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In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
A rapid HPLC-DAD method for separation and determination of omeprazole extracted from human plasma
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid
PHARMACOGENETICS
Effects of genotypic differences in CYP2C19 status on cure rates for Helicobacter pylori infection by dual therapy with rabeprazole plus amoxicillin
PHARMACOGENETICS
Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in Aborigines from Western Australia
PHARMACOGENETICS
Proton pump inhibitors and their drug interactions: an evidence-based approach
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Genetic differences in CYP2C19 single nucleotide polymorphisms among four Asian populations
JOURNAL OF GASTROENTEROLOGY
CYP2C19 genotype and pharmacokinetics of three proton pump inhibitors in healthy subjects
PHARMACEUTICAL RESEARCH
CYP2C19 genotype related effect of omeprazole on intragastric pH and antimicrobial stability
PHARMACEUTICAL RESEARCH
Molecular basis of ethnic differences in drug disposition and response
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
Clinical relevance of genetic polymorphisms in the human CYP2C subfamily
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Plasma concentrations of haloperidol are related to CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
The effect of CYP2C19 and CYP2D6 genotypes on the metabolism of clomipramine in Japanese psychiatric patients
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
Heterogeneity of the CYP2D6 gene among Malays in Malaysia
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
Phenotype analysis of cytochrome P4502C19 in Chinese subjects with mephenytoin S/R enantiomeric ratio in urine measured by chiral GC
BIOMEDICAL CHROMATOGRAPHY
Pharmacodynamic effects and kinetic disposition of rabeprazole in relationto CYP2C19 genotypes
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Cytochrome P450 2D6 genotyping and association with tardive dyskinesia in Chinese schizophrenic patients
PHARMACOPSYCHIATRY
P-hydroxylation of phenobarbital: Relationship to (s)-mephenytoin hydroxylation (CYP2C19) polymorphism
THERAPEUTIC DRUG MONITORING
Human drug metabolism and the cytochromes P450: Application and relevance of in vitro models
JOURNAL OF CLINICAL PHARMACOLOGY
Implications of polymorphic cytochrome P450-dependent drug metabolism for drug development
DRUG METABOLISM AND DISPOSITION
Induction of CYP2C genes in human hepatocytes in primary culture
DRUG METABOLISM AND DISPOSITION
Metabolic characterization of the major human small intestinal cytochrome P450S
DRUG METABOLISM AND DISPOSITION
Effects of CYP3A4 inhibition by diltiazem on pharmacokinetics and dynamicsof diazepam in relation to CYP2C19 genotype status
DRUG METABOLISM AND DISPOSITION
Inhibition of drug metabolism in human liver microsomes by nizatidine, cimetidine and omeprazole
XENOBIOTICA
CYP2C19 polymorphism is not important for the in vivo metabolism of selegiline
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Effect of high-dose lansoprazole on intragastic pH in subjects who are homozygous extensive metabolizers of cytochrome P4502C19
CLINICAL PHARMACOLOGY & THERAPEUTICS
Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19
CLINICAL PHARMACOLOGY & THERAPEUTICS
Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19
CLINICAL PHARMACOLOGY & THERAPEUTICS
Effect of genotypic differences in CYP2C19 on cure rates for Helicobacter pylori infection by triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin
CLINICAL PHARMACOLOGY & THERAPEUTICS
Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P4502C19
BIOCHEMISTRY
CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages
ACTA PSYCHIATRICA SCANDINAVICA
Ethnic differences in drug metabolism
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
A rapid electron-capture gas chromatographic procedure for the analysis ofp-hydroxymephenytoin
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
Cytochrome P450-mediated drug interactions
CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA
The possession of the CYP2C9*3 allele is associated with low dose requirement of acenocoumarol
PHARMACOGENETICS
Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia
PHARMACOGENETICS
Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes
PHARMACOGENETICS
Interethnic differences of drug-metabolizing enzymes
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
Inhibition of drug-metabolizing enzyme activity in human hepatic cytochrome P450s by bisphenol A
BIOLOGICAL & PHARMACEUTICAL BULLETIN
High throughput detection of drug-metabolizing enzyme polymorphisms by allele-specific fluorogenic 5 ' nuclease chain reaction assay
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Development of a semi-quantitative assay to detect full-length CYP2C19 RNA
BIOTECHNIQUES
Pharmacokinetic considerations in the eradication of Helicobacter pylori
CLINICAL PHARMACOKINETICS
Single and multiple dose pharmacokinetics of nelfinavir and CYP2C19 activity in human immunodeficiency virus-infected patients with chronic liver disease
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Formation of omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by grapefruit juice
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
CYP2D6 phenotypes among Malays in Malaysia
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
Pharmacogenetics and psychopharmacotherapy
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
Omeprazole and CYP2C19 polymorphism: effects of long-term treatment on gastrin, pepsinogen I, and chromogranin A in patients with acid related disorders
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
CYP2C19 genotype status and intragastric pH during dosing with lansoprazole or rabeprazole
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
New perspectives in gastric acid suppression: Genetic polymorphisms predict the efficacy of proton pump inhibitors
DIGESTIVE DISEASES
Probing CYP2C19 and CYP3A4 activities in Chinese liver microsomes by quantification of 5-hydroxyomeprazole and omeprazole sulphone
ACTA PHARMACOLOGICA SINICA
Individual and ethnic differences in CYP2C19 activity in Chinese populations
ACTA PHARMACOLOGICA SINICA
Marked increase of venlafaxine enantiomer concentrations as a consequence of metabolic interactions: A case report
PHARMACOPSYCHIATRY
In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model
DRUG METABOLISM AND DISPOSITION
CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes
DRUG METABOLISM AND DISPOSITION
Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s
DRUG METABOLISM AND DISPOSITION
Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms
XENOBIOTICA
The CYP2C19 enzyme polymorphism
PHARMACOLOGY
The impact of the CYP2D6 and CYP2C19 genotypes on venlafaxine pharmacokinetics in a Japanese population
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
CYP2C19 polymorphism effect on phenobarbitone - Pharmacokineties in Japanese patients with epilepsy: analysis by population pharmacokinetics
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
5-hydroxylation of omeprazole by human liver microsomal fractions from Chinese populations related to CYP2C19 gene dose and individual ethnicity
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism
GASTROENTEROLOGY
Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail"
CLINICAL PHARMACOLOGY & THERAPEUTICS
In vivo modulation of CYP enzymes by quinidine and rifampin
CLINICAL PHARMACOLOGY & THERAPEUTICS
CYP2C19 genetic mutations in North Indians
CLINICAL PHARMACOLOGY & THERAPEUTICS
No sex-related differences but significant inhibition by oral contraceptives of CYP2C19 activity as measured by the probe drugs mephenytoin and omeprazole in healthy Swedish white subjects
CLINICAL PHARMACOLOGY & THERAPEUTICS
Slow chloroguanide metabolism in Tanzanians compared with white subjects and Asian subjects confirms a decreased CYP2C19 activity in relation to genotype
CLINICAL PHARMACOLOGY & THERAPEUTICS
Cure of refractory duodenal ulcer and infection caused by Helicobacter pylori by high doses of omeprazole and amoxicillin in a homozygous CYP2C19 extensive metabolizer patient
CLINICAL PHARMACOLOGY & THERAPEUTICS
Relationship of paroxetine disposition to metoprolol metabolic ratio and CPsi P2D6*10 genotype of Korean subjects
CLINICAL PHARMACOLOGY & THERAPEUTICS
Cytochrome P4502D6 (debrisoquine 4-hydroxylase) and Parkinson's disease inChinese and Caucasians
EUROPEAN JOURNAL OF NEUROLOGY
Pharmacogenetics in the practice of laboratory medicine
MOLECULAR DIAGNOSIS
Decreased capacity for debrisoquine metabolism among black Tanzanians: analyses of the CYP2D6 genotype and phenotype
PHARMACOGENETICS
Allelic, genotypic and phenotypic distributions of S-mephenytoin 4 '-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world
PHARMACOGENETICS
High and variable frequencies of CYP2C19 mutations: medical consequences of poor drug metabolism in Vanuatu and other Pacific islands
PHARMACOGENETICS
Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutations
PHARMACOGENETICS
Detection of CYP2C19 alleles*1,*2 and*3 by multiplex polymerase chain reaction
PHARMACOGENETICS
Omeprazole weakly inhibits CYP1A2 activity in man
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
Effect of clarithromycin and other macrolides on the sulfoxidation and 5-hydroxylation of lansoprazole in dogs
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Rifampicin treatment greatly increases the apparent oral clearance of quinidine
PHARMACOLOGY & TOXICOLOGY
Homology modeling and substrate binding study of human CYP2C9 enzyme
PROTEINS-STRUCTURE FUNCTION AND GENETICS
Homology modeling and substrate binding study of human CYP2C18 and CYP2C19enzymes
PROTEINS-STRUCTURE FUNCTION AND GENETICS
Stereospecific analysis of omeprazole supports artemisinin as a potent inducer of CYP2C19
FUNDAMENTAL & CLINICAL PHARMACOLOGY
Phenotypes and genotypes for CYP2D6 and CYP2C19 in a black Tanzanian population
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Genetic polymorphism of (S)-mephenytoin 4 '-hydroxylation in populations of African descent
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Frequency of cytochrome P450CYP2C9 variants in a Turkish population and functional relevance for phenytoin
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Tolterodine does not affect the human in vivo metabolism of the probe drugs caffeine, debrisoquine and omeprazole
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping:possible effect of age, liver disease and length of therapy
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Absence of effect of stimulants on the pharmacokinetics of desipramine in children
PHARMACOTHERAPY
Polymorphic cytochromes P450 and drugs used in psychiatry
CELLULAR AND MOLECULAR NEUROBIOLOGY
Pronounced differences in the disposition of clomipramine between Japaneseand Swedish patients
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
Update: genetic polymorphism of drug metabolizing enzymes in humans
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
Clinically significant pharmacokinetic drug interactions with benzodiazepines
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
Clinically significant pharmacokinetic drug interactions between antiepileptic drugs
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
Clinically significant pharmacokinetic drug interactions with psychoactivedrugs: antidepressants and antipsychotics and the cytochrome P450 system
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
Effect of CYP2C19 polymorphism on serum levels of vitamin B-12 in patientson long-term omeprazole treatment
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Review article: pharmacokinetic concerns in the selection of anti-ulcer therapy
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Review article: cytochrome P450 and the metabolism of proton pump inhibitors - emphasis on rabeprazole
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
High-dose omeprazole: Use of a multiple-dose study design to assess bioequivalence and accuracy of CYP2C19 phenotyping
THERAPEUTIC DRUG MONITORING
Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro
DRUG METABOLISM AND DISPOSITION
Azelastine N-demethylation by cytochrome P-450 (CYP) 3A4, CYP2D6, and CYP1A2 in human liver microsomes: Evaluation of approach to predict the contribution of multiple CYPS
DRUG METABOLISM AND DISPOSITION