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Inflammation, carcinogenesis and cancer
INTERNATIONAL IMMUNOPHARMACOLOGY
Regulation of cyclo-oxygenase-2
BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppressionof NF-kappa B activation
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Lipoxygenase gene expression in baboon intrauterine tissues in late pregnancy and parturition
MOLECULAR HUMAN REPRODUCTION
Expression of connective tissue growth factor in human renal fibroblasts: Regulatory roles of RhoA and cAMP
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis
JOURNAL OF BONE AND MINERAL RESEARCH
Research strategies for design and development of NSAIDs: Clue to balance potency and toxicity of acetanilide compounds.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
Metabolic, but not respiratory, acidosis increases bone PGE(2) levels and calcium release
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
Novel effects of nitric oxide
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
Immunohistochemical expression of cyclooxygenase-2 in skin cancers
JOURNAL OF CUTANEOUS PATHOLOGY
Cytokines and the initiation of parturition
ENDOCRINOLOGY OF PARTURITION: BASIC SCIENCE AND CLINICAL APPLICATION
Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer
ANTICANCER RESEARCH
COX-2 inhibitory effects of naturally occurring and modified fatty acids
JOURNAL OF NATURAL PRODUCTS
Hypoxia attenuates PGE(2) but increases prostacyclin and thromboxane production in human term villous trophoblast
PLACENTA
Thromboxane A(2) limits differentiation and enhances apoptosis of culturedhuman trophoblasts
PEDIATRIC RESEARCH
FR167653, a cytokine synthesis inhibitor, exhibits anti-inflammatory effects early in rat carrageenin-induced pleurisy but no effect later
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Expression of cyclooxygenase isoforms in normal human skin and chronic venous ulcers
JOURNAL OF PATHOLOGY
Differential effects of ethanol on the expression of cyclo-oxygenase in cultured cortical astrocytes and neurons
JOURNAL OF NEUROCHEMISTRY
Expression of cyclo-oxygenase-2 in naturally occurring squamous cell carcinomas in dogs
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells
JOURNAL OF CLINICAL INVESTIGATION
Up-regulation of endothelial cyclooxygenase-2 and prostanoid synthesis by platelets - Role of thromboxane A(2)
JOURNAL OF BIOLOGICAL CHEMISTRY
Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol
JOURNAL OF BIOLOGICAL CHEMISTRY
Selective suppression of CCAAT/enhancer-binding protein beta finding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts
JOURNAL OF BIOLOGICAL CHEMISTRY
Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells
EXPERIMENTAL CELL RESEARCH
Prostaglandin H synthase-2 inhibitors interfere with prostaglandin H synthase-1 inhibition by nonsteroidal anti-inflammatory drugs
EUROPEAN JOURNAL OF PHARMACOLOGY
Inhibition of prostaglandin synthesis by nitric oxide in RAW 264.7 macrophages
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Prostaglandin endoperoxide H synthase type 1 and type 2 messenger ribonucleic acid in human fetal tissues throughout gestation and in the newborn infant
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
NF-kappa B and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line (WISH)
MOLECULAR HUMAN REPRODUCTION
Synthesis and biological evaluation of 1,3,4-triaryl-3-pyrrolin-2-ones, a new class of selective cyclooxygenase-2 inhibitors
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Comparative molecular field analysis of selective cyclooxygenase-2 (COX-2)inhibitors
QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS
Alzheimer's disease and non steroidal anti-inflammatory drugs with selectivity for cyclo-oxygenase-2: Rationale and perspectives
PRESSE MEDICALE
Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions
YONSEI MEDICAL JOURNAL
Cyclooxygenase-2 inhibitors constrict the fetal lamb ductus arteriosus both in vitro and in vivo
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
Selective inhibition of cyclooxygenase-2 enhances mitomycin-C-induced apoptosis
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Effect of prostaglandin E-2 on the proliferation, Ca2+ mobilization and cAMP in HT-29 human colon adenocarcinoma cells
CANCER LETTERS
Attenuation of macrophage apoptosis by the cAMP-signalling system
MOLECULAR AND CELLULAR BIOCHEMISTRY
Anti-inflammatory compounds as ligands in metal complexes as revealed in x-ray structural studies
COMMENTS ON INORGANIC CHEMISTRY
Induction of apoptosis by JTE-522, a specific cyclooxygenase-2 inhibitor, in human gastric cancer cell lines
ANTICANCER RESEARCH
Anchoring of a monotopic membrane protein: the binding of prostaglandin H-2 synthase-1 to the surface of a phospholipid bilayer
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Endocrine and paracrine regulation of birth at term and preterm
ENDOCRINE REVIEWS
Induction of cyclooxygenase expression and enhancement of malignant cell transformation by 2,3,7,8-tetrachlorodibenzo-p-dioxin
CARCINOGENESIS
Cox-2 and osteopontin in cocultured platelets and mesangial cells: Role ofglucocorticoids
KIDNEY INTERNATIONAL
Aspirin and other anti-inflammatory drugs
THORAX
Intracellular unesterified arachidonic acid signals apoptosis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation
JOURNAL OF CLINICAL INVESTIGATION
Expression of cyclooxygenase-2 and prostanoid receptors by human myometrium
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Peroxisome proliferator-activated receptor-gamma modulates differentiationof human trophoblast in a ligand-specific manner
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Induction of connective tissue growth factor by activation of heptahelicalreceptors - Modulation by Rho proteins and the actin cytoskeleton
JOURNAL OF BIOLOGICAL CHEMISTRY
Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2 - Evidence for involvement of ERK1/2 and p38 mitogen-activated proteinkinase pathways
JOURNAL OF BIOLOGICAL CHEMISTRY
Post-transcriptional control of cyclooxygenase-2 gene expression - The role of the 3 '-untranslated region
JOURNAL OF BIOLOGICAL CHEMISTRY
Are the anti-inflammatory effects of dexamethasone responsible for inhibition of the induction of enzymes involved in prostanoid formation in rat carrageenin-induced pleurisy?
EUROPEAN JOURNAL OF PHARMACOLOGY
Effect of cytochrome P-450 inhibitors econazole, bifonazole and clotrimazole on prostanoid formation
BRITISH JOURNAL OF PHARMACOLOGY
Basic biology and clinical application of specific cyclooxygenase-2 inhibitors
ARTHRITIS AND RHEUMATISM
Cyclo-oxygenase isoenzymes: physiological and pharmacological role
ANAESTHESIA
A new concept of the significance of regional distribution of prostaglandin H synthase 2 throughout the uterus during late pregnancy: Investigations in a baboon model
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Molecular model of the interaction between nimesulide and human cyclooxygenase-2
RHEUMATOLOGY
Phospholipase D, tumor promoters, proliferation and prostaglandins
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Cyclooxygenase-independent induction of p21(WAF-1/cip1), apoptosis and differentiation by L-745,337, a selective PGH synthase-2 inhibitor, and salicylate in HT-29 cells
APOPTOSIS
NO-evoked macrophage apoptosis is attenuated by cAMP-induced gene expression
MOLECULAR MEDICINE
Signal transduction pathways involved in lipopolysaccharide-induced production of PGE(2) by human microvascular endothelial cells
JOURNAL OF ENDOTOXIN RESEARCH
Sar in the alkoxy lactone series: The discovery of DFP, a potent and orally active COX-2 inhibitor
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Regulation of cyclooxygenase-2 pathway by HER2 receptor
ONCOGENE
Induction of cytosolic phospholipase A(2) and prostaglandin H-2 synthase-2by lipopolysaccharide in human polymorphonuclear leukocytes
EUROPEAN JOURNAL OF HAEMATOLOGY
Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms
MOLECULAR CARCINOGENESIS
Specific cyclooxygenase 2 inhibitors: A new choice of nonsteroidal anti-inflammatory drug therapy
ARTHRITIS CARE AND RESEARCH
Synergy between cyclo-oxygenase-2 induction and arachidonic acid supply invivo: consequences for nonsteroidal antiinflammatory drug efficacy
FASEB JOURNAL
Blockade of nitric oxide formation down-regulates cyclooxygenase-2 and decreases PGE(2) biosynthesis in macrophages
JOURNAL OF LEUKOCYTE BIOLOGY
Comparison of suppressive effects of a new anti-inflammatory compound, FR167653, on production of PGE(2) and inflammatory cytokines, human monocytes,and alveolar macrophages in response to endotoxin
JOURNAL OF LEUKOCYTE BIOLOGY
Computer simulation of the interaction of non-steroidal anti-inflammatory drugs: Indoprofen and NS398 with cyclooxygenase
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
Ischemia-reperfusion rapidly increases COX-2 expression in piglet cerebralarteries
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Cyclooxygenase-2 expression and function in the medullary thick ascending limb
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
Central nervous system regulation of reflex responses to hypotension during fetal life
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
Independent regulation of cyclo-oxygenase 2 expression by p42/44 mitogen-activated protein kinases and Ca2+/calmodulin-dependent kinase
BIOCHEMICAL JOURNAL
Cellular localization of cyclo-oxygenase isozymes in Crohn's disease and colorectal cancer
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
Protein abundance alterations in matched sets of macroscopically normal colon mucosa and colorectal carcinoma
ELECTROPHORESIS
Progesterone and prostaglandin H synthase-2 involvement in alcohol-inducedpreterm birth in mice
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
Regulation of cytosolic phospholipase A2 expression by cytokines in human amnion cells
PLACENTA
Immunomodulators in human seminal plasma: a vital protection for spermatozoa in the presence of infection?
INTERNATIONAL JOURNAL OF ANDROLOGY
Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Expression and function of cyclooxygenase-2 in mesothelial cells during late phase of rat carrageenin-induced pleurisy
LIFE SCIENCES
Characterization of cellular and vascular changes in equine follicles during hCG-induced ovulation
JOURNAL OF REPRODUCTION AND FERTILITY
Synthesis, structure - Activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, andorally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series
JOURNAL OF MEDICINAL CHEMISTRY
Paradoxical preservation of a lipopolysaccharide response in C3H/HeJ macrophages: Induction of matrix metalloproteinase-9
JOURNAL OF IMMUNOLOGY
Crystallization of recombinant cyclo-oxygenase-2
JOURNAL OF CRYSTAL GROWTH
Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity
JOURNAL OF BIOLOGICAL CHEMISTRY
Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelialcells
JOURNAL OF BIOLOGICAL CHEMISTRY
p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes
JOURNAL OF BIOLOGICAL CHEMISTRY
Redox mechanisms at the glutamate synapse and their significance: a review
EUROPEAN JOURNAL OF PHARMACOLOGY
Human chorionic gonadotropin induces an inverse regulation of steroidogenic acute regulatory protein messenger ribonucleic acid in theca interna and granulosa cells of equine preovulatory follicles
ENDOCRINOLOGY
Cyclooxygenase-1 and-2 are expressed by human T cells
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Expression of 15-lipoxygenase-1 in human colorectal cancer
CANCER RESEARCH
Cyclooxygenase-2 expression in human esophageal carcinoma
CANCER RESEARCH
Ultraviolet irradiation induces cyclooxygenase-2 expression in keratinocytes
BRITISH JOURNAL OF DERMATOLOGY
Differential expression of immunobiological mediators by immortalized human cervical and vaginal epithelial cells
BIOLOGY OF REPRODUCTION
Tissue-specific ontogenic expression of prostaglandin H synthase 2 in the ovine myometrium, endometrium, and placenta during late gestation and at spontaneous term labor
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Hypoxia limits differentiation and up-regulates expression and activity ofprostaglandin H synthase 2 in cultured trophoblast from term human placenta
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
In vitro modulation of the expression of 15-hydroxyprostaglandin dehydrogenase by trophoblast differentiation
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
COMPARISON OF THE REGULATIONS BY TH2-TYPE CYTOKINES OF THE ARACHIDONIC-ACID METABOLIC PATHWAY IN HUMAN ALVEOLAR MACROPHAGES AND MONOCYTES
American journal of respiratory cell and molecular biology
CYCLOOXYGENASE ISOENZYME LOCALIZATION AND MESSENGER-RNA EXPRESSION INRAT LUNGS
American journal of respiratory cell and molecular biology