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La ricerca find articoli where soggetti phrase all words 'PRESENILIN-1' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 438 riferimenti
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    1. Sastre, M; Steiner, H; Fuchs, K; Capell, A; Multhaup, G; Condron, MM; Teplow, DB; Haass, C
      Presenilin dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

      EMBO REPORTS
    2. Petit, A; Bihel, F; da Costa, CA; Pourquie, O; Checler, F; Kraus, JL
      New protease inhibitors prevent gamma-secretase-mediated production of A beta 40/42 without affecting Notch cleavage

      NATURE CELL BIOLOGY
    3. Davidsson, P; Bogdanovic, N; Lannfelt, L; Blennow, K
      Reduced expression of amyloid precursor protein, presenilin-1 and rab3a incortical brain regions in Alzheimer's disease

      DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
    4. Huse, JT; Doms, RW
      Neurotoxic traffic: Uncovering the mechanics of amyloid production in Alzheimer's disease

      TRAFFIC
    5. Jankowsky, JL; Slunt, HH; Ratovitski, T; Jenkins, NA; Copeland, NG; Borchelt, DR
      Co-expression of multiple transgenes in mouse CNS: a comparison of strategies

      BIOMOLECULAR ENGINEERING
    6. Jhee, S; Shiovitz, T; Crawford, AW; Cutler, NR
      beta-amyloid therapies in Alzheimer's disease

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    7. Calabrese, EJ
      Amyloid beta-peptide: Biphasic dose responses

      CRITICAL REVIEWS IN TOXICOLOGY
    8. Refolo, LM; Pappolla, MA; LaFrancois, J; Malester, B; Schmidt, SD; Thomas-Bryant, T; Tint, GS; Wang, R; Mercken, M; Petanceska, SS; Duff, KE
      A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenicmouse model of Alzheimer's disease

      NEUROBIOLOGY OF DISEASE
    9. Poduslo, JF; Curran, GL; Wengenack, TM; Malester, B; Duff, K
      Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease

      NEUROBIOLOGY OF DISEASE
    10. Leissring, MA; LaFerla, FM; Callamaras, N; Parker, I
      Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling

      NEUROBIOLOGY OF DISEASE
    11. Eckert, A; Schindowski, K; Leutner, S; Luckhaus, C; Touchet, N; Czech, C; Muller, WE
      Alzheimer's disease-like alterations in peripheral cells from presenilin-1transgenic mice

      NEUROBIOLOGY OF DISEASE
    12. Russo, C; Salis, S; Dolcini, V; Venezia, V; Song, XH; Teller, JK; Schettini, G
      Identification of amino-terminally and phosphotyrosine-modified carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain

      NEUROBIOLOGY OF DISEASE
    13. De Jonghe, C; Esselens, C; Kumar-Singh, S; Craessaerts, K; Serneels, S; Checler, F; Annaert, W; Van Broeckhoven, C; De Strooper, B
      Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect A beta secretion and APP C-terminal fragment stability

      HUMAN MOLECULAR GENETICS
    14. Roberds, SL; Anderson, J; Basi, G; Bienkowski, MJ; Branstetter, DG; Chen, KS; Freedman, SB; Frigon, NL; Games, D; Hu, K; Johnson-Wood, K; Kappenman, KE; Kawabe, TT; Kola, I; Kuehn, R; Lee, M; Liu, WQ; Motter, R; Nichols, NF; Power, M; Robertson, DW; Schenk, D; Schoor, M; Shopp, GM; Shuck, ME; Sinha, S; Svensson, KA; Tatsuno, G; Tintrup, H; Wijsman, J; Wright, S; McConlogue, L
      BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

      HUMAN MOLECULAR GENETICS
    15. Walter, J; Kaether, C; Steiner, H; Haass, C
      The cell biology of Alzheimer's disease: uncovering the secrets of secretases

      CURRENT OPINION IN NEUROBIOLOGY
    16. Matsumoto, A; Itoh, K; Seki, T; Motozaki, K; Matsuyama, S
      Human brain carboxypeptidase B, which cleaves beta-amyloid peptides in vitro, is expressed in the endoplasmic reticulum of neurons

      EUROPEAN JOURNAL OF NEUROSCIENCE
    17. Demeester, N; Mertens, C; Caster, H; Goethals, M; Vandekerckhove, J; Rosseneu, M; Labeur, C
      Comparison of the aggregation properties, secondary structure and apoptotic effects of wild-type, Flemish and Dutch N-terminally truncated amyloid beta peptides

      EUROPEAN JOURNAL OF NEUROSCIENCE
    18. Koizumi, K; Nakajima, M; Yuasa, S; Saga, Y; Sakai, T; Kuriyama, T; Shirasawa, T; Koseki, H
      The role of presenilin 1 during somite segmentation

      DEVELOPMENT
    19. Hartmann, D; Tournoy, J; Saftig, P; Annaert, W; De Strooper, B
      Implication of APP secretases in notch signaling

      JOURNAL OF MOLECULAR NEUROSCIENCE
    20. Thinakaran, G
      Metabolism of presenilins

      JOURNAL OF MOLECULAR NEUROSCIENCE
    21. Schenk, D; Games, D; Seubert, P
      Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and A beta immunization

      JOURNAL OF MOLECULAR NEUROSCIENCE
    22. Pinnix, I; Council, JE; Roseberry, B; Onstead, L; Mallender, W; Sucic, J; Sambamurti, K
      Convertases other than furin cleave beta-secretase to its mature form

      FASEB JOURNAL
    23. Russo, E
      Hot papers - Interpreting the signaling of notch - Comment

      SCIENTIST
    24. Ertekin-Taner, N; Graff-Radford, N; Younkin, LH; Eckman, C; Adamson, J; Schaid, DJ; Blangero, J; Hutton, M; Younkin, SG
      Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees

      GENETIC EPIDEMIOLOGY
    25. Vidal, R; Calero, M; Revesz, T; Plant, G; Ghiso, J; Frangione, B
      Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family

      GENE
    26. Smith, MJ; Kwok, JBJ; McLean, CA; Kril, JJ; Broe, GA; Nicholson, GA; Cappai, R; Hallupp, M; Cotton, RGH; Masters, CL; Schofield, PR; Brooks, WS
      Variable phenotype of Alzheimer's disease with spastic paraparesis

      ANNALS OF NEUROLOGY
    27. Vestling, M; Wiehager, B; Tanii, H; Cowburn, RF
      Akt activity in presenilin 1 wild-type and mutation transfected human SH-SY5Y neuroblastoma cells after serum deprivation and high glucose stress

      JOURNAL OF NEUROSCIENCE RESEARCH
    28. Popescu, BO; Cedazo-Minguez, A; Popescu, LM; Winblad, B; Cowburn, RF; Ankarcrona, M
      Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells

      JOURNAL OF NEUROSCIENCE RESEARCH
    29. Dermaut, B; Roks, G; Theuns, J; Rademakers, R; Houwing-Duistermaat, JJ; Serneels, S; Hofman, A; Breteler, MMB; Cruts, M; Van Broeckhoven, C; van Duijn, CM
      Variable expression of presenilin 1 is not a major determinant of risk forlate-onset Alzheimer's Disease

      JOURNAL OF NEUROLOGY
    30. D'Andrea, MR; Nagele, RG; Wang, HY; Peterson, PA; Lee, DHS
      Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

      HISTOPATHOLOGY
    31. Layfield, R
      Does an inhibition of the uhiquitin/26S proteasome pathway of protein degradation underlie the pathogenesis of non-familial Alzheimer's disease?

      MEDICAL HYPOTHESES
    32. Matsuoka, Y; Picciano, M; La Francois, J; Duff, K
      Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse modelof Alzheimer's disease

      NEUROSCIENCE
    33. Dowjat, WK; Wisniewski, H; Wisniewski, T
      Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments

      NEUROSCIENCE
    34. Mann, DMA; Takeuchi, A; Sato, S; Cairns, NJ; Lantos, PL; Rossor, MN; Haltia, M; Kalimo, H; Iwatsubo, T
      Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1gene show an unusual but characteristic beta-amyloid pathology known as 'cotton wool' plaques

      NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
    35. Queralt, R; Ezquerra, M; Castellvi, M; Lleo, A; Blesa, R; Oliva, R
      Detection of the presenilin 1 gene mutation (M139T) in early-onset familial Alzheimer disease in Spain

      NEUROSCIENCE LETTERS
    36. Wiltfang, J; Esselmann, H; Maler, JM; Bleich, S; Huther, G; Kornhuber, J
      Molecular biology of Alzheimer's dementia and its clinical relevance to early diagnosis and new therapeutic strategies

      GERONTOLOGY
    37. Pigino, G; Pelsman, A; Mori, H; Busciglio, J
      Presenilin-1 mutations reduce cytoskeletal association, deregulate neuritegrowth, and potentiate neuronal dystrophy and tau phosphorylation

      JOURNAL OF NEUROSCIENCE
    38. Fitzjohn, SM; Morton, RA; Kuenzi, F; Rosahl, TW; Shearman, M; Lewis, H; Smith, D; Reynolds, DS; Davies, CH; Collingridge, GL; Seabrook, GR
      Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant formof amyloid precursor protein

      JOURNAL OF NEUROSCIENCE
    39. Mattson, MP; Chan, SL; Camandola, S
      Presenilin mutations and calcium signaling defects in the nervous and immune systems

      BIOESSAYS
    40. Lucas, JL; Hernandez, F; Gomez-Ramos, P; Moran, MA; Hen, R; Avila, J
      Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3 beta conditional transgenic mice

      EMBO JOURNAL
    41. Ishii, K; Lippa, C; Tomiyama, T; Miyatake, F; Ozawa, K; Tamaoka, A; Hasegawa, T; Fraser, PE; Shoji, S; Nee, LE; Pollen, DA; St George-Hyslop, PH; Ii, K; Ohtake, T; Kalaria, RN; Rossor, MN; Lantos, PL; Cairns, NJ; Farrer, LA; Mori, H
      Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition

      NEUROBIOLOGY OF AGING
    42. Gordon, MN; King, DL; Diamond, DM; Jantzen, PT; Boyett, KV; Hope, CE; Hatcher, JM; DiCarlo, G; Gottschall, WPE; Morgan, D; Arendash, GW
      Correlation between cognitive deficits and A beta deposits in transgenic APP+PS1 mice

      NEUROBIOLOGY OF AGING
    43. Dirami, G; Ravindranath, N; Achi, MV; Dym, M
      Expression of Notch pathway components in spermatogonia and Sertoli cells of neonatal mice

      JOURNAL OF ANDROLOGY
    44. Chapman, PF; Falinska, AM; Knevett, SG; Ramsay, MF
      Genes, models and Alzheimer's disease

      TRENDS IN GENETICS
    45. Janson, CG; McPhee, SWJ; Leone, P; Freese, A; During, MJ
      Viral-based gene transfer to the mammalian CNS for functional genomic studies

      TRENDS IN NEUROSCIENCES
    46. Sisodia, SS; Annaert, W; Kim, SH; De Strooper, B
      gamma-secretase: Never more enigmatic

      TRENDS IN NEUROSCIENCES
    47. Fishman, CE; Cummins, DJ; Bales, KR; DeLong, CA; Esterman, MA; Hanson, JC; White, SL; Paul, SM; Jordan, WH
      Statistical aspects of quantitative image analysis of beta-amyloid in the APP(V717F) transgenic mouse model of Alzheimer's disease

      JOURNAL OF NEUROSCIENCE METHODS
    48. Sorbi, S; Forleo, P; Tedde, A; Cellini, E; Ciantelli, M; Bagnoli, S; Nacmias, B
      Genetic risk factors in familial Alzheimer's disease

      MECHANISMS OF AGEING AND DEVELOPMENT
    49. Esler, WP; Wolfe, MS
      Biomedicine - A portrait of Alzheimer secretases - New features and familiar faces

      SCIENCE
    50. Lewis, J; Dickson, DW; Lin, WL; Chisholm, L; Corral, A; Jones, G; Yen, SH; Sahara, N; Skipper, L; Yager, D; Eckman, C; Hardy, J; Hutton, M; McGowan, E
      Enhanced neurofibrillary degeneration in transgenic mice expressing mutanttau and APP

      SCIENCE
    51. Iwata, N; Tsubuki, S; Takaki, Y; Shirotani, K; Lu, B; Gerard, NP; Gerard, C; Hama, E; Lee, HJ; Saido, TC
      Metabolic regulation of brain A beta by neprilysin

      SCIENCE
    52. Hannequin, D; Campion, D
      Dominant forms of Alzheimer's disease: from genotype to phenotype.

      REVUE NEUROLOGIQUE
    53. Janus, C; Westaway, D
      Transgenic mouse models of Alzheimer's disease

      PHYSIOLOGY & BEHAVIOR
    54. Rogaeva, EA; Fafel, KC; Song, YQ; Medeiros, H; Sato, C; Liang, Y; Richard, E; Rogaev, EI; Frommelt, P; Sadovnick, AD; Meschino, W; Rockwood, K; Boss, MA; Mayeux, R; St George-Hyslop, P
      Screening for PS1 mutations in a referral-based series of AD cases - 21 Novel mutations

      NEUROLOGY
    55. De Strooper, B; Konig, G
      Alzheimer's disease - An inflammatory drug prospect

      NATURE
    56. Weggen, S; Eriksen, JL; Das, P; Sagi, SA; Wang, R; Pietrzik, CU; Findlay, KA; Smith, TW; Murphy, MP; Butler, T; Kang, DE; Marquez-Sterling, N; Golde, TE; Koo, EH
      A subset of NSAIDs lower amyloidogenic A beta 42 independently of cyclooxygenase activity

      NATURE
    57. Kitazume, S; Tachida, Y; Oka, R; Shirotani, K; Saido, TC; Hashimoto, Y
      Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    58. Hartmann, D
      From Alzheimer's disease to skin tumors: The catenin connection

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    59. Monsonego, A; Maron, R; Zota, V; Selkoe, DJ; Weiner, HL
      Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    60. Fassbender, K; Simons, M; Bergmann, C; Stroick, M; Lutjohann, D; Keller, P; Runz, H; Kuhl, S; Bertsch, T; von Bergmannn, K; Hennerici, M; Beyreuther, K; Hartmann, T
      Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides A beta 42 and A beta 40 in vitro and in vivo

      PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
    61. Kametani, F; Tanaka, K; Usami, M; Maruyama, K; Mori, H
      Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the processing of Alzheimer's amyloid precursor protein in PC12D cells

      JOURNAL OF THE NEUROLOGICAL SCIENCES
    62. Baskin, F; Rosenberg, RN; Iyer, L; Schellenberg, GD; Hynan, L; Nee, LE
      Platelet APP isoform ratios in asymptomatic young adults expressing an AD-related presenilin-1 mutation

      JOURNAL OF THE NEUROLOGICAL SCIENCES
    63. Tomidokoro, Y; Harigaya, Y; Matsubara, E; Ikeda, M; Kawarabayashi, T; Shirao, T; Ishiguro, K; Okamoto, K; Younkin, SG; Shoji, M
      Brain A beta amyloidosis in APPsw mice induces accumulation of presenilin-I and tau

      JOURNAL OF PATHOLOGY
    64. Le, R; Cruz, L; Urbanc, B; Knowles, RB; Hsiao-Ashe, K; Duff, K; Irizarry, MC; Stanley, HE; Hyman, BT
      Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: Implications for neural system disruption

      JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
    65. Verkkoniemi, A; Kalimo, H; Paetau, A; Somer, M; Iwatsubo, T; Hardy, J; Haltia, M
      Variant Alzheimer disease with spastic paraparesis: Neuropathological phenotype

      JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
    66. Takao, M; Ghetti, B; Murrell, JR; Unverzagt, FW; Giaccone, G; Tagliavini, F; Bugiani, O; Piccardo, P; Hulette, CM; Crain, BJ; Farlow, MR; Heyman, A
      Ectopic white matter neurons, a developmental abnormality that may be caused by the PSEN1 S169L mutation in a case of familial AD with myoclonus and seizures

      JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
    67. Le, TV; Crook, R; Hardy, J; Dickson, DW
      Cotton wool plaques in non-familial late-onset Alzheimer disease

      JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
    68. Dumanchin-Njock, C; da Costa, CA; Mercken, L; Pradier, L; Checler, F
      The caspase-derived C-terminal fragment of beta APP induces caspase-independent toxicity and triggers selective increase of A beta 42 in mammalian cells

      JOURNAL OF NEUROCHEMISTRY
    69. Cupers, P; Orlans, I; Craessaerts, K; Annaert, W; De Strooper, B
      The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

      JOURNAL OF NEUROCHEMISTRY
    70. Nakajima, M; Miura, M; Aosaki, T; Shirasawa, T
      Deficiency of presenilin-1 increases calcium-dependent vulnerability of neurons to oxidative stress in vitro

      JOURNAL OF NEUROCHEMISTRY
    71. Counts, SE; Lah, JJ; Levey, AI
      The regulation of presenilin-1 by nerve growth factor

      JOURNAL OF NEUROCHEMISTRY
    72. Skovronsky, DM; Fath, S; Lee, VMY; Milla, ME
      Neuronal localization of the TNF alpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques

      JOURNAL OF NEUROBIOLOGY
    73. Vezina, J; Grossmuller, F; Muller, K
      Influence of a transiently transfected gene on apoptosis, measurements guided by cotransfected GFP

      JOURNAL OF IMMUNOLOGICAL METHODS
    74. Tomita, M; Sugi, K; Ozawa, K; Tsong, TY; Yoshimura, T
      Targeting antigen-specific receptors on B lymphocytes to generate high yields of specific monoclonal antibodies directed against biologically active lower antigenic peptides within presenilin 1

      JOURNAL OF IMMUNOLOGICAL METHODS
    75. Dingwall, C
      Spotlight on BACE: The secretases as targets for treatment in Alzheimer disease

      JOURNAL OF CLINICAL INVESTIGATION
    76. Cupers, P; Bentahir, M; Craessaerts, K; Orlans, I; Vanderstichele, H; Saftig, P; De Strooper, B; Annaert, W
      The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

      JOURNAL OF CELL BIOLOGY
    77. Kim, JW; Chang, TS; Lee, JE; Huh, SH; Yeon, SW; Yang, WS; Joe, CO; Mook-Jung, I; Tanzi, RE; Kim, TW; Choi, EJ
      Negative regulation of the SAPK/JNK signaling pathway by presenilin 1

      JOURNAL OF CELL BIOLOGY
    78. Wiltfang, J; Esselmann, H; Cupers, P; Neumann, M; Kretzschmar, H; Beyermann, M; Schleuder, D; Jahn, H; Ruther, E; Kornhuber, J; Annaert, W; De Strooper, B; Saftig, P
      Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells

      JOURNAL OF BIOLOGICAL CHEMISTRY
    79. Kim, SH; Leem, JY; Lah, JJ; Slunt, HH; Levey, AI; Thinakaran, G; Sisodia, SS
      Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

      JOURNAL OF BIOLOGICAL CHEMISTRY
    80. Tomita, T; Watabiki, T; Takikawa, R; Morohashi, Y; Takasugi, N; Kopan, R; De Strooper, B; Iwatsubo, T
      The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

      JOURNAL OF BIOLOGICAL CHEMISTRY
    81. Kirschenbaum, F; Hsu, SC; Cordell, B; McCarthy, JV
      Glycogen synthase kinase-3 beta regulates presenilin 1 C-terminal fragmentlevels

      JOURNAL OF BIOLOGICAL CHEMISTRY
    82. Berezovska, O; Jack, C; Deng, A; Gastineau, N; Rebeck, GW; Hyman, BT
      Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage

      JOURNAL OF BIOLOGICAL CHEMISTRY
    83. Hussain, I; Christie, G; Schneider, K; Moore, S; Dingwall, C
      Prodomain processing of Asp1 (BACE2) is autocatalytic

      JOURNAL OF BIOLOGICAL CHEMISTRY
    84. Chishti, MA; Yang, DS; Janus, C; Phinney, AL; Horne, P; Pearson, J; Strome, R; Zuker, N; Loukides, J; French, J; Turner, S; Lozza, G; Grilli, M; Kunicki, S; Morissette, C; Paquette, J; Gervais, F; Bergeron, C; Fraser, PE; Carlson, GA; St George-Hyslop, P; Westaway, D
      Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695

      JOURNAL OF BIOLOGICAL CHEMISTRY
    85. Kuo, YM; Kokjohn, TA; Beach, TG; Sue, LI; Brune, D; Lopez, JC; Kalback, WM; Abramowski, D; Sturchler-Pierrat, C; Staufenbiel, M; Roher, AE
      Comparative analysis of amyloid-beta chemical structure and amyloid plaquemorphology of transgenic mouse and Alzheimer's disease brains

      JOURNAL OF BIOLOGICAL CHEMISTRY
    86. Pinnix, I; Musunuru, U; Tun, H; Sridharan, A; Golde, T; Eckman, C; Ziani-Cherif, C; Onstead, L; Sambamurti, K
      A novel gamma-secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor

      JOURNAL OF BIOLOGICAL CHEMISTRY
    87. Qiu, ZH; Naten, DL; Liston, JC; Yess, J; Rebeck, GW
      A novel approach for studying endogenous A beta processing using cultured primary neurons isolated from APP transgenic mice

      EXPERIMENTAL NEUROLOGY
    88. Benussi, L; Alberici, A; Mayhaus, M; Langer, U; Ghidoni, R; Mazzoli, F; Nicosia, F; Barbiero, L; Frisoni, G; Zanetti, O; Gasparini, L; Nitsch, RM; Binetti, G
      Detection of the presenilin 1 COOH-terminal fragment in the extracellular compartment: A release enhanced by apoptosis

      EXPERIMENTAL CELL RESEARCH
    89. Singh, N; Talalayeva, Y; Tsiper, M; Romanov, V; Dranovsky, A; Colflesh, D; Rudamen, G; Vitek, MP; Shen, J; Yang, XD; Goldgaber, D; Schwarzman, AL
      The role of Alzheimer's disease-related presenilin 1 in intercellular adhesion

      EXPERIMENTAL CELL RESEARCH
    90. Kawamura, Y; Kikuchi, A; Takada, R; Takada, S; Sudoh, S; Shibamoto, S; Yanagisawa, K; Komano, H
      Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathwayby enhancement of beta-catenin phosphorylation

      EUROPEAN JOURNAL OF BIOCHEMISTRY
    91. Yasojima, K; McGeer, EG; McGeer, PL
      Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain

      BRAIN RESEARCH
    92. Xie, J; Chang, XW; Zhang, XJ; Guo, Q
      Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice

      BRAIN RESEARCH
    93. Kasa, P; Papp, H; Pakaski, M
      Presenilin-1 and its N-terminal and C-terminal fragments are transported in the sciatic nerve of rat

      BRAIN RESEARCH
    94. Heyn, SN; Vulliet, PR
      Presenilin 1 mutations increase amyloid precursor protein production and proteolysis in Xenopus laevis oocytes

      BRAIN RESEARCH
    95. Guo, Q; Xie, J; Chang, XW; Zhang, XJ; Du, HM
      Par-4 is a synaptic protein that regulates neurite outgrowth by altering calcium homeostasis and transcription factor AP-1 activation

      BRAIN RESEARCH
    96. Arendash, GW; King, DL; Gordon, MN; Morgan, D; Hatcher, JM; Hope, CE; Diamond, DM
      Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes

      BRAIN RESEARCH
    97. Zhang, LL; Song, LX; Terracina, G; Liu, YH; Pramanik, B; Parker, E
      Biochemical characterization of the gamma-secretase activity that producesbeta-amyloid peptides

      BIOCHEMISTRY
    98. Park, IH; Jung, MW; Mori, H; Mook-Jung, I
      Zinc enhances synthesis of presenilin 1 in mouse primary cortical culture

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    99. Hashimoto, Y; Ito, Y; Niikura, T; Shao, Z; Hata, M; Oyama, F; Nishimoto, I
      Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    100. Hare, JF
      Protease inhibitors divert amyloid precursor protein to the secretory pathway

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS


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Documento generato il 18/02/20 alle ore 23:53:54