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    1. Bahceciler, NN; Isik, U; Barlan, IB; Basaran, MM
      Efficacy of sublingual immunotherapy in children with asthma and rhinitis:A double-blind, placebo-controlled study

      PEDIATRIC PULMONOLOGY
    2. Hiramatsu, Y; Miyazaki, Y
      Effect of volatile matter from wood chins on the activity of house dust mites and on the sensory evaluation of humans

      JOURNAL OF WOOD SCIENCE
    3. Mastrandrea, F
      Immunotherapy in atopic dermatitis

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    4. Solarz, K
      Risk of exposure to house dust pyroglyphid mites in Poland

      ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
    5. Racewicz, M
      House dust mites (Acari : pyroglyphidae) in the cities of Gdansk and Gdynia (Northern Poland)

      ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
    6. Creticos, PS
      The consideration of immunotherapy in the treatment of allergic asthma

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    7. Portnoy, JM
      Immunotherapy for asthma: unfavorable studies

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    8. Finegold, I
      Analyzing meta-analyses of specific immunotherapy in the treatment of asthma

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    9. Miller, RL; Chew, GL; Bell, CA; Biedermann, SA; Aggarwal, M; Kinney, PL; Tsai, WY; Whyatt, RM; Perera, FP; Ford, JG
      Prenatal exposure, maternal sensitization,, and sensitization in utero to indoor allergens in an inner-city cohort

      AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
    10. Moffatt, MF; Schou, C; Faux, JA; Abecasis, GR; James, A; Musk, AW; Cookson, WOCM
      Association between quantitative traits underlying asthma and the HLA-DRB1locus in a family-based population sample

      EUROPEAN JOURNAL OF HUMAN GENETICS
    11. Olsson, S; van Hage-Hamsten, M; Magnusson, CGM
      IgG1, IgG4 and IgE antibody reactivity to mutant forms of the major dust mite allergen Lep d 2 among atopic and nonatopic subjects naturally exposed to Lepidoglyphus destructor

      INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
    12. Massaer, M; Mazzu, P; Haumont, M; Magi, M; Daminet, V; Bollen, A; Jacquet, A
      High-level expression in mammalian cells of recombinant house dust mite allergen ProDer p 1 with optimized codon usage

      INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
    13. Smith, AM; Benjamin, DC; Derewenda, U; Smith, WA; Thomas, WR; Chapman, MD
      Sequence polymorphisms and antibody binding to the group 2 dust mite allergens

      INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
    14. de Weck, AL; Sanz, ML; Sanchez-Lopez, G; Uasuf, C; Chazot, M
      Determination by flow cytometry of activated basophils in patients sensitized to Dermatophagoides pteronyssinus and Lolium perenne

      INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
    15. Jenmalm, MC; Bjorksten, B
      Immune responses to birch during the first seven pollen seasons of life

      INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
    16. Pajno, GB; Barberio, G; De Luca, F; Morabito, L; Parmiani, S
      Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study.

      CLINICAL AND EXPERIMENTAL ALLERGY
    17. Kim, YK; Oh, SY; Jung, JW; Min, KU; Kim, YY; Cho, SH
      IgE binding components in Tetranychus urticae and Panonychus ulmi-derived crude extracts and their crossreactivity with domestic mites

      CLINICAL AND EXPERIMENTAL ALLERGY
    18. Kim, YK; Park, HS; Kim, HY; Jee, YK; Son, JW; Bae, JM; Lee, MH; Cho, SH; Min, KU; Kim, YY
      Citrus red mite (Panonychus citri) may be an important allergen in the development of asthma among exposed children

      CLINICAL AND EXPERIMENTAL ALLERGY
    19. Peebles, RS; Hamilton, RG; Lichtenstein, LM; Schlosberg, M; Liu, MC; Proud, D; Togias, A
      Antigen-specific IgE and IgA antibodies in bronchoalveolar lavage fluid are associated with stronger antigen-induced late phase reactions

      CLINICAL AND EXPERIMENTAL ALLERGY
    20. Gough, L; Sewell, HF; Shakib, F
      The proteolytic activity of the major dust mite allergen Der p 1 enhances the IgE antibody response to a bystander antigen

      CLINICAL AND EXPERIMENTAL ALLERGY
    21. Kim, YK; Oh, HB; Oh, SY; Cho, SH; Kim, YY; Min, KU
      HLA-DRB1*07 may have a susceptibility and DRB1*04 a protective effect uponthe development of a sensitization to house dust mite Dermatophagoides pteronyssinus

      CLINICAL AND EXPERIMENTAL ALLERGY
    22. Yasuhara, T; Takai, T; Yuuki, T; Okudaira, H; Okumura, Y
      Biologically active recombinant forms of a major house dust mite group 1 allergen Der f 1 with full activities of both cysteine protease and IgE binding

      CLINICAL AND EXPERIMENTAL ALLERGY
    23. Bertel, F; Mortemousque, B; Sicard, H; Andre, C
      Conjunctival provocation test

      JOURNAL FRANCAIS D OPHTALMOLOGIE
    24. Hill, PB; DeBoer, DJ
      The ACVD task force on canine atopic dermatitis (IV): Environmental allergens

      VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
    25. Griffin, CE; Hillier, A
      The ACVD task force on canine atopic dermatitis (XXIV): allergen-specific immunotherapy

      VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
    26. Sidenius, KE; Hallas, TE; Poulsen, LK; Mosbech, H
      Allergen cross-reactivity between house-dust mites and other invertebrates

      ALLERGY
    27. Pichler, CE; Helbling, A; Pichler, WJ
      Three years of specific immunotherapy with house-dust-mite extracts in patients with rhinitis and asthma: significant improvement of allergen-specific parameters and of nonspecific bronchial hyperreactivity

      ALLERGY
    28. Torres-Galvan, MJ; Quiralte, J; Pestano, JJ; Ortega, N; Blanco, C; Castillo, R; Carrillo, T; Perez-Aciego, P; Sanchez-Garcia, F
      IL4-R1 (5q31-q33) and Fc epsilon RI-beta ca (11q13) markers and atopy: a case/control study in a Spanish population

      ALLERGY
    29. Okano, M; Kino, K; Takishita, T; Hattori, H; Ogawa, T; Yoshino, T; Yokoyama, M; Nishizaki, K
      Roles of carbohydrates on Cry j 1, the major allergen of Japanese cedar pollen, in specific T-cell responses

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    30. Smith, AM; Benjamin, DC; Hozic, N; Derewenda, U; Smith, WA; Thomas, WR; Gafvelin, G; van Hage-Hamsten, M; Chapman, MD
      The molecular basis of antigenic cross-reactivity between the group 2 miteallergens

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    31. Smith, WA; Hales, BJ; Jarnicki, AG; Thomas, WR
      Allergens of wild house dust mites: Environmental Der p 1 and Der p 2 sequence polymorphisms

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    32. Arlian, LG; Platts-Mills, TAE
      The biology of dust mites and the remediation of mite allergens in allergic disease

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    33. Frew, AJ; Smith, HE
      Sublingual immunotherapy

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    34. Walker, SM; Pajno, GB; Lima, MT; Wilson, DR; Durham, SR
      Grass pollen immunotherapy for seasonal rhinitis and asthma: A randomized,controlled trial

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    35. Arlian, LG; Neal, JS; Morgan, MS; Vyszenski-Moher, DL; Rapp, CM; Alexander, AK
      Reducing relative humidity is a practical way to control dust mites and their allergens in homes in temperate climates

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    36. Nuttall, TJ; Lamb, JR; Hill, PB
      Characterisation of major and minor Dermatophagoides allergens in canine atopic dermatitis

      RESEARCH IN VETERINARY SCIENCE
    37. Hirsch, T
      Allergen immnunotherapy in allergic diseases with special regard to atopiceczema

      MONATSSCHRIFT KINDERHEILKUNDE
    38. Kanda, N; Watanabe, S
      Intracellular 3 ',5 '-adenosine cyclic monophosphate level regulates housedust mite-induced interleukin-13 production by T cells from mite-sensitivepatients with atopic dermatitis

      JOURNAL OF INVESTIGATIVE DERMATOLOGY
    39. Sun, G; Stacey, MA; Schmidt, M; Mori, L; Mattoli, S
      Interaction of mite allergens Der P3 and Der P9 with protease-activated receptor-2 expressed by lung epithelial cells

      JOURNAL OF IMMUNOLOGY
    40. Kutting, B; Brehler, R
      House-dust mite-crustaceans-molluscs-syndrome. A rare variant of food allergy due to cross-reactivity by primary sensitisation to inhaled allergens

      HAUTARZT
    41. Gellrich, S; Zuberbier, T
      Indoor allergens

      HAUTARZT
    42. Eriksson, TLJ; Rasool, O; Huecas, S; Whitley, P; Crameri, R; Appenzeller, U; Gafvelin, G; van Hage-Hamsten, M
      Cloning of three new allergens from the dust mite Lepidoglyphus destructorusing phage surface display technology

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    43. Mansour, M; Lanphear, BP; Hornung, R; Khoury, J; Bernstein, DI; Menrath, W; Decolongon, J
      A side-by-side comparison of sampling methods for settled, indoor allergens

      ENVIRONMENTAL RESEARCH
    44. Yang, X
      Does allergen immunotherapy alter the natural course of allergic disorders?

      DRUGS
    45. Alvarez-Puebla, MJ; Olaguibel-Rivera, JM; Urbiola-Marcilla, E; Garcia, BE; Tabar-Purroy, AI
      Determinants of allergen-induced late bronchial responses in mild asthmatics

      CHEST
    46. Schumann, RJ; Morgan, MS; Glass, R; Arlian, LG
      Characterization of house dust mite and scabies mite allergens by use of canine serum antibodies

      AMERICAN JOURNAL OF VETERINARY RESEARCH
    47. Mueller, RS; Bettenay, SV
      Evaluation of the safety of an abbreviated course of injections of allergen extracts (rush immunotherapy) for the treatment of dogs with atopic dermatitis

      AMERICAN JOURNAL OF VETERINARY RESEARCH
    48. Krco, CJ; Harders, J; Chapoval, S; David, CS
      Immune response of HLA-DQ transgenic mice to house dust mite allergen p2: Identification of HLA-DQ restricted minimal epitopes and critical residues

      CLINICAL IMMUNOLOGY
    49. Rolland, JM; Douglass, J; O'Hehir, RE
      Allergen immunotherapy: current and new therapeutic strategies

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    50. Schadlich, PK; Brecht, JG
      Economic evaluation of specific immunotherapy versus symptomatic treatmentof allergic rhinitis in Germany

      PHARMACOECONOMICS
    51. Theodoropoulos, DS; Lockey, RF
      Allergen immunotherapy: Guidelines, update, and recommendations of the World Health Organization

      ALLERGY AND ASTHMA PROCEEDINGS
    52. Akcakaya, N; Hassanzadeh, A; Camcioglu, Y; Cokugras, H
      Local and systemic reactions during immunotherapy with adsorbed extracts of house dust mite in children

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    53. Lee, MH; Cho, SH; Park, HS; Bahn, JW; Lee, BJ; Son, JW; Kim, YK; Koh, YY; Min, KU; Kim, YY
      Citrus red mite (Panonychus citri) is a common sensitizing allergen among children living around citrus orchards

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    54. Jee, YK; Park, HS; Kim, HY; Park, JS; Lee, KY; Kim, KY; Kim, YK; Cho, SH; Min, KU; Kim, YY
      Two-spotted spider mite (Tetranychus urticae): an important allergen in asthmatic non-farmers symptomatic in summer and fall months

      ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
    55. Smith, AM; Pomes, A; Chapman, MD
      Molecular biology of indoor allergens

      CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
    56. Platts-Mills, TAE; Blumenthal, K; Perzanowski, M; Woodfolk, JA
      Determinants of clinical allergic disease - The relevance of indoor allergens to the increase in asthma

      AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
    57. Duez, C; Kips, J; Pestel, J; Tournoy, K; Tonnel, AB; Pauwels, R
      House dust mite-induced airway changes in hu-SCID mice

      AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
    58. Best, EA; Stedman, KE; Bozic, CM; Hunter, SW; Vailes, L; Chapman, MD; McCall, CA; McDermott, MJ
      A recombinant group 1 house dust mite allergen, rDer f 1, with biological activities similar to those of the native allergen

      PROTEIN EXPRESSION AND PURIFICATION
    59. Musken, H; Franz, JT; Wahl, R; Paap, A; Cromwell, O; Masuch, G; Bergmann, KC
      Sensitization to different mite species in German farmers: Clinical aspects

      JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY
    60. Croce, M; Costa-Manso, E; Baggio, D; Croce, J
      House dust mites in the city of Lime, Peru

      JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY
    61. Boquete, M; Carballada, F; Armisen, M; Nieto, A; Martin, S; Polo, F; Carreira, J
      Factors influencing the clinical picture and the differential sensitization to house dust mites and storage mites

      JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY
    62. Sopelete, MC; Silva, DAO; Arruda, LK; Chapman, MD; Taketomi, EA
      Dermatophagoides farinae (Der f 1) and Dermatophagoides pteronyssinus (Derp 1) allergen exposure among subjects living in Uberlandia, Brazil

      INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
    63. Tsai, JJ; Shen, HD; Chua, KY
      Purification of group 2 Dermatophagoides pteronyssinus allergen and prevalence of its specific IgE in asthmatics

      INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
    64. Park, GM; Lee, SM; Lee, IY; Ree, HI; Kim, KS; Hong, CS; Yong, TS
      Localization of a major allergen, Der p 2, in the gut and faecal pellets of Dermatophagoides pteronyssinus

      CLINICAL AND EXPERIMENTAL ALLERGY
    65. Furmonaviciene, R; Sewell, HF; Shakib, F
      Comparative molecular modelling identifies a common putative IgE epitope on cysteine protease allergens of diverse sources

      CLINICAL AND EXPERIMENTAL ALLERGY
    66. Olsson, S; Van Hage-Hamsten, M
      Allergens from house dust and storage mites: similarities and differences,with emphasis on the storage mite Lepidoglyphus destructor

      CLINICAL AND EXPERIMENTAL ALLERGY
    67. Hales, BJ; Shen, HD; Thomas, WR
      Cross-reactivity of T-cell responses to Dermatophagoides pteronyssinus andD-farinae. Studies with group 1 and 7 allergens

      CLINICAL AND EXPERIMENTAL ALLERGY
    68. Hales, BJ; Shen, HD; Thomas, WR
      Cytokine responses to Der p 1 and Der p 7: house dust mite allergens with different IgE-binding activities

      CLINICAL AND EXPERIMENTAL ALLERGY
    69. John, RJ; Rusznak, C; Ramjee, M; Lamont, AG; Abrahamson, M; Hewitt, EL
      Functional effects of the inhibition of the cysteine protease activity of the major house dust mite allergen Der p 1 by a novel peptide-based inhibitor

      CLINICAL AND EXPERIMENTAL ALLERGY
    70. Kronqvist, M; Johansson, E; Magnusson, CGM; Olsson, S; Eriksson, TLJ; Gafvelin, G; Van Hage-Hamsten, M
      Skin prick test and serological analysis with recombinant group 2 allergens of the dust mites L-destructor and T-putrescentiae

      CLINICAL AND EXPERIMENTAL ALLERGY
    71. Jacquet, A; Haumont, M; Massaer, M; Daminet, V; Garcia, L; Mazzu, P; Jacobs, P; Bollen, A
      Biochemical and immunological characterization of a recombinant precursor form of the house dust mite allergen Der p 1 produced by Drosophila cells

      CLINICAL AND EXPERIMENTAL ALLERGY
    72. Wan, H; Winton, HL; Soeller, C; Gruenert, DC; Thompson, PJ; Cannell, MB; Stewart, GA; Garrod, DR; Robinson, C
      Quantitative structural and biochemical analyses of tight junction dynamics following exposure of epithelial cells to house dust mite allergen Der p 1

      CLINICAL AND EXPERIMENTAL ALLERGY
    73. Gross, I; Heinrich, J; Fahlbusch, B; Jager, L; Bischof, W; Wichmann, HE
      Indoor determinants of Der p 1 and Der f 1 concentrations in house dust are different

      CLINICAL AND EXPERIMENTAL ALLERGY
    74. Kim, YK; Cho, SH; Min, KU; Kim, YY
      Spider mites: common outdoor allergens among individuals living in rural areas

      CLINICAL AND EXPERIMENTAL ALLERGY
    75. Jenmalm, MC; Bjorksten, B
      Cord blood levels of immunoglobulin G subclass antibodies to food and inhalant allergens in relation to maternal atopy and the development of atopic disease during the first 8 years of life

      CLINICAL AND EXPERIMENTAL ALLERGY
    76. Tournoy, KG; Kips, JC; Schou, C; Pauwels, RA
      Airway eosinophilia is not a requirement for allergen-induced airway hyperresponsiveness

      CLINICAL AND EXPERIMENTAL ALLERGY
    77. Roche, N; Chinet, TC; Belouchi, NE; Julie, C; Huchon, GJ
      Dermatophagoides pteronyssinus and bioelectric properties of airway epithelium: role of cysteine proteases

      EUROPEAN RESPIRATORY JOURNAL
    78. Ledford, DK
      Efficacy of immunotherapy

      IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
    79. Kemp, SF
      Adverse effects of allergen immunotherapy - Assessment and treatment

      IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
    80. Li, JT
      Immunotherapy for allergic rhinitis

      IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
    81. Stenton, SC
      Determinants of whether occupational agents cause early, late, or dual asthmatic responses

      OCCUPATIONAL MEDICINE-STATE OF THE ART REVIEWS
    82. Ortego, F; Sanchez-Ramos, I; Ruiz, M; Castanera, P
      Characterization of proteases from a stored product mite, Tyrophagus putrescentiae

      ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
    83. Kanceljak-Macan, B; Macan, J; Buneta, L; Milkovic-Kraus, S
      Sensitization to non-pyroglyphid mites in urban population of Croatia

      CROATIAN MEDICAL JOURNAL
    84. Wahn, V
      Immunologic therapies in allergic disorders - current aspects

      ALLERGOLOGIE
    85. Arlian, LG; Morgan, MS
      Serum antibody to Sarcoptes scabiei and house dust mite prior to and during infestation with S-scabiei

      VETERINARY PARASITOLOGY
    86. Uehara, K; Toyoda, Y; Konishi, E
      Contamination of passenger trains with Dermatophagoides (Acari : Pyroglyphidae) mite antigen in Japan

      EXPERIMENTAL AND APPLIED ACAROLOGY
    87. Kawamoto, S; Ohno, K; Tategaki, A; Aki, T; Shigeta, S; Jyo, T; Suzuki, O; Ono, K
      T-cell epitope analysis of Mag 3, an important allergen from the house dust mite, Dermatophagoides farinae

      IMMUNOLOGY LETTERS
    88. Ross, RN; Nelson, HS; Finegold, I
      Effectiveness of specific immunotherapy in the treatment of asthma: A meta-analysis of prospective, randomized, double-blind, placebo-controlled studies

      CLINICAL THERAPEUTICS
    89. Malling, HJ
      Minimising the risks of allergen-specific injection immunotherapy

      DRUG SAFETY
    90. Winther, L; Malling, HJ; Mosbech, H
      Allergen-specific immunotherapy in birch- and grass-pollen-allergic rhinitis. II. Side-effects

      ALLERGY
    91. Pajno, GB; Morabito, L; Barberio, G; Parmiani, S
      Clinical and immunologic effects of long-term sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, placebo-controlled study

      ALLERGY
    92. Moscato, G; Perfetti, L; Galdi, E; Pozzi, V; Minoia, C
      Levels of house-dust-mite allergen in homes of nonallergic people in Pavia, Italy

      ALLERGY
    93. Torres-Galvan, MJ; Quiralte, J; Blanco, C; Castillo, R; Carrillo, T; Perez-Aciego, P; Sanchez-Garcia, F
      Pocket 4 in the HLA-DRB1 antigen-binding groove: an association with atopy

      ALLERGY
    94. Radon, K; Schottky, A; Garz, S; Koops, F; Szadkowski, D; Radon, K; Nowak, D; Luczynska, C
      Distribution of dust-mite allergens (Lep d 2, Der p 1, Der f 1, Der 2) in pig-farming environments and sensitization of the respective farmers

      ALLERGY
    95. Tsai, LC; Chao, PL; Hung, MW; Sun, YC; Kuo, IC; Chua, KY; Liaw, SH; Chua, KY; Kuo, IC
      Protein sequence analysis and mapping of IgE and IgG epitopes of an allergenic 98-kDa Dermatophagoides farinae paramyosin, Der f 11

      ALLERGY
    96. Alvarez, MJ; Olaguibel, JM; Acero, S; Garcia, BE; Tabar, AI; Urbiola, E
      Effect of current exposure to Der p 1 on asthma symptoms, airway inflammation, and bronchial hyperresponsiveness in mite-allergic asthmatics

      ALLERGY
    97. Chapman, MD; Smith, AM; Vailes, LD; Arruda, LK; Dhanaraj, V; Pomes, A
      Recombinant allergens for diagnosis and therapy of allergic disease

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    98. Creticos, PS
      The consideration of immunotherapy in the treatment of allergic asthma

      JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
    99. Vinuya, RZ
      Specific allergen immunotherapy for allergic rhinitis and asthma

      PEDIATRIC ANNALS
    100. Petrova, AD; Zheltikova, TM
      Long-term dynamics and structure of house dust mite community in Moscow (Acariformes, Astigmata)

      ZOOLOGICHESKY ZHURNAL


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Documento generato il 19/01/21 alle ore 23:30:28