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Multiple roles of mouse Numb in tuning developmental cell fates
CURRENT BIOLOGY
Integrin tyrosine phosphorylation in platelet signaling
CURRENT OPINION IN CELL BIOLOGY
Signaling via Shc family adapter proteins
ONCOGENE
The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret
ONCOGENE
Amyloid precursor protein associates independently and collaboratively with PTB and PDZ domains of mint on vesicles and at cell membrane
NEUROSCIENCE
Protein-protein interactions probed by nuclear magnetic resonance spectroscopy
NUCLEAR MAGNETIC RESONANCE OF BIOLOGICAL MACROMOLECULES, PT B
Peptide library screening for determination of SH2 or phosphotyrosine-binding domain sequences
REGULATORS AND EFFECTORS OF SMALL GTPASES, PT F, RAS FAMILY I
The N-terminal domain of Homer/Vesl is a new class II EVH1 domain
JOURNAL OF MOLECULAR BIOLOGY
ConSurf: An algorithmic tool for the identification of functional regions in proteins by surface mapping of phylogenetic information
JOURNAL OF MOLECULAR BIOLOGY
Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling
JOURNAL OF BIOLOGICAL CHEMISTRY
Tyrosine-phosphorylated low density lipoprotein receptor-related protein 1(LRP1) associates with the adaptor protein SHC in SRC-transformed cells
JOURNAL OF BIOLOGICAL CHEMISTRY
A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C - Characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly binds protein kinase C3
JOURNAL OF BIOLOGICAL CHEMISTRY
Structural properties and mechanisms that govern association of C kinase adapter 1 with protein kinase C3 and the cell periphery
JOURNAL OF BIOLOGICAL CHEMISTRY
Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase
EUROPEAN JOURNAL OF BIOCHEMISTRY
Insulin-independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin receptor from that of IRS-1
DIABETOLOGIA
The promiscuous and specific sides of SecB
NATURE STRUCTURAL BIOLOGY
Phosphothreonine recognition comes into focus
NATURE STRUCTURAL BIOLOGY
Letter to the Editor: H-1, C-13 and N-15 resonance assignments of the SNT PTB domain in complex with FGFR1 peptide
JOURNAL OF BIOMOLECULAR NMR
FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors
MOLECULAR AND CELLULAR BIOLOGY
Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb
EMBO JOURNAL
Structural basis of the membrane-targeting and unmasking mechanisms of theradixin FERM domain
EMBO JOURNAL
The juxtamembrane region of MuSK has a critical role in agrin-mediated signaling
EMBO JOURNAL
The Shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3
BLOOD
The role of adapter proteins in T cell activation
CELLULAR AND MOLECULAR LIFE SCIENCES
Adapter molecules in T cell receptor signaling
INFLAMMATORY BOWEL DISEASES
The PH superfold: a structural scaffold for multiple functions
TRENDS IN BIOCHEMICAL SCIENCES
Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effecters to a multifunctional docking site
HUMAN MOLECULAR GENETICS
Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A
CURRENT BIOLOGY
Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6
CURRENT BIOLOGY
Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease
EUROPEAN JOURNAL OF NEUROSCIENCE
Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site
ONCOGENE
Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain
MAMMALIAN GENOME
SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor
LEUKEMIA
The IL-4 receptor: Signaling mechanisms and biologic functions
ANNUAL REVIEW OF IMMUNOLOGY
The disabled 1 phosphotyrosine-binding domain binds to the internalizationsignals of transmembrane glycoproteins and to phospholipids
MOLECULAR AND CELLULAR BIOLOGY
Phosphotyrosine protein of molecular mass 30 kDa binds specifically to thepositively charged region of the pleckstrin N-terminal pleckstrin homologydomain
BIOCHEMICAL JOURNAL
The structure-function characterization of proteins, substrates of insulinreceptor, and molecular mechanisms of their interaction with insulin superfamily tyrosine kinase receptors and effector proteins
BIOLOGICHESKIE MEMBRANY
Structure of the enabled VASP homology 1 domain-peptide complex: A key component in the spatial control of actin assembly
CELL
Activated ERK2 interacts with and phosphorylates the docking protein GAB1
JOURNAL OF BIOLOGICAL CHEMISTRY
Characterization of four mammalian numb protein isoforms - Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain
JOURNAL OF BIOLOGICAL CHEMISTRY
Phosphotyrosine binding domains of Shc and insulin receptor substrate 1 recognize the NPXpY motif in a thermodynamically distinct manner
JOURNAL OF BIOLOGICAL CHEMISTRY
Multiple in vivo tyrosine phosphorylation sites in EphB receptors
BIOCHEMISTRY
Phospholipid-binding protein domains
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
FRIP, A HEMATOPOIETIC CELL-SPECIFIC RASGAP-INTERACTING PROTEIN PHOSPHORYLATED IN RESPONSE TO CYTOKINE STIMULATION
Immunity (Cambridge, Mass.)
THE TEK TIE2 RECEPTOR SIGNALS THROUGH A NOVEL DOK-RELATED DOCKING PROTEIN, DOK-R/
Oncogene
STIMULATION THROUGH THE T-CELL RECEPTOR LEADS TO INTERACTIONS BETWEENSHB AND SEVERAL SIGNALING PROTEINS
Oncogene
SHC PHOSPHOTYROSINE-BINDING DOMAIN DOMINANTLY INTERACTS WITH EPIDERMAL GROWTH-FACTOR RECEPTORS AND MEDIATES RAS ACTIVATION IN INTACT-CELLS
Molecular endocrinology
THE FE65 AND XII-FAMILIES OF PROTEINS - PROTEINS THAT INTERACT WITH THE ALZHEIMERS-DISEASE AMYLOID PRECURSOR PROTEIN
Biochemical Society transactions
2 DISTANTLY POSITIONED PDZ DOMAINS MEDIATE MULTIVALENT INAD-PHOSPHOLIPASE-C INTERACTIONS ESSENTIAL FOR G-PROTEIN-COUPLED SIGNALING
EMBO journal
Mint 3: A ubiquitous mint isoform that does not bind to munc18-1 or -2
EUROPEAN JOURNAL OF CELL BIOLOGY
CANDIDATE ADAPTER PROTEIN CED-6 PROMOTES THE ENGULFMENT OF APOPTOTIC CELLS IN C-ELEGANS
Cell
THE LDL RECEPTOR CLUSTERING MOTIF INTERACTS WITH THE CLATHRIN TERMINAL DOMAIN IN A REVERSE TURN CONFORMATION
The Journal of cell biology
THE SOLUTION STRUCTURE AND DYNAMICS OF THE PLECKSTRIN HOMOLOGY DOMAINOF G PROTEIN-COUPLED RECEPTOR KINASE-2 (BETA-ADRENERGIC-RECEPTOR KINASE-1) - A BINDING PARTNER OF G(BETA-GAMMA) SUBUNITS
The Journal of biological chemistry
NOVEL RECOGNITION MOTIF ON FIBROBLAST-GROWTH-FACTOR RECEPTOR MEDIATESDIRECT ASSOCIATION AND ACTIVATION OF SNT ADAPTER PROTEINS
The Journal of biological chemistry
A ROLE FOR THE INSULIN-INTERLEUKIN (IL)-4 RECEPTOR MOTIF OF THE IL-4 RECEPTOR ALPHA-CHAIN IN REGULATING ACTIVATION OF THE INSULIN-RECEPTOR SUBSTRATE 2 AND SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 8 PATHWAYS - ANALYSIS BY MUTAGENESIS
The Journal of biological chemistry
THE MAMMALIAN NUMB PHOSPHOTYROSINE-BINDING DOMAIN - CHARACTERIZATION OF BINDING-SPECIFICITY AND IDENTIFICATION OF A NOVEL PDZ DOMAIN-CONTAINING NUMB BINDING-PROTEIN, LNX
The Journal of biological chemistry
Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein
JOURNAL OF BIOLOGICAL CHEMISTRY
ROLES OF LCK, SYK AND ZAP-70 TYROSINE KINASES IN TCR-MEDIATED PHOSPHORYLATION OF THE ADAPTER PROTEIN SHC
European Journal of Immunology
MOLECULAR-IDENTIFICATION AND FUNCTIONAL-CHARACTERIZATION OF A NOVEL PROTEIN THAT MEDIATES THE ATTACHMENT OF ERYTHROBLASTS TO MACROPHAGES
Blood
MULTIPLE FORMS OF THE SH2-CONTAINING INOSITOL PHOSPHATASE, SHIP, ARE GENERATED BY C-TERMINAL TRUNCATION
Blood
INSIGHTS INTO TYROSINE PHOSPHORYLATION CONTROL OF PROTEIN-PROTEIN ASSOCIATION FROM THE NMR STRUCTURE OF A BAND-3 PEPTIDE INHIBITOR BOUND TOGLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
Biochemistry
SIGNIFICANTLY IMPROVED RESOLUTION FOR NOE CORRELATIONS FROM VALINE AND ISOLEUCINE (C-GAMMA-2) METHYL-GROUPS IN N-15,C-13-LABELED AND N-15,C-13,H-2-LABELED PROTEINS
Journal of the American Chemical Society
INTERACTION OF THE MAIZE AND ARABIDOPSIS KINASE INTERACTION DOMAINS WITH A SUBSET OF RECEPTOR-LIKE PROTEIN-KINASES - IMPLICATIONS FOR TRANSMEMBRANE SIGNALING IN PLANTS
Plant journal
EVIDENCE FOR A REQUIREMENT FOR BOTH PHOSPHOLIPID AND PHOSPHOTYROSINE BINDING VIA THE SHC PHOSPHOTYROSINE-BINDING DOMAIN IN-VIVO
Molecular and cellular biology
SEQUENCE-SPECIFIC RECOGNITION OF THE INTERNALIZATION MOTIF OF THE ALZHEIMERS AMYLOID PRECURSOR PROTEIN BY THE X11 PTB DOMAIN
EMBO journal
A MULTIVALENT PDZ-DOMAIN PROTEIN ASSEMBLES SIGNALING COMPLEXES IN A G-PROTEIN-COUPLED CASCADE
Nature
EXPRESSION AND ACTIVATION OF EPIDERMAL GROWTH-FACTOR RECEPTORS IN MENINGIOMAS
Journal of neurosurgery
MODIFIED PHAGE PEPTIDE LIBRARIES AS A TOOL TO STUDY SPECIFICITY OF PHOSPHORYLATION AND RECOGNITION OF TYROSINE-CONTAINING PEPTIDES
Journal of Molecular Biology
THE CBL PHOSPHOTYROSINE-BINDING DOMAIN SELECTS A D(N D)XPY MOTIF AND FINDS TO THE TYR(292) NEGATIVE REGULATORY PHOSPHORYLATION SITE OF ZAP-70/
The Journal of biological chemistry
MINTS, MUNC18-INTERACTING PROTEINS IN SYNAPTIC VESICLE EXOCYTOSIS
The Journal of biological chemistry
THE 66-KDA SHC ISOFORM IS A NEGATIVE REGULATOR OF THE EPIDERMAL GROWTH FACTOR-STIMULATED MITOGEN-ACTIVATED PROTEIN-KINASE PATHWAY
The Journal of biological chemistry
SHC INTERACTION WITH SRC HOMOLOGY-2 DOMAIN-CONTAINING INOSITOL PHOSPHATASE (SHIP) IN-VIVO REQUIRES THE SHC-PHOSPHOTYROSINE BINDING DOMAIN AND 2 SPECIFIC PHOSPHOTYROSINES ON SHIP
The Journal of biological chemistry
ERYTHROPOIETIN ACTIVATES RAF1 BY AN SHC-INDEPENDENT PATHWAY IN CTLL-EPO-R CELLS
Blood
TYROSINE RESIDUE-239 AND RESIDUE-240 OF SHC ARE PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-DEPENDENT PHOSPHORYLATION SITES BY C-SRC
Biochemical and biophysical research communications
MAMMALIAN NUMB IS AN EVOLUTIONARILY CONSERVED SIGNALING ADAPTER PROTEIN THAT SPECIFIES CELL FATE
Current biology
THE AMINOTERMINAL PHOSPHOTYROSINE BINDING DOMAIN OF SHC ASSOCIATES WITH ZAP-70 AND MEDIATES TCR DEPENDENT GENE ACTIVATION
Oncogene
P150(SHIP), A SIGNAL-TRANSDUCTION MOLECULE WITH INOSITOL POLYPHOSPHATE-5-PHOSPHATASE ACTIVITY
Genes & development
FUNCTIONAL ROLES OF THE SHC PHOSPHOTYROSINE BINDING AND SRC HOMOLOGY-2 DOMAINS IN INSULIN AND EPIDERMAL GROWTH-FACTOR SIGNALING
The Journal of biological chemistry