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La ricerca find articoli where soggetti phrase all words 'POLYPEPTIDE' sort by level,fasc_key/DESCEND, pagina_ini_num/ASCEND ha restituito 9566 riferimenti
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    1. Karnik, SS
      Analysis of structure-function from expression of G protein-coupled receptor fragments

      G PROTEIN PATHWAYS, PT A, RECEPTORS
    2. Lipkin, A; Kozlov, S; Nosyreva, E; Blake, A; Windass, JD; Grishin, E
      Novel insecticidal toxins from the venom of the spider Segestria florentina

      TOXICON
    3. Leroux, P
      Localization and characterization of NPY/PYY receptors in rat frontoparietal cortex during development

      JOURNAL OF COMPARATIVE NEUROLOGY
    4. Munch, IC; Moller, M; Larsen, PJ; Vrang, N
      Light-induced c-fos expression in suprachiasmatic nuclei neurons targetingthe paraventricular nucleus of the hamster hypothalamus: Phase dependence and immunochemical identification

      JOURNAL OF COMPARATIVE NEUROLOGY
    5. Hayashi, T; Kanai, H; Yodoya, S; Oka, M; Hayashi, T
      Biodegradation of random co-polypeptide hydrogels consisting of N-hydroxypropyl L-glutamine as one component

      EUROPEAN POLYMER JOURNAL
    6. Bliziotes, MM; Eshleman, AJ; Zhang, XW; Wiren, KM
      Neurotransmitter action in osteoblasts: Expression of a functional system for serotonin receptor activation and reuptake

      BONE
    7. Cremaschi, D; Dossena, S; Porta, C; Rossi, V; Pinza, M
      Further analysis of transcytosis of free polypeptides and polypeptide-coated nanobeads in rabbit nasal mucosa

      JOURNAL OF APPLIED PHYSIOLOGY
    8. Ma, Y; Jakowitsch, J; Maier, TL; Bayer, MG; Muller, NE; Schenk, HEA; Loffelhardt, W
      ATP citrate lyase in the glaucocystophyte alga Cyanophora paradoxa is a cytosolic enzyme: characterisation of the gene for the large subunit at the cDNA and genomic levels

      MOLECULAR GENETICS AND GENOMICS
    9. Wulfkuhle, JD; McLean, KC; Paweletz, CP; Sgroi, DC; Trock, BJ; Steeg, PS; Petricoin, EF
      New approaches to proteomic analysis of breast cancer

      PROTEOMICS
    10. Hondermarck, H; Vercoutter-Edouart, AS; Revillion, F; Lemoine, J; El-Yazidi-Belkoura, I; Nurcombe, V; Peyrat, JP
      Proteomics of breast cancer for marker discovery and signal pathway profiling

      PROTEOMICS
    11. Gessmann, R; Bruckner, H; Kokkinidis, M
      Tripeptide Z-Aib-Aib-Hyp-OMe

      ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE
    12. Hasan, W; Cowen, T; Barnett, PS; Elliot, E; Coskeran, P; Bouloux, PMG
      The sweating apparatus in growth hormone deficiency, following treatment with r-hGH and in acromegaly

      AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
    13. Halfacree, ZJ; Read, PA; Edwards, AV
      Pancreatic exocrine responses to parasympathetic stimulation in anaesthetized pigs

      AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
    14. Kawakami, T; Akaji, K; Aimoto, S
      Peptide bond formation mediated by 4,5-dimethoxy-2-mercaptobenzylamine after periodate oxidation of the N-terminal serine residue

      ORGANIC LETTERS
    15. Johansson, J; Curstedt, T; Robertson, B
      Artificial surfactants based on analogues of SP-B and SP-C

      PEDIATRIC PATHOLOGY & MOLECULAR MEDICINE
    16. de Wit, TR; van Mourik, JA
      Biosynthesis, processing and secretion of von Willebrand factor: biological implications

      BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
    17. Zylicz, M; Wawrzynow, A
      Insights into the function of Hsp70 chaperones

      IUBMB LIFE
    18. Sigfridsson, E; Olsson, MHM; Ryde, U
      Comparison of the inner-sphere reorganization energies of cytochromes, iron-sulfur clusters, and blue copper proteins

      JOURNAL OF PHYSICAL CHEMISTRY B
    19. Lee, DK; Wei, YF; Ramamoorthy, A
      A two-dimensional magic-angle decoupling and magic-angle turning solid-state NMR method: An application to study chemical shift tensors from peptidesthat are nonselectively labeled with N-15 isotope

      JOURNAL OF PHYSICAL CHEMISTRY B
    20. Morris, GE
      The role of the nuclear envelope in Emery-Dreifuss muscular dystrophy

      TRENDS IN MOLECULAR MEDICINE
    21. McBain, CJ; Fisahn, A
      Interneurons unbound

      NATURE REVIEWS NEUROSCIENCE
    22. Bae, SE; Corcoran, BM; Watson, ED
      Immunohistochemical study of the distribution of adrenergic and peptidergic innervation in the equine uterus and the cervix

      REPRODUCTION
    23. Sullivan, ME; Keoghane, SR; Miller, MAW
      Vascular risk factors and erectile dysfunction

      BJU INTERNATIONAL
    24. Meuleman, E; Cuzin, B; Opsomer, RJ; Hartmann, U; Bailey, MJ; Maytom, MC; Smith, MD; Osterloh, IH
      A dose-escalation study to assess the efficacy and safety of sildenafil citrate in men with erectile dysfunction

      BJU INTERNATIONAL
    25. Butler, T; Schumacher, T; Namdjou, DJ; Gallego, RG; Clausen, H; Elling, L
      Chemoenzymatic synthesis of biotinylated nucleotide sugars as substrates for glycosyltransferases

      CHEMBIOCHEM
    26. Iida, A; Saito, S; Sekine, A; Mishima, C; Kondo, K; Kitamura, Y; Harigae, S; Osawa, S; Nakamura, Y
      Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH : ubiquinone oxidoreductase flavoproteins

      JOURNAL OF HUMAN GENETICS
    27. Mazaleyrat, JP; Wright, K; Wakselman, M; Formaggio, F; Crisma, M; Toniolo, C
      9-amino-4,5-diazafluorene-9-carboxylic acid (Daf), a new C-alpha,C-alpha-disubstituted glycine containing a spatially constrained bipyridine-like ligand for transition metals - Synthesis and evaluation of peptide-coupling conditions at its C- and N-termini

      EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
    28. Chin, JW; Schepartz, A
      Design and evolution of a miniature bcl-2 binding protein

      ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    29. Hanisch, FA
      O-glycosylation of the mucin type

      BIOLOGICAL CHEMISTRY
    30. Pineiro, A; Bugia, MB; Arias, MP; Cordero, OJ; Nogueira, M
      Identification of receptors for prothymosin alpha on human lymphocytes

      BIOLOGICAL CHEMISTRY
    31. Eckard, CP; Cabrele, C; Wieland, HA; Beck-Sickinger, AG
      Characterisation of neuropeptide Y receptor subtypes by synthetic NPY analogues and by anti-receptor antibodies

      MOLECULES
    32. Jideus, L; Ericson, M; Stridsberg, M; Nilsson, L; Blomstrom, P; Blomstrorm-Lundqvist, C
      Diminished circadian variation in heart rate variability before surgery inpatients developing postoperative atrial fibrillation

      SCANDINAVIAN CARDIOVASCULAR JOURNAL
    33. Ball, HL; King, DS; Cohen, FE; Prusiner, SB; Baldwin, MA
      Engineering the prion protein using chemical synthesis

      JOURNAL OF PEPTIDE RESEARCH
    34. Hammarstrom, LGJ; Gauthier, TJ; Hammer, RP; McLaughlin, ML
      Amphipathic control of the 3(10)-/alpha-helix equilibrium in synthetic peptides

      JOURNAL OF PEPTIDE RESEARCH
    35. Iovino, M; Falconi, M; Marcellini, A; Desideri, A
      Molecular dynamics simulation of the antimicrobial salivary peptide histatin-5 in water and in trifluoroethanol: a microscopic description of the water destructuring effect

      JOURNAL OF PEPTIDE RESEARCH
    36. Scheuermann-Freestone, M; Freestone, NS; Langenickel, T; Hohnel, K; Dietz, R; Willenbrock, R
      A new model of congestive heart failure in the mouse due to chronic volumeoverload

      EUROPEAN JOURNAL OF HEART FAILURE
    37. Alvite, G; Di Pietro, SM; Santome, JA; Ehrlich, R; Esteves, A
      Binding properties of Echinococcus granulosus fatty acid binding protein

      BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
    38. Doi, N; Yanagawa, H
      Genotype-phenotype linkage for directed evolution and screening of combinatorial protein libraries

      COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
    39. Aimoto, S
      Contemporary methods for peptide and protein synthesis

      CURRENT ORGANIC CHEMISTRY
    40. Gomariz, RP; Martinez, C; Abad, C; Leceta, J; Delgado, M
      Immunology of VIP: A review and therapeutical perspectives

      CURRENT PHARMACEUTICAL DESIGN
    41. Weyer, C; Maggs, DG; Young, AA; Kolterman, OG
      Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: A physiological approach toward improvedmetabolic control

      CURRENT PHARMACEUTICAL DESIGN
    42. Drucker, DJ
      Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes

      CURRENT PHARMACEUTICAL DESIGN
    43. Prata-Vidal, M; Bouhallab, S; Henry, G; Aimar, P
      An experimental study of caseinomacropeptide hydrolysis by trypsin in a continuous membrane reactor

      BIOCHEMICAL ENGINEERING JOURNAL
    44. Francis, DA
      Glatiramer acetate (Copaxone)

      INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
    45. Yuan, ZY; Trias, J; White, RJ
      Deformylase as a novel antibacterial target

      DRUG DISCOVERY TODAY
    46. Lin, YH; Fang, WL; Lin, WJ; Huang, SW; Chou, CP
      Improving production of penicillin acylase in Escherichia coli via efficient DegP-mediated processing of precursors in periplasm

      PROCESS BIOCHEMISTRY
    47. Kramer, G; Ramachandiran, V; Hardesty, B
      Cotranslational folding - omnia mea mecum porto?

      INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
    48. Harrison, S; Geppetti, P
      Substance P

      INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
    49. Agarwal, M; Katiyar-Agarwal, S; Sahi, C; Gallie, DR; Grover, A
      Arabidopsis thaliana Hsp100 proteins: kith and kin

      CELL STRESS & CHAPERONES
    50. Ou, WC; Chen, LH; Wang, ML; Hseu, TH; Chang, DC
      Analysis of minimal sequences on JC virus VP1 required for capsid assembly

      JOURNAL OF NEUROVIROLOGY
    51. Danaher, RJ; Savells-Arb, AD; Black, SA; Jacob, RJ; Miller, CS
      Herpesvirus quiescence in neuronal cells IV*: Virus activation induced by pituitary adenylate cyclase-activating polypeptide (PACAP) involves the protein kinase A pathway

      JOURNAL OF NEUROVIROLOGY
    52. Nakamura, Y; Son, Y; Kohno, Y; Shimono, D; Kuwamura, N; Koshiyama, H; Sasano, H; Matsuda, T
      Case of adrenocorticotropic hormone-independent macronodular adrenal hyperplasia with possible adrenal hypersensitivity to angiotensin II

      ENDOCRINE
    53. Nyholm, B; Brock, B; Orskov, L; Schmitz, O
      Amylin receptor agonists: a novel pharmacological approach in the management of insulin-treated diabetes mellitus

      EXPERT OPINION ON INVESTIGATIONAL DRUGS
    54. Feurle, GE; Pfeiffer, A; Schmidt, T; Dominguez-Munoz, E; Malfertheiner, P; Hamscher, G
      Phase III of the migrating motor complex: associated with endogenous xeninplasma peaks and induced by exogenous xenin

      NEUROGASTROENTEROLOGY AND MOTILITY
    55. Schneider, J; Jehle, EC; Starlinger, MJ; Neunlist, M; Michel, K; Hoppe, S; Schemann, M
      Neurotransmitter coding of enteric neurones in the submucous plexus is changed in non-inflamed rectum of patients with Crohn's disease

      NEUROGASTROENTEROLOGY AND MOTILITY
    56. Depoortere, I; Van Assche, G; Peeters, TL
      Motilin receptor density in inflamed and noninflamed tissue in rabbit TNBS-induced colitis

      NEUROGASTROENTEROLOGY AND MOTILITY
    57. Haas, M; Beyer, D; Gahlmann, R; Freiberg, C
      YkrB is the main peptide deformylase in Bacillus subtilis, a eubacterium containing two functional peptide deformylases

      MICROBIOLOGY-SGM
    58. Ganea, D; Delgado, L
      Inhibitory neuropeptide receptors on macrophages

      MICROBES AND INFECTION
    59. Zabielski, R; Pierzynowski, SG
      Development and regulation of pancreatic juice secretion in cattle. State-of-the-art

      JOURNAL OF ANIMAL AND FEED SCIENCES
    60. Ueda, H; Nakatsu, T; Murakami, T; Kusachi, S; Tominaga, Y; Yamane, S; Uesugi, T; Komatsubara, I; Iwabu, A; Tsuji, T
      Effects of cilostazol on heart rate and its variability in patients with sick sinus syndrome

      CLINICAL DRUG INVESTIGATION
    61. Gattegno, B; Chopin, D
      Diagnosis

      PROGRES EN UROLOGIE
    62. Virgilio, F; Sciarrillo, R; Laforgia, V; Cavagnuolo, A; De Falco, M; Varano, L
      Morphological and biochemical changes in the thyroid gland of the lizard Podarcis sicula (Reptilia, Squamata) induced by VIP treatment

      ITALIAN JOURNAL OF ZOOLOGY
    63. Weissman, JS
      The ins and outs of GroEL-mediated protein folding

      MOLECULAR CELL
    64. Zappulla, JP; DesGroseillers, L
      Neutral endopeptidase is expressed on the follicular granulosa cells of rabbit ovaries

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
    65. Yaron, Z; Gur, G; Melamed, P; Rosenfeld, H; Levavi-Sivan, B; Elizur, A
      Regulation of gonadotropin subunit genes in tilapia

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
    66. Sivarajah, P; Wheeler, MB; Irwin, DM
      Evolution of receptors for proglucagon-derived peptides: isolation of frogglucagon receptors

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
    67. Duhlmeier, R; Deegen, E; Fuhrmann, H; Widdel, A; Sallmann, HP
      Glucose-dependent insulinotropic polypeptide (GIP) and the enteroinsular axis in equines (Equus caballus)

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
    68. Plasencia, I; Rivas, L; Casals, C; Keough, KMW; Perez-Gil, J
      Intrinsic structural differences in the N-terminal segment of pulmonary surfactant protein SP-C from different species

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
    69. Jensen, J
      Regulatory peptides and control of food intake in non-mammalian vertebrates

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
    70. Olsson, C; Holmgren, S
      The control of gut motility

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
    71. Farrell, AP; Thorarensen, H; Axelsson, M; Crocker, CE; Gamperl, AK; Cech, JJ
      Gut blood flow in fish during exercise and severe hypercapnia

      COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
    72. Jones, DH; Golding, MC; Barr, KJ; Fong, GH; Kidder, GM
      The mouse Na+-K+-ATPase gamma-subunit gene (Fxyd2) encodes three developmentally regulated transcripts

      PHYSIOLOGICAL GENOMICS
    73. Macario, AJL; de Macario, EC
      The molecular chaperone system and other anti-stress mechanisms in archaea

      FRONTIERS IN BIOSCIENCE
    74. Goldblatt, MI; Choi, SH; Swartz-Basile, DA; Nakeeb, A; Sarna, SKS; Pitt, HA
      Iron deficiency suppresses ileal nitric oxide synthase activity

      JOURNAL OF GASTROINTESTINAL SURGERY
    75. Tanaka, T; VanKlompenberg, LH; Sarr, MG
      Selective role of vagal and nonvagal innervation in initiation and coordination of gastric and small bowel patterns of interdigestive and postprandial motility

      JOURNAL OF GASTROINTESTINAL SURGERY
    76. Chen, G; Hayhurst, A; Thomas, JG; Harvey, BR; Iverson, BL; Georgiou, G
      Isolation of high-affinity ligand-binding proteins by periplasmic expression with cytometric screening (PECS)

      NATURE BIOTECHNOLOGY
    77. Binder, WJ; Brin, MF; Blitzer, A; Pogoda, JM
      Botulinum toxin type A (BOTOX) for treatment of migraine

      SEMINARS IN CUTANEOUS MEDICINE AND SURGERY
    78. Burchell, JM; Mungul, A; Taylor-Papadimitriou, J
      O-linked glycosylation in the mammary gland: Changes that occur during malignancy

      JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
    79. Autieri, MV; Carbone, CM
      Overexpression of allograft inflammatory factor-1 promotes proliferation of vascular smooth muscle cells by cell cycle deregulation

      ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
    80. Korosi, J; McIntosh, CHS; Pederson, RA; Demuth, HU; Habener, JF; Gingerich, R; Egan, JM; Elahi, D; Meneilly, GS
      Effect of aging and diabetes on the enteroinsular axis

      JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
    81. Vento, P; Kiviluoto, T; Jarvinen, HJ; Karkkainen, P; Kivilaakso, E; Soinila, S
      Expression of inducible and endothelial nitric oxide synthases in pouchitis

      INFLAMMATORY BOWEL DISEASES
    82. Avent, ND
      Molecular biology of the Rh blood group system

      JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
    83. Kawakami, T; Hasegawa, K; Teruya, K; Akaji, K; Horiuchi, M; Inagaki, F; Kurihara, Y; Uesugi, S; Aimoto, S
      Polypeptide synthesis using an expressed peptide as a building block for condensation with a peptide thioester: Application to the synthesis of phosphorylated p21Max protein(1-101)

      JOURNAL OF PEPTIDE SCIENCE
    84. Villain, M; Vizzavona, J; Rose, K
      Covalent capture: a new tool for the purification of synthetic and recombinant polypeptides

      CHEMISTRY & BIOLOGY
    85. Silakowski, B; Nordsiek, G; Kunze, B; Blocker, H; Muller, R
      Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15

      CHEMISTRY & BIOLOGY
    86. Chen, JW; Walter, S; Horwich, AL; Smith, DL
      Folding of malate dehydrogenase inside the GroEL-GroES cavity

      NATURE STRUCTURAL BIOLOGY
    87. Inooka, H; Ohtaki, T; Kitahara, O; Ikegami, T; Endo, S; Kitada, C; Ogi, K; Onda, H; Fujino, M; Shirakawa, M
      Conformation of a peptide ligand bound to its G-protein coupled receptor

      NATURE STRUCTURAL BIOLOGY
    88. Hanazaki, K; Nose, Y; Brunicardi, FC
      Artificial endocrine pancreas

      JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
    89. Roberto, M; Scuri, R; Brunelli, M
      Differential effects of PACAP-38 on synaptic responses in rat hippocampal CA1 region

      LEARNING & MEMORY
    90. Sainsbury, A; Wilks, D; Cooney, GJ
      Central but not peripheral glucocorticoid infusion in adrenalectomized male rats increases basal and substrate-induced insulinemia through a parasympathetic pathway

      OBESITY RESEARCH
    91. Hefler, LA; Tempfer, CB; Bancher-Todesca, D; Schatten, C; Husslein, P; Heinze, G; Gregg, AR
      Placental expression and serum levels of cytokeratin-18 are increased in women with preeclampsia

      JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
    92. Loeb, MJ; Martin, PAW; Narang, N; Hakim, RS; Goto, S; Takeda, M
      Control of life, death, and differentiation in cultured midgut cells of the lepidopteran, Heliothis virescens

      IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
    93. Tahmasebi-Sarvestani, A; Tedman, R; Goss, AN
      The influence of experimentally induced osteoarthrosis on articular nerve fibers of the sheep temporomandibular joint

      JOURNAL OF OROFACIAL PAIN
    94. Bancher-Todesca, D; Hefler, L; Zeisler, H; Schatten, C; Husslein, P; Heinze, G; Tempfer, C
      Placental expression of cytokeratin 18 and serum levels of tissue polypeptide antigen in women with pregnancy-induced hypertension

      HYPERTENSION IN PREGNANCY
    95. Weitgasser, R; Sungler, P; Hauser-Kronberger, C; Dietze, O; Sattlegger, P; Hacker, GW
      Immunohistochemical assessment of an asymptomatic glucagonoma in a patientwith hypergastrinemia and marked antral angiodysplasia

      APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
    96. Ventura, CA; Fresta, M; Paolino, D; Pedotti, S; Corsaro, A; Puglisi, G
      Biomembrane model interaction and percutaneous absorption of papaverine through rat skin: Effects of cyclodextrins as penetration enhancers

      JOURNAL OF DRUG TARGETING
    97. Vachon, P; Lin, ZM; Carrier, S
      Postnatal development of penile NADPH diaphorase in male rats (Rattus norvegicus): an indicator of erectile function

      CONTEMPORARY TOPICS IN LABORATORY ANIMAL SCIENCE
    98. Jurkevich, A; Grossmann, R; Balthazart, J; Viglietti-Panzica, C
      Gender-related changes in the avian vasotocin system during ontogeny

      MICROSCOPY RESEARCH AND TECHNIQUE
    99. Lazar, G
      Peptides in frog brain areas processing visual information

      MICROSCOPY RESEARCH AND TECHNIQUE
    100. Milani, S; Calabro, A
      Role of growth factors and their receptors in gastric ulcer healing

      MICROSCOPY RESEARCH AND TECHNIQUE


ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 04:24:02