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Effects of cortisol and estradiol on pituitary expression of proopiomelanocortin, prohormone convertase-1, prohormone convertase-2, and glucocorticoid receptor mRNA in fetal sheep
ENDOCRINE
Pituitary adenylate cyclase-activating polypeptide and its receptors in amphibians
MICROSCOPY RESEARCH AND TECHNIQUE
Dynamics and plasticity of peptidergic control centres in the retino-brain-pituitary system of Xenopus laevis
MICROSCOPY RESEARCH AND TECHNIQUE
Missense polymorphism in the human carboxypeptlidase E gene alters enzymatic activity
HUMAN MUTATION
pH-Induced conformational transitions of a molten-globule-like state of the inhibitory prodomain of furin: Implications for zymogen activation
PROTEIN SCIENCE
The genetics of obesity: practical implications
INTERNATIONAL JOURNAL OF OBESITY
Distribution of proSAAS-derived peptides in rat neuroendocrine tissues
NEUROSCIENCE
Key peptide processing enzymes are expressed by breast cancer cells
CANCER LETTERS
Replication of HIV-1 viruses in the presence of the Portland alpha 1-antitrypsin variant (alpha 1-PDX) inhibitor
BIOCHEMICAL JOURNAL
Neuroendocrine secretory protein 7B2: structure, expression and functions
BIOCHEMICAL JOURNAL
Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides
BIOCHEMICAL JOURNAL
Neuronal cell lines expressing PC5, but not PC1 or PC2, process pro-CCK into glycine-extended CCK 12 and 22
PEPTIDES
Inactivation of the 7B2 inhibitory CT peptide depends on a functional furin cleavage site
JOURNAL OF NEUROCHEMISTRY
Tissue distribution and processing of proSAAS by proprotein convertases
JOURNAL OF NEUROCHEMISTRY
Ontogeny of pituitary adenylate cyclase-activating polypeptide (PACAP) in the frog (Rana ridibunda) tadpole brain: Immunohistochemical localization and biochemical characterization
JOURNAL OF COMPARATIVE NEUROLOGY
Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1
JOURNAL OF BIOLOGICAL CHEMISTRY
Response of an integral granule membrane protein to changes in pH
JOURNAL OF BIOLOGICAL CHEMISTRY
A conserved alpha-helix at the amino terminus of prosomatostatin serves asa sorting signal for the regulated secretory pathway
JOURNAL OF BIOLOGICAL CHEMISTRY
Structure, localization and potential role of a novel molluscan trypsin inhibitor in Lymnaea
EUROPEAN JOURNAL OF BIOCHEMISTRY
Coexpression of proprotein convertase SPC3 and the neuroendocrine precursor proSAAS
ENDOCRINOLOGY
Prepro-thyrotropin releasing hormone 178-199 immunoreactivity is altered in the hypothalamus of the Wistar-Kyoto strain of rat
BRAIN RESEARCH
Oxytocin and autistic disorder: Alterations in peptide forms
BIOLOGICAL PSYCHIATRY
Biogenesis of processing-competent secretory organelles in vitro
BIOCHEMISTRY
Effects of labor on pituitary expression of proopiomelanocortin, prohormone convertase (PC)-1, PC-2, and glucocorticoid receptor mRNA in fetal sheep
ENDOCRINE
Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Insulin and glucagon mRNA expression and prohormone convertase immunoreactivity in normal and neoplastic pancreatic endocrine tissue
ENDOCRINE PATHOLOGY
Implications of proopiomelanocortin (POMC) mutations in humans: The POMC deficiency syndrome
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Expression and localization of prohormone convertase 1/3 (SPC3) in porcineovary
MOLECULAR REPRODUCTION AND DEVELOPMENT
A temperature-sensitive Krp1 allows in vivo characterization of kexin activation
MOLECULAR MICROBIOLOGY
Immunohistochemical expression of chromogranins A and B, prohormone convertases 2 and 3, and amidating enzyme in carcinoid tumors and pancreatic endocrine tumors
MODERN PATHOLOGY
Basic mechanisms of secretion: sorting into the regulated secretory pathway
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
New aspects of proinsulin physiology and pathophysiology
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing
JOURNAL OF NEUROSCIENCE
A look at the Caenorhabditis elegans Kex2/subtilisin-like proprotein convertase family
BIOESSAYS
Coordinate regulation of neuroendocrine convertase PC2 and peptide 7B2 in P19 neurons
PEPTIDES
Differential onset of expression of mRNAs encoding proopiomelanocortin, prohormone convertases 1 and 2, and granin family members during Xenopus laevis development
MOLECULAR BRAIN RESEARCH
Effects of aging on expression of genes involved in regulation of proliferation and apoptosis in the colonic epithelium
MECHANISMS OF AGEING AND DEVELOPMENT
Expression of proopiomelanocortin peptides in human dermal microvascular endothelial cells: Evidence for a regulation by ultraviolet light and interleukin-1
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats
JOURNAL OF CLINICAL INVESTIGATION
The SAAS granin exhibits structural and functional homology to 7B2 and contains a highly potent hexapeptide inhibitor of PC1
FEBS LETTERS
Inhibition of the vacuolar H+-ATPase perturbs the transport, sorting, processing and release of regulated secretory proteins
EUROPEAN JOURNAL OF BIOCHEMISTRY
Endocrine disruptive effects of polychlorinated aromatic hydrocarbons on intestinal cholecystokinin in rats
ENDOCRINOLOGY
PC2 and 7B2 null mice demonstrate that PC2 is essential for normal pro-CCKprocessing
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Structure-function analysis of the 7B2 CT peptide
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Expression of endoprotease furin, prohormone convertase (PC)1/3 and PC2 inpulmonary neuroendocrine lesions: Correlation of functional differentiation of neuroendocrine cells with posttranslational processing of prohormones
ENDOCRINE PATHOLOGY
Isolation and characterization of insect PC2-like prohormone convertase cDNA
INSECT MOLECULAR BIOLOGY
Maternal impact on egg development in Lymnaea stagnalis: a growth factor is produced by the albumen gland in the reproductive tract
INVERTEBRATE REPRODUCTION & DEVELOPMENT
Alternative splicing creates sex-specific transcripts and truncated forms of the furin protease in the parasite Dirofilaria immitis
GENE
Immunohistochemical distribution of the prohormone convertase PC5-A in ratbrain
NEUROSCIENCE
Biosynthesis of secretogranin II in Xenopus intermediate pituitary
MOLECULAR AND CELLULAR ENDOCRINOLOGY
A role for amontillado, the Drosophila homolog of the neuropeptide precursor processing protease PC2, in triggering hatching behavior
JOURNAL OF NEUROSCIENCE
The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease
CELL
Modulation of prohormone convertase 2 in spinal cord during gestation and hormone-simulated pregnancy
NEUROENDOCRINOLOGY
Proprotein convertase activity contributes to the processing of the Alzheimer's beta-amyloid precursor protein in human cells: Evidence for a role ofthe prohormone convertase PC7 in the constitutive alpha-secretase pathway
JOURNAL OF NEUROCHEMISTRY
The role of the 7B2 CT peptide in the inhibition of prohormone convertase 2 in endocrine cell lines
JOURNAL OF NEUROCHEMISTRY
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases - In vitro and ex vivo assessment of their efficacy and selectivity
JOURNAL OF BIOLOGICAL CHEMISTRY
Proteolytic processing in the secretory pathway
JOURNAL OF BIOLOGICAL CHEMISTRY
Protein 7B2 is essential for the targeting and activation of PC2 into the regulated secretory pathway of rMTC 6-23 cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
THE PROPROTEIN CONVERTASES
CURRENT OPINION IN CHEMICAL BIOLOGY
MOLECULAR AND CELLULAR-REGULATION OF PROHORMONE PROCESSING
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
SUBTILISIN-RELATED SERINE PROTEASES IN THE MAMMALIAN CONSTITUTIVE SECRETORY PATHWAY
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Molecular characterization, enzymatic analysis, and purification of murineproprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells
PROTEIN EXPRESSION AND PURIFICATION
CLONING AND FUNCTIONAL-ANALYSIS OF C-ELEGANS 7B2
DNA and cell biology
Neuroendocrine protein 7B2 is essential for proteolytic conversion and activation of proprotein convertase 2 in vivo
DNA AND CELL BIOLOGY
SORTING OF PC2 TO THE REGULATED SECRETORY PATHWAY IN ATT20 CELLS
Journal of molecular endocrinology
LOCALIZATION OF PROHORMONE CONVERTASE-1 3 AND CONVERTASE-2 IN THE HUMAN PITUITARY-GLAND AND PITUITARY-ADENOMAS - ANALYSIS BY IMMUNOHISTOCHEMISTRY, IMMUNOELECTRON MICROSCOPY, AND LASER-SCANNING MICROSCOPY/
Modern pathology
MOLECULAR DIVERSITY IN NEUROSECRETION - REFLECTIONS ON THE HYPOTHALAMONEUROHYPOPHYSEAL SYSTEM
Cellular and molecular neurobiology
DIFFERENCES IN THE AUTOCATALYTIC CLEAVAGE OF PRO-PC2 AND PRO-PC3 CAN BE ATTRIBUTED TO SEQUENCES WITHIN THE PROPEPTIDE AND ASP(310) OF PRO-PC2
Biochemical journal
Key peptide processing enzymes are expressed by a variant form of small-cell carcinoma of the lung
PEPTIDES
ENDOCRINOPATHIES IN THE FAMILY OF ENDOPLASMIC-RETICULUM (ER) STORAGE DISEASES - DISORDERS OF PROTEIN TRAFFICKING AND THE ROLE OF ER MOLECULAR CHAPERONES
Endocrine reviews
MANIPULATION OF DISULFIDE BONDS DIFFERENTIALLY AFFECTS THE INTRACELLULAR-TRANSPORT, SORTING, AND PROCESSING OF NEUROENDOCRINE SECRETORY PROTEINS
Journal of neurochemistry
DIFFERENTIAL CLEAVAGE OF PROVASOPRESSIN BY THE MAJOR MOLECULAR-FORMS OF SPC3
Journal of neurochemistry
Homotypic fusion of immature secretory granules during maturation in a cell-free assay
JOURNAL OF CELL BIOLOGY
PRODYNORPHIN PROCESSING BY PROPROTEIN CONVERTASE-2 - CLEAVAGE AT SINGLE BASIC RESIDUES AND ENHANCED PROCESSING IN THE PRESENCE OF CARBOXYPEPTIDASE ACTIVITY
The Journal of biological chemistry
STRUCTURAL ELEMENTS OF PC2 REQUIRED FOR INTERACTION WITH ITS HELPER PROTEIN 7B2
The Journal of biological chemistry
IN-VITRO CLEAVAGE OF INTERNALLY QUENCHED FLUOROGENIC HUMAN PROPARATHYROID HORMONE AND PROPARATHYROID-RELATED PEPTIDE-SUBSTRATES BY FURIN - GENERATION OF A POTENT INHIBITOR
The Journal of biological chemistry
BIOSYNTHETIC PROCESSING AND QUATERNARY INTERACTIONS OF PROPROTEIN CONVERTASE SPC4 (PACE4)
FEBS letters
THE PROPEPTIDE OF PROHORMONE CONVERTASE PC2 ACTS AS A TRANSFERABLE AGGREGATION AND MEMBRANE-ASSOCIATION SIGNAL
European journal of biochemistry
DEPLETION OF CARBOXYPEPTIDASE-E, A REGULATED SECRETORY PATHWAY SORTING RECEPTOR, CAUSES MISROUTING AND CONSTITUTIVE SECRETION OF PROINSULINAND PROENKEPHALIN, BUT NOT CHROMOGRANIN-A
Endocrinology
HISTIDINE-RICH HUMAN SALIVARY PEPTIDES ARE INHIBITORS OF PROPROTEIN CONVERTASES FURIN AND PC7 BUT ACT AS SUBSTRATES FOR PC1
The journal of peptide research
BACKGROUND ADAPTATION BY XENOPUS-LAEVIS - A MODEL FOR STUDYING NEURONAL INFORMATION-PROCESSING IN THE PITUITARY PARS-INTERMEDIA
Comparative biochemistry and physiology. Section A: Comparative physiology
ISOLATION OF A CDNA-ENCODING A KEX2-LIKE ENDOPROTEASE WITH HOMOLOGY TO FURIN FROM THE NEMATODE CAENORHABDITIS-ELEGANS
DNA and cell biology
CONVERTASE PC2 AND THE NEUROENDOCRINE POLYPEPTIDE 7B2 ARE CO-INDUCED AND PROCESSED DURING NEURONAL DIFFERENTIATION OF P19 EMBRYONAL CARCINOMA-CELLS
DNA and cell biology
EUKARYOTIC PROTEIN PROCESSING - ENDOPROTEOLYSIS OF PRECURSOR PROTEINS
Current opinion in biotechnology
A POTENTIAL PROCESSING ENZYME IN PROKARYOTES - OLIGOPEPTIDASE-B, A NEW-TYPE OF SERINE PEPTIDASE
Proteins
INTRACELLULAR-TRANSPORT, SORTING, AND PROTEOLYTIC PROCESSING OF REGULATED SECRETORY PROTEINS DOES NOT REQUIRE PROTEIN SULFATION
Molecular and cellular endocrinology
IMMUNOCYTOCHEMICAL LOCALIZATION OF PROHORMONE CONVERTASES PC1 AND PC2IN THE ANURAN PITUITARY-GLAND - SUBCELLULAR-LOCALIZATION IN CORTICOTROPE AND MELANOTROPE CELLS
Cell and tissue research
ENDOPLASMIC-RETICULUM CA2-TRANSPORT OF PROINSULIN IN THE PANCREATIC BETA-CELL( IS IMPORTANT FOR THE PROTEOLYTIC PROCESSING AND INTRACELLULAR)
Biochemical journal
MUTATIONS WITHIN THE PROPEPTIDE, THE PRIMARY CLEAVAGE SITE OR THE CATALYTIC SITE, OR DELETION OF C-TERMINAL SEQUENCES, PREVENTS SECRETION OF PROPC2 FROM TRANSFECTED COS-7 CELLS
Biochemical journal
PH-DEPENDENT PROCESSING OF SECRETOGRANIN-II BY THE ENDOPEPTIDASE PC2 IN ISOLATED IMMATURE SECRETORY GRANULES
Biochemical journal
ACTIVATION OF THE FURIN ENDOPROTEASE IS A MULTIPLE-STEP PROCESS - REQUIREMENTS FOR ACIDIFICATION AND INTERNAL PROPEPTIDE CLEAVAGE
EMBO journal
MURINE SUBTILISIN-LIKE PROTEINASE SPC6 IS EXPRESSED DURING EMBRYONIC IMPLANTATION, SOMITOGENESIS, AND SKELETAL FORMATION
Developmental genetics
ONTOGENIC DEVELOPMENT OF SECRETOGRANIN-II AND OF ITS PROCESSING TO SECRETONEURIN IN RAT-BRAIN
Developmental brain research
REGULATION BY GASTRIC-ACID OF THE PROCESSING OF PROGASTRIN-DERIVED PEPTIDES IN RAT ANTRAL MUCOSA
Journal of physiology
PROHORMONE CONVERTASES IN MOUSE SUBMANDIBULAR-GLAND - COLOCALIZATION OF FURIN AND NERVE GROWTH-FACTOR
The Journal of histochemistry and cytochemistry
PROTEOLYTIC PROCESSING OF PROOPIOMELANOCORTIN OCCURS IN ACIDIFYING SECRETORY GRANULES OF ATT-20 CELLS
The Journal of histochemistry and cytochemistry
POSTTRANSLATIONAL PROCESSING OF HUMAN PROCORTICOTROPHIN-RELEASING FACTOR IN TRANSFECTED MOUSE NEUROBLASTOMA AND CHINESE-HAMSTER OVARY CELL-LINES
Journal of Endocrinology
AGGREGATION AS A DETERMINANT OF PROTEIN FATE IN POST-GOLGI COMPARTMENTS - ROLE OF THE LUMINAL DOMAIN OF FURIN IN LYSOSOMAL TARGETING
The Journal of cell biology
MECHANISM OF THE FACILITATION OF PC2 MATURATION BY 7B2 - INVOLVEMENT IN PROPC2 TRANSPORT AND ACTIVATION BUT NOT FOLDING
The Journal of cell biology
IDENTIFICATION OF A MOLLUSCAN HOMOLOG OF THE NEUROENDOCRINE POLYPEPTIDE 7B2
The Journal of biological chemistry