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1. Nuttinck, F; Reinaud, P; Tricoire, H; Vigneron, C; Peynot, N; Mialot, JP; Mermillod, P; Charpigny, G
   Cyclooxygenase-2 is expressed by cumulus cells during oocyte maturation incattle
   MOLECULAR REPRODUCTION AND DEVELOPMENT
   
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2. Sato, T; Michizu, H; Hashizume, K; Ito, A
   Hormonal regulation of PGE(2) and COX-2 production in rabbit uterine cervical fibroblasts
   JOURNAL OF APPLIED PHYSIOLOGY
   
   T. Sato et al., "Hormonal regulation of PGE(2) and COX-2 production in rabbit uterine cervical fibroblasts", J APP PHYSL, 90(4), 2001, pp. 1227-1231
3. Fitzpatrick, FA
   Inflammation, carcinogenesis and cancer
   INTERNATIONAL IMMUNOPHARMACOLOGY
   
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4. Stack, E; Dubois, RN
   Regulation of cyclo-oxygenase-2
   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
   
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5. Surh, YJ; Chun, KS; Cha, HH; Han, SS; Keum, YS; Park, KK; Lee, SS
   Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppressionof NF-kappa B activation
   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
   
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6. Stiborova, M; Frei, E; Breuer, A; Wiessler, M; Schmeiser, HH
   Evidence for reductive activation of carcinogenic aristolochic acids by prostaglandin H synthase - P-32-postlabeling analysis of DNA adduct formation
   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
   
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7. Kulkarni, AP
   Role of biotransformation in conceptal toxicity of drugs and other chemicals
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8. Smith, GCS; Wu, WX; Nathanielsz, PW
   Lipoxygenase gene expression in baboon intrauterine tissues in late pregnancy and parturition
   MOLECULAR HUMAN REPRODUCTION
   
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9. Geiger, J
   Inhibitors of platelet signal transduction as anti-aggregatory drugs
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10. Colville-Nash, PR; Gilroy, DW
    Potential adverse effects of cyclooxygenase-2 inhibition: Evidence from animal models of inflammation
    BIODRUGS
    
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11. St John, MK; Arnold, LL; Anderson, T; Cano, M; Johansson, SL; Cohen, SM
    Dietary effects of ortho-phenylphenol and sodium ortho-phenylphenate on rat urothelium
    TOXICOLOGICAL SCIENCES
    
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12. Coffey, MJ; Coles, B; O'Donnell, VB
    Interactions of nitric oxide-derived reactive nitrogen species with peroxidases and lipoxygenases
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13. Heusinger-Ribeiro, J; Eberlein, M; Wahab, NA; Goppelt-Struebe, M
    Expression of connective tissue growth factor in human renal fibroblasts: Regulatory roles of RhoA and cAMP
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
    
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14. Clutton, P; Folts, JD; Freedman, JE
    Pharmacological control of platelet function
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15. Bessems, JGM; Vermeulen, NPE
    Paracetamol (acetaminophen)-induced toxicity: Molecular and biochemical mechanisms, analogues and protective approaches
    CRITICAL REVIEWS IN TOXICOLOGY
    
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16. Savla, U; Appel, HJ; Sporn, PHS; Waters, CM
    Prostaglandin E-2 regulates wound closure in airway epithelium
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
    
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17. Suzuki, M; Hayashi, I; Nara, Y; Kumagai, Y; Okamoto, H; Hoka, S; Majima, M
    Participation of cyclooxygenases in cutaneous thermal nociception under non-inflamed and inflamed conditions
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18. Conner, CE; Kelly, RW; Hume, R
    Regulation of prostaglandin availability in human fetal lung by differential localisation of prostaglandin H synthase-1 and prostaglandin dehydrogenase
    HISTOCHEMISTRY AND CELL BIOLOGY
    
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19. Tanaka, A; Araki, H; Komoike, Y; Hase, S; Takeuchi, K
    Inhibition of both COX-1 and COX-2 is required for development of gastric damage in response to nonsteroidal antiinflammatory drugs
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20. Burger, MS; Torino, JL; Swaminathan, S
    DNA damage in human transitional cell carcinoma cells after exposure to the proximate metabolite of the bladder carcinogen 4-aminobiphenyl
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
    
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21. Nikolic, D; van Breemen, RB
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22. Gautier, JC; Richoz, J; Welti, DH; Markovic, J; Gremaud, E; Guengerich, FP; Turesky, RJ
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23. Zhang, XP; Morham, SG; Langenbach, R; Young, DA; Xing, LP; Boyce, BF; Puzas, EJ; Rosier, RN; O'Keefe, RJ; Schwarz, EM
    Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis
    JOURNAL OF BONE AND MINERAL RESEARCH
    
    X.P. Zhang et al., "Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis", J BONE MIN, 16(4), 2001, pp. 660-670
24. Pal, AK; Sen, S; Ghosh, S; Bera, AK; Bhattacharya, S; Chakraborty, S; Banerjee, A
    Research strategies for design and development of NSAIDs: Clue to balance potency and toxicity of acetanilide compounds.
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
    
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25. Sylvia, VL; Del Toro, F; Dean, DD; Hardin, RR; Schwartz, Z; Boyan, BD
    Effects of 1 alpha,25-(OH)(2)D-3 on rat growth zone chondrocytes are mediated via cyclooxygenase-l and phospholipase A(2)
    JOURNAL OF CELLULAR BIOCHEMISTRY
    
    V.L. Sylvia et al., "Effects of 1 alpha,25-(OH)(2)D-3 on rat growth zone chondrocytes are mediated via cyclooxygenase-l and phospholipase A(2)", J CELL BIOC, 2001, pp. 32-45
26. Bushinsky, DA; Parker, WR; Alexander, KM; Krieger, NS
    Metabolic, but not respiratory, acidosis increases bone PGE(2) levels and calcium release
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
    
    D.A. Bushinsky et al., "Metabolic, but not respiratory, acidosis increases bone PGE(2) levels and calcium release", AM J P-REN, 281(6), 2001, pp. F1058-F1066
27. Davis, KL; Martin, E; Turko, IV; Murad, F
    Novel effects of nitric oxide
    ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
    
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28. Kagoura, M; Toyoda, M; Matsui, C; Morohashi, M
    Immunohistochemical expression of cyclooxygenase-2 in skin cancers
    JOURNAL OF CUTANEOUS PATHOLOGY
    
    M. Kagoura et al., "Immunohistochemical expression of cyclooxygenase-2 in skin cancers", J CUT PATH, 28(6), 2001, pp. 298-302
29. Young, IR
    The comparative physiology of parturition in mammals
    ENDOCRINOLOGY OF PARTURITION: BASIC SCIENCE AND CLINICAL APPLICATION
    
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30. Rice, GE
    Cytokines and the initiation of parturition
    ENDOCRINOLOGY OF PARTURITION: BASIC SCIENCE AND CLINICAL APPLICATION
    
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31. Kothekar, V; Sahi, S; Srinivasan, M; Mohan, A; Mishra, J
    Recognition of cyclooxygenase-2 (COX-2) active site by NSAIDs: A computer modelling study
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32. Hayashi, N; Yamamoto, H; Hiraoka, N; Dono, K; Ito, Y; Okami, J; Kondo, M; Nagano, H; Umeshita, K; Sakon, M; Matsuura, N; Nakamori, S; Monden, M
    Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm
    HEPATOLOGY
    
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33. Walker, MC; Kurumbail, RG; Kiefer, JR; Moreland, KT; Koboldt, CM; Isakson, PC; Seibert, K; Gierse, JK
    A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors
    BIOCHEMICAL JOURNAL
    
    M.C. Walker et al., "A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors", BIOCHEM J, 357, 2001, pp. 709-718
34. Moody, TW; Leyton, J; Zakowicz, H; Hida, T; Kang, Y; Jakowlew, S; You, L; Ozbun, L; Zia, H; Youngberg, J; Malkinson, A
    Indomethacin reduces lung adenoma number in A/J mice
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35. Dimberg, J; Hugander, A; Sirsjo, A; Soderkvist, P
    Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer
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36. Stiborova, M; Schmeiser, HH; Breuer, A; Frei, E
    Evidence for activation of carcinogenic o-anisidine by prostaglandin H synthase: P-32-postlabelling analysis of DNA adduct formation
    GENERAL PHYSIOLOGY AND BIOPHYSICS
    
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37. Son, HJ; Kim, YH; Park, DI; Kim, JJ; Rhee, PL; Paik, SW; Choi, KW; Song, SY; Rhee, JC
    Interaction between cyclooxygenase-2 and inducible nitric oxide synthase in gastric cancer
    JOURNAL OF CLINICAL GASTROENTEROLOGY
    
    H.J. Son et al., "Interaction between cyclooxygenase-2 and inducible nitric oxide synthase in gastric cancer", J CLIN GAST, 33(5), 2001, pp. 383-388
38. Ringbom, T; Huss, U; Stenholm, A; Flock, S; Skattebol, L; Perera, P; Bohlin, L
    COX-2 inhibitory effects of naturally occurring and modified fatty acids
    JOURNAL OF NATURAL PRODUCTS
    
    T. Ringbom et al., "COX-2 inhibitory effects of naturally occurring and modified fatty acids", J NAT PROD, 64(6), 2001, pp. 745-749
39. Brown, WA; Skinner, SA; Vogiagis, D; O'Brien, PE
    Inhibition of beta-catenin translocation in rodent colorectal tumors - A novel explanation for the protective effect of nonsteroidal antiinflammatorydrugs in colorectal cancer
    DIGESTIVE DISEASES AND SCIENCES
    
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40. Blumenstein, M; Keelan, JA; Mitchell, MD
    Hypoxia attenuates PGE(2) but increases prostacyclin and thromboxane production in human term villous trophoblast
    PLACENTA
    
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41. Sharma, RA; Gescher, A; Plastaras, JP; Leuratti, C; Singh, R; Gallacher-Horley, B; Offord, E; Marnett, LJ; Steward, WP; Plummer, SM
    Cyclooxygenase-2, malondialdehyde and pyrimidopurinone adducts of deoxyguanosine in human colon cells
    CARCINOGENESIS
    
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42. Wiese, FW; Thompson, PA; Kadlubar, FF
    Carcinogen substrate specificity of human COX-1 and COX-2
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43. Zenser, TV; Lakshmi, VM; Hsu, FF; Davis, BB
    Methemoglobin oxidation of N-acetylbenzidine to form a sulfinamide
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44. Chaudhuri, P; Wiegrardt, K
    Phenoxyl radical complexes
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45. Pesavento, RP; Van Der Donk, WA
    Tyrosyl radical cofactors
    ADVANCES IN PROTEIN CHEMISTRY, VOL 58
    
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46. Rogers, MS; Dooley, DM
    Posttranslationally modified tyrosines from galactose oxidase and cytochrome C oxidase
    ADVANCES IN PROTEIN CHEMISTRY, VOL 58
    
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47. van Rees, BP; Ristimaki, A
    Cyclooxygenase-2 in carcinogenesis of the gastrointestinal tract
    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
    
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48. Yusuf, K; Smith, SD; Levy, R; Schaiff, WT; Wyatt, SM; Sadovsky, Y; Nelson, DM
    Thromboxane A(2) limits differentiation and enhances apoptosis of culturedhuman trophoblasts
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49. Ouellet, M; Riendeau, D; Percival, MD
    A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    
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50. Valmsen, K; Jarving, I; Boeglin, WE; Varvas, K; Koljak, R; Pehk, T; Brash, AR; Samel, N
    The origin of 15R-prostaglandins in the Caribbean coral Plexaura homomalla: Molecular cloning and expression of a novel cyclooxygenase
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    
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51. O'Sullivan, MG; Goodrich, JA; Adams, MR
    Increased prostacyclin synthesis by atherosclerotic arteries from estrogen-treated monkeys
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52. Terano, A; Sakata-Horie, K; Shimada, T; Hiraishi, H; Yoshiura, K; Yoneda, M; Takahashi, M; Fujimori, T
    The role of cellular migration in the repair process of gastric epithelialcells
    LIFE SCIENCES
    
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53. Hatanaka, K; Kawamura, M; Murai, N; Ogino, M; Majima, M; Ogino, K; Harada, Y
    FR167653, a cytokine synthesis inhibitor, exhibits anti-inflammatory effects early in rat carrageenin-induced pleurisy but no effect later
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
    
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54. Riendeau, D; Percival, MD; Brideau, C; Charleson, S; Dube, D; Ethier, D; Falgueyret, JP; Friesen, RW; Gordon, R; Greig, G; Guay, J; Mancini, J; Ouellet, M; Wong, E; Xu, L; Boyce, S; Visco, D; Girard, Y; Prasit, P; Zamboni, R; Rodger, IW; Gresser, M; Ford-Hutchinson, AW; Young, RN; Chan, CC
    Etoricoxib (MK-0663): Preclinical profile and comparison with other agentsthat selectively inhibit cyclooxygenase-2
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55. Abd-El-Aleem, SA; Ferguson, MWJ; Appleton, I; Bhowmick, A; McCollum, CN; Ireland, GW
    Expression of cyclooxygenase isoforms in normal human skin and chronic venous ulcers
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56. Schneider, N; Lanz, S; Ramer, R; Schaefer, D; Goppelt-Struebe, M
    Up-regulation of cyclooxygenase-1 in neuroblastoma cell lines by retinoic acid and corticosteroids
    JOURNAL OF NEUROCHEMISTRY
    
    N. Schneider et al., "Up-regulation of cyclooxygenase-1 in neuroblastoma cell lines by retinoic acid and corticosteroids", J NEUROCHEM, 77(2), 2001, pp. 416-424
57. Luo, J; Lindstrom, CLB; Donahue, A; Miller, MW
    Differential effects of ethanol on the expression of cyclo-oxygenase in cultured cortical astrocytes and neurons
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58. Jiang, YJ; Hatch, GM; Mymin, D; Dembinski, T; Kroeger, EA; Choy, PC
    Modulation of cytosolic phospholipase A(2) by PPAR activators in human preadipocytes
    JOURNAL OF LIPID RESEARCH
    
    Y.J. Jiang et al., "Modulation of cytosolic phospholipase A(2) by PPAR activators in human preadipocytes", J LIPID RES, 42(5), 2001, pp. 716-724
59. de Almeida, EMP; Piche, C; Sirois, J; Dore, M
    Expression of cyclo-oxygenase-2 in naturally occurring squamous cell carcinomas in dogs
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
    
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60. Dixon, DA; Tolley, ND; King, PH; Nabors, LB; McIntyre, TM; Zimmerman, GA; Prescott, SM
    Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells
    JOURNAL OF CLINICAL INVESTIGATION
    
    D.A. Dixon et al., "Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells", J CLIN INV, 108(11), 2001, pp. 1657-1665
61. Caughey, GE; Cleland, LG; Gamble, JR; James, MJ
    Up-regulation of endothelial cyclooxygenase-2 and prostanoid synthesis by platelets - Role of thromboxane A(2)
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62. Kozak, KR; Prusakiewicz, JJ; Rowlinson, SW; Schneider, C; Marnett, LJ
    Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol
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63. Saunders, MA; Sansores-Garcia, L; Gilroy, DW; Wu, KK
    Selective suppression of CCAAT/enhancer-binding protein beta finding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts
    JOURNAL OF BIOLOGICAL CHEMISTRY
    
    M.A. Saunders et al., "Selective suppression of CCAAT/enhancer-binding protein beta finding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts", J BIOL CHEM, 276(22), 2001, pp. 18897-18904
64. Wong, E; Huang, JQ; Tagari, P; Riendeau, D
    Effects of COX-2 inhibitors on aortic prostacyclin production in cholesterol-fed rabbits
    ATHEROSCLEROSIS
    
    E. Wong et al., "Effects of COX-2 inhibitors on aortic prostacyclin production in cholesterol-fed rabbits", ATHEROSCLER, 157(2), 2001, pp. 393-402
65. Ochi, T; Yamane-Sugiyama, A; Ohkubo, Y; Sakane, K; Tanaka, H
    The anti-inflammatory effect of FR188582, a highly selective inhibitor of cyclooxygenase-2, with an ulcerogenic sparing effect in rats
    JAPANESE JOURNAL OF PHARMACOLOGY
    
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66. Brown, WA; Skinner, SA; Malcontenti-Wilson, C; Vogiagis, D; O'Brien, PE
    Non-steroidal anti-inflammatory drugs with activity against either cyclooxygenase 1 or cyclooxygenase 2 inhibit colorectal cancer in a DMH rodent model by inducing apoptosis and inhibiting cell proliferation
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67. Ikawa, H; Kameda, H; Kamitani, H; Baek, SJ; Nixon, JB; Hsi, LC; Eling, TE
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68. Rosenstock, M; Danon, A; Rubin, M; Rimon, G
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69. Kothekar, V; Sahi, S; Mishra, J
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70. Miksanova, M; Hudecek, J; Paca, J; Stiborova, M
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71. Miura, T; Muraoka, S; Fujimoto, Y
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72. Oshima, M; Murai, N; Kargman, S; Arguello, M; Luk, P; Kwong, E; Taketo, MM; Evans, JF
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73. Denkert, C; Kobel, M; Berger, S; Siegert, A; Leclere, A; Trefzer, U; Hauptmann, S
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74. Ohno, R; Yoshinaga, K; Fujita, T; Hasegawa, K; Iseki, H; Tsunozaki, H; Ichikawa, W; Nihei, Z; Sugihara, K
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75. Fabi, F; Calabrese, R; Stati, T; del Basso, P
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76. Coceani, F; Ackerley, C; Seidlitz, E; Kelsey, L
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77. Tanaka, Y; Igimi, S; Amano, F
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78. Ouellet, M; Percival, MD
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79. Loneragan, GH; Gould, DH; Mason, GL; Garry, FB; Yost, GS; Lanza, DL; Miles, DG; Hoffman, BW; Mills, LJ
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80. Olson, DM; Mijovic, JE; Zaragoza, DB; Cook, JL
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81. Steiner, AA; Branco, LGS
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82. Lands, WEM
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83. Annas, A; Brittebo, E; Hellman, B
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84. Yermakova, A; O'Banion, MK
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85. Marnett, LJ
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86. Allport, VC; Slater, DM; Newton, R; Bennett, PR
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87. Carter, JS
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88. Abdel-Haq, H; Palmery, M; Leone, MG; Saso, L; Silvestrini, B
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89. Ma, XH; Wu, WX; Brenna, JT; Nathanielsz, PW
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90. Botting, RM
    Mechanism of action of acetaminophen: Is there a cyclooxygenase 3?
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91. Bosch, J; Roca, T; Catena, JL; Llorens, O; Perez, JJ; Lagunas, C; Fernandez, AG; Miquel, I; Fernandez-Serrat, A; Farrerons, C
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    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
    
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92. Marks, F; Furstenberger, G
    Cancer chemoprevention through interruption of multistage carcinogenesis: the lessons learnt by comparing mouse skin carcinogenesis and human large bowel cancer
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93. Domoki, F; Thrikawala, N; Robins, GS; Bari, F; Busija, DW
    Kainic acid rapidly induces cyclooxygenase (COX)-2 in piglet cerebral cortex
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94. Wen, FQ; Watanabe, K; Yoshida, M
    Nitric oxide enhances PGI(2) production by human pulmonary artery smooth muscle cells
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95. Martinez, SP; Farina, M; Ogando, D; Ribeiro, ML; Gimeno, M; Franchi, AM
    Nitric oxide inhibits prostanoid synthesis in the rat oviduct
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96. Gilroy, DW; Colville-Nash, PR
    New insights into the role of COX 2 in inflammation
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97. Marot, C; Chavatte, P; Lesieur, D
    Comparative molecular field analysis of selective cyclooxygenase-2 (COX-2)inhibitors
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98. Dannhardt, G; Laufer, S
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    CURRENT MEDICINAL CHEMISTRY
    
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99. Meyer-Kirchrath, J; Schror, K
    Cyclooxygenase-2 inhibition and side-effects of non-steroidal anti-inflammatory drugs in the gastrointestinal tract
    CURRENT MEDICINAL CHEMISTRY
    
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100. Moore, BC; Simmons, DL
     COX-2 inhibition, apoptosis, and chemoprevention by nonsteroidal anti-inflammatory drugs
     CURRENT MEDICINAL CHEMISTRY
     
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