      METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
    83. Unni, L; Vicari, S; Moriearty, P; Schaefer, F; Becker, R
      The recovery of cerebrospinal fluid acetylcholinesterase activity in Alzheimer's disease patients after treatment with metrifonate

      METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
    84. Kim, JH; Cho, YJ; Choi, HK
      Effect of vehicles and pressure sensitive adhesives on the permeation of tacrine across hairless mouse skin

      INTERNATIONAL JOURNAL OF PHARMACEUTICS
    85. Giacobini, E
      Cholinesterase inhibitors stabilize Alzheimer disease

      NEUROCHEMICAL RESEARCH
    86. De Vos, F; Santens, P; Slegers, G; Vermeirsch, H; Dierckx, RA; De Reuck, J
      Synthesis of 1-benzyl-4-[(5,[C-11]6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine: a promising ligand for visualisation of acetylcholine esterase by PET

      JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
    87. Barnes, CA; Meltzer, J; Houston, F; Orr, G; McGann, K; Wenk, GL
      Chronic treatment of old rats with donepezil or galantamine: Effects on memory, hippocampal plasticity and nicotinic receptors

      NEUROSCIENCE
    88. Xiao, XQ; Lee, NTK; Carlier, PR; Pang, YP; Han, YF
      Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine

      NEUROSCIENCE LETTERS
    89. Han, YF; Wu, DC; Xiao, XA; Chen, PMY; Chung, W; Lee, NTK; Pang, YP; Carlier, PR
      Protection against ischemic injury in primary cultured astrocytes of mousecerebral cortex by bis(7)-tacrine, a novel anti-Alzheimer's agent

      NEUROSCIENCE LETTERS
    90. Liu, J; Ho, WL; Lee, NTK; Carlier, PR; Pang, YP; Han, YF
      Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats

      NEUROSCIENCE LETTERS
    91. Kameda, G; Dadmarz, M; Vogel, WH
      Influence of various drugs on the voluntary intake of nicotine by rats

      NEUROPSYCHOBIOLOGY
    92. Alhomida, AS; Al-Rajhi, AA; Kamal, MA; Al-Jafari, AA
      Kinetic analysis of the toxicological effect of tacrine (Cognex (R)) on human retinal acetylcholinesterase activity

      TOXICOLOGY
    93. Issa, AM; Keyserlingk, EW
      Current and future clinical trials for Alzheimer's disease: Evolving ethical concerns

      PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
    94. Dronfield, S; Egan, K; Marsden, CA; Green, AR
      Comparison of donepezil-, tacrine-, rivastigmine- and metrifonate-induced central and peripheral cholinergically mediated responses in the rat

      JOURNAL OF PSYCHOPHARMACOLOGY
    95. Pan, SY; Han, YF
      Learning deficits induced by 4 belladonna alkaloids are preferentially attenuated by tacrine

      ACTA PHARMACOLOGICA SINICA
    96. Gao, Y; Tang, XC; Guan, LC; Kuang, PZ
      Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick

      ACTA PHARMACOLOGICA SINICA
    97. Ye, JW; Shang, YZ; Wang, ZM; Tang, XC
      Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance

      ACTA PHARMACOLOGICA SINICA
    98. Martinez, A; Fernandez, E; Castro, A; Conde, S; Rodriguez-Franco, I; Banos, JE; Badia, A
      N-benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors

      EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
    99. Andreani, A; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Pietra, C; Villetti, G
      4-aminopyridine derivatives with antiamnesic activity

      EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
    100. Dringenberg, HC; Diavolitsis, P; Noseworthy, PA
      Effect of tacrine on EEG slowing in the rat: Enhancement by concurrent monoamine therapy

      NEUROBIOLOGY OF AGING


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Documento generato il 26/10/20 alle ore 03:54:30