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La ricerca find articoli where soggetti phrase all words 'RIBONUCLEIC-ACID' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 5407 riferimenti
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    1. Ricketts, SL; Garcia, NF; Betz, BL; Coleman, WB
      Identification of candidate liver tumor suppressor genes from human 11p11.2-p12

      GENES CHROMOSOMES & CANCER
    2. Nuttinck, F; Reinaud, P; Tricoire, H; Vigneron, C; Peynot, N; Mialot, JP; Mermillod, P; Charpigny, G
      Cyclooxygenase-2 is expressed by cumulus cells during oocyte maturation incattle

      MOLECULAR REPRODUCTION AND DEVELOPMENT
    3. Taner, CB; Severson, SR; Best, PJM; Lerman, A; Miller, VM
      Treatment with endothelin-receptor antagonists increases NOS activity in hypercholesterolemia

      JOURNAL OF APPLIED PHYSIOLOGY
    4. Wadley, GD; Tunstall, RJ; Sanigorski, A; Collier, GR; Hargreaves, M; Cameron-Smith, D
      Differential effects of exercise on insulin-signaling gene expression in human skeletal muscle

      JOURNAL OF APPLIED PHYSIOLOGY
    5. Funk, JL
      A role for parathyroid hormone-related protein in the pathogenesis of inflammatory/autoimmune diseases

      INTERNATIONAL IMMUNOPHARMACOLOGY
    6. Naftolin, F; Horvath, TL; Balthazart, J
      Estrogen synthetase (aromatase) immunohistochemistry reveals concordance between avian and rodent limbic systems and hypothalami

      EXPERIMENTAL BIOLOGY AND MEDICINE
    7. Jacob, DA; Temple, JL; Patisaul, HB; Young, LJ; Rissman, EF
      Coumestrol antagonizes neuroendocrine actions of estrogen via the estrogenreceptor alpha

      EXPERIMENTAL BIOLOGY AND MEDICINE
    8. Spencer, F; Chi, LM; Zhu, MX
      Temporal relationships among uterine pituitary adenylate cyclase-activating polypeptide, decidual prolactin-related protein and progesterone receptormRNAs expressions during decidualization and gestation in rats

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
    9. Rao, CV
      An overview of the past, present, and future of nongonadal LH/hCG actions in reproductive biology and medicine

      SEMINARS IN REPRODUCTIVE MEDICINE
    10. Licht, P; Russu, V; Wildt, L
      On the role of human chorionic gonadotropin (hCC) in the embryo-endometrial microenvironment: Implications for differentiation and implantation

      SEMINARS IN REPRODUCTIVE MEDICINE
    11. Shemesh, M; Mizrachi, D; Gurevich, M; Stram, Y; Shore, LS; Fields, MJ
      Functional importance of bovine myometrial and vascular LH receptors and cervical FSH receptors

      SEMINARS IN REPRODUCTIVE MEDICINE
    12. Ghinea, N; Milgrom, E
      A new function for the LH/CG receptor: Transcytosis or hormone across the endothelial barrier in target organs

      SEMINARS IN REPRODUCTIVE MEDICINE
    13. Hu, XT; Zuckerman, KS
      Transforming growth factor: signal transduction pathways, cell cycle mediation, and effects on hematopoiesis

      JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
    14. Patel, JL; Keyes, PL
      Immune cells in the corpus luteum: friends or foes?

      REPRODUCTION
    15. Rhodes, FM; Peterson, AJ; Jolly, PD
      Gonadotrophin responsiveness, aromatase activity and insulin-like growth factor binding protein content of bovine ovarian follicles during the first follicular wave

      REPRODUCTION
    16. Yaseen, MA; Wrenzycki, C; Herrmann, D; Carnwath, JW; Niemann, H
      Changes in the relative abundance of mRNA transcripts for insulin-like growth factor (IGF-I and IGF-II) ligands and their receptors (IGF-IR/IGF-IIR) in preimplantation bovine embryos derived from different in vitro systems

      REPRODUCTION
    17. Rosenfeld, CS; Wagner, JS; Roberts, RM; Lubahn, DB
      Intraovarian actions of oestrogen

      REPRODUCTION
    18. Tsai, SJ; Wiltbank, MC
      Differential effects of prostaglandin F-2 alpha on in vitro luteinized bovine granulosa cells

      REPRODUCTION
    19. Smith, MJ; Jennes, L
      Neural signals that regulate GnRH neurones directly during the oestrous cycle

      REPRODUCTION
    20. Vermeirsch, H; Simoens, P; Coryn, M; Van den Broeck, W
      Immunolocalization of progesterone receptors in the canine ovary and theirrelation to sex steroid hormone concentrations

      REPRODUCTION
    21. Shemesh, M
      Actions of gonadotrophins on the uterus

      REPRODUCTION
    22. Tsai, SJ; Kot, K; Ginther, OJ; Wiltbank, MC
      Temporal gene expression in bovine corpora lutea after treatment with PGF(2 alpha) based on serial biopsies in vivo

      REPRODUCTION
    23. Conley, A; Hinshelwood, M
      Mammalian aromatases

      REPRODUCTION
    24. Petroff, MG; Petroff, BK; Pate, JL
      Mechanisms of cytokine-induced death of cultured bovine luteal cells

      REPRODUCTION
    25. Fallah-Rad, AH; Connor, ML; Del Vecchio, RP
      Effect of transient early hyperthyroidism on onset of puberty in Suffolk ram lambs

      REPRODUCTION
    26. Derr, P; Yeung, CH; Cooper, TG; Kirchhoff, C
      Synthesis and glycosylation of CD52, the major 'maturation-associated' antigen of rat spermatozoa, in the cauda epididymidis

      REPRODUCTION
    27. Asboth, G; Price, SA; Bellinger, J; Ledger, W; Barlow, DH; Bernal, AL
      Characterization of adenylyl cyclases in cultured human granulosa cells

      REPRODUCTION
    28. Reynaud, K; Cortvrindt, R; Smitz, J; Bernex, F; Panthier, JJ; Driancourt, MA
      Alterations in ovarian function of mice with reduced amounts of KIT receptor

      REPRODUCTION
    29. Walters, KW; Roser, JF; Anderson, GB
      Maternal-conceptus signalling during early pregnancy in mares: oestrogen and insulin-like growth factor 1

      REPRODUCTION
    30. Kelly, RW; King, AE; Critchley, HOD
      Cytokine control in human endometrium

      REPRODUCTION
    31. Padmanabhan, V; McNeilly, AS
      Is there an FSH-releasing factor?

      REPRODUCTION
    32. Wright, CS; Becker, DL; Lin, JS; Warner, AE; Hardy, K
      Stage-specific and differential expression of gap junctions in the mouse ovary: connexin-specific roles in follicular regulation

      REPRODUCTION
    33. Reichert, AS; Thurlow, DL; Morl, M
      A eubacterial origin for the human tRNA nucleotidyltransferase?

      BIOLOGICAL CHEMISTRY
    34. Fechter, P; Rudinger-Thirion, J; Florentz, C; Giege, R
      Novel features in the tRNA-like world of plant viral RNAs

      CELLULAR AND MOLECULAR LIFE SCIENCES
    35. Drucker, DJ
      Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes

      CURRENT PHARMACEUTICAL DESIGN
    36. Duffy, DM; Stouffer, RL
      The ovulatory gonadotrophin surge stimulates cyclooxygenase expression andprostaglandin production by the monkey follicle

      MOLECULAR HUMAN REPRODUCTION
    37. Tsai, SJ; Wu, MH; Chuang, PC; Chen, HM
      Distinct regulation of gene expression by prostaglandin F-2 alpha (PGF(2 alpha)) is associated with PGF(2 alpha) resistance or susceptibility in human granulosa-luteal cells

      MOLECULAR HUMAN REPRODUCTION
    38. Hombach-Klonisch, S; Seeger, S; Tscheudschilsuren, G; Buchmann, J; Huppertz, B; Seliger, G; Fischer, B; Klonisch, T
      Cellular localization of human relaxin-like factor in the cyclic endometrium and placenta

      MOLECULAR HUMAN REPRODUCTION
    39. Driver, PM; Kilby, MD; Bujalska, I; Walker, EA; Hewison, M; Stewart, PM
      Expression of 11 beta-hydroxysteroid dehydrogenase isozymes and corticosteroid hormone receptors in primary cultures of human trophoblast and placental bed biopsies

      MOLECULAR HUMAN REPRODUCTION
    40. Hosokawa, K; Ottander, U; Wahlberg, P; Ny, T; Cajander, S; Olofsson, IJ
      Dominant expression and distribution of oestrogen receptor beta over oestrogen receptor alpha in the human corpus luteum

      MOLECULAR HUMAN REPRODUCTION
    41. Karube-Harada, A; Sugino, N; Kashida, S; Takiguchi, S; Takayama, H; Yamagata, Y; Nakamura, Y; Kato, H
      Induction of manganese superoxide dismutase by tumour necrosis factor-alpha in human endometrial stromal cells

      MOLECULAR HUMAN REPRODUCTION
    42. Kovacs, KA; Oszter, A; Gocze, PM; Kornyei, JL; Szabo, I
      Comparative analysis of cyclin D1 and oestrogen receptor (alpha and beta) levels in human leiomyoma and adjacent myometrium

      MOLECULAR HUMAN REPRODUCTION
    43. Telgmann, R; Brosens, JJ; Kappler-Hanno, K; Ivell, R; Kirchhoff, C
      Epididymal epithelium immortalized by simian virus 40 large T antigen: a model to study epididymal gene expression

      MOLECULAR HUMAN REPRODUCTION
    44. Oksjoki, S; Soderstrom, M; Vuorio, E; Anttila, L
      Differential expression patterns of cathepsins B, H, K, L and S in the mouse ovary

      MOLECULAR HUMAN REPRODUCTION
    45. Wolfahrt, S; Kleine, B; Jarry, H; Rossmanith, WG
      Endogenous regulation of the GnRH receptor by GnRH in the human placenta

      MOLECULAR HUMAN REPRODUCTION
    46. Malee, MP; Wu, KY
      Adrenocortical activity and placental glucocorticoid metabolism in the diabetic rat

      PRENATAL AND NEONATAL MEDICINE
    47. Lee, D; Wang, L; Dong, P; Tran, T; Copolov, D; Lim, AT
      Progesterone modulation of D5 receptor expression in hypothalamic ANP neurons, the role of estrogen

      MOLECULAR PSYCHIATRY
    48. Cheon, M; Park, D; Park, Y; Kam, K; Park, SD; Ryu, K
      Progesterone together with estrogen attenuates homologous upregulation of gonadotropin-releasing hormone receptor mRNA in primary cultured rat pituitary cells (vol 13, pg 379, 2000)

      ENDOCRINE
    49. Holloway, AC; Whittle, WL; Challis, JRG
      Effects of cortisol and estradiol on pituitary expression of proopiomelanocortin, prohormone convertase-1, prohormone convertase-2, and glucocorticoid receptor mRNA in fetal sheep

      ENDOCRINE
    50. Lopez, D; Nackley, AC; Shea-Eaton, W; Xue, JP; Schimmer, BP; McLean, MP
      Effects of mutating different steroidogenic factor-1 protein regions on gene regulation

      ENDOCRINE
    51. Gore, AC
      Environmental toxicant effects on neuroendocrine function

      ENDOCRINE
    52. Bluet-Pajot, MT; Tolle, V; Zizzari, P; Robert, C; Hammond, C; Mitchell, V; Beauvillain, JC; Viollet, C; Epelbaum, J; Kordon, C
      Growth hormone secretagogues and hypothalamic networks

      ENDOCRINE
    53. Arvat, E; Gianotti, L; Giordano, R; Broglio, F; Maccario, M; Lanfranco, F; Muccioli, G; Papotti, M; Graziani, A; Ghigo, E; Deghenghi, R
      Growth hormone-releasing hormone and growth hormone secretagogue-receptor ligands - Focus on reproductive system

      ENDOCRINE
    54. Veldhuis, JD; Evans, WS; Bowers, CY; Anderson, S
      Interactive regulation of postmenopausal growth hormone insulin-like growth factor axis by estrogen and growth hormone-releasing peptide-2

      ENDOCRINE
    55. Limonta, P; Marelli, MM; Moretti, RM
      LHRH analogues as anticancer agents: pituitary and extrapituitary sites ofaction

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    56. Sachdev, D; Yee, D
      The IGF system and breast cancer

      ENDOCRINE-RELATED CANCER
    57. Long, E; Capuco, AV; Wood, DL; Sonstegard, T; Tomita, G; Paape, MJ; Zhao, X
      Escherichia coli induces apoptosis and proliferation of mammary cells

      CELL DEATH AND DIFFERENTIATION
    58. Moorehead, RA; Fata, JE; Johnson, MB; Khokha, R
      Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice

      CELL DEATH AND DIFFERENTIATION
    59. Cutolo, M; Villaggio, B; Bisso, A; Sulli, A; Coviello, D; Dayer, JM
      Presence of estrogen receptors in human myeloid monocytic cells (THP-1 cell line)

      EUROPEAN CYTOKINE NETWORK
    60. Morris, RC; Elliott, MS
      Queuosine modification of tRNA: A case for convergent evolution

      MOLECULAR GENETICS AND METABOLISM
    61. Lang, CH; Nystrom, GJ; Frost, RA
      Tissue-specific regulation of IGF-I and IGF-binding proteins in response to TNF alpha

      GROWTH HORMONE & IGF RESEARCH
    62. Fu, Z; Kubo, T; Noguchi, T; Kato, H
      Developmental changes in the mRNA levels of IGF-I and its related genes inthe reproductive organs of Japanese quail (Coturnix coturnix japonica)

      GROWTH HORMONE & IGF RESEARCH
    63. Papaconstantinou, AD; Fisher, BR; Umbreit, TH; Goering, PL; Lappas, NT; Brown, KM
      Effects of beta-estradiol and bisphenol a on heat shock protein levels andlocalization in the mouse uterus are antagonized by the antiestrogen ICI 182,780

      TOXICOLOGICAL SCIENCES
    64. Melton, CM; Zaunbrecher, GM; Yoshizaki, G; Patino, R; Whisnant, S; Rendon, A; Lee, VH
      Expression of connexin 43 mRNA and protein in developing follicles of prepubertal porcine ovaries

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
    65. Schulz, RW; Vischer, HF; Cavaco, JEB; Santos, EM; Tyler, CR; Goos, HJT; Bogerd, J
      Gonadotropins, their receptors, and the regulation of testicular functionsin fish

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
    66. Yaron, Z; Gur, G; Melamed, P; Rosenfeld, H; Levavi-Sivan, B; Elizur, A
      Regulation of gonadotropin subunit genes in tilapia

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
    67. Yamamura, N; Takeishi, M; Goto, H; Tagami, M; Mizutani, T; Miyamoto, K; Doi, O; Kamiyoshi, P
      Expression of messenger RNA for gonadotropin receptor in the granulosa layer during the ovulatory cycle of hens

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
    68. Li, HS; Zhang, JY; Thompson, BS; Deng, XY; Ford, ME; Wood, PG; Stolz, DB; Eagon, PK; Whitcomb, DC
      Rat mitochondrial ATP synthase ATP5G3: cloning and upregulation in pancreas after chronic ethanol feeding

      PHYSIOLOGICAL GENOMICS
    69. Ebrahimi, M; Rossi, P; Rogers, C; Harbison, GS
      Dependence of C-13 NMR chemical shifts on conformations of RNA nucleosidesand nucleotides

      JOURNAL OF MAGNETIC RESONANCE
    70. Taylor, AH; Pringle, JH; Bell, SC; Al-Azzawi, F
      Specific inhibition of estrogen receptor alpha function by antisense oligodeoxyribonucleotides

      ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT
    71. Han, ES; Evans, TR; Shu, JH; Lee, S; Nelson, JF
      Food restriction enhances endogenous and corticotropin-induced plasma elevations of free but not total corticosterone throughout life in rats

      JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
    72. Chan, TW; Pollak, M; Huynh, H
      Inhibition of insulin-like growth factor signaling pathways in mammary gland by pure antiestrogen ICI 182,780

      CLINICAL CANCER RESEARCH
    73. Mitchell, BF; Schmid, B
      Oxytocin and its receptor in the process of parturition

      JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
    74. Wu, WX; Ma, XH; Yoshizato, T; Shinozuka, N; Nathanielsz, PW
      Increase in prostaglandin H synthase 2, but not prostaglandin F-2 alpha synthase mRNA in intrauterine tissues during betamethasone-induced premature labor and spontaneous term labor in sheep

      JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
    75. Jayachandran, G; Fallon, AM
      Antisense expression of the 20-hydroxyecdysone receptor (EcR) in transfected mosquito cells uncovers a new EcR isoform that varies at the C-terminal end

      IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
    76. Yon, L; Alexandre, D; Montero, M; Chartrel, N; Jeandel, L; Vallarino, M; Conlon, JM; Kikuyama, S; Fournier, A; Gracia-Navarro, F; Roubos, E; Chow, B; Arimura, A; Anouar, Y; Vaudry, H
      Pituitary adenylate cyclase-activating polypeptide and its receptors in amphibians

      MICROSCOPY RESEARCH AND TECHNIQUE
    77. Meyer, U; van Kampen, M; Isovich, E; Flugge, G; Fuchs, E
      Chronic psychosocial stress regulates the expression of both GR and MR mRNA in the hippocampal formation of tree shrews

      HIPPOCAMPUS
    78. Heufelder, AE; Morgenthaler, N; Schipper, ML; Joba, W
      Sodium iodide symporter-based strategies for diagnosis and treatment of thyroidal and nonthyroidal malignancies

      THYROID
    79. Gonzalez-Sarmiento, R; Corral, J; Mories, MT; Corrales, JJ; Miguel-Velado, E; Miralles-Garcia, JM
      Monoallelic deletion in the 5 ' region of the thyroglobulin gene as a cause of sporadic nonendemic simple goiter

      THYROID
    80. Targovnik, HM; Rivolta, CM; Mendive, FM; Moya, CM; Vono, J; Medeiros-Neto, G
      Congenital goiter with hypothyroidism caused by a 5 ' splice site mutationin the thyroglobulin gene

      THYROID
    81. Shen, DHY; Kloos, RT; Mazzaferri, EL; Jhiang, SM
      Sodium iodide symporter in health and disease

      THYROID
    82. Imai, Y; Toyoda, N; Maeda, A; Kadobayashi, T; Wang, FZ; Kuma, K; Nishikawa, M; Iwasaka, T
      Type 2 iodothyronine deiodinase expression is upregulated by the protein kinase A-dependent pathway and is downregulated by the protein kinase C-dependent pathway in cultured human thyroid cells

      THYROID
    83. Balaram, P; John, M; Enose, S; Symaladevi, PK
      Demonstration of TGF-alpha-EGFR and EGF-EGFR autocrine loops and their relation to proliferation in complete hydatidiform moles (CHM)

      INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
    84. Huleihel, M; Zeyse, D; Lunenfeld, E; Beck, M; Prinsloo, I; Potashnik, G; Mazor, M
      Immunohistochemical staining of IL-1 alpha and IL-1 receptor antagonist but not IL-1 beta in cultures of Sertoli cells

      AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
    85. Ren, ZG; Porzgen, P; Zhang, JM; Chen, XR; Amara, SG; Blakely, RD; Sieber-Blum, M
      Autocrine regulation of norepinephrine transporter expression

      MOLECULAR AND CELLULAR NEUROSCIENCE
    86. Ohsaka, Y; Ohgiya, S; Hoshino, T; Ishizaki, K
      Cold-stimulated increase in a regulatory subunit of cAMP-dependent proteinkinase in human hepatoblastoma cells

      DNA AND CELL BIOLOGY
    87. Le Roith, D; Scavo, L; Butler, A
      What is the role of circulating IGF-I?

      TRENDS IN ENDOCRINOLOGY AND METABOLISM
    88. Carling, T
      Molecular pathology of parathyroid tumors

      TRENDS IN ENDOCRINOLOGY AND METABOLISM
    89. Sandeep, TC; Walker, BR
      Pathophysiology of modulation of local glucocorticoid levels by 11 beta-hydroxysteroid dehydrogenases

      TRENDS IN ENDOCRINOLOGY AND METABOLISM
    90. van den Hurk, R; van de Pavert, SA
      Localization of an activin/activin receptor system in the porcine ovary

      MOLECULAR REPRODUCTION AND DEVELOPMENT
    91. Bobe, J; Goetz, FW
      Cysteine protease inhibitor is specifically expressed in pre- and early-vitellogenic oocytes from the brook trout periovulatory ovary

      MOLECULAR REPRODUCTION AND DEVELOPMENT
    92. Beau, C; Vivian, N; Munsterberg, A; Dresser, DW; Lovell-Badge, R; Guerrier, D
      In vivo analysis of the regulation of the anti-Mullerian hormone, as a marker of Sertoli cell differentiation during testicualar development, revealsa multi-step process

      MOLECULAR REPRODUCTION AND DEVELOPMENT
    93. Uzbekova, S; Ferriere, F; Guiguen, Y; Bailhache, T; Breton, B; Lareyre, JJ
      Stage-dependent and alternative splicing of sGnRH messengers in rainbow trout testis during spermatogenesis

      MOLECULAR REPRODUCTION AND DEVELOPMENT
    94. Lai, JN; Shao, XM; Pan, RW; Dy, E; Huang, CH; Feldman, JL
      RT-PCR reveals muscarinic acetylcholine receptor mRNA in the pre-Botzingercomplex

      AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
    95. Rubenstein, RC; Lyons, BM
      Sodium 4-phenylbutyrate downregulates HSC70 expression by facilitating mRNA degradation

      AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
    96. Bove, K; Neumann, P; Gertzberg, N; Johnson, A
      Role of ecNOS-derived NO in mediating TNF-induced endothelial barrier dysfunction

      AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
    97. Paananen, R; Glumoff, V; Sormunen, R; Voorhout, W; Hallman, M
      Expression and localization of lung surfactant protein B in Eustachian tube epithelium

      AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
    98. Hess, RA; Zhou, Q; Nie, R; Oliveira, C; Cho, H; Nakai, M; Carnes, K
      Estrogens and epididymal function

      REPRODUCTION FERTILITY AND DEVELOPMENT
    99. Lau, HL; Zhu, XM; Leung, PCK; Chan, LW; Chen, GF; Chan, PSF; Yu, KL; Chan, FL
      Detection of mRNA expression of gonadotropin-releasing hormone and its receptor in normal and neoplastic rat prostates

      INTERNATIONAL JOURNAL OF ONCOLOGY
    100. Montgomery, DW
      Prolactin production by immune cells

      LUPUS


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Documento generato il 30/05/20 alle ore 02:14:15