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La ricerca find articoli where soggetti phrase all words 'SEASONAL ALLERGIC RHINITIS' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 253 riferimenti
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    1. Maune, S; Schmidt, C; Kuchler, T
      Total quality management in otorhinolaryngology: Quality of the outcome.

      LARYNGO-RHINO-OTOLOGIE
    2. Amichai, B; Grunwald, MH; Brenner, L
      Fexofenadine hydrochloride - A new anti-histaminic drug

      ISRAEL MEDICAL ASSOCIATION JOURNAL
    3. Agrawal, DK
      Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    4. Prenner, BM
      The evolution of pharmacotherapy for rhinitis and urticaria

      ALLERGY AND ASTHMA PROCEEDINGS
    5. Bousquet, J; Demoly, P; Michel, FB
      Specific immunotherapy in rhinitis and asthma

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    6. Purohit, A; Duvernelle, C; Melac, M; Pauli, G; Frossard, N
      Twenty-four hours of activity of cetirizine and fexofenadine in the skin

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    7. Meltzer, EO; Rickard, KA; Westlund, RE; Cook, CK
      Onset of therapeutic effect of fluticasone propionate aqueous nasal spray

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    8. Nathan, RA; Nayak, AS; Graft, DF; Lawrence, M; Picone, FJ; Ahmed, T; Wolfe, J; Vanderwalker, ML; Nolop, KB; Harrison, JE
      Mometasone furoate: efficacy and safety in moderate asthma compared with beclomethasone dipropionate

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    9. Banov, CH; Lieberman, P
      Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    10. Cooper, JAD; Ridgeway, AL; Pearson, J; Culbreth, RR
      Attenuation of interleukin 8-induced nasal inflammation by an inhibitor peptide

      AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
    11. Turvey, SE
      Atopic diseases of childhood

      CURRENT OPINION IN PEDIATRICS
    12. Horak, F; Stubner, P; Zieglmayer, R; Kavina, A; De Vos, C; Burtin, B; Donnelly, F
      Controlled comparison of the efficacy and safety of cetirizine 10 mg od and fexofenadine 120 mg od in reducing symptoms of seasonal allergic rhinitis

      INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
    13. Ragab, S; Parikh, A; Darby, YC; Scadding, GK
      An open audit of montelukast, a leukotriene receptor antagonist, in nasal polyposis associated with asthma

      CLINICAL AND EXPERIMENTAL ALLERGY
    14. Kivisaari, E; Baker, RC; Price, MJ
      Comparison of once daily fluticasone propionate aqueous nasal spray with once daily budesonide reservoir powder device in patients with perennial rhinitis

      CLINICAL AND EXPERIMENTAL ALLERGY
    15. Yakuo, I; Yabuuchi, M; Ito, T
      Preclinical comparison of ebastine and other second generation H-1-antihistamines

      PHARMACOLOGY & TOXICOLOGY
    16. Baroody, FM; Cheng, CC; Moylan, B; de Tineo, M; Haney, L; Reed, KD; Cook, CK; Westlund, RE; Sengupta, E; Corey, JP; Togias, A; Naclerio, RM
      Absence of nasal mucosal atrophy with fluticasone aqueous nasal spray

      ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
    17. Klimek, L; Johannssen, V; Hundorf, I; Hommel, G; Hormann, K
      A nasal rinsing with isoosmotic Emser brine solution is able to reduce drug use in seasonal allergic rhinitis

      ALLERGOLOGIE
    18. Amon, U; Zollinger, A
      Fexofenadine as H-1 receptor antagonist of the new generation: a review

      ALLERGOLOGIE
    19. Dutau, G; Micheau, P; Didier, A; Rance, F; Bremont, F; Murris-Espin, M
      HI antihistamine

      REVUE FRANCAISE D ALLERGOLOGIE ET D IMMUNOLOGIE CLINIQUE
    20. Hernandez, MTE; Gil, RS; Dominguez, AC; Gutierrez, FJA; Contreras, JAR; Fernandez, AG; Garcia, AV; Gomez, JC
      Risk factors for bronchial asthma in patients with rhinitis

      ARCHIVOS DE BRONCONEUMOLOGIA
    21. Wilson, AM; White, PS; Gardiner, Q; Nassif, R; Lipworth, BJ
      Effects of leukotriene receptor antagonist therapy in patients with chronic rhinosinusitis in a real life rhinology clinic setting

      RHINOLOGY
    22. Mygind, N
      Nasal inflammation and anti-inflammatory treatment. Semantics or clinical reality?

      RHINOLOGY
    23. Parikh, A; Scadding, GK; Darby, Y; Baker, RC
      Topical corticosteroids in chronic rhinosinusitis: a randomized, double-blind, placebo-controlled trial using fluticasone propionate aqueous nasal spray

      RHINOLOGY
    24. Ten Eick, AP; Blumer, JL; Reed, MD
      Safety of antihistamines in children

      DRUG SAFETY
    25. Frossard, N; Vital-Durand, D; Mounedji, N; Valleteau, A
      Duration of the antihistaminic effect after discontinuation of ebastine

      ALLERGY
    26. Majani, G; Baiardini, I; Giardini, A; Senna, GE; Minale, P; D'Ulisse, S; Ciprandi, G; Canonica, GW
      Health-related quality of life assessment in young adults with seasonal allergic rhinitis

      ALLERGY
    27. Wang, DY; Hanotte, F; De Vos, C; Clement, P
      Effect of cetirizine, levocetirizine, and dextrocetirizine on histamine-induced nasal response in healthy adult volunteers

      ALLERGY
    28. Nayak, AS; Schenkel, E
      Desloratadine reduces nasal congestion in patients with intermittent allergic rhinitis

      ALLERGY
    29. Gani, F; Pozzi, E; Crivellaro, MA; Senna, G; Landi, M; Lombardi, C; Canonica, GW; Passalacqua, G
      The role of patient training in the management of seasonal rhinitis and asthma: clinical implications

      ALLERGY
    30. Bousquet, J; Ait-Khaled, N; Annesi-Maesano, I; Baena-Cagnani, C; Bateman, E; Bonini, S; Canonica, GW; Carlsen, KH; Demoly, P; Durham, SR; Enarson, D; Fokkens, WJ; van Wijk, RG; Howarth, P; Ivanova, NA; Kemp, JP; Klossek, JM; Lockey, RF; Lund, V; Mackay, I; Malling, HJ; Meltzer, EO; Mygind, N; Okunda, M; Pawankar, R; Price, D; Scadding, GK; Simons, FER; Szczeklik, A; Valovirta, E; Vignola, AM; Wang, DY; Warner, JO; Weiss, KB
      Recommendations

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    31. Mygind, N; Nielsen, LP; Hoffmann, HJ; Shukla, A; Blumberga, G; Dahl, R; Jacobi, H
      Mode of action of intranasal corticosteroids

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    32. Szefler, SJ
      Pharmacokinetics of intranasal corticosteroids

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    33. Boner, AL
      Effects of intranasal corticosteroids on the hypothalamic-pituitary-adrenal axis in children

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    34. Geha, RS; Meltzer, EO
      Desloratadine: A new, nonsedating. oral antihistamine

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    35. Sullivan, SD; Weiss, KB
      Health economics of asthma and rhinitis. II. Assessing the value of interventions

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    36. Fujikura, T; Shimosawa, T; Yakuo, I
      Regulatory effect of histamine H1 receptor antagonist on the expression ofmessenger RNA encoding CC chemokines in the human nasal mucosa

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    37. De Ponti, F; Poluzzi, E; Montanaro, N
      Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs: A call for consensus

      EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
    38. van Zuijlen, DA; van de Graaf, EA; van Bolhuis, EM; Versluis, C; Knol, EF; van der Baan, S
      Measuring plasma exudation in nasal lavage fluid and in induced sputum as a tool for studying respiratory tract inflammation

      JOURNAL OF IMMUNOLOGICAL METHODS
    39. Walsh, GM; Annunziato, L; Frossard, N; Knol, K; Levander, S; Nicolas, JM; Taglialatela, M; Tharp, MD; Tillement, JP; Timmerman, H
      New insights into the second generation antihistamines

      DRUGS
    40. Falser, N; Wober, W; Rahlfs, VW; Baehre, M
      Comparative efficacy and safety of azelastine and levocabastine nasal sprays in patients with seasonal allergic rhinitis

      ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
    41. Bauer, CP; Unkauf, M
      Efficacy and safety of intranasally applied dimetindene maleate solution -Multicenter study in children under 14 years suffering from seasonal allergic rhinitis

      ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
    42. Graziano, FM; Cook, EB; Stahl, JL
      Antihistamines and epithelial cells

      ALLERGY AND ASTHMA PROCEEDINGS
    43. Grant, JA
      Molecular pharmacology of second-generation antihistamines

      ALLERGY AND ASTHMA PROCEEDINGS
    44. Nayak, AS; Banov, C; Corren, J; Feinstein, BK; Floreani, A; Friedman, BF; Goldsobel, A; Gottschlich, GM; Hannaway, PJ; Lampl, KL; Lapidus, RJ; Lawrence, M; Lumry, W; Munk, Z; Pearlman, D; Scardella, AT; Schenkel, EJ; Segal, AT; Segall, N; Silverman, B; Shneyer, L; Nolop, KB; Harrison, JE
      Once-daily mometasone furoate dry powder inhaler in the treatment of patients with persistent asthma

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    45. Georgitis, JW; Meltzer, EO; Kaliner, M; Weiler, J; Berkowitz, R
      Onset-of-action for antihistamine and decongestant combinations during an outdoor challenge

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    46. Benedetto, SR; Sloan, AS; Duncan, BS
      Impact of interventions designed to increase market share and prescribing of fexofenadine at HMOs

      AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
    47. Jean, CD; Triplett, JW
      Investigating patient experiences after a formulary change

      AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
    48. Howarth, PH
      Leukotrienes in rhinitis

      AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
    49. Olivieri, M; Zadeh, MRM; Talamini, G; Lampronti, G; Lo Cascio, V
      Local nasal immunotherapy and bronchial hyperreactivity in seasonal allergic rhinitis: An observational pilot study

      JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY
    50. Wilson, A; Dempsey, OJ; Sims, EJ; Coutie, WJR; Paterson, MC; Lipworth, BJ
      Evaluation of treatment response in patients with seasonal allergic rhinitis using domiciliary nasal peak inspiratory flow

      CLINICAL AND EXPERIMENTAL ALLERGY
    51. Van Cauwenberge, P; Juniper, EF
      Comparison of the efficacy, safety and quality of life provided by fexofenadine hydrochloride 120 mg, loratadine 10 mg and placebo administered once daily for the treatment of seasonal allergic rhinitis

      CLINICAL AND EXPERIMENTAL ALLERGY
    52. Keith, P; Nieminen, J; Hollingworth, K; Dolovich, J
      Efficacy and tolerability of fluticasone propionate nasal drops 400 mu g once daily compared with placebo for the treatment of bilateral polyposis inadults

      CLINICAL AND EXPERIMENTAL ALLERGY
    53. Penttila, M; Poulsen, P; Hollingworth, K; Holmstrom, M
      Dose-related efficacy and tolerability of fluticasone propionate nasal drops 400 mu g once daily and twice daily in the treatment of bilateral nasal polyposis: a placebo-controlled randomized study in adult patients

      CLINICAL AND EXPERIMENTAL ALLERGY
    54. Simons, FER; Johnston, L; Simons, KJ
      Clinical pharmacology of the H-1-receptor antagonists cetirizine and loratadine in children

      PEDIATRIC ALLERGY AND IMMUNOLOGY
    55. Bousquet, J; D'Urzo, A; Hebert, J; Barraza, CH; Boulet, LP; Suarez-Chacon, R; Harnest, U; Lundback, B; Morales, GM; Nieminen, MM; Nolop, KB; Visser, S; Lutsky, BN
      Comparison of the efficacy and safety of mometasone furoate dry powder inhaler to budesonide Turbuhaler (R)

      EUROPEAN RESPIRATORY JOURNAL
    56. Pien, LC
      Appropriate use of second generation antihistamines

      CLEVELAND CLINIC JOURNAL OF MEDICINE
    57. Puchner, TC; Fink, JN
      Occupational rhinitis

      IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
    58. Williams, PV
      Treatment of rhinitis - Corticosteroids and cromolyn sodium

      IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
    59. Zacharisen, MC
      Rhinitis in children, adolescents, the elderly, and pregnant women - Special considerations

      IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
    60. Kakinoki, Y; Ohashi, Y; Nakai, Y; Tanaka, A; Washio, Y
      Pollen immunotherapy inhibits T helper 1 and 2 cell responses, but suppression of T helper 2 cell response is a more important mechanism related to the clinical efficacy

      ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
    61. Frossard, N; Benabdesselam, O; Purohit, A; Mounedji, N; Pauli, G
      Activity of ebastine (10 and 20 mg) and cetirizine at 24 hours of a steadystate treatment in the skin of healthy volunteers

      FUNDAMENTAL & CLINICAL PHARMACOLOGY
    62. Klimek, L; Gene-Schneider, S; Mosges, R; Hormann, K
      SIMAROline has no effect in seasonal allergic rhinitis

      ALLERGOLOGIE
    63. Simons, FER
      Prospective, long-term safety evaluation of the H-1-receptor antagonist cetirizine in very young children with atopic dermatitis

      ALLERGOLOGIE
    64. Bousquet, J
      What are the perspectives in the future for H-1-antihistamines?

      REVUE FRANCAISE D ALLERGOLOGIE ET D IMMUNOLOGIE CLINIQUE
    65. Prenner, BM; Capano, D; Harris, AG
      Efficacy and tolerability of loratadine versus fexofenadine in the treatment of seasonal allergic rhinitis: A double-blind comparison with crossover treatment of nonresponders

      CLINICAL THERAPEUTICS
    66. Horak, F
      Clinical advantages of dual activity in allergic rhinitis

      ALLERGY
    67. Foresi, A
      A comparison of the clinical efficacy and safety of intranasal fluticasonepropionate and antihistamines in the treatment of rhinitis

      ALLERGY
    68. Walsh, GM
      The clinical relevance of the anti-inflammatory properties of antihistamines

      ALLERGY
    69. Kulig, M; Klettke, U; Wahn, V; Forster, J; Bauer, CP; Wahn, U
      Development of seasonal allergic rhinitis during the first 7 years of life

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    70. Allen, DB
      Systemic effects of intranasal steroids: An endocrinologist's perspective

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    71. Meltzer, EO; Charous, BL; Busse, WW; Zinreich, SJ; Lorber, RR; Danzig, MR
      Added relief in the treatment of acute recurrent sinusitis with adjunctivemometasone furoate nasal spray

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    72. Ratner, PH; Lim, JC; Georges, GC
      Comparison of once-daily ebastine 20 mg, ebastine 10 mg, loratadine 10 mg,and placebo in the treatment of seasonal allergic rhinitis

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    73. Meltzer, EO; Malmstrom, K; Lu, S; Prenner, BM; Wei, LX; Weinstein, SF; Wolfe, JD; Reiss, TF
      Concomitant montelukast and loratadine as treatment for seasonal allergic rhinitis: A randomized, placebo-controlled clinical trial

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    74. Day, JH; Briscoe, MP; Rafeiro, E; Ellis, AK; Pettersson, E; Akerlund, A
      Onset of action of intranasal budesonide (Rhinocort Aqua) in seasonal allergic rhinitis studied in a controlled exposure model

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    75. Dempsey, OJ
      Leukotriene receptor antagonist therapy

      POSTGRADUATE MEDICAL JOURNAL
    76. Storaas, T; Andersson, M; Persson, CGA; Steinsvag, SK; Marko-Varga, G; Greiff, L
      Effects of benzalkonium chloride on innate immunity physiology of the human nasal mucosa in vivo

      LARYNGOSCOPE
    77. Simpson, K; Jarvis, B
      Fexofenadine - A review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticaria

      DRUGS
    78. Didier, A; Doussau-Thuron, S; Murris-Espin, M
      Comparative analysis of the sedative effects of mequitazine and other antihistaminic drugs: Review of the literature

      CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
    79. Deschamps, C; Dubruc, C; Mentre, F; Rosenzweig, P
      Pharmacokinetic and pharmacodynamic modeling of mizolastine in healthy volunteers with an indirect response model

      CLINICAL PHARMACOLOGY & THERAPEUTICS
    80. Horak, F; Unkauf, M; Beckers, C; Mittermaier, EM
      Efficacy and tolerability of intranasally applied dimetindene maleate solution versus placebo in the treatment of seasonal allergic rhinitis

      ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
    81. Dockhorn, R; Aaronson, D; Bronsky, E; Chervinsky, P; Cohen, R; Ehtessabian, R; Finn, A; Grossman, J; Howland, W; Kaiser, H; Pearlman, D; Sublett, J; Ratner, P; Settipane, G; Sim, T; Storms, W; Webb, R; Drda, K; Wood, C
      Ipratropium bromide nasal spray 0.03% and beclomethasone nasal spray aloneand in combination for the treatment of rhinorrhea in perennial rhinitis

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    82. Rachelefsky, GS
      National guidelines needed to manage rhinitis and prevent complications

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    83. Weiser, M; Gegenheimer, LH; Klein, P
      A randomized equivalence trial comparing the efficacy and safety of Luffa comp.-Heel Nasal Spray with cromolyn sodium spray in the treatment of seasonal allergic rhinitis

      FORSCHENDE KOMPLEMENTARMEDIZIN
    84. Florido, JF; Delgado, PG; de San Pedro, BS; Quiralte, J; de Saavedra, JMA; Peralta, V; Valenzuela, LR
      High levels of Olea europaea pollen and relation with clinical findings

      INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
    85. Bachert, C; van Kempen, M; Van Cauwenberge, P
      Regulation of proinflammatory cytokines in seasonal allergic rhinitis

      INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
    86. Arnold, R; Rihoux, JP; Konig, W
      Cetirizine counter-regulates interleukin-8 release from human epithelial cells (A549)

      CLINICAL AND EXPERIMENTAL ALLERGY
    87. Jacobson, MR; Juliusson, S; Lowhagen, O; Balder, B; Kay, AB; Durham, SR
      Effect of topical corticosteroids on seasonal increases in epithelial eosinophils and mast cells in allergic rhinitis: a comparison of nasal brush and biopsy methods

      CLINICAL AND EXPERIMENTAL ALLERGY
    88. Scadding, GK
      Clinical assessment of antihistamines in rhinitis

      CLINICAL AND EXPERIMENTAL ALLERGY
    89. Simons, FER
      Non-cardiac adverse effects of antihistamines (H-1-receptor antagonists)

      CLINICAL AND EXPERIMENTAL ALLERGY
    90. Mason, J; Reynolds, R; Rao, N
      The systemic safety of fexofenadine HCl

      CLINICAL AND EXPERIMENTAL ALLERGY
    91. Bousquet, J
      Rapid symptom relief in rhinitis

      CLINICAL AND EXPERIMENTAL ALLERGY
    92. Bernstein, DI; Berkowitz, RB; Chervinsky, P; Dvorin, DJ; Finn, A; Gross, GN; Karetzky, M; Kemp, JP; Laforce, C; Lumry, W; Mendelson, LM; Nelson, H; Pearlman, D; Rachelefsky, G; Ratner, P; Repsher, L; Segal, AT; Selner, JC; Settipane, GA; Wanderer, A; Cuss, FM; Nolop, KB; Harrison, JE
      Dose-ranging study of a new steroid for asthma: mometasone furoate dry powder inhaler

      RESPIRATORY MEDICINE
    93. Varga, EM; Jacobson, MR; Masuyama, K; Rak, S; Till, SJ; Darby, Y; Hamid, Q; Lund, V; Scadding, GK; Durham, SR
      Inflammatory cell populations and cytokine mRNA expression in the nasal mucosa in aspirin-sensitive rhinitis

      EUROPEAN RESPIRATORY JOURNAL
    94. Lung, CL; Lung, ML; Lung, CL
      Medications in the allergy/asthma office

      IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
    95. Day, JH; Briscoe, M; Widlitz, MD
      Cetirizine, loratadine, or placebo in subjects with seasonal allergic rhinitis: effects after controlled ragweed pollen challenge in an environmentalexposure unit

      ALLERGOLOGIE
    96. Rudack, C; Bachert, C
      Fluticasone propionate in the treatment of seasonal allergic rhinitis: efficacy, tolerability and quality of life

      ALLERGOLOGIE
    97. Simons, FER; Simons, KJ
      Clinical pharmacology of new histamine H-1 receptor antagonists

      CLINICAL PHARMACOKINETICS
    98. Thorsson, L; Borga, O; Edsbacker, S
      Systemic availability of budesonide after nasal administration of three different formulations: pressurized aerosol, aqueous pump spray, and powder

      BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
    99. DuBuske, LM
      Second-generation antihistamines: The risk of ventricular arrhythmias

      CLINICAL THERAPEUTICS
    100. Ricard, N; Kind, P; Christian, S; Jensen, M; Stewart, J
      Link between patient preferences and treatment outcomes in seasonal allergic rhinitis: An empiric investigation

      CLINICAL THERAPEUTICS


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Documento generato il 20/10/20 alle ore 00:51:15