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Induction by a lactic acid bacterium of a population of CD4(+) T cells with low proliferative capacity that produce transforming growth factor beta and interleukin-10
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
Mechanisms of cytokine synergy essential for vaccine protection against viral challenge
INTERNATIONAL IMMUNOLOGY
Signals delivered through TCR instruct IL-12 receptor (IL-12R) expression:IL-12 and tumor necrosis factor-alpha synergize for IL-12R expression at low antigen dose
INTERNATIONAL IMMUNOLOGY
IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis
EUROPEAN RESPIRATORY JOURNAL
T cell effector subsets: Extending the Th1/Th2 paradigm
ADVANCES IN IMMUNOLOGY, VOL 78
Contribution of Th1 and Th2 cells to protection and pathology in experimental models of granulomatous lung disease
JOURNAL OF IMMUNOLOGY
An instructive component in T helper cell type 2 (Th2) development mediated by GATA-3
JOURNAL OF EXPERIMENTAL MEDICINE
Non-major histocompatibility complex control of antibody isotype and Th1 versus Th2 cytokines during experimental infection of mice with Mycobacterium avium
INFECTION AND IMMUNITY
Signaling via interleukin-4, receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice
INFECTION AND IMMUNITY
Preferential production of interferon-gamma by CD4(+) T cells expressing the homing receptor integrin alpha(4)/beta(7)
IMMUNOLOGY
CD4(+) T cells that evade deletion by a self peptide display Th1-biased differentiation
EUROPEAN JOURNAL OF IMMUNOLOGY
Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
IMMUNITY
Modulation of allergen-specific immune responses to the major shrimp allergen, tropomyosin, by specific targeting to scavenger receptors on macrophages
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
Dose-dependent selective priming of Th1 and Th2 immune responses is achieved only by an antigen with an affinity over a certain threshold level
MOLECULES AND CELLS
Control of CD4 T cell fate by antigen re-stimulation with or without CTLA-4 engagement 24 h after priming
INTERNATIONAL IMMUNOLOGY
Induction of long-lasting cytokine effect by injection of IL-12 encoding plasmid DNA
CANCER GENE THERAPY
Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation
MOLECULAR AND CELLULAR BIOLOGY
Antigen dose defines T helper 1 and T helper 2 responses in the lungs of C57BL/6 and BALB/c mice independently of splenic responses
IMMUNOLOGY LETTERS
Dendritic cells prime in vivo alloreactive CD4 T lymphocytes toward type 2cytokine- and TGF-beta-producing cells in the absence of CD8 T cell activation
JOURNAL OF IMMUNOLOGY
Conventional, naive CD4(+) T cells provide an initial source of IL-4 during Th2 differentiation
JOURNAL OF IMMUNOLOGY
Defective Th function induced by a dominant-negative cAMP response elementbinding protein mutation is reversed by Bcl-2
JOURNAL OF IMMUNOLOGY
The balance of protein kinase C and calcium signaling directs T cell subset development
JOURNAL OF IMMUNOLOGY
Inhibition of IL-4 responses after T cell priming in the context of LFA-1 costimulation is not reversed by restimulation in the presence of CD28 costimulation
JOURNAL OF IMMUNOLOGY
Multiplexed particle-based flow cytometric assays
JOURNAL OF IMMUNOLOGICAL METHODS
Interleukin 4-producing CD4 T cells arise from different precursors depending on the conditions of antigen exposure in vivo
JOURNAL OF EXPERIMENTAL MEDICINE
Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2
JOURNAL OF BIOLOGICAL CHEMISTRY
Interleukin-4 receptor alpha-deficient BALB/c mice show an unimpaired T helper 2 polarization in response to Leishmania major infection
INFECTION AND IMMUNITY
Interaction within clusters of dendritic cells and helper T cells during initial Th1/Th2 commitment
EUROPEAN JOURNAL OF IMMUNOLOGY
Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression
BLOOD
Primed and replicating but uncommitted T helper precursor cells show kinetics of differentiation and commitment similar to those of naive T helper cells
MICROBES AND INFECTION
New insight into the mechanisms underlying Th2 cell development and susceptibility to Leishmania major in BALB c mice
MICROBES AND INFECTION
Influence of host and parasite factors on the innate immune response and Th2 stability following infection with Leishmania major
MICROBES AND INFECTION
Non-MHC-linked genetic polymorphism controls selective development of Th2 but not inhibition of Th1 cells by soluble antigen administration
MICROBES AND INFECTION
Loci influencing development of Th responses. Identification from in vitroanalysis
MICROBES AND INFECTION
Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effector function
IMMUNITY
Dealing from the evolutionary pawnshop: How lymphocytes make decisions
IMMUNITY
Early interleukin-4: Its role in the switch towards a Th2 response and IgE-mediated allergy
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
Experimental hypersensitivity pneumonitis: influence of Th2 bias
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
Memory/effector T cells in TCR transgenic mice develop via recognition of enteric antigens by a second, endogenous TCR
INTERNATIONAL IMMUNOLOGY
Nature versus nurture in T cell cytokine production
JOURNAL OF LEUKOCYTE BIOLOGY
Educating T cells: Early events in the differentiation and commitment of cytokine-producing CD4(+) and CD8(+) T cells
SPRINGER SEMINARS IN IMMUNOPATHOLOGY
Type 1 and type 2 immune responses in children: their relevance in juvenile arthritis
SPRINGER SEMINARS IN IMMUNOPATHOLOGY
Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases
BIOESSAYS
Cytokine, chemokine and chemokine receptor mRNA expression in different strains of normal mice: implications for establishment of a Th1/Th2 bias
JOURNAL OF NEUROIMMUNOLOGY
Self-priming cell culture system for monitoring genetically-controlled spontaneous cytokine-producing ability in mice
IMMUNOLOGY LETTERS
The influence of dietary protein antigen on Th1/Th2 balance and cellular immunity
IMMUNOLOGY LETTERS
Functional skewing of bone marrow-derived dendritic cells by Th1- or Th2-inducing cytokines
IMMUNOLOGY LETTERS
Signals involved in the early T-H1/T-H2 polarization of an immune responsedepending on the type of antigen
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
T helper differentiation proceeds through Stat1-dependent, Stat4-dependentand Stat4-independent phases
REDIRECTION OF TH1 AND TH2 RESPONSES
The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
CD28 costimulation accelerates IL-4 receptor sensitivity and IL-4-mediatedTh2 differentiation
JOURNAL OF IMMUNOLOGY
The role of CTLA-4 in regulating Th2 differentiation
JOURNAL OF IMMUNOLOGY
Altered memory T cell differentiation in patients with early rheumatoid arthritis
JOURNAL OF IMMUNOLOGY
Adjuvant-guided type-1 and type-2 immunity: Infectious/noninfectious dichotomy defines the class of response
JOURNAL OF IMMUNOLOGY
Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4
JOURNAL OF IMMUNOLOGY
TCR-independent pathways mediate the effects of antigen dose and altered peptide ligands on Th cell polarization
JOURNAL OF IMMUNOLOGY
Modulation of airway inflammation by passive transfer of allergen-specificTh1 and Th2 cells in a mouse model of asthma
JOURNAL OF IMMUNOLOGY
Tpm1, a locus controlling IL-12 responsiveness, acts by a cell-autonomous mechanism
JOURNAL OF IMMUNOLOGY
IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs
JOURNAL OF IMMUNOLOGY
Effect of an orally active Th1/Th2 balance modulator, M50367, on IgE production, eosinophilia, and airway hyperresponsiveness in mice
JOURNAL OF IMMUNOLOGY
Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay
JOURNAL OF IMMUNOLOGICAL METHODS
Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells
JOURNAL OF EXPERIMENTAL MEDICINE
Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation
JOURNAL OF CLINICAL INVESTIGATION
Polarized helper-T-cell responses against Leishmania major in the absence of B cells
INFECTION AND IMMUNITY
Impact of V beta 8(+/+) T cells on the development of increased airway reactivity and IgE production in SJL mice
EUROPEAN JOURNAL OF IMMUNOLOGY
DISEASE SUSCEPTIBILITY AND DEVELOPMENT OF THE CYTOKINE REPERTOIRE IN THE MURINE LEISHMANIA-MAJOR MODEL
European cytokine network
REGULATION OF IL-4 EXPRESSION BY ACTIVATION OF INDIVIDUAL ALLELES
Immunity (Cambridge, Mass.)
HELPER T-CELL DIFFERENTIATION IS CONTROLLED BY THE CELL-CYCLE
Immunity (Cambridge, Mass.)
CYTOKINES INDUCE THE DEVELOPMENT OF FUNCTIONALLY HETEROGENEOUS T-HELPER CELL SUBSETS
Immunity
Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism
IMMUNITY
LACTOBACILLUS-CASEI INHIBITS ANTIGEN-INDUCED IGE SECRETION THROUGH REGULATION OF CYTOKINE PRODUCTION IN MURINE SPLENOCYTE CULTURES
International archives of allergy and immunology
INDUCTION OF T(H)2 CELL-DIFFERENTIATION IN THE PRIMARY IMMUNE-RESPONSE - DENDRITIC CELLS ISOLATED FROM ADHERENT CELL-CULTURE TREATED WITH IL-10 PRIME NAIVE CD4(-CELLS TO SECRETE IL-4() T)
International immunology (Print)
Interferon-alpha and its effects on post-transplant lymphoproliferative disorders
SPRINGER SEMINARS IN IMMUNOPATHOLOGY
ADJUVANT IS THE MAJOR PARAMETER INFLUENCING THE ISOTYPE PROFILES GENERATED DURING IMMUNIZATION WITH A PROTEIN ANTIGEN, THE SCHISTOSOMA-MANSONI SM28-GST
Scandinavian journal of immunology
MATURATION OF HUMAN NEONATAL CD4(-LYMPHOCYTES INTO TH1() AND CD8(+) T)TH2 EFFECTORS/
Vaccine
HETEROGENEITY IN THE CLONAL T-CELL RESPONSE - IMPLICATIONS FOR MODELSOF T-CELL ACTIVATION AND CYTOKINE PHENOTYPE DEVELOPMENT
Immunologic research
HELPER T-CELL SUBSETS - HETEROGENEITY, FUNCTIONS AND DEVELOPMENT
Veterinary immunology and immunopathology
Setting in motion the immune mechanisms underlying genetically determined resistance and susceptibility to infection with Leishmania major
PARASITE IMMUNOLOGY
INDEPENDENT REGULATION OF CYTOKINE GENES IN T-CELLS - THE PARADOX IN THE PARADIGM
Transplantation
CD81 ON B-CELLS PROMOTES INTERLEUKIN-4 SECRETION AND ANTIBODY-PRODUCTION DURING T-HELPER TYPE-2 IMMUNE-RESPONSES
Proceedings of the National Academy of Sciences of the United Statesof America
CELL-DIVISION REGULATES THE T-CELL CYTOKINE REPERTOIRE, REVEALING A MECHANISM UNDERLYING IMMUNE CLASS REGULATION
Proceedings of the National Academy of Sciences of the United Statesof America
HIGH ANTIGEN DENSITY AND IL-2 ARE REQUIRED FOR GENERATION OF CD4 EFFECTORS SECRETING TH1 RATHER THAN TH0 CYTOKINES
The Journal of immunology (1950)
COMMITMENT OF INDIVIDUAL TH1-LIKE LYMPHOCYTES TO EXPRESSION OF IFN-GAMMA VERSUS IL-4 AND IL-10 - SELECTIVE INDUCTION OF IL-10 BY SEQUENTIALSTIMULATION OF NAIVE TH CELLS WITH IL-12 AND IL-4
The Journal of immunology (1950)
LOW-DOSE TGF-BETA ATTENUATES IL-12 RESPONSIVENESS IN MURINE TH CELLS
The Journal of immunology (1950)
REGULATION OF THE ACTIVITY OF IFN-GAMMA PROMOTER ELEMENTS DURING TH CELL-DIFFERENTIATION
The Journal of immunology (1950)
THE IL-4 RAPIDLY PRODUCED IN BALB C MICE AFTER INFECTION WITH LEISHMANIA-MAJOR DOWN-REGULATES IL-12 RECEPTOR BETA-2-CHAIN EXPRESSION ON CD4(+) T-CELLS RESULTING IN A STATE OF UNRESPONSIVENESS TO IL-12/
The Journal of immunology (1950)
IL-4 ENHANCES LONG-TERM SURVIVAL OF CD28-DEFICIENT T-CELLS
The Journal of immunology
IL-1-ALPHA AND TNF-ALPHA ARE REQUIRED FOR IL-12-INDUCED DEVELOPMENT OF TH1 CELLS PRODUCING HIGH-LEVELS OF IFN-GAMMA IN BALB C BUT NOT C57BL/6 MICE/
The Journal of immunology
INTERFERON-GAMMA DERIVED FROM CD4-CELLS IS SUFFICIENT TO MEDIATE T-HELPER CELL-TYPE-1 DEVELOPMENT( T)
The Journal of experimental medicine
Genetic regulation of commitment to interleukin 4 production by a CD4(+) Tcell-intrinsic mechanism
JOURNAL OF EXPERIMENTAL MEDICINE
ANTIGEN-STIMULATED IL-4, IL-13 AND IFN-GAMMA PRODUCTION BY HUMAN T-CELLS AT A SINGLE-CELL LEVEL
European Journal of Immunology
REGULATION OF THE IL-12 RECEPTOR BETA-2 SUBUNIT BY SOLUBLE-ANTIGEN AND IL-12 IN-VIVO
European Journal of Immunology
MULTISTAGE REGULATION OF TH1-TYPE IMMUNE-RESPONSES BY THE TRANSCRIPTION FACTOR IRF-1
Immunity
INTERFERON REGULATORY FACTOR-I IS REQUIRED FOR A T-HELPER-1 IMMUNE-RESPONSE IN-VIVO
Immunity
IL-4 RAPIDLY PRODUCED BY V-BETA-4 V-ALPHA-8 CD4(-CELLS INSTRUCTS THE DEVELOPMENT AND SUSCEPTIBILITY TO LEISHMANIA-MAJOR IN BALB() T)C MICE/
Immunity
IN-VITRO MATURATION OF NAIVE HUMAN CD4-LYMPHOCYTES INTO TH1, TH2 EFFECTORS( T)
International archives of allergy and immunology
REQUIREMENT OF CD28-CD86 CO-STIMULATION IN THE INTERACTION BETWEEN ANTIGEN-PRIMED T-HELPER TYPE-2 AND B-CELLS
International immunology
LACK OF T(H)1 OR T(H)2 POLARIZATION OF CD4(-CELL RESPONSE INDUCED BY PARTICULATE ANTIGEN TARGETED TO PHAGOCYTIC-CELLS() T)
International immunology