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Transient up-regulation of liver mitochondrial thymidine kinase activity in proliferating mitochondria
IUBMB LIFE
Influence of conjugated linoleic acid on body composition and target gene expression in peroxisome proliferator-activated receptor alpha-null mice
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Rare side-effects of fenofibrate
DIABETES & METABOLISM
Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7 alpha-hydroxylaseand sterol 27-hydroxylase expression
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
PPARs, metabolic disease and atherosclerosis
PHARMACOLOGICAL RESEARCH
Lipid-lowering drugs in lupus: an unexplored therapeutic intervention
LUPUS
Variation at position 162 of peroxisome proliferator-activated receptor alpha does not influence the effect of fibrates on cholesterol or triacylglycerol concentrations in hyperlipidaemic subjects
PHARMACOGENETICS
Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice
CURRENT OPINION IN LIPIDOLOGY
RXR alpha ablation in skin keratinocytes results in alopecia and epidermalalterations
DEVELOPMENT
Localization of mRNAs encoding peroxisomal proteins in cell culture by non-radioactive in situ hybridization. Comparison of rat and human hepatoma cells and their responses to two divergent hypolipidemic drugs
HISTOCHEMISTRY AND CELL BIOLOGY
A polymorphism, L162V, in the peroxisome proliferator-activated receptor alpha (PPAR alpha) gene is associated with lower body mass index in patientswith non-insulin-dependent diabetes mellitus
JOURNAL OF MOLECULAR MEDICINE-JMM
Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor alpha in the adult rodent heart
FASEB JOURNAL
The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism
FASEB JOURNAL
Gene expression profile of the aging process in rat liver: Normalizing effects of growth hormone replacement
MOLECULAR ENDOCRINOLOGY
Role of cytokines in non-genotoxic hepatocarcinogenesis: cause or effect?
TOXICOLOGY LETTERS
Tissue distribution of porcine peroxisome proliferator-activated receptor alpha: detection of an alternatively spliced mRNA
GENE
Activation of the peroxisome proliferator-activated receptor-alpha enhances cell death in cultured cerebellar granule cells
JOURNAL OF NEUROSCIENCE RESEARCH
Quantitative proteomic analysis of mouse liver response to the peroxisome proliferator diethylhexylphthalate (DEHP)
ARCHIVES OF TOXICOLOGY
The chlorophyll metabolite phytanic acid is a natural rexinoid - potentialfor treatment and prevention of diabetes
MEDICAL HYPOTHESES
Coordinately regulated expression of FAT/CD36 and FACS1 in rat skeletal muscle
MOLECULAR AND CELLULAR BIOCHEMISTRY
Benzafibrate induces acyl-CoA oxidase mRNA levels and fatty acid peroxisomal beta-oxidation in rat white adipose tissue
MOLECULAR AND CELLULAR BIOCHEMISTRY
Peroxisome-proliferator-activated receptors as physiological sensors of fatty acid metabolism: molecular regulation in peroxisomes
BIOCHEMICAL SOCIETY TRANSACTIONS
Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids
BIOCHEMICAL SOCIETY TRANSACTIONS
Immunocytochemical localization of acyl-CoA oxidase in the rat central nervous system
JOURNAL OF NEUROCYTOLOGY
Altered expression of the carboxylesterases ES-4 and ES-10 by peroxisome proliferator chemicals
TOXICOLOGY
Weight-of-evidence versus strength-of-evidence in toxicologic hazard identification: Di(2-ethylhexyl)phthalate (DEHP)
TOXICOLOGY
Peroxisomal beta-oxidation and steatohepatitis
SEMINARS IN LIVER DISEASE
Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886
BIOCHEMICAL JOURNAL
Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine
BIOCHEMICAL JOURNAL
Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptoralpha (PPAR alpha)-independent pathway
BIOCHEMICAL JOURNAL
Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: An adaptive metabolic system
ANNUAL REVIEW OF NUTRITION
Impaired biliary lipid secretion in obese Zucker rats: leptin promotes hepatic cholesterol clearance
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Role of thyroid hormones in hepatic effects of peroxisome proliferators
TOXICOLOGIC PATHOLOGY
The biochemistry of hypo- and hyperlipidemic fatty acid derivatives: metabolism and metabolic effects
PROGRESS IN LIPID RESEARCH
Effect of fenofibrate on fatty liver in rats treated with alcohol
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
Peroxisome proliferators do not increase DNA synthesis in purified rat hepatocytes
CARCINOGENESIS
Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)?
ENVIRONMENTAL HEALTH PERSPECTIVES
Exposure to peroxisome proliferators: Reassessment of the potential carcinogenic hazard
ENVIRONMENTAL HEALTH PERSPECTIVES
Activation of the activator protein-1 by the peroxisome proliferator clofibric acid in rat H4IIEC3 hepatoma cells
TOXICOLOGY AND APPLIED PHARMACOLOGY
Metabolic effects of rexinoids: Tissue-specific regulation of lipoprotein lipase activity
MOLECULAR PHARMACOLOGY
Peroxisome proliferator-activated receptor subtype-specific regulation of hepatic and peripheral gene expression in the Zucker diabetic fatty rat
METABOLISM-CLINICAL AND EXPERIMENTAL
Effects of free fatty acids on beta-cell functions: A possible involvementof peroxisome proliferator-activated receptors alpha or pancreatic/duodenal homeobox
METABOLISM-CLINICAL AND EXPERIMENTAL
Effect of peroxisome proliferator-activated receptor a activation on leukotriene B-4 metabolism in isolated rat hepatocytes
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Modulation of cytosolic phospholipase A(2) by PPAR activators in human preadipocytes
JOURNAL OF LIPID RESEARCH
Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D
JOURNAL OF LIPID RESEARCH
Fasting-induced changes in the expression of genes controlling substrate metabolism in the rat heart
JOURNAL OF LIPID RESEARCH
Effects of fenofibrate on lipid parameters in obese rhesus monkeys
JOURNAL OF LIPID RESEARCH
Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia
JOURNAL OF IMMUNOLOGY
p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha - A potential role in the cardiac metabolic stress response
JOURNAL OF BIOLOGICAL CHEMISTRY
Transcriptional regulation of the human sterol 12 alpha-hydroxylase gene (CYP8B1) - Roles of hepatocyte nuclear factor 4 alpha in mediating bile acidrepression
JOURNAL OF BIOLOGICAL CHEMISTRY
Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11 beta-hydroxysteroid dehydrogenase type 1 null mice.
JOURNAL OF BIOLOGICAL CHEMISTRY
Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity - Studies with congenic mouse lines
JOURNAL OF BIOLOGICAL CHEMISTRY
Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta
JOURNAL OF BIOLOGICAL CHEMISTRY
Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor a in HepG2 cells
JOURNAL OF BIOLOGICAL CHEMISTRY
GATA-4 and serum response factor regulate transcription of the muscle-specific carnitine palmitoyltransferase I beta in rat heart
JOURNAL OF BIOLOGICAL CHEMISTRY
Tetradecylthioacetic acid reduces stenosis development after balloon angioplasty injury of rabbit iliac arteries
ATHEROSCLEROSIS
Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidasenull mice
EXPERIMENTAL CELL RESEARCH
Effects of bezafibrate on beta-cell function of rat pancreatic islets
EUROPEAN JOURNAL OF PHARMACOLOGY
Fibrate induction of the adrenoleukodystrophy-related gene (ABCD2) - Promoter analysis and role of the peroxisome proliferator-activated receptor PPAR alpha
EUROPEAN JOURNAL OF BIOCHEMISTRY
Lipid-lowering agents and artery endothelial function
CHEST
Reduction in stroke with gemfibrozil in men with coronary heart disease and low HDL cholesterol - The veterans affairs HDL intervention trial (VA-HIT)
CIRCULATION
Automatic inducer addition and harvesting of recombinant Escherichia coli cultures based on indirect on-line estimation of biomass concentration and specific growth rate
BIOTECHNOLOGY AND BIOENGINEERING
Suppression of hepatocyte nuclear factor-4 alpha by acyl-CoA thioesters ofhypolipidemic peroxisome proliferators
BIOCHEMICAL PHARMACOLOGY
Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Role of peroxisome proliferator-activated receptor-alpha in the mechanism underlying changes in renal pyruvate dehydrogenase kinase isoform 4 proteinexpression in starvation and after refeeding
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Nutritionally induced changes in the peroxisome proliferator-activated receptor-alpha gene expression in liver of suckling rats are dependent on insulinaemia
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
New conceptions in the mechanism of action of fibrates and prospective therapeutics in atherosclerosis
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
Frequency of stromal lineage colony forming units in bone marrow of peroxisome proliferator-activated receptor-alpha-null mice
BONE
Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPAR alpha and TNF alpha
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Species differences in peroxisome proliferation; mechanisms and relevance
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Species differences in hepatic peroxisome proliferation, cell replication and transforming growth factor-beta 1 gene expression in the rat, Syrian hamster and guinea pig
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Regulation of vascular endothelial nitric oxide production by fatty acids
CURRENT ORGANIC CHEMISTRY
Patent focus on agents for atherosclerosis: September 1999-February 2000
EXPERT OPINION ON THERAPEUTIC PATENTS
Mutation screening of the PPAR alpha gene in type 2 diabetes associated with coronary heart disease
DIABETES & METABOLISM
Genomics of the human carnitine acyltransferase genes
MOLECULAR GENETICS AND METABOLISM
Peroxisome proliferator-activated receptor alpha-null mice lack resistanceto acetaminophen hepatotoxicity following clofibrate exposure
TOXICOLOGICAL SCIENCES
Peroxisome proliferator-activated receptor alpha is an androgen-responsivegene in human prostate and is highly expressed in prostatic adenocarcinoma
CLINICAL CANCER RESEARCH
8S-lipoxygenase products activate peroxisome proliferator-activated receptor alpha and induce differentiation in murine keratinocytes
CELL GROWTH & DIFFERENTIATION
The human peroxisome proliferator-activated receptor a gene: identification and functional characterization of two natural allelic variants
PHARMACOGENETICS
Peroxisome proliferator-activated receptors in tumorigenesis: Targets of tumour promotion and treatment
IMMUNOLOGY AND CELL BIOLOGY
The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes
CELL BIOLOGY AND TOXICOLOGY
Characterization of peroxisome proliferator-activated receptor alpha in normal rat mammary gland and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mammary gland tumors from rats fed high and low fat diets
TOXICOLOGY LETTERS
Apoptosis and proliferation in nongenotoxic carcinogenesis: species differences and role of PPAR alpha
TOXICOLOGY LETTERS
Thrombin induces endothelin expression in arterial smooth muscle cells
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Species differences in response to diethylhexylphthalate: suppression of apoptosis, induction of DNA synthesis and peroxisome proliferator activated receptor alpha-mediated gene expression
ARCHIVES OF TOXICOLOGY
Peroxisome proliferator-activated receptors and skin development
HORMONE RESEARCH
The role of inhibition of gap junctional intercellular communication in rodent liver tumor induction by phthalates: Review of data on selected phthalates and the potential relevance to man
REGULATORY TOXICOLOGY AND PHARMACOLOGY
The effect of peroxisome-proliferator-activated receptor-alpha on the activity of the cholesterol 7 alpha-hydroxylase gene
BIOCHEMICAL JOURNAL
Di(isononyl) phthalate (DINP) and di(isodecyl) phthalate (DIDP) are not mutagenic
JOURNAL OF APPLIED TOXICOLOGY
Proliferation of mitochondria and gene expression of carnitine palmitoyltransferase and fatty acyl-CoA oxidase in rat skeletal muscle, heart and liver by hypolipidemic fatty acids
BIOLOGY OF THE CELL
Tumour necrosis factor alpha (TNF alpha): Role in suppression of apoptosisby the peroxisome proliferator nafenopin
CELLULAR AND MOLECULAR BIOLOGY
Apoptosis, mitosis and cyclophilin-40 expression in regressing peroxisome proliferator-induced adenomas
CARCINOGENESIS
Role of hepatic non-parenchymal cells in the response of rat hepatocytes to the peroxisome proliferator nafenopin in vitro
CARCINOGENESIS
Skin abnormalities generated by temporally controlled RXR alpha mutations in mouse epidermis
NATURE
Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect - Reduction of MRNA levels for interleukin-1 beta, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor alpha (PPAR alpha) in primary endothelial cells
LIFE SCIENCES
Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis
JOURNAL OF MOLECULAR BIOLOGY
Molecular scanning of the human PPAR alpha gene: association of the L162V mutation with hyperapobetalipoproteinemia
JOURNAL OF LIPID RESEARCH
Involvement of the peroxisome proliferator-activated receptor alpha in regulating long-chain acyl-CoA thioesterases
JOURNAL OF LIPID RESEARCH
Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferater-activated receptor alpha
JOURNAL OF LIPID RESEARCH
Peroxisome proliferator-activated receptor-alpha enhances lipid metabolismin a skin equivalent model
JOURNAL OF INVESTIGATIVE DERMATOLOGY