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Assaying phosphatidylinositol bisphosphate regulation of potassium channels
G PROTEIN PATHWAYS: PT C, EFFECTOR MECHANISMS
Phox domain interaction with Ptdlns(S)P targets the Vam7 t-SNARE to vacuole membranes
NATURE CELL BIOLOGY
Phosphatidylinositol 3-kinase and the control of endosome dynamics: New players defined by structural motifs
TRAFFIC
Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Pharmacology of phosphoinositides, regulators of multiple cellular functions
CURRENT PHARMACEUTICAL DESIGN
Phosphoinositide 3-kinase inhibition in cancer treatment
EXPERT OPINION ON INVESTIGATIONAL DRUGS
The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate
MOLECULAR CELL
Biological basket weaving: Formation and function of clathrin-coated vesicles
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
Regulation of ROMK trafficking and channel activity
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
Selective protection of mitogenically stimulated human lymphocytes but notleukemic cells from cytosine arabinoside-induced apoptosis by LY294002, a phosphoinositol-3 kinase inhibitor
INTERNATIONAL JOURNAL OF ONCOLOGY
Cytohesins and centaurins: mediators of PI 3-kinase regulated Arf signaling
TRENDS IN BIOCHEMICAL SCIENCES
Structural properties of lipid-binding sites in cytoskeletal proteins
TRENDS IN BIOCHEMICAL SCIENCES
Modular phosphoinositide-binding domains - their role in signalling and membrane trafficking
CURRENT BIOLOGY
Subcellular targeting by membrane lipids
CURRENT OPINION IN CELL BIOLOGY
Tec kinases: modulators of lymphocyte signaling and development
CURRENT OPINION IN IMMUNOLOGY
Signaling via Shc family adapter proteins
ONCOGENE
Adaptor proteins in protein kinase C-mediated signal transduction
ONCOGENE
Signaling networks regulating beta 1 integrin-mediated adhesion of T lymphocytes to extracellular matrix
JOURNAL OF LEUKOCYTE BIOLOGY
IgG Fc receptors
ANNUAL REVIEW OF IMMUNOLOGY
FYVE zinc-finger proteins in the plant model Arabidopsis thaliana: identification of PtdIns3P-binding residues by comparison of classic and variant FYVE domains
BIOCHEMICAL JOURNAL
Single-cell imaging of graded Ins(1,4,5)P-3 production following G-protein-coupled-receptor activation
BIOCHEMICAL JOURNAL
Membrane recruitment of DOCK180 by binding to Ptdlns(3,4,5)P-3
BIOCHEMICAL JOURNAL
The Dictyostelium Bcr/Abr-related protein DRG regulates both Rac- and Rab-dependent pathways
EMBO JOURNAL
Enteropathogenic Escherichia coli mediates antiphagocytosis through the inhibition of PI 3-kinase-dependent pathways
EMBO JOURNAL
A mathematical model for chemoattractant gradient sensing based on receptor-regulated membrane phospholipid signaling dynamics
ANNALS OF BIOMEDICAL ENGINEERING
Isolation and properties of GRP1, an ADP-ribosylation factor (ARF)-guaninenucleotide exchange protein regulated by phosphatidylinositol 3,4,5-trisphosphate
REGULATORS AND EFFECTORS OF SMALL GTPASES, PT E
G-protein signaling through tubby proteins
SCIENCE
Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis
SCIENCE
ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Signal transduction by human-restricted Fc gamma RIIa involves three distinct cytoplasmic kinase families leading to phagocytosis
JOURNAL OF IMMUNOLOGY
Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D
JOURNAL OF CELL BIOLOGY
Desensitization of the luteinizing hormone/choriogonadotropin receptor in ovarian follicular membranes is inhibited by catalytically inactive ARNO(+)
JOURNAL OF BIOLOGICAL CHEMISTRY
Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1
JOURNAL OF BIOLOGICAL CHEMISTRY
Actin cytoskeletal association of cytohesin-1 is regulated by specific phosphorylation of its carboxyl-terminal polybasic domain
JOURNAL OF BIOLOGICAL CHEMISTRY
Reassembly of phospholipase C-beta(2) from separated domains - Analysis ofbasal and G protein-stimulated activities
JOURNAL OF BIOLOGICAL CHEMISTRY
G-protein-coupled receptor activation induces the membrane translocation and activation of phosphatidylinositol-4-phosphate 5-kinase I alpha by a Rac- and Rho-dependent pathway
JOURNAL OF BIOLOGICAL CHEMISTRY
Insulin induces suppressor of cytokine signaling-3 tyrosine phosphorylation through janus-activated kinase
JOURNAL OF BIOLOGICAL CHEMISTRY
Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides
JOURNAL OF BIOLOGICAL CHEMISTRY
Reassessment of the Ca2+ sensing property of a type I metabotropic glutamate receptor by simultaneous measurement of inositol 1,4,5-trisphosphate andCa2+ in single cells
JOURNAL OF BIOLOGICAL CHEMISTRY
Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk
JOURNAL OF BIOLOGICAL CHEMISTRY
Phosphoinositide 3-kinase facilitates antigen-stimulated Ca2+ influx in RBL-2H3 mast cells via a phosphatidylinositol 3,4,5-trisphosphate-sensitive Ca2+ entry mechanism
JOURNAL OF BIOLOGICAL CHEMISTRY
Monitoring agonist-induced phospholipase C activation in live cells by fluorescence resonance energy transfer
JOURNAL OF BIOLOGICAL CHEMISTRY
A critical pole for phosphoinositide 3-kinase upstream of Gab1 and SHP2 inthe activation of Ras and mitogen-activated protein kinases by epidermal growth factor
JOURNAL OF BIOLOGICAL CHEMISTRY
High-affinity binding of a FYVE domain to phosphatidylinositol 3-phosphaterequires intact phospholipid but not FYVE domain oligomerization
BIOCHEMISTRY
Isolation of a novel human gene, ARHGAP9, encoding a Rho-GTPase activatingprotein
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
The Rac1-and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin
NATURE CELL BIOLOGY
Nuclear inositides: inconsistent consistencies
CELLULAR AND MOLECULAR LIFE SCIENCES
The tail domain of myosin M catalyses nucleotide exchange on Rac1 GTPases and can induce actin-driven surface protrusions
TRAFFIC
Intracellular signaling events at the leading edge of migrating cells
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Nuclear inositides
EUROPEAN JOURNAL OF HISTOCHEMISTRY
Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast
MOLECULAR BIOLOGY OF THE CELL
Signaling of G(alpha 12) family of g proteins through a tyrosine kinase and a Ras-GAP
TRENDS IN CARDIOVASCULAR MEDICINE
The dynamin family of mechanoenzymes: pinching in new places
TRENDS IN BIOCHEMICAL SCIENCES
Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling
TRENDS IN BIOCHEMICAL SCIENCES
Large and diverse numbers of human diseases with HIKE mutations
HUMAN MOLECULAR GENETICS
Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-bisphosphate-specific PH domain
CURRENT BIOLOGY
Signaling network of the Btk family kinases
ONCOGENE
A phospholipid kinase regulates actin organization and intercellular bridge formation during germline cytokinesis
DEVELOPMENT
In vivo functional analysis of the Daughter of Sevenless protein in receptor tyrosine kinase signaling
MECHANISMS OF DEVELOPMENT
beta-adrenergic mechanisms in cardiac diseases - A perspective
CELLULAR SIGNALLING
Structure and function of phosphatidylinositol-3,4 kinase
CELLULAR SIGNALLING
Novel functional PI 3-kinase antagonists inhibit cell growth and tumorigenicity in human cancer cell lines
FASEB JOURNAL
Patterns within protein/polyphosphoinositide interactions provide specifictargets for therapeutic intervention
FASEB JOURNAL
Structure, function, and biology of SHIP proteins
GENES & DEVELOPMENT
Mechanisms of small CTP-binding proteins activation by their exchange factors
M S-MEDECINE SCIENCES
Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-B beta
MOLECULAR AND CELLULAR BIOLOGY
Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components
BIOCHEMICAL JOURNAL
Rho GTPases and their effector proteins
BIOCHEMICAL JOURNAL
Structural basis of the membrane-targeting and unmasking mechanisms of theradixin FERM domain
EMBO JOURNAL
Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein
EMBO JOURNAL
Phosphatidylinositol 3,4,5-trisphosphate regulates Ca2+ entry via Btk in platelets and megakaryocytes without increasing phospholipase C activity
EMBO JOURNAL
Lipid metabolism in vertebrate retinal rod outer segments
PROGRESS IN LIPID RESEARCH
PIP2 and PIP3: Complex roles at the cell surface
CELL
Bacterial expressed DH and DH/PH domains
REGULATORS AND EFFECTORS OF SMALL GTPASES, PT D
Activation of Rac1 by human Tiam1
REGULATORS AND EFFECTORS OF SMALL GTPASES, PT D
The B-cell antigen receptor: Formation of signaling complexes and the function of adaptor proteins
SIGNAL TRANSDUCTION AND THE COORDINATION OF B LYMPHOCYTE DEVELOPMENT AND FUNCTION I
Intermediary signaling effectors coupling the B-cell receptor to the nucleus
SIGNAL TRANSDUCTION AND THE COORDINATION OF B LYMPHOCYTE DEVELOPMENT AND FUNCTION I
Phosphorylation of unnatural phosphatidylinositols with phosphatidylinositol 3-kinase
TETRAHEDRON
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
SCIENCE
A sensitized genetic system for the analysis of murine B lymphocyte signaltransduction pathways dependent on Bruton's tyrosine kinase
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Membrane phospholipid asymmetry and signal transduction
JOURNAL OF MEMBRANE BIOLOGY
A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase
JOURNAL OF EXPERIMENTAL MEDICINE
N-terminal targeting of guanine nucleotide exchange factors (GEF) for ADP ribosylation factors (ARF) to the Golgi
JOURNAL OF CELL SCIENCE
Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis
JOURNAL OF CELL BIOLOGY
Intracellular pH regulation by Na+/H+ exchange requires phosphatidylinositol 4,5-bisphosphate
JOURNAL OF CELL BIOLOGY
Impaired Kit- but not Fc epsilon RI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85 alpha gene products
JOURNAL OF BIOLOGICAL CHEMISTRY
Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases
JOURNAL OF BIOLOGICAL CHEMISTRY
Identification of a plasma membrane-associated guanine nucleotide exchangefactor for ARF6 in chromaffin cells - Possible role in the regulated exocytotic pathway
JOURNAL OF BIOLOGICAL CHEMISTRY
Identification and characterization of a new family of guanine nucleotide exchange factors for the Ras-related GTPase Ral
JOURNAL OF BIOLOGICAL CHEMISTRY
Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts
JOURNAL OF BIOLOGICAL CHEMISTRY
Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14 - Characterization of a new receptor binding partner
JOURNAL OF BIOLOGICAL CHEMISTRY
Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases
EUROPEAN JOURNAL OF IMMUNOLOGY
Identification of a region at the N-terminus of phospholipase C-beta 3 that interacts with G protein beta gamma subunits
BIOCHEMISTRY
Binding of the PH and polybasic C-terminal domains of ARNO to phosphoinositides and to acidic lipids
BIOCHEMISTRY
Mouse myosin X: Molecular architecture and tissue expression as revealed by northern blot and in situ hybridization analyses
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Fluorescently labeled neomycin as a probe of phosphatidylinositol-4,5-bisphosphate in membranes
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring
NATURE CELL BIOLOGY
Tails of unconventional myosins
CELLULAR AND MOLECULAR LIFE SCIENCES
Regulation of phospholipase D by phosphorylation-dependent mechanisms
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS