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Relation between the flexibility of the WPD loop and the activity of the catalytic domain of protein tyrosine phosphatase SHP-1
JOURNAL OF CELLULAR BIOCHEMISTRY
Synthesis of protected L-4-[sulfono(difluoromethyl)]phenylalanine and its incorporation into a peptide
ORGANIC LETTERS
Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family
CLINICAL IMMUNOLOGY
Rapid sequencing of library-derived peptides by partial Edman degradation and mass spectrometry
JOURNAL OF COMBINATORIAL CHEMISTRY
Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway
NATURE CELL BIOLOGY
Inhibitors of p56(lck): assessing their potential as tools for manipulating T-lymphocyte activation
EXPERT OPINION ON THERAPEUTIC PATENTS
A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux
NATURE NEUROSCIENCE
Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling
MOLECULAR CELL
Maternal repression of the human GRB10 gene in the developing central nervous system; evaluation of the role for GRB70 in Silver-Russell syndrome
EUROPEAN JOURNAL OF HUMAN GENETICS
alpha-Ketocarboxylic acid-based inhibitors of protein tyrosine phosphatases
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Integrin tyrosine phosphorylation in platelet signaling
CURRENT OPINION IN CELL BIOLOGY
Proximal protein tyrosine kinases it immunoreceptor signaling
CURRENT OPINION IN IMMUNOLOGY
Src homology-2 domain binding assays by scintillation proximity and surface plasmon resonance
JOURNAL OF MOLECULAR RECOGNITION
Cell transformation by the middle T-antigen of polyoma virus
ONCOGENE
The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors
ONCOGENE
The adapter protein, Grb10, is a positive regulator of vascular endothelial growth factor signaling
ONCOGENE
Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia
ONCOGENE
Grb2 promotes reinitiation of meiosis in Xenopus oocytes
CELLULAR SIGNALLING
Hierarchy of simulation models in predicting molecular recognition mechanisms from the binding energy landscapes: Structural analysis of the peptide complexes with SH2 domains
PROTEINS-STRUCTURE FUNCTION AND GENETICS
The role of phosphoinositide 3-kinase in spreading osteoclasts induced by colony-stimulating factor-1
EUROPEAN JOURNAL OF ENDOCRINOLOGY
X-linked lymphoproliferative disease: A progressive immunodeficiency
ANNUAL REVIEW OF IMMUNOLOGY
Peptidomimetic SH2 domain antagonists for targeting signal transduction
BIOORGANIC CHEMISTRY OF BIOLOGICAL SIGNAL TRANSDUCTION
Specific inhibition by hGRB10 zeta of insulin-induced glycogen synthase activation: evidence for a novel signaling pathway
MOLECULAR AND CELLULAR ENDOCRINOLOGY
SH2-containing inositol 5 '-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading
MOLECULAR AND CELLULAR BIOLOGY
Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells
BIOCHEMICAL JOURNAL
A model of activation of the protein tyrosine phosphatase SHP-2 by the human leptin receptor
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
Profiling the global tyrosine phosphorylation state by Src homology 2 domain binding
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: Inhibition of PI3-K activity inhibits viral replication and virus-induced signaling
JOURNAL OF VIROLOGY
A redundant role of the CD3 gamma-immunoreceptor tyrosine-based activationmotif in mature T cell function
JOURNAL OF IMMUNOLOGY
Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor
JOURNAL OF CELL BIOLOGY
Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin
JOURNAL OF BIOLOGICAL CHEMISTRY
Insulin receptor-mediated p62(dok) tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt
JOURNAL OF BIOLOGICAL CHEMISTRY
Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptor
JOURNAL OF BIOLOGICAL CHEMISTRY
Multiple ErbB-2/Neu phosphorylation sites mediate transformation through distinct effector proteins
JOURNAL OF BIOLOGICAL CHEMISTRY
In vivo tyrosine phosphorylation sites of activated ephrin-B1 and EphB2 from neural tissue
JOURNAL OF BIOLOGICAL CHEMISTRY
Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells
JOURNAL OF BIOLOGICAL CHEMISTRY
Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts
JOURNAL OF BIOLOGICAL CHEMISTRY
Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2
JOURNAL OF BIOLOGICAL CHEMISTRY
Identification of a novel human tankyrase through its interaction with theadaptor protein Grb14
JOURNAL OF BIOLOGICAL CHEMISTRY
Negative regulation of receptor tyrosine kinase signals
FEBS LETTERS
EGF-dependent translocation of green fluorescent protein-tagged PLC-gamma 1 to the plasma membrane and endosomes
EXPERIMENTAL CELL RESEARCH
FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate
EXPERIMENTAL CELL RESEARCH
Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha
EUROPEAN JOURNAL OF IMMUNOLOGY
The protein tyrosine kinase Syk activity is reduced by clustering the mastcell function-associated antigen
EUROPEAN JOURNAL OF IMMUNOLOGY
Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells
ENDOCRINOLOGY
Tyrosine phosphorylation-dependent and -independent role of Shc in the regulation of IGF-1-induced mitogenesis and glycogen synthesis
ENDOCRINOLOGY
Insulin-independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin receptor from that of IRS-1
DIABETOLOGIA
Transformation of interleukin-3-dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor kappa B-mediated antiapoptosis involving c-IAP2
BLOOD
Visual detection of specific, native interactions between soluble and microbead-tethered alpha-helices from membrane proteins
BIOCHEMISTRY
TNF alpha elicits association of PI 3-kinase with the p60TNFR and activation of PI 3-kinase in adherent neutrophils
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Inhibitors to the Src SH2 domain: A lesson in structure-thermodynamic correlation in drug design
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Assay of protein tyrosine phosphatases by using matrix-assisted laser desorption ionization time-of-flight mass spectrometry
ANALYTICAL BIOCHEMISTRY
Control of B cell production by the adaptor protein Lnk: Definition of a conserved family of signal-modulating proteins
IMMUNITY
The regulation of protein function by multisite phosphorylation - a 25 year update
TRENDS IN BIOCHEMICAL SCIENCES
RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia
HUMAN MOLECULAR GENETICS
Why cytoplasmic signalling proteins should be recruited to cell membranes
TRENDS IN CELL BIOLOGY
Networks in signal transduction: the role of adaptor proteins in platelet activation
PLATELETS
Exploitation of host cell signaling machinery: activation of macrophage phosphotyrosine phosphatases as a novel mechanism of molecular microbial pathogenesis
JOURNAL OF LEUKOCYTE BIOLOGY
Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity
MOLECULAR AND CELLULAR BIOLOGY
Pleiotropic contributions of phospholipase C-gamma 1 (PLC-gamma 1) to T-cell antigen receptor-mediated signaling: Reconstitution studies of a PLC-gamma 1-deficient Jurkat T-cell line
MOLECULAR AND CELLULAR BIOLOGY
Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates itsRNA binding ability
MOLECULAR AND CELLULAR BIOLOGY
Adrenocorticotrophic hormone stimulates phosphotyrosine phosphatase SHP2 in bovine adrenocortical cells: phosphorylation and activation by cAMP-dependent protein kinase
BIOCHEMICAL JOURNAL
Early signaling via inhibitory and activating NK receptors
HUMAN IMMUNOLOGY
Association of phosphatidylinositol 3-kinase with the insulin receptor: compartmentation in rat liver
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Perinuclear localisation of the protein-tyrosine phosphatase SHP-1 and inhibition of epidermal growth factor-stimulated STAT1/3 activation in A431 cells
EUROPEAN JOURNAL OF CELL BIOLOGY
Tyrosine kinase SYK: essential functions for immunoreceptor signalling
IMMUNOLOGY TODAY
Lymphocytes with a complex: adapter proteins in antigen receptor signaling
IMMUNOLOGY TODAY
An unsolved problem of the clonal selection theory and the model of an oligomeric B-cell antigen receptor
IMMUNOLOGICAL REVIEWS
Signaling takes shape in the immune system
CELL
Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries
APPLICATIONS OF CHIMERIC GENES AND HYBRID PROTEINS, PT C
Different initiation of pre-TCR and gamma delta TCR signalling
NATURE
The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signaltransduction
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Ras-GAP binding and phosphorylation by herpes simplex virus type 2 RR1 PK (ICP10) and activation of the Ras/MEK/MAPK mitogenic pathway are required for timely onset of virus growth
JOURNAL OF VIROLOGY
Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M:Structural receptor requirements for signal attenuation
JOURNAL OF IMMUNOLOGY
Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation
JOURNAL OF IMMUNOLOGY
FMet-Leu-Phe stimulates proinflammatory cytokine gene expression in human peripheral blood monocytes: The role of phosphatidylinositol 3-kinase
JOURNAL OF IMMUNOLOGY
Phosphatidylinositol-3 ' kinase-dependent vesicle formation in macrophagesin response to macrophage colony stimulating factor
JOURNAL OF CELL SCIENCE
Differential roles of the Src homology 2 domains of phospholipase C-gamma l (PLC-gamma l) in platelet-derived growth factor-induced activation of PLC-gamma l in intact cells
JOURNAL OF BIOLOGICAL CHEMISTRY
Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs
JOURNAL OF BIOLOGICAL CHEMISTRY
ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells
JOURNAL OF BIOLOGICAL CHEMISTRY
Structural basis for substrate specificity of protein-tyrosine phosphataseSHP-1
JOURNAL OF BIOLOGICAL CHEMISTRY
PILR alpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearingprotein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILR beta
JOURNAL OF BIOLOGICAL CHEMISTRY
Phosphorylation of Syk activation loop tyrosines is essential for Syk function - An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibody
JOURNAL OF BIOLOGICAL CHEMISTRY
Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells
JOURNAL OF BIOLOGICAL CHEMISTRY
Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor
JOURNAL OF BIOLOGICAL CHEMISTRY
Insulin receptor substrate-1 expression is regulated by estrogen in the MCF-7 human breast cancer cell line
JOURNAL OF BIOLOGICAL CHEMISTRY
Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor
JOURNAL OF BIOLOGICAL CHEMISTRY
Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin II in endothelial cells - Roles of Yes tyrosine kinase and tyrosine phosphatase SHP-2
JOURNAL OF BIOLOGICAL CHEMISTRY
The APS adapter protein couples the insulin receptor to the phosphorylation of c-Cbl and facilitates ligand-stimulated ubiquitination of the insulin receptor
FEBS LETTERS
Two YxxL segments of a single immunoreceptor tyrosine-based activation motif in the CD3 zeta molecule differentially activate calcium mobilization and mitogen-activated protein kinase family pathways
EUROPEAN JOURNAL OF IMMUNOLOGY
An immunoreceptor tyrosine-based inhibitory motif, with serine at site Y-2, binds SH2-domain-containing phosphatases
EUROPEAN JOURNAL OF BIOCHEMISTRY
Nongenomic action of progesterone: Activation of Xenopus oocyte phospholipase C through a plasma membrane-associated tyrosine kinase
ENDOCRINOLOGY
Potential involvement of FRS2 in insulin signaling
ENDOCRINOLOGY
Glut-1 translocation in FRTL-5 thyroid cells: Role of phosphatidylinositol3-kinase and N-glycosylation
ENDOCRINOLOGY
Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity
DIABETOLOGIA
Pancreastatin modulates insulin signaling in rat adipocytes - Mechanisms of cross-talk
DIABETES
Sequential phosphorylation of protein band 3 by Syk and Lyn tyrosine kinases in intact human erythrocytes: identification of primary and secondary phosphorylation sites
BLOOD
Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation
BIOCHEMISTRY-MOSCOW
Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro
BIOCHEMISTRY
Molecular cloning of the mouse APS as a member of the LnK family adaptor proteins
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS