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Orthotopic liver transplantation using low-dose tacrolimus and sirolimus
LIVER TRANSPLANTATION
mTOR inhibitors: An overview
LIVER TRANSPLANTATION
Liver transplantation using sirolimus and minimal corticosteroids (3-day taper)
LIVER TRANSPLANTATION
Azodicarbonamide as a new T cell immunosuppressant: Synergy with cyclosporin A
CLINICAL IMMUNOLOGY
A new and efficient route to derivatives of (R)-4-hydroxycyclohex-2-enone
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
PI 3-kinase, mTOR, protein synthesis and cancer
TRENDS IN MOLECULAR MEDICINE
The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila
NATURE CELL BIOLOGY
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy andcan prevent muscle atrophy in vivo
NATURE CELL BIOLOGY
Origin and true nature of the starter unit for the rapamycin polyketide synthase
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Macrocyclic immunosuppressants
NEW DRUGS FOR ASTHMA, ALLERGY AND COPD
The 12th Annual Report of the North American Pediatric Renal Transplant Cooperative Study: Renal transplantation from 1987 through 1998
PEDIATRIC TRANSPLANTATION
Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
Alterations in interprotein interactions between translation initiation factors assessed by fluorescence resonance energy transfer
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
ENDOCRINE-RELATED CANCER
Staurosporine inhibits phosphorylation of translational regulators linked to mTOR
CELL DEATH AND DIFFERENTIATION
TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway
MOLECULAR CELL
Insulin-like growth factor-I augments prolactin and inhibits growth hormone release through distinct as well as overlapping cellular signaling pathways
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
Review: Uveitis and immunosuppressive drugs
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
Rapamycin blocks IL-2-driven T cell cycle progression while preserving T cell survival
BLOOD CELLS MOLECULES AND DISEASES
In vitro immunosuppressive activity of tacrolimus dihydrodiol precursors obtained by chemical oxidation and identification of a new metabolite of SDZ-RAD by electrospray and electrospray-linked scan mass spectrometry
JOURNAL OF MASS SPECTROMETRY
Spontaneous N -> O acyl shift in the [M+H](+) ions of [MeBmt(1)]-cyclosporins in an ion trap
JOURNAL OF MASS SPECTROMETRY
Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase
CHEMISTRY & BIOLOGY
40-O-(2-hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertensionand neointimal formation in rats
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Crystal structure of Mip, a prolylisomerase from Legionella pneumophila
NATURE STRUCTURAL BIOLOGY
Pharmacokinetic interactions augment toxicities of sirolimus/cyclosporine combinations
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family
MOLECULES AND CELLS
Prevention of neointimal proliferation by immunosuppression in synthetic vascular grafts
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
Inhibition of cytokine production and cytokine-stimulated T-cell activation by FK506 (Tacrolimus)1
CELL TRANSPLANTATION
N-terminal extension changes the folding mechanism of the FK506-binding protein
PROTEIN SCIENCE
Cell cycle-dependent phosphorylation of the translational repressor eIF-4Ebinding protein-1 (4E-BP1)
CURRENT BIOLOGY
Protein kinases: Getting NEKed for S6K activation
CURRENT BIOLOGY
Rapamycin increases the cellular concentration of the BCL-2 protein and exerts an anti-apoptotic effect
EUROPEAN JOURNAL OF CANCER
High-throughput semi-automated 96-well liquid/liquid extraction and liquidchromatography/mass spectrometric analysis of everolimus (RAD 001) and cyclosporin a (CsA) in whole blood
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase
ONCOGENE
Sirolimus improves the two-year outcome of renal allografts in African-American patients
TRANSPLANT INTERNATIONAL
Chronic rejection in H-2 matched cardiac allografts: early emergence of vasculopathy, alloantibody, and accumulation of IFN-gamma and IL-10 mRNA
TRANSPLANT INTERNATIONAL
Impaired phosphate handling of renal allografts is aggravated under rapamycin-based immunosuppression
NEPHROLOGY DIALYSIS TRANSPLANTATION
Sirolimus: a new promising immunosuppressive drug. Towards a rationale forits use in renal transplantation
NEPHROLOGY DIALYSIS TRANSPLANTATION
Use of rapamycin in a transplant patient who developed cyclosporin neurotoxicity
PEDIATRIC NEPHROLOGY
Positive effect on T-cell regulatory apoptosis by mycophenolate mofetil
CLINICAL TRANSPLANTATION
Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells
FASEB JOURNAL
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
GENES & DEVELOPMENT
Effects of nitric oxide synthesis inhibition on FK506-induced nephrotoxicity in rats
RENAL FAILURE
Immunosuppressant use without bone loss - Implications for bone loss aftertransplantation
JOURNAL OF BONE AND MINERAL RESEARCH
A new vascularized adrenal transplantation model in the rat
MICROSURGERY
RAD, a new immunosuppressive macrolide in murine corneal transplantation
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Solubilization of rapamycin
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Angiotensin II regulates phosphorylation of translation elongation factor-2 in cardiac myocytes
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
The Saccharomyces cerevisiae MLF6/YPL244C gene, which encodes a possible yeast homologue of mammalian UDP-galactose transporter, confers resistance to the immunosuppressive drug, leflunomide
CURRENT MICROBIOLOGY
Regulation of glycogen synthesis in human muscle cells
BIOCHEMICAL SOCIETY TRANSACTIONS
Cyclosporine elimination in the presence of TOR inhibitors: Effects on renal function, acute rejection, and safety
AMERICAN JOURNAL OF KIDNEY DISEASES
Safety and efficacy of TOR inhibitors and other immunosuppressive regimensin African-American renal transplant recipients
AMERICAN JOURNAL OF KIDNEY DISEASES
Safety and efficacy of TOR inhibitors in pediatric renal transplant recipients
AMERICAN JOURNAL OF KIDNEY DISEASES
Effects of altered cyclophilin A expression on growth and differentiation of human and mouse neuronal cells
CELLULAR AND MOLECULAR NEUROBIOLOGY
Renal transplantation
SEMINARS IN NEPHROLOGY
Serotonin activates s6 kinase in a rapamycin-sensitive manner in Aplysia synaptosomes
JOURNAL OF NEUROSCIENCE
A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols
EMBO JOURNAL
Activation of Cdh1-dependent APC is required for G(1) cell cycle arrest and DNA damage-induced G(2) checkpoint in vertebrate cells
EMBO JOURNAL
The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1
EMBO JOURNAL
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase
EMBO JOURNAL
The sirolimus coated stent: will the Achilles heel of interventional cardiology finally be cured?
EUROPEAN HEART JOURNAL
Coronary restenosis elimination with a sirolimus eluting stent - First European human experience with 6-month angiographic and intravascular ultrasonic follow-up
EUROPEAN HEART JOURNAL
Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Zinc stimulates the activity of the insulin- and nutrient-regulated protein kinase mTOR
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Estrogen and rapamycin effects on cell cycle progression in T47D breast cancer cells
BREAST CANCER RESEARCH AND TREATMENT
Binding of the La autoantigen to the 5 ' untranslated region of a chimerichuman translation elongation factor 1A reporter mRNA inhibits translation in vitro
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
Cap-independent translation conferred by the 5 '-untranslated region of human thymidine kinase mRNA
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts theinteraction with FKBP12 and FKBP52
REGULATORY PEPTIDES
Single-point calibration for sirolimus quantification
THERAPEUTIC DRUG MONITORING
From beach to bedside: History of the development of sirolimus
THERAPEUTIC DRUG MONITORING
Comparative study analyzing effects of sirolimus-cyclosporin and sirolimus-tacrolimus combinations on bile flow in the rat
DIGESTIVE DISEASES AND SCIENCES
Search for new synthetic immunosuppressants. Antamanide analogues containing the tetrazole ring as a cis-peptide bond mimetic
POLISH JOURNAL OF CHEMISTRY
Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells
KIDNEY INTERNATIONAL
Rapamycin in transplantation: A review of the evidence
KIDNEY INTERNATIONAL
Sirolimus inhibition of lymphocyte proliferation is not antagonized by ciprofloxacin and other quinolone antibiotics
TRANSPLANTATION PROCEEDINGS
Phase III trial of rapamune versus placebo in primary renal allograft recipients
TRANSPLANTATION PROCEEDINGS
RAD reduces compensatory renal graft hypertrophy in a rat model of chronicrejection
TRANSPLANTATION PROCEEDINGS
Interaction of immunophilin-binding immunosuppressives with the glucocorticoid receptor signaling pathway: Implications for transplantation
TRANSPLANTATION PROCEEDINGS
Sirolimus does not potentiate indices of chronic cyclosporin nephrotoxicity
TRANSPLANTATION PROCEEDINGS
Rescue therapy: A role for sirolimus in lung and heart transplant recipients
TRANSPLANTATION PROCEEDINGS
Fast quantification method for sirolimus and its major metabolites
TRANSPLANTATION PROCEEDINGS
Sirolimus permits steroid withdrawal from a cyclosporine regimen
TRANSPLANTATION PROCEEDINGS
A calcineurin antagonist-free induction immunosuppression strategy for delayed graft function in renal transplantation
TRANSPLANTATION PROCEEDINGS
Rapamycin: Clinical results and future opportunities
TRANSPLANTATION
Effect of sirolimus on the metabolism of ApoB100-containing lipoproteins in renal transplant patients
TRANSPLANTATION
Fluvastatin in combination with rad significantly reduces graft vascular disease in rat cardiac allografts
TRANSPLANTATION
Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressure.
TRANSPLANTATION
Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograftrecipients
TRANSPLANTATION
Another nail in the coffin for conventional immunosuppressive regimens with the advent of tolerizing regimens
TRANSPLANTATION
Sirolimus-associated eyelid edema in kidney transplant recipients
TRANSPLANTATION
A calcineurin antagonist-free induction strategy for immunosuppression in cadaveric kidney transplant recipients at risk for delayed graft function
TRANSPLANTATION
A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts
TRANSPLANTATION
Histopathology of chronic renal allograft dysfunction
TRANSPLANTATION
Vascular and cellular mechanisms of chronic renal allograft dysfunction
TRANSPLANTATION
Potential therapeutic interventions to avoid or treat chronic allograft dysfunction
TRANSPLANTATION
Sirolimus rescue therapy for refractory rejection in renal transplantation
TRANSPLANTATION
Effect of low dose cyclosporine and sirolimus on hepatic drug metabolism in the rat
TRANSPLANTATION
RAD in de novo renal transplantation: Comparison of three doses on the incidence and severity of acute rejection
TRANSPLANTATION
Pharamacokinetics and tolerability of 40-0-[2-hydroxyethyl]rapamycin in denovo liver transplant recipients
TRANSPLANTATION
Stereoselective synthesis of polyketide fragments using a novel intramolecular Claisen-like condensation/reduction sequence
TETRAHEDRON LETTERS