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    1. McAlister, VC; Peltekian, KM; Malatjalian, DA; Colohan, S; MacDonald, S; Bitter-Suermann, H; MacDonald, AS
      Orthotopic liver transplantation using low-dose tacrolimus and sirolimus

      LIVER TRANSPLANTATION
    2. Neuhaus, P; Klupp, J; Langrehr, JM
      mTOR inhibitors: An overview

      LIVER TRANSPLANTATION
    3. Trotter, JF; Wachs, M; Bak, T; Trouillot, T; Stolpman, N; Everson, GT; Kam, I
      Liver transplantation using sirolimus and minimal corticosteroids (3-day taper)

      LIVER TRANSPLANTATION
    4. Tassignon, J; Vandevelde, M; Goldman, M
      Azodicarbonamide as a new T cell immunosuppressant: Synergy with cyclosporin A

      CLINICAL IMMUNOLOGY
    5. Yu, LB; Zhang, RZ; Wang, ZQ
      A new and efficient route to derivatives of (R)-4-hydroxycyclohex-2-enone

      JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
    6. Vogt, PK
      PI 3-kinase, mTOR, protein synthesis and cancer

      TRENDS IN MOLECULAR MEDICINE
    7. Miron, M; Verdu, J; Lachance, PED; Birnbaum, MJ; Lasko, PF; Sonenberg, N
      The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

      NATURE CELL BIOLOGY
    8. Bodine, SC; Stitt, TN; Gonzalez, M; Kline, WO; Stover, GL; Bauerlein, R; Zlotchenko, E; Scrimgeour, A; Lawrence, JC; Glass, DJ; Yancopoulos, GD
      Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy andcan prevent muscle atrophy in vivo

      NATURE CELL BIOLOGY
    9. Lowden, PAS; Wilkinson, B; Bohm, GA; Handa, S; Floss, HG; Leadlay, PF; Staunton, J
      Origin and true nature of the starter unit for the rapamycin polyketide synthase

      ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    10. Keller, TH; Hersperger, R; Della Cioppa, G
      Macrocyclic immunosuppressants

      NEW DRUGS FOR ASTHMA, ALLERGY AND COPD
    11. Seikaly, M; Ho, PL; Emmett, L; Tejani, A
      The 12th Annual Report of the North American Pediatric Renal Transplant Cooperative Study: Renal transplantation from 1987 through 1998

      PEDIATRIC TRANSPLANTATION
    12. Ikeda, H; Nonomiya, T; Omura, S
      Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases

      JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
    13. Kimball, SR; Horetsky, RL
      Alterations in interprotein interactions between translation initiation factors assessed by fluorescence resonance energy transfer

      INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
    14. Yu, K; Toral-Barza, L; Discafani, C; Zhang, WG; Skotnicki, J; Frost, P; Gibbons, JJ
      mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer

      ENDOCRINE-RELATED CANCER
    15. Tee, AR; Proud, CG
      Staurosporine inhibits phosphorylation of translational regulators linked to mTOR

      CELL DEATH AND DIFFERENTIATION
    16. Jacinto, E; Guo, B; Arndt, KT; Schmelzle, T; Hall, MN
      TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway

      MOLECULAR CELL
    17. Fruchtman, S; Gift, B; Howes, B; Borski, R
      Insulin-like growth factor-I augments prolactin and inhibits growth hormone release through distinct as well as overlapping cellular signaling pathways

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
    18. Kulkarni, P
      Review: Uveitis and immunosuppressive drugs

      JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
    19. Gonzalez, J; Harris, T; Childs, G; Prystowsky, MB
      Rapamycin blocks IL-2-driven T cell cycle progression while preserving T cell survival

      BLOOD CELLS MOLECULES AND DISEASES
    20. Lhoest, G; Hertsens, R; Verbeeck, RK; Maton, N; Wallemacq, P; Dehoux, JP; Latinne, D
      In vitro immunosuppressive activity of tacrolimus dihydrodiol precursors obtained by chemical oxidation and identification of a new metabolite of SDZ-RAD by electrospray and electrospray-linked scan mass spectrometry

      JOURNAL OF MASS SPECTROMETRY
    21. Jegorov, A; Havlicek, V
      Spontaneous N -> O acyl shift in the [M+H](+) ions of [MeBmt(1)]-cyclosporins in an ion trap

      JOURNAL OF MASS SPECTROMETRY
    22. Rowe, CJ; Bohm, IU; Thomas, IP; Wilkinson, B; Rudd, BAM; Foster, G; Blackaby, AP; Sidebottom, PJ; Roddis, Y; Buss, AD; Staunton, J; Leadlay, PF
      Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase

      CHEMISTRY & BIOLOGY
    23. Nishimura, T; Faul, JL; Berry, GI; Veve, I; Pearl, RG; Kao, PN
      40-O-(2-hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertensionand neointimal formation in rats

      AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
    24. Riboldi-Tunnicliffe, A; Konig, B; Jessen, S; Weiss, MS; Rahfeld, J; Hacker, J; Fischer, G; Hilgenfeld, R
      Crystal structure of Mip, a prolylisomerase from Legionella pneumophila

      NATURE STRUCTURAL BIOLOGY
    25. Podder, H; Stepkowski, SM; Napoli, KL; Clark, J; Verani, RR; Chou, TC; Kahan, BD
      Pharmacokinetic interactions augment toxicities of sirolimus/cyclosporine combinations

      JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
    26. Jo, D; Lyu, MS; Cho, EG; Park, D; Kozak, CA; Kim, MG
      Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family

      MOLECULES AND CELLS
    27. Walpoth, BH; Pavlicek, M; Celik, B; Nicolaus, B; Schaffner, T; Althaus, U; Hess, OM; Carrel, T; Morris, RE
      Prevention of neointimal proliferation by immunosuppression in synthetic vascular grafts

      EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
    28. Almawi, WY; Assi, JW; Chudzik, DM; Abou Jaoude, MM; Rieder, MJ
      Inhibition of cytokine production and cytokine-stimulated T-cell activation by FK506 (Tacrolimus)1

      CELL TRANSPLANTATION
    29. Korepanova, A; Douglas, C; Leyngold, I; Logan, TM
      N-terminal extension changes the folding mechanism of the FK506-binding protein

      PROTEIN SCIENCE
    30. Heesom, KJ; Gampel, A; Mellor, H; Denton, RM
      Cell cycle-dependent phosphorylation of the translational repressor eIF-4Ebinding protein-1 (4E-BP1)

      CURRENT BIOLOGY
    31. Templeton, DJ
      Protein kinases: Getting NEKed for S6K activation

      CURRENT BIOLOGY
    32. Calastretti, A; Rancati, F; Ceriani, MC; Asnaghi, L; Canti, G; Nicolin, A
      Rapamycin increases the cellular concentration of the BCL-2 protein and exerts an anti-apoptotic effect

      EUROPEAN JOURNAL OF CANCER
    33. Brignol, N; McMahon, LM; Luo, S; Tse, FLS
      High-throughput semi-automated 96-well liquid/liquid extraction and liquidchromatography/mass spectrometric analysis of everolimus (RAD 001) and cyclosporin a (CsA) in whole blood

      RAPID COMMUNICATIONS IN MASS SPECTROMETRY
    34. Calastretti, A; Bevilacqua, A; Ceriani, C; Vigano, S; Zancai, P; Capaccioli, S; Nicolin, A
      Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase

      ONCOGENE
    35. Podder, H; Podbielski, J; Hussein, I; Katz, S; Van Buren, C; Kahan, BD
      Sirolimus improves the two-year outcome of renal allografts in African-American patients

      TRANSPLANT INTERNATIONAL
    36. Zhang, QW; Tomita, Y; Matsuzaki, G; Uchida, T; Yoshikawa, M; Nakashima, Y; Sueishi, K; Nomoto, K; Yasui, H
      Chronic rejection in H-2 matched cardiac allografts: early emergence of vasculopathy, alloantibody, and accumulation of IFN-gamma and IL-10 mRNA

      TRANSPLANT INTERNATIONAL
    37. Schwarz, C; Bohmig, GA; Steininger, R; Mayer, G; Oberbauer, R
      Impaired phosphate handling of renal allografts is aggravated under rapamycin-based immunosuppression

      NEPHROLOGY DIALYSIS TRANSPLANTATION
    38. Morelon, E; Mamzer-Bruneel, MF; Peraldi, MN; Kreis, H
      Sirolimus: a new promising immunosuppressive drug. Towards a rationale forits use in renal transplantation

      NEPHROLOGY DIALYSIS TRANSPLANTATION
    39. Hodges, CB; Maxwell, H; Beattie, TJ; Murphy, AV; Jindal, RM
      Use of rapamycin in a transplant patient who developed cyclosporin neurotoxicity

      PEDIATRIC NEPHROLOGY
    40. Nakamura, M; Ogawa, N; Shalabi, A; Maley, WR; Longo, D; Burdick, JF
      Positive effect on T-cell regulatory apoptosis by mycophenolate mofetil

      CLINICAL TRANSPLANTATION
    41. Emami, S; Le Floch, N; Bruyneel, E; Thim, L; May, F; Westley, B; Rio, MC; Mareel, M; Gespach, C
      Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells

      FASEB JOURNAL
    42. Gingras, AC; Raught, B; Gygi, SP; Niedzwiecka, A; Miron, M; Burley, SK; Polakiewicz, RD; Wyslouch-Cieszynska, A; Aebersold, R; Sonenberg, N
      Hierarchical phosphorylation of the translation inhibitor 4E-BP1

      GENES & DEVELOPMENT
    43. Wang, LM; Kubodera, S; Ueno, A; Takeda, M
      Effects of nitric oxide synthesis inhibition on FK506-induced nephrotoxicity in rats

      RENAL FAILURE
    44. Goodman, GR; Dissanayake, IR; Sodam, BR; Gorodetsky, E; Lu, J; Ma, YF; Jee, WSS; Epstein, S
      Immunosuppressant use without bone loss - Implications for bone loss aftertransplantation

      JOURNAL OF BONE AND MINERAL RESEARCH
    45. Liu, DY; Qi, SJ; Xu, DS; Zhu, SY; Chen, HF
      A new vascularized adrenal transplantation model in the rat

      MICROSURGERY
    46. Reis, A; Megahed, M; Reinhard, T; Braunstein, C; Godehardt, E; Sundmacher, R
      RAD, a new immunosuppressive macrolide in murine corneal transplantation

      GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
    47. Simamora, P; Alvarez, JM; Yalkowsky, SH
      Solubilization of rapamycin

      INTERNATIONAL JOURNAL OF PHARMACEUTICS
    48. Everett, AD; Stoops, TD; Nairn, AC; Brautigan, D
      Angiotensin II regulates phosphorylation of translation elongation factor-2 in cardiac myocytes

      AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
    49. Fujimura, HA
      The Saccharomyces cerevisiae MLF6/YPL244C gene, which encodes a possible yeast homologue of mammalian UDP-galactose transporter, confers resistance to the immunosuppressive drug, leflunomide

      CURRENT MICROBIOLOGY
    50. Yeaman, SJ; Armstrong, JL; Bonavaud, SM; Poinasamy, D; Pickersgill, L; Halse, R
      Regulation of glycogen synthesis in human muscle cells

      BIOCHEMICAL SOCIETY TRANSACTIONS
    51. Velosa, JA; Larson, TS; Gloor, JM; Stegall, MD
      Cyclosporine elimination in the presence of TOR inhibitors: Effects on renal function, acute rejection, and safety

      AMERICAN JOURNAL OF KIDNEY DISEASES
    52. Hricik, DE
      Safety and efficacy of TOR inhibitors and other immunosuppressive regimensin African-American renal transplant recipients

      AMERICAN JOURNAL OF KIDNEY DISEASES
    53. Ettenger, RB; Grimm, EM
      Safety and efficacy of TOR inhibitors in pediatric renal transplant recipients

      AMERICAN JOURNAL OF KIDNEY DISEASES
    54. Nahreini, P; Hovland, AR; Kumar, B; Andreatta, C; Edwards-Prasad, J; Prasad, KN
      Effects of altered cyclophilin A expression on growth and differentiation of human and mouse neuronal cells

      CELLULAR AND MOLECULAR NEUROBIOLOGY
    55. Ramanathan, V; Goral, S; Helderman, JH
      Renal transplantation

      SEMINARS IN NEPHROLOGY
    56. Khan, A; Pepio, AM; Sossin, WS
      Serotonin activates s6 kinase in a rapamycin-sensitive manner in Aplysia synaptosomes

      JOURNAL OF NEUROSCIENCE
    57. Ashe, MP; Slaven, JW; De Long, SK; Ibrahimo, S; Sachs, AB
      A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols

      EMBO JOURNAL
    58. Sudo, T; Ota, Y; Kotani, S; Nakao, M; Takami, Y; Takeda, S; Saya, H
      Activation of Cdh1-dependent APC is required for G(1) cell cycle arrest and DNA damage-induced G(2) checkpoint in vertebrate cells

      EMBO JOURNAL
    59. Yang, WM; Yao, YL; Seto, E
      The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1

      EMBO JOURNAL
    60. Wang, XM; Li, W; Williams, M; Terada, N; Alessi, DR; Proud, CG
      Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase

      EMBO JOURNAL
    61. Beyar, R; Roguin, A
      The sirolimus coated stent: will the Achilles heel of interventional cardiology finally be cured?

      EUROPEAN HEART JOURNAL
    62. Rensing, BJ; Vos, J; Smits, PC; Foley, DP; van den Brand, MJBM; van der Giessen, WJ; de Feijter, PJ; Serruys, PW
      Coronary restenosis elimination with a sirolimus eluting stent - First European human experience with 6-month angiographic and intravascular ultrasonic follow-up

      EUROPEAN HEART JOURNAL
    63. Greiwe, JS; Kwon, G; McDaniel, ML; Semenkovich, CF
      Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle

      AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
    64. Lynch, CJ; Patson, BJ; Goodman, SA; Trapolsi, D; Kimball, SR
      Zinc stimulates the activity of the insulin- and nutrient-regulated protein kinase mTOR

      AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
    65. Pang, HY; Faber, LE
      Estrogen and rapamycin effects on cell cycle progression in T47D breast cancer cells

      BREAST CANCER RESEARCH AND TREATMENT
    66. Zhu, JF; Hayakawa, A; Kakegawa, T; Kaspar, RL
      Binding of the La autoantigen to the 5 ' untranslated region of a chimerichuman translation elongation factor 1A reporter mRNA inhibits translation in vitro

      BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
    67. Chou, WL; Chang, ZF
      Cap-independent translation conferred by the 5 '-untranslated region of human thymidine kinase mRNA

      BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
    68. Neye, H
      Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts theinteraction with FKBP12 and FKBP52

      REGULATORY PEPTIDES
    69. Taylor, PJ; Forrest, KK; Salm, P; Pillans, PI
      Single-point calibration for sirolimus quantification

      THERAPEUTIC DRUG MONITORING
    70. Napoli, KL; Taylor, PJ
      From beach to bedside: History of the development of sirolimus

      THERAPEUTIC DRUG MONITORING
    71. Deters, M; Nolte, K; Kirchner, G; Resch, K; Kaever, V
      Comparative study analyzing effects of sirolimus-cyclosporin and sirolimus-tacrolimus combinations on bile flow in the rat

      DIGESTIVE DISEASES AND SCIENCES
    72. Zubrzak, P; Kaczmarek, K; Kowalski, ML; Szkudlinska, B; Zabrocki, J
      Search for new synthetic immunosuppressants. Antamanide analogues containing the tetrazole ring as a cis-peptide bond mimetic

      POLISH JOURNAL OF CHEMISTRY
    73. Bhandari, BK; Feliers, D; Duraisamy, S; Stewart, JL; Gingras, AC; Abboud, HE; Choudhury, GG; Sonenberg, N; Kasinath, BS
      Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells

      KIDNEY INTERNATIONAL
    74. Saunders, RN; Metcalfe, MS; Nicholson, ML
      Rapamycin in transplantation: A review of the evidence

      KIDNEY INTERNATIONAL
    75. Yu, CC; Kelly, PA; Burckart, GJ; Zeevi, A
      Sirolimus inhibition of lymphocyte proliferation is not antagonized by ciprofloxacin and other quinolone antibiotics

      TRANSPLANTATION PROCEEDINGS
    76. Ponticelli, C; MacDonald, AS; Rajagopalan, P; Sindhi, R; Mathew, T
      Phase III trial of rapamune versus placebo in primary renal allograft recipients

      TRANSPLANTATION PROCEEDINGS
    77. Viklicky, O; Muller, V; Zou, H; Szabo, A; Vitko, S; Heemann, U
      RAD reduces compensatory renal graft hypertrophy in a rat model of chronicrejection

      TRANSPLANTATION PROCEEDINGS
    78. Brogan, IJ; Geraghty, PJ; Hutchinson, IV
      Interaction of immunophilin-binding immunosuppressives with the glucocorticoid receptor signaling pathway: Implications for transplantation

      TRANSPLANTATION PROCEEDINGS
    79. Tang, AWC; Walker, RG; Nicholls, KM; Becker, GJ
      Sirolimus does not potentiate indices of chronic cyclosporin nephrotoxicity

      TRANSPLANTATION PROCEEDINGS
    80. Snell, GI; Levvey, BJ; Chin, W; Kotsimbos, ATC; Whitford, H; Williams, TJ; Richardson, M
      Rescue therapy: A role for sirolimus in lung and heart transplant recipients

      TRANSPLANTATION PROCEEDINGS
    81. Kirchner, GI; Jacobsen, W; Deters, M; Christians, U; Nashan, B; Winkler, M; Vidal, C; Kaever, V; Sewing, KF; Manns, MP
      Fast quantification method for sirolimus and its major metabolites

      TRANSPLANTATION PROCEEDINGS
    82. Mahalati, K; Kahan, BD
      Sirolimus permits steroid withdrawal from a cyclosporine regimen

      TRANSPLANTATION PROCEEDINGS
    83. Hong, JC; Kahan, BD
      A calcineurin antagonist-free induction immunosuppression strategy for delayed graft function in renal transplantation

      TRANSPLANTATION PROCEEDINGS
    84. Kahan, BD; Camardo, JS
      Rapamycin: Clinical results and future opportunities

      TRANSPLANTATION
    85. Hoogeveen, RC; Ballantyne, CM; Pownall, HJ; Opekun, AR; Hachey, DL; Jaffe, JS; Oppermann, S; Kahan, BD; Morrisett, JD
      Effect of sirolimus on the metabolism of ApoB100-containing lipoproteins in renal transplant patients

      TRANSPLANTATION
    86. Gregory, CR; Katznelson, S; Griffey, SM; Kyles, AE; Berryman, ER
      Fluvastatin in combination with rad significantly reduces graft vascular disease in rat cardiac allografts

      TRANSPLANTATION
    87. Johnson, RWG; Kreis, H; Oberbauer, R; Brattstrom, C; Claesson, K; Eris, J
      Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressure.

      TRANSPLANTATION
    88. Cho, CS; Burkly, LC; Fechner, JH; Kirk, AD; Oberley, TD; Dong, YC; Brunner, KG; Peters, D; Tenhoor, CN; Nadeau, K; Yagci, G; Ishido, N; Schultz, JM; Tsuchida, M; Hamawy, MM; Knechtle, SJ
      Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograftrecipients

      TRANSPLANTATION
    89. Goddard, SH; Adams, DH
      Another nail in the coffin for conventional immunosuppressive regimens with the advent of tolerizing regimens

      TRANSPLANTATION
    90. Mohaupt, MG; Vogt, B; Frey, FJ
      Sirolimus-associated eyelid edema in kidney transplant recipients

      TRANSPLANTATION
    91. Hong, JC; Kahan, BD
      A calcineurin antagonist-free induction strategy for immunosuppression in cadaveric kidney transplant recipients at risk for delayed graft function

      TRANSPLANTATION
    92. MacDonald, AS
      A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts

      TRANSPLANTATION
    93. Furness, PN
      Histopathology of chronic renal allograft dysfunction

      TRANSPLANTATION
    94. Morris, RE
      Vascular and cellular mechanisms of chronic renal allograft dysfunction

      TRANSPLANTATION
    95. Kahan, BD
      Potential therapeutic interventions to avoid or treat chronic allograft dysfunction

      TRANSPLANTATION
    96. Hong, JC; Kahan, BD
      Sirolimus rescue therapy for refractory rejection in renal transplantation

      TRANSPLANTATION
    97. Bai, S; Brunner, LJ; Stepkowski, SM; Napoli, KL; Kahan, BD
      Effect of low dose cyclosporine and sirolimus on hepatic drug metabolism in the rat

      TRANSPLANTATION
    98. Kahan, BD; Kaplan, B; Lorber, MI; Winkler, M; Cambon, N; Boger, RS
      RAD in de novo renal transplantation: Comparison of three doses on the incidence and severity of acute rejection

      TRANSPLANTATION
    99. Levy, GA; Grant, D; Paradis, K; Campestrini, J; Smith, T; Kovarik, JM
      Pharamacokinetics and tolerability of 40-0-[2-hydroxyethyl]rapamycin in denovo liver transplant recipients

      TRANSPLANTATION
    100. Hinterding, K; Singhanat, S; Oberer, L
      Stereoselective synthesis of polyketide fragments using a novel intramolecular Claisen-like condensation/reduction sequence

      TETRAHEDRON LETTERS


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 03:50:51