Le informazioni sugli articoli di fonte ISI sono coperte da copyright

Per ulteriori informazioni selezionare i riferimenti di interesse.

1. Farmer, WR; Liao, JC
   Precursor balancing for metabolic engineering of lycopene production in Escherichia coli
   BIOTECHNOLOGY PROGRESS
   
   W.R. Farmer e J.C. Liao, "Precursor balancing for metabolic engineering of lycopene production in Escherichia coli", BIOTECH PR, 17(1), 2001, pp. 57-61
2. Walczak, RJ; Hines, JV; Strohl, WR; Priestley, ND
   Bioconversion of the anthracycline analogue desacetyladriamycin by recombinant DoxA, a p450-monooxygena from Streptomyces sp strain c5
   ORGANIC LETTERS
   
   R.J. Walczak et al., "Bioconversion of the anthracycline analogue desacetyladriamycin by recombinant DoxA, a p450-monooxygena from Streptomyces sp strain c5", ORG LETT, 3(15), 2001, pp. 2277-2279
3. Keating, TA; Ehmann, DE; Kohli, RM; Marshall, CG; Trauger, JW; Walsh, CT
   Chain termination steps in nonribosomal peptide synthetase assembly lines:Directed acyl-S-enzyme breakdown in antibiotic and siderophore biosynthesis
   CHEMBIOCHEM
   
   T.A. Keating et al., "Chain termination steps in nonribosomal peptide synthetase assembly lines:Directed acyl-S-enzyme breakdown in antibiotic and siderophore biosynthesis", CHEMBIOCHEM, 2(2), 2001, pp. 99-107
4. Rodriguez, E; McDaniel, R
   Combinatorial biosynthesis of antimicrobials and other natural products
   CURRENT OPINION IN MICROBIOLOGY
   
   E. Rodriguez e R. McDaniel, "Combinatorial biosynthesis of antimicrobials and other natural products", CURR OPIN M, 4(5), 2001, pp. 526-534
5. Walsh, CT; Chen, HW; Keating, TA; Hubbard, BK; Losey, HC; Luo, LS; Marshall, CG; Miller, DA; Patel, HM
   Tailoring enzymes that modify nonribosomal peptides during and after chainelongation on NRPS assembly lines
   CURRENT OPINION IN CHEMICAL BIOLOGY
   
   C.T. Walsh et al., "Tailoring enzymes that modify nonribosomal peptides during and after chainelongation on NRPS assembly lines", CURR OP C B, 5(5), 2001, pp. 525-534
6. Ikeda, H; Nonomiya, T; Omura, S
   Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases
   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
   
   H. Ikeda et al., "Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases", J IND MIC B, 27(3), 2001, pp. 170-176
7. Floss, HG
   Antibiotic biosynthesis: from natural to unnatural compounds
   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
   
   H.G. Floss, "Antibiotic biosynthesis: from natural to unnatural compounds", J IND MIC B, 27(3), 2001, pp. 183-194
8. Huang, GZ; Zhang, LH; Birch, RG
   Multifunctional polyketide-peptide synthetase essential for albicidin biosynthesis in Xanthomonas albilineans
   MICROBIOLOGY-UK
   
   G.Z. Huang et al., "Multifunctional polyketide-peptide synthetase essential for albicidin biosynthesis in Xanthomonas albilineans", MICROBIO-UK, 147, 2001, pp. 631-642
9. Dezotti, NOCR; Zucchi, TMAD
   Identification of Aspergillus nidulans genes essential for the accumulation of sterigmatocystin
   FUNGAL GENETICS AND BIOLOGY
   
   N.O.C.R. Dezotti e T.M.A.D. Zucchi, "Identification of Aspergillus nidulans genes essential for the accumulation of sterigmatocystin", FUNGAL G B, 34(2), 2001, pp. 93-105
10. Chen, HW; O'Connor, S; Cane, DE; Walsh, CT
    Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit
    CHEMISTRY & BIOLOGY
    
    H.W. Chen et al., "Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit", CHEM BIOL, 8(9), 2001, pp. 899-912
11. Cerdeno, AM; Bibb, MJ; Challis, GL
    Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes
    CHEMISTRY & BIOLOGY
    
    A.M. Cerdeno et al., "Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes", CHEM BIOL, 8(8), 2001, pp. 817-829
12. Mendes, MV; Recio, E; Fouces, R; Luiten, R; Martin, JF; Aparicio, JF
    Engineered biosynthesis of novel polyenes: a pimaricin derivative producedby targeted gene disruption in Streptomyces natalensis
    CHEMISTRY & BIOLOGY
    
    M.V. Mendes et al., "Engineered biosynthesis of novel polyenes: a pimaricin derivative producedby targeted gene disruption in Streptomyces natalensis", CHEM BIOL, 8(7), 2001, pp. 635-644
13. Caffrey, P; Lynch, S; Flood, E; Finnan, S; Oliynyk, M
    Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes
    CHEMISTRY & BIOLOGY
    
    P. Caffrey et al., "Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes", CHEM BIOL, 8(7), 2001, pp. 713-723
14. Rowe, CJ; Bohm, IU; Thomas, IP; Wilkinson, B; Rudd, BAM; Foster, G; Blackaby, AP; Sidebottom, PJ; Roddis, Y; Buss, AD; Staunton, J; Leadlay, PF
    Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase
    CHEMISTRY & BIOLOGY
    
    C.J. Rowe et al., "Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase", CHEM BIOL, 8(5), 2001, pp. 475-485
15. Holzbaur, IE; Ranganathan, A; Thomas, IP; Kearney, DJA; Reather, JA; Rudd, BAM; Staunton, J; Leadlay, PF
    Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates
    CHEMISTRY & BIOLOGY
    
    I.E. Holzbaur et al., "Molecular basis of Celmer's rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates", CHEM BIOL, 8(4), 2001, pp. 329-340
16. Nicholson, TP; Rudd, BAM; Dawson, M; Lazarus, CM; Simpson, TJ; Cox, RJ
    Design and utility of oligonucleotide gene probes for fungal polyketide synthases
    CHEMISTRY & BIOLOGY
    
    T.P. Nicholson et al., "Design and utility of oligonucleotide gene probes for fungal polyketide synthases", CHEM BIOL, 8(2), 2001, pp. 157-178
17. Fujii, I; Watanabe, A; Sankawa, U; Ebizuka, Y
    Identification of Claisen cyclase domain in fungal polyketide synthase WA,a naphthopyrone synthase of Aspergillus nidulans
    CHEMISTRY & BIOLOGY
    
    I. Fujii et al., "Identification of Claisen cyclase domain in fungal polyketide synthase WA,a naphthopyrone synthase of Aspergillus nidulans", CHEM BIOL, 8(2), 2001, pp. 189-197
18. Heathcole, ML; Staunton, J; Leadlay, PF
    Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units
    CHEMISTRY & BIOLOGY
    
    M.L. Heathcole et al., "Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units", CHEM BIOL, 8(2), 2001, pp. 207-220
19. Schwarzer, D; Mootz, HD; Marahiel, MA
    Exploring the impact of different thioesterase domains for the design of hybrid peptide synthetases
    CHEMISTRY & BIOLOGY
    
    D. Schwarzer et al., "Exploring the impact of different thioesterase domains for the design of hybrid peptide synthetases", CHEM BIOL, 8(10), 2001, pp. 997-1010
20. Silakowski, B; Nordsiek, G; Kunze, B; Blocker, H; Muller, R
    Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15
    CHEMISTRY & BIOLOGY
    
    B. Silakowski et al., "Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15", CHEM BIOL, 8(1), 2001, pp. 59-69
21. Xu, GY; Tam, A; Lin, L; Hixon, J; Fritz, CC; Powers, R
    Solution structure of B-subtilis acyl carrier protein
    STRUCTURE
    
    G.Y. Xu et al., "Solution structure of B-subtilis acyl carrier protein", STRUCTURE, 9(4), 2001, pp. 277-287
22. Iyer, LM; Koonin, EV; Aravind, L
    Adaptations of the helix-grip fold for ligand binding and catalysis in theSTART domain superfamily
    PROTEINS-STRUCTURE FUNCTION AND GENETICS
    
    L.M. Iyer et al., "Adaptations of the helix-grip fold for ligand binding and catalysis in theSTART domain superfamily", PROTEINS, 43(2), 2001, pp. 134-144
23. Jiralerspong, S; Rangaswamy, V; Bender, CL; Parry, RJ
    Analysis of the enzymatic domains in the modular portion of the coronafacic acid polyketide synthase
    GENE
    
    S. Jiralerspong et al., "Analysis of the enzymatic domains in the modular portion of the coronafacic acid polyketide synthase", GENE, 270(1-2), 2001, pp. 191-200
24. Paitan, Y; Orr, E; Ron, EZ; Rosenberg, E
    An unusual beta-ketoacyl : acyl carrier protein synthase and acyltransferase motifs in TaK, a putative protein required for biosynthesis of the antibiotic TA in Myxococcus xanthus
    FEMS MICROBIOLOGY LETTERS
    
    Y. Paitan et al., "An unusual beta-ketoacyl : acyl carrier protein synthase and acyltransferase motifs in TaK, a putative protein required for biosynthesis of the antibiotic TA in Myxococcus xanthus", FEMS MICROB, 203(2), 2001, pp. 191-197
25. Moffitt, MC; Neilan, BA
    On the presence of peptide synthetase and polyketide synthase genes in thecyanobacterial genus Nodularia
    FEMS MICROBIOLOGY LETTERS
    
    M.C. Moffitt e B.A. Neilan, "On the presence of peptide synthetase and polyketide synthase genes in thecyanobacterial genus Nodularia", FEMS MICROB, 196(2), 2001, pp. 207-214
26. Bugg, TDH
    The development of mechanistic enzymology in the 20th century
    NATURAL PRODUCT REPORTS
    
    T.D.H. Bugg, "The development of mechanistic enzymology in the 20th century", NAT PROD R, 18(5), 2001, pp. 465-493
27. Cornish, K
    Biochemistry of natural rubber, a vital raw material, emphasizing biosynthetic rate, molecular weight and compartmentalization, in evolutionarily divergent plant species
    NATURAL PRODUCT REPORTS
    
    K. Cornish, "Biochemistry of natural rubber, a vital raw material, emphasizing biosynthetic rate, molecular weight and compartmentalization, in evolutionarily divergent plant species", NAT PROD R, 18(2), 2001, pp. 182-227
28. Nielsen, J
    Metabolic engineering
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
    
    J. Nielsen, "Metabolic engineering", APPL MICR B, 55(3), 2001, pp. 263-283
29. Miao, V; Coeffet-LeGal, MF; Brown, D; Sinnemann, S; Donaldson, G; Davies, J
    Genetic approaches to harvesting lichen products
    TRENDS IN BIOTECHNOLOGY
    
    V. Miao et al., "Genetic approaches to harvesting lichen products", TRENDS BIOT, 19(9), 2001, pp. 349-355
30. Kurosaki, F; Togashi, K; Arisawa, M
    Regulation of catalytic activity of a multifunctional polyketide biosynthetic enzyme, 6-hydroxymellein synthase, by interaction between NADPH and phenylglyoxal-sensitive amino acid residue at the reaction center
    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
    
    F. Kurosaki et al., "Regulation of catalytic activity of a multifunctional polyketide biosynthetic enzyme, 6-hydroxymellein synthase, by interaction between NADPH and phenylglyoxal-sensitive amino acid residue at the reaction center", BBA-PROT ST, 1549(1), 2001, pp. 51-60
31. Zheng, DS; Schroder, G; Schroder, J; Hrazdina, G
    Molecular and biochemical characterization of three aromatic polyketide synthase genes from Rubus idaeus
    PLANT MOLECULAR BIOLOGY
    
    D.S. Zheng et al., "Molecular and biochemical characterization of three aromatic polyketide synthase genes from Rubus idaeus", PLANT MOL B, 46(1), 2001, pp. 1-15
32. Zhang, QB; Sherman, DH
    Isolation and structure determination of novamethymycin, a new bioactive metabolite of the methymycin biosynthetic pathway in Streptomyces venezuelae
    JOURNAL OF NATURAL PRODUCTS
    
    Q.B. Zhang e D.H. Sherman, "Isolation and structure determination of novamethymycin, a new bioactive metabolite of the methymycin biosynthetic pathway in Streptomyces venezuelae", J NAT PROD, 64(11), 2001, pp. 1447-1450
33. Hu, HF; Ochi, K
    Novel approach for improving the productivity of antibiotic-producing strains by inducing combined resistant mutations
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY
    
    H.F. Hu e K. Ochi, "Novel approach for improving the productivity of antibiotic-producing strains by inducing combined resistant mutations", APPL ENVIR, 67(4), 2001, pp. 1885-1892
34. Ostermeier, M; Benkovic, SJ
    Evolution of protein function by domain swapping
    ADVANCES IN PROTEIN CHEMISTRY, VOL 55
    
    M. Ostermeier e S.J. Benkovic, "Evolution of protein function by domain swapping", ADV PROTEIN, 55, 2001, pp. 29-77
35. Hitchman, TS; Schmidt, EW; Trail, F; Rarick, MD; Linz, JE; Townsend, CA
    Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B-1 biosynthesis
    BIOORGANIC CHEMISTRY
    
    T.S. Hitchman et al., "Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B-1 biosynthesis", BIOORG CHEM, 29(5), 2001, pp. 293-307
36. Chakraborty, TK; Tapadar, S
    Diastereoselective opening of trisubstituted epoxy alcohols: application in the synthesis of (+)-prelactone C
    TETRAHEDRON LETTERS
    
    T.K. Chakraborty e S. Tapadar, "Diastereoselective opening of trisubstituted epoxy alcohols: application in the synthesis of (+)-prelactone C", TETRAHEDR L, 42(7), 2001, pp. 1375-1377
37. Kim, SJ; Kang, HY; Sherman, DH
    Synthesis of triketide delta-lactones
    SYNTHESIS-STUTTGART
    
    S.J. Kim et al., "Synthesis of triketide delta-lactones", SYNTHESIS-S, (12), 2001, pp. 1790-1793
38. Yamazaki, Y; Suh, DY; Sitthithaworn, W; Ishiguro, K; Kobayashi, Y; Shibuya, M; Ebizuka, Y; Sankawa, U
    Diverse chalcone synthase superfamily enzymes from the most primitive vascular plant, Psilotum nudum
    PLANTA
    
    Y. Yamazaki et al., "Diverse chalcone synthase superfamily enzymes from the most primitive vascular plant, Psilotum nudum", PLANTA, 214(1), 2001, pp. 75-84
39. Khosla, C; Harbury, PB
    Modular enzymes
    NATURE
    
    C. Khosla e P.B. Harbury, "Modular enzymes", NATURE, 409(6817), 2001, pp. 247-252
40. Qiu, XY; Janson, CA; Smith, WW; Head, M; Lonsdale, J; Konstantinidis, AK
    Refined structures of beta-ketoacyl-acyl carrier protein synthase III
    JOURNAL OF MOLECULAR BIOLOGY
    
    X.Y. Qiu et al., "Refined structures of beta-ketoacyl-acyl carrier protein synthase III", J MOL BIOL, 307(1), 2001, pp. 341-356
41. Moche, M; Dehesh, K; Edwards, P; Lindqvist, Y
    The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54 angstrom resolution and its relationship to other condensing enzymes
    JOURNAL OF MOLECULAR BIOLOGY
    
    M. Moche et al., "The crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Synechocystis sp. at 1.54 angstrom resolution and its relationship to other condensing enzymes", J MOL BIOL, 305(3), 2001, pp. 491-503
42. Flaman, AS; Chen, JM; Van Iderstine, SC; Byers, DM
    Site-directed mutagenesis of acyl carrier protein (ACP) reveals amino acidresidues involved in ACP structure and acyl-ACP synthetase activity
    JOURNAL OF BIOLOGICAL CHEMISTRY
    
    A.S. Flaman et al., "Site-directed mutagenesis of acyl carrier protein (ACP) reveals amino acidresidues involved in ACP structure and acyl-ACP synthetase activity", J BIOL CHEM, 276(38), 2001, pp. 35934-35939
43. Tsai, HF; Fujii, I; Watanabe, A; Wheeler, AH; Chang, YC; Yasuoka, Y; Ebizuka, Y; Kwon-Chung, KJ
    Pentaketide melanin biosynthesis in Aspergillus fumigatus requires chain-length shortening of a heptaketide precursor
    JOURNAL OF BIOLOGICAL CHEMISTRY
    
    H.F. Tsai et al., "Pentaketide melanin biosynthesis in Aspergillus fumigatus requires chain-length shortening of a heptaketide precursor", J BIOL CHEM, 276(31), 2001, pp. 29292-29298
44. Kremer, L; Nampoothiri, KM; Lesjean, S; Dover, LG; Graham, S; Betts, J; Brennan, PJ; Minnikin, DE; Locht, C; Besra, GS
    Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA : AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II
    JOURNAL OF BIOLOGICAL CHEMISTRY
    
    L. Kremer et al., "Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA : AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II", J BIOL CHEM, 276(30), 2001, pp. 27967-27974
45. Smirnova, N; Reynolds, KA
    Engineered fatty acid biosynthesis in Streptomyces by altered catalytic function of beta-ketoacyl-acyl carrier protein synthase III
    JOURNAL OF BACTERIOLOGY
    
    N. Smirnova e K.A. Reynolds, "Engineered fatty acid biosynthesis in Streptomyces by altered catalytic function of beta-ketoacyl-acyl carrier protein synthase III", J BACT, 183(7), 2001, pp. 2335-2342
46. Rodriguez, L; Rodriguez, D; Olano, C; Brana, AF; Mendez, C; Salas, JA
    Functional analysis of oleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus
    JOURNAL OF BACTERIOLOGY
    
    L. Rodriguez et al., "Functional analysis of oleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus", J BACT, 183(18), 2001, pp. 5358-5363
47. Wilson, DJ; Xue, YQ; Reynolds, KA; Sherman, DH
    Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae
    JOURNAL OF BACTERIOLOGY
    
    D.J. Wilson et al., "Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae", J BACT, 183(11), 2001, pp. 3468-3475
48. Chung, L; Liu, L; Patel, S; Carney, JR; Reeves, CD
    Deletion of rapQNML from the rapamycin gene cluster of Streptomyces hygroscopicus gives production of the 16-O-desmethyl-27-desmethoxy analog
    JOURNAL OF ANTIBIOTICS
    
    L. Chung et al., "Deletion of rapQNML from the rapamycin gene cluster of Streptomyces hygroscopicus gives production of the 16-O-desmethyl-27-desmethoxy analog", J ANTIBIOT, 54(3), 2001, pp. 250-256
49. Feng, B; Wang, X; Hauser, M; Kaufmann, S; Jentsch, S; Haase, G; Becker, JM; Szaniszlo, PJ
    Molecular cloning and characterization of WdPKS1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in Wangiella (Exophiala)dermatitidis
    INFECTION AND IMMUNITY
    
    B. Feng et al., "Molecular cloning and characterization of WdPKS1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in Wangiella (Exophiala)dermatitidis", INFEC IMMUN, 69(3), 2001, pp. 1781-1794
50. Morita, H; Noguchi, H; Schroder, J; Abe, I
    Novel polyketides synthesized with a higher plant stilbene synthase
    EUROPEAN JOURNAL OF BIOCHEMISTRY
    
    H. Morita et al., "Novel polyketides synthesized with a higher plant stilbene synthase", EUR J BIOCH, 268(13), 2001, pp. 3759-3766
51. Abe, I; Takahashi, Y; Morita, H; Noguchi, H
    Benzalacetone synthase - A novel polyketide synthase that plays a crucial role in the biosynthesis of phenylbutanones in Rheum palmatum
    EUROPEAN JOURNAL OF BIOCHEMISTRY
    
    I. Abe et al., "Benzalacetone synthase - A novel polyketide synthase that plays a crucial role in the biosynthesis of phenylbutanones in Rheum palmatum", EUR J BIOCH, 268(11), 2001, pp. 3354-3359
52. Frykman, S; Leaf, T; Carreras, C; Licari, P
    Precursor-directed production of erythromycin analogs by Saccharopolysporaerythraea
    BIOTECHNOLOGY AND BIOENGINEERING
    
    S. Frykman et al., "Precursor-directed production of erythromycin analogs by Saccharopolysporaerythraea", BIOTECH BIO, 76(4), 2001, pp. 303-310
53. Dreier, J; Li, Q; Khosla, C
    Malonyl-CoA : ACP transacylase from Streptomyces coelicolor has two alternative catalytically active nucleophiles
    BIOCHEMISTRY
    
    J. Dreier et al., "Malonyl-CoA : ACP transacylase from Streptomyces coelicolor has two alternative catalytically active nucleophiles", BIOCHEM, 40(41), 2001, pp. 12407-12411
54. Chen, HW; Thomas, MG; O'Connor, SE; Hubbard, BK; Burkart, MD; Walsh, CT
    Aminoacyl-S-enzyme intermediates in beta-hydroxylations and alpha,beta-desaturations of amino acids in peptide antibiotics
    BIOCHEMISTRY
    
    H.W. Chen et al., "Aminoacyl-S-enzyme intermediates in beta-hydroxylations and alpha,beta-desaturations of amino acids in peptide antibiotics", BIOCHEM, 40(39), 2001, pp. 11651-11659
55. Lobo, S; Florova, G; Reynolds, KA
    A Streptomyces collinus thiolase with novel Acetyl-CoA : Acyl carrier protein transacylase activity
    BIOCHEMISTRY
    
    S. Lobo et al., "A Streptomyces collinus thiolase with novel Acetyl-CoA : Acyl carrier protein transacylase activity", BIOCHEM, 40(39), 2001, pp. 11955-11964
56. Kohli, RM; Trauger, JW; Schwarzer, D; Marahiel, MA; Walsh, CT
    Generality of peptide cyclization catalyzed by isolated thioesterase domains of nonribosomal peptide synthetases
    BIOCHEMISTRY
    
    R.M. Kohli et al., "Generality of peptide cyclization catalyzed by isolated thioesterase domains of nonribosomal peptide synthetases", BIOCHEM, 40(24), 2001, pp. 7099-7108
57. Admiraal, SJ; Walsh, CT; Khosla, C
    The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates
    BIOCHEMISTRY
    
    S.J. Admiraal et al., "The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates", BIOCHEM, 40(20), 2001, pp. 6116-6123
58. Taguchi, T; Ebizuka, Y; Hopwood, DA; Ichinose, K
    A new mode of stereochemical control revealed by analysis of the biosynthesis of dihydrogranaticin in Streptomyces violaceoruber Tu22
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
    
    T. Taguchi et al., "A new mode of stereochemical control revealed by analysis of the biosynthesis of dihydrogranaticin in Streptomyces violaceoruber Tu22", J AM CHEM S, 123(46), 2001, pp. 11376-11380
59. Miller, DA; Walsh, CT; Luo, LS
    C-methyltransferase and cyclization domain activity at the intraprotein PK/NRP switch point of yersiniabactin synthetase
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
    
    D.A. Miller et al., "C-methyltransferase and cyclization domain activity at the intraprotein PK/NRP switch point of yersiniabactin synthetase", J AM CHEM S, 123(34), 2001, pp. 8434-8435
60. Leaf, T; Cadapan, L; Carreras, C; Regentin, R; Ou, S; Woo, E; Ashley, G; Licari, P
    Precursor-directed biosynthesis of 6-deoxyerythronolide B analogs in Streptomyces coelicolor: Understanding precursor effects
    BIOTECHNOLOGY PROGRESS
    
    T. Leaf et al., "Precursor-directed biosynthesis of 6-deoxyerythronolide B analogs in Streptomyces coelicolor: Understanding precursor effects", BIOTECH PR, 16(4), 2000, pp. 553-556
61. Harrison, PHM; Duspara, PA; Jenkins, SI; Kassam, SA; Liscombe, DK; Hughes, DW
    The biosynthesis of pramanicin in Stagonospora sp ATCC 74235: a modified acyltetramic acid
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
    
    P.H.M. Harrison et al., "The biosynthesis of pramanicin in Stagonospora sp ATCC 74235: a modified acyltetramic acid", J CHEM S P1, (24), 2000, pp. 4390-4402
62. Anson, CE; Bibb, MJ; Booker-Milburn, KI; Clissold, C; Haley, PJ; Hopwood, DA; Ichinose, K; Revill, WP; Stephenson, GR; Surti, CM
    Genetic engineering of Streptomyces coelicolor A3(2) for the enantioselective reduction of unnatural beta-keto-ester substrates
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
    
    C.E. Anson et al., "Genetic engineering of Streptomyces coelicolor A3(2) for the enantioselective reduction of unnatural beta-keto-ester substrates", ANGEW CHEM, 39(1), 2000, pp. 224-227
63. Ryu, DDY; Nam, DH
    Biomolecular engineering: a new frontier in biotechnology
    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
    
    D.D.Y. Ryu e D.H. Nam, "Biomolecular engineering: a new frontier in biotechnology", J MOL CAT B, 10(1-3), 2000, pp. 23-37
64. Kaneko, T; McArthur, H; Sutcliffe, J
    Recent developments in the area of macrolide antibiotics
    EXPERT OPINION ON THERAPEUTIC PATENTS
    
    T. Kaneko et al., "Recent developments in the area of macrolide antibiotics", EXPERT OP T, 10(4), 2000, pp. 403-425
65. Mankelow, DP; Neilan, BA
    Non-ribosomal peptide antibiotics
    EXPERT OPINION ON THERAPEUTIC PATENTS
    
    D.P. Mankelow e B.A. Neilan, "Non-ribosomal peptide antibiotics", EXPERT OP T, 10(10), 2000, pp. 1583-1591
66. Faust, B; Hoffmeister, D; Weitnauer, G; Westrich, L; Haag, S; Schneider, P; Decker, H; Kunzel, E; Rohr, J; Bechthold, A
    Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomycesfradiae Tu2717
    MICROBIOLOGY-UK
    
    B. Faust et al., "Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomycesfradiae Tu2717", MICROBIO-UK, 146, 2000, pp. 147-154
67. Kantola, J; Kunnari, T; Hautala, A; Hakala, J; Ylihonko, K; Mantsala, P
    Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp.
    MICROBIOLOGY-UK
    
    J. Kantola et al., "Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp.", MICROBIO-UK, 146, 2000, pp. 155-163
68. Walton, JD
    Horizontal gene transfer and the evolution of secondary metabolite gene clusters in fungi: An hypothesis
    FUNGAL GENETICS AND BIOLOGY
    
    J.D. Walton, "Horizontal gene transfer and the evolution of secondary metabolite gene clusters in fungi: An hypothesis", FUNGAL G B, 30(3), 2000, pp. 167-171
69. Cropp, TA; Wilson, DJ; Reynolds, KA
    Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectin
    NATURE BIOTECHNOLOGY
    
    T.A. Cropp et al., "Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectin", NAT BIOTECH, 18(9), 2000, pp. 980-983
70. Du, LC; Sanchez, C; Chen, M; Edwards, DJ; Shen, B
    The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase
    CHEMISTRY & BIOLOGY
    
    L.C. Du et al., "The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase", CHEM BIOL, 7(8), 2000, pp. 623-642
71. Brautaset, T; Sekurova, ON; Sletta, H; Ellingsen, TE; Strom, AR; Valla, S; Zotchev, SB
    Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomycesnoursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway
    CHEMISTRY & BIOLOGY
    
    T. Brautaset et al., "Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomycesnoursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway", CHEM BIOL, 7(6), 2000, pp. 395-403
72. Tang, L; Fu, H; McDaniel, R
    Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases
    CHEMISTRY & BIOLOGY
    
    L. Tang et al., "Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases", CHEM BIOL, 7(2), 2000, pp. 77-84
73. Wilkinson, B; Foster, G; Rudd, BAM; Taylor, NL; Blackaby, AP; Sidebottom, PJ; Cooper, DJ; Dawson, MJ; Buss, AD; Gaisser, S; Bohm, IU; Rowe, CJ; Cortes, J; Leadlay, PF; Staunton, J
    Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase
    CHEMISTRY & BIOLOGY
    
    B. Wilkinson et al., "Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase", CHEM BIOL, 7(2), 2000, pp. 111-117
74. Trefzer, A; Hoffmeister, D; Kunzel, E; Stockert, S; Weitnauer, G; Westrich, L; Rix, U; Fuchser, J; Bindseil, KU; Rohr, J; Bechthold, A
    Function of glycosyltransferase genes involved in urdamycin A biosynthesis
    CHEMISTRY & BIOLOGY
    
    A. Trefzer et al., "Function of glycosyltransferase genes involved in urdamycin A biosynthesis", CHEM BIOL, 7(2), 2000, pp. 133-142
75. Chen, S; Xue, YQ; Sherman, DH; Reynolds, KA
    Mechanisms of molecular recognition in the pikromycin polyketide synthase
    CHEMISTRY & BIOLOGY
    
    S. Chen et al., "Mechanisms of molecular recognition in the pikromycin polyketide synthase", CHEM BIOL, 7(12), 2000, pp. 907-918
76. Jez, JM; Austin, MB; Ferrer, JL; Bowman, ME; Schroder, J; Noel, JP
    Structural control of polyketide formation in plant-specific polyketide synthases
    CHEMISTRY & BIOLOGY
    
    J.M. Jez et al., "Structural control of polyketide formation in plant-specific polyketide synthases", CHEM BIOL, 7(12), 2000, pp. 919-930
77. Piel, J; Hertweck, C; Shipley, PR; Hunt, DM; Newman, MS; Moore, BS
    Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase
    CHEMISTRY & BIOLOGY
    
    J. Piel et al., "Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase", CHEM BIOL, 7(12), 2000, pp. 943-955
78. Aparicio, JF; Fouces, R; Mendes, MV; Olivera, N; Martin, JF
    A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricinin Streptomyces natalensis
    CHEMISTRY & BIOLOGY
    
    J.F. Aparicio et al., "A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricinin Streptomyces natalensis", CHEM BIOL, 7(11), 2000, pp. 895-905
79. Tillett, D; Dittmann, E; Erhard, M; von Dohren, H; Borner, T; Neilan, BA
    Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system
    CHEMISTRY & BIOLOGY
    
    D. Tillett et al., "Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system", CHEM BIOL, 7(10), 2000, pp. 753-764
80. Ehmann, DE; Trauger, JW; Stachelhaus, T; Walsh, CT
    Aminoacyl-SNACs as small-molecule substrates for the condensation domains of nonribosomal peptide synthetases
    CHEMISTRY & BIOLOGY
    
    D.E. Ehmann et al., "Aminoacyl-SNACs as small-molecule substrates for the condensation domains of nonribosomal peptide synthetases", CHEM BIOL, 7(10), 2000, pp. 765-772
81. Chartrain, M; Salmon, PM; Robinson, DK; Buckland, BC
    Metabolic engineering and directed evolution for the production of pharmaceuticals
    CURRENT OPINION IN BIOTECHNOLOGY
    
    M. Chartrain et al., "Metabolic engineering and directed evolution for the production of pharmaceuticals", CURR OPIN B, 11(2), 2000, pp. 209-214
82. Firn, RD; Jones, CG
    The evolution of secondary metabolism - a unifying model
    MOLECULAR MICROBIOLOGY
    
    R.D. Firn e C.G. Jones, "The evolution of secondary metabolism - a unifying model", MOL MICROB, 37(5), 2000, pp. 989-994
83. Volchegursky, Y; Hu, ZH; Katz, L; McDaniel, R
    Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea
    MOLECULAR MICROBIOLOGY
    
    Y. Volchegursky et al., "Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea", MOL MICROB, 37(4), 2000, pp. 752-762
84. Julien, B; Shah, S; Ziermann, R; Goldman, R; Katz, L; Khosla, C
    Isolation and characterization of the epothilone biosynthetic gene clusterfrom Sorangium cellulosum
    GENE
    
    B. Julien et al., "Isolation and characterization of the epothilone biosynthetic gene clusterfrom Sorangium cellulosum", GENE, 249(1-2), 2000, pp. 153-160
85. Watanabe, A; Fujii, I; Tsai, HF; Chang, YC; Kwon-Chung, KJ; Ebizuka, Y
    Aspergillus fumigatus alb1 encodes naphthopyrone synthase when expressed in Aspergillus oryzae
    FEMS MICROBIOLOGY LETTERS
    
    A. Watanabe et al., "Aspergillus fumigatus alb1 encodes naphthopyrone synthase when expressed in Aspergillus oryzae", FEMS MICROB, 192(1), 2000, pp. 39-44
86. Shen, B
    Biosynthesis of aromatic polyketides
    BIOSYNTHESIS: AROMATIC POLYKETIDES, ISOPRENOIDS, ALKALOIDS
    
    B. Shen, "Biosynthesis of aromatic polyketides", T CURR CHEM, 209, 2000, pp. 1-51
87. Chirgadze, NY; Briggs, SL; McAllister, KA; Fischl, AS; Zhao, GS
    Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis
    EMBO JOURNAL
    
    N.Y. Chirgadze et al., "Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis", EMBO J, 19(20), 2000, pp. 5281-5287
88. Lal, R; Kumari, R; Kaur, H; Khanna, R; Dhingra, N; Tuteja, D
    Regulation and manipulation of the gene clusters encoding type-I PKSs
    TRENDS IN BIOTECHNOLOGY
    
    R. Lal et al., "Regulation and manipulation of the gene clusters encoding type-I PKSs", TRENDS BIOT, 18(6), 2000, pp. 264-274
89. Zhu, G; Marchewka, MJ; Woods, KM; Upton, SJ; Keithly, JS
    Molecular analysis of a Type I fatty acid synthase in Cryptosporidium parvum
    MOLECULAR AND BIOCHEMICAL PARASITOLOGY
    
    G. Zhu et al., "Molecular analysis of a Type I fatty acid synthase in Cryptosporidium parvum", MOL BIOCH P, 105(2), 2000, pp. 253-260
90. Pirrung, MC; Silva, CM; Jaegers, J
    Available pathways database (APD): An essential resource for combinatorialbiology
    JOURNAL OF NATURAL PRODUCTS
    
    M.C. Pirrung et al., "Available pathways database (APD): An essential resource for combinatorialbiology", J NAT PROD, 63(10), 2000, pp. 1400-1405
91. Hu, ZH; Hopwood, DA; Khosla, C
    Directed transfer of large DNA fragments between Streptomyces species
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY
    
    Z.H. Hu et al., "Directed transfer of large DNA fragments between Streptomyces species", APPL ENVIR, 66(5), 2000, pp. 2274-2277
92. Keller, NP; Watanabe, CMH; Kelkar, HS; Adams, TH; Townsend, CA
    Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY
    
    N.P. Keller et al., "Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans", APPL ENVIR, 66(1), 2000, pp. 359-362
93. Smith, WC; Xiang, LK; Shen, B
    Genetic localization and molecular characterization of the nonS gene required for macrotetrolide biosynthesis in Streptomyces griseus DSM40695
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    
    W.C. Smith et al., "Genetic localization and molecular characterization of the nonS gene required for macrotetrolide biosynthesis in Streptomyces griseus DSM40695", ANTIM AG CH, 44(7), 2000, pp. 1809-1817
94. Liu, W; Shen, B
    Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027apoprotein
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
    
    W. Liu e B. Shen, "Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027apoprotein", ANTIM AG CH, 44(2), 2000, pp. 382-392
95. Perham, RN
    Swinging arms and swinging domains in multifunctional enzymes: Catalytic machines for multistep reactions
    ANNUAL REVIEW OF BIOCHEMISTRY
    
    R.N. Perham, "Swinging arms and swinging domains in multifunctional enzymes: Catalytic machines for multistep reactions", ANN R BIOCH, 69, 2000, pp. 961-1004
96. Vanden Boom, TJ
    Recent developments in the molecular genetics of the erythromycin-producing organism Saccharopolyspora erythraea
    ADVANCES IN APPLIED MICROBIOLOGY, VOL 47
    
    T.J. Vanden Boom, "Recent developments in the molecular genetics of the erythromycin-producing organism Saccharopolyspora erythraea", ADV APPL MI, 47, 2000, pp. 79-111
97. Cordell, GA
    Biodiversity and drug discovery - a symbiotic relationship
    PHYTOCHEMISTRY
    
    G.A. Cordell, "Biodiversity and drug discovery - a symbiotic relationship", PHYTOCHEM, 55(6), 2000, pp. 463-480
98. Trauger, JW; Kohli, RM; Mootz, HD; Marahiel, MA; Walsh, CT
    Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase
    NATURE
    
    J.W. Trauger et al., "Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase", NATURE, 407(6801), 2000, pp. 215-218
99. Zhou, R; Rasooly, R; Linz, JE
    Isolation and analysis of fluP, a gene associated with hyphal growth and sporulation in Aspergillus parasiticus
    MOLECULAR AND GENERAL GENETICS
    
    R. Zhou et al., "Isolation and analysis of fluP, a gene associated with hyphal growth and sporulation in Aspergillus parasiticus", MOL G GENET, 264(4), 2000, pp. 514-520
100. Khosla, C
     Natural product biosynthesis: A new interface between enzymology and medicine
     JOURNAL OF ORGANIC CHEMISTRY
     
     C. Khosla, "Natural product biosynthesis: A new interface between enzymology and medicine", J ORG CHEM, 65(24), 2000, pp. 8127-8133