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t(15;17) reverse transcription-polymerase chain reaction with alternative splicing
JOURNAL OF MOLECULAR DIAGNOSTICS
The clinical significance of cytogenetic abnormalities in acute myeloid leukaemia
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
Molecular genetics of acute myeloid leukaemia
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
Histone acetylation: plants and fungi as model systems for the investigation of histone deacetylases
CELLULAR AND MOLECULAR LIFE SCIENCES
Modeling acute promyelocytic leukemia in the mouse: New insights in the pathogenesis of human leukemias
BLOOD CELLS MOLECULES AND DISEASES
Mouse models of acute promyelocytic leukemia
CURRENT OPINION IN HEMATOLOGY
Acute promyelocytic leukemia with apparently normal karyotype: Molecular findings and response to all-trans retinoic acid
LEUKEMIA & LYMPHOMA
Arsenic trioxide in the management of acute promyelocytic leukaemia
NATIONAL MEDICAL JOURNAL OF INDIA
Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia
HUMAN MOLECULAR GENETICS
Mouse models for multistep tumorigenesis
TRENDS IN CELL BIOLOGY
Building 'validated' mouse models of human cancer
CURRENT OPINION IN CELL BIOLOGY
APL, a model disease for cancer therapies?
ONCOGENE
Arsenic trioxide, a therapeutic agent for APL
ONCOGENE
Biological features of primary APL blasts: their relevance to the understanding of granulopoiesis, leukemogenesis and patient management
ONCOGENE
Orchestration of multiple arrays of signal cross-talk and combinatorial interactions for maturation and cell death: another vision of t(15;17) preleukemic blast and APL-cell maturation
ONCOGENE
Transcriptional regulation in acute promyelocytic leukemia
ONCOGENE
The theory of APL
ONCOGENE
Pathways of retinoic acid- or arsenic trioxide-induced PML/RAR alpha catabolism, role of oncogene degradation in disease remission
ONCOGENE
Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes
ONCOGENE
In vivo analysis of the molecular genetics of acute promyelocytic leukemia
ONCOGENE
In vivo effects of a histone deacetylase inhibitor, FK228, on human acute promyelocytic leukemia in NOD/Shi-scid/scid mice
JAPANESE JOURNAL OF CANCER RESEARCH
Autonomous rexinoid death signaling is suppressed by converging signaling pathways in immature leukemia cells
MOLECULAR ENDOCRINOLOGY
A novel differentiation-inducing therapy for acute promyelocytic leukemia with a combination of arsenic trioxide and GM-CSF
LEUKEMIA
Monitoring minimal residual disease and predicting relapse in APL by quantitating PML-RAR alpha transcripts with a sensitive competitive RT-PCR method
LEUKEMIA
Promyelocytic leukemia, a unique model to design treatments targeting oncogenes
M S-MEDECINE SCIENCES
United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia
JOURNAL OF CLINICAL ONCOLOGY
ATRA(ouble) in the treatment of acute promyelocytic leukemia
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
Molecular characterization of acute myeloblastic leukemia according to thenew WHO classification: a different distribution in Central-West Spain
HAEMATOLOGICA
CD34-positive acute promyelocytic leukemia is associated with leukocytosis, microgranular/hypogranular morphology, expression of CD2 and bcr3 isoform
AMERICAN JOURNAL OF HEMATOLOGY
Analysis of prognostic factors in newly diagnosed patients with acute promyelocytic leukemia: the APL92 study of the Japan Adult Leukemia Study Group(JALSG)
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Novel mutation in the PML/RAR alpha chimeric gene exhibits dramatically decreased ligand-binding activity and confers acquired resistance to retinoicacid in acute promyelocytic leukemia
EXPERIMENTAL HEMATOLOGY
Common properties of nuclear body protein SP100 and TIF1 alpha chromatin factor: Role of SUMO modification
MOLECULAR AND CELLULAR BIOLOGY
Arsenic trioxide: its role in acute promyelocytic leukemia and potential in other hematologic malignancies
BLOOD REVIEWS
The role of bone marrow transplantation in acute promyelocytic leukemia
BONE MARROW TRANSPLANTATION
Monitoring of minimal residual disease in children with acute promyelocytic leukemia by RT-PCR detecting PML/RAR alpha chimeric gene: A retrospectivestudy of clinical feasibility
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
Effects of the acute myeloid leukemia-associated fusion proteins on nuclear architecture
SEMINARS IN HEMATOLOGY
Analysis of the molecular genetics of acute promyelocytic leukemia in mouse models
SEMINARS IN HEMATOLOGY
Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Epstein-Barr virus immediate-early protein BZLF1 is SUMO-1 modified and disrupts promyelocytic leukemia bodies
JOURNAL OF VIROLOGY
BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRAR alpha) to block neutrophil differentiation and initiate acute leukemia
JOURNAL OF EXPERIMENTAL MEDICINE
Haploinsufficiency for tumor suppression: The hazards of being single and living a long time
JOURNAL OF EXPERIMENTAL MEDICINE
Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia
JOURNAL OF CLINICAL INVESTIGATION
Dynamic nuclear localization of the baculovirus proteins IE2 and PE38 during the infection cycle: The promyelocytic leukemia protein colocalizes withIE2
EXPERIMENTAL CELL RESEARCH
Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites
CANCER RESEARCH
Inhibition of promyelocytic leukemia (PML)/retinoic acid receptor-alpha and PML expression in acute promyelocytic leukemia cells by anti-PML peptide nucleic acid
CANCER RESEARCH
Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia
CANCER RESEARCH
Prolonged molecular remission in advanced acute promyelocytic leukaemia after treatment with gemtuzumab ozogamicin (Mylotarg (TM) CMA-676)
BRITISH JOURNAL OF HAEMATOLOGY
Acute myeloblastic leukaemias of FAB types M6 and M4, with cryptic PML/RARalpha fusion gene formation, relapsing as acute promyelocytic leukaemia M3
BRITISH JOURNAL OF HAEMATOLOGY
Pretreatment characteristics and clinical outcome of acute promyelocytic leukaemia patients according to the PML-RAR alpha isoforms: a study of the PETHEMA group
BRITISH JOURNAL OF HAEMATOLOGY
Prognostic significance of minimal residual disease detection and PML/RAR-alpha isoform type: long-term follow-up in acute promyelocytic leukemia
BLOOD
Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid
BLOOD
Tyrosine kinase inhibitor ST1571 potentiates the pharmacologic activity ofretinoic acid in acute promyelocytic leukemia cells: effects on the degradation of RAR alpha and PML-RAR alpha
BLOOD
Transcription therapy for acute promyelocytic leukaemia
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Two critical hits for promyelocytic leukemia
MOLECULAR CELL
Retinoic acid receptor alpha (RAR alpha) mutations in human leukemia
LEUKEMIA & LYMPHOMA
Establishment of a myeloid cell line, YM711, characterized by retinoid resistance
LEUKEMIA & LYMPHOMA
Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: an useful salvage therapy
LEUKEMIA & LYMPHOMA
Prolonged third remission in a patient with acute promyelocytic leukemia after consolidation chemotherapy with intermittent intermediate dose Ara-C and maintenance with intermittent all-trans retinoic acid (ATRA)
LEUKEMIA & LYMPHOMA
Clinical significance of minimal residual disease in leukemia (Review)
INTERNATIONAL JOURNAL OF ONCOLOGY
Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF
ONCOGENE
Current issues in the management of acute promyelocytic leukemia
ANNALS OF HEMATOLOGY
The incidence of acute promyelocytic leukemia appears constant over most of a human lifespan, implying only one rate limiting mutation
LEUKEMIA
Arsenic trioxide (As2O3)-induced apoptosis and differentiation in retinoicacid-resistant acute promyelocytic leukemia model in hGM-CSF-producing transgenic SCID mice
LEUKEMIA
Differentiation therapy in acute myelogenous leukemia (non-APL)
LEUKEMIA
Quantitation of minimal residual disease in acute promyelocytic leukemia patients with t(15;17) translocation using real-time RT-PCR
LEUKEMIA
Defect in the regulation of 4E-BP1 and 2, two repressors of translation initiation, in the retinoid acid resistant cell lines, NB4-R1 and NE4-R2
LEUKEMIA
Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis
LEUKEMIA
Modified intranuclear organization of regulatory factors in human acute leukemias: Reversal after treatment
JOURNAL OF CELLULAR BIOCHEMISTRY
Alterations in subnuclear trafficking of nuclear regulatory factors in acute leukemia
JOURNAL OF CELLULAR BIOCHEMISTRY
Translocation (15;17)(q22;q21) not associated with acute promyelocytic leukemia and negative for PML/RAR alpha rearrangement
HAEMATOLOGICA
Retinoic acid receptor fusion proteins: friend or foe
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Acute promyelocytic leukemia - From morphology to molecular lesions
CLINICS IN LABORATORY MEDICINE
Minimal residual disease in acute promyelocytic leukemia
CLINICS IN LABORATORY MEDICINE
Molecular diagnosis in pediatric acute leukemias
CLINICS IN LABORATORY MEDICINE
Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway
EMBO JOURNAL
Mechanisms of all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells
JOURNAL OF BIOSCIENCES
Retinoids in chemoprevention and differentiation therapy
CARCINOGENESIS
White cells 2: impact of understanding the molecular basis of haematological malignant disorders on clinical practice
LANCET
Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RAR alpha and PLZF-RAR alpha oncoproteins
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Monitoring of minimal residual disease by combined detection of PML/RAR alpha and RAR alpha/PML rearrangements in acute promyelocytic leukemia
MEDICINA CLINICA
Identification of B94 (TNFAIP2) as a potential retinoic acid target gene in acute promyelocytic leukemia
CANCER RESEARCH
Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-transretinoic acid
BRITISH JOURNAL OF HAEMATOLOGY
Altered ligand binding and transcriptional regulation by mutations in the PML/RAR alpha ligand-binding domain arising in retinoic acid-resistant patients with acute promyelocytic leukemia
BLOOD
Ligand-inducible interaction of the DRTP/TRAP coactivator complex with retinoid receptors in retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells
BLOOD
Characterization of acute promyelocytic leukemia cases lacking the classict(15;17): results of the European Working Party
BLOOD
PML/RAR alpha fusion protein expression in normal human hematopoietic progenitors dictates myeloid commitment and the promyelocytic phenotype
BLOOD
Differentiation-independent retinoid induction of folate receptor type beta, a potential tumor target in myeloid leukemia
BLOOD
Isolation and characterization of an acute promyelocytic leukemia cell line selectively resistant to the novel antileukemic and apoptogenic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid
BLOOD
PML/RAR alpha(+) hypergranular acute promyelocytic leukemia (M3) developing into an M3 acute myelocytic leukemia without PML/RAR alpha
ACTA HAEMATOLOGICA
A novel retinoic acid-resistant acute promyelocytic leukemia model in vitro and in vivo (review)
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
A novel, non-nested reverse-transcriptase polymerase chain reaction (RT-PCR) test for the detection of the t(15;17) translocation: A comparative study of RT-PCR cytogenetics, and fluorescence in situ hybridization
MOLECULAR DIAGNOSIS
Extramedullary disease in acute promyelocytic leukemia
LEUKEMIA & LYMPHOMA
Aml1/ETO and Pml/RARA rearrangements in a case of AML-M2 acute myeloblastic leukemia with t(15;17)
LEUKEMIA & LYMPHOMA
Diagnostic approaches to acute promyelocytic leukaemia
LEUKEMIA & LYMPHOMA
Efficacy of all-trans retinoic acid for molecular relapse of acute promyelocytic leukemia during remission
ONCOLOGY REPORTS
MID2, a homologue of the Opitz syndrome gene MID1: similarities in subcellular localization and differences in expression during development
HUMAN MOLECULAR GENETICS
Formation of PML/RAR alpha high molecular weight nuclear complexes throughthe PML coiled-coil region is essential for the PML/RAR alpha-mediated retinoic acid response
ONCOGENE
Acute promyelocytic leukemia: from treatment to genetics and back
ONCOGENE
In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications
ONCOGENE