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    1. Romney, CA; Paulauskis, JD; Little, JB
      X-ray induction of microsatellite instability at autosomal loci in human lymphoblastoid WTK1 cells

      MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
    2. Habib, NA; Sarraf, CE; Mitry, RR; Havlik, R; Nicholls, J; Kelly, M; Vernon, GC; Gueret-Wardle, D; El-Masry, R; Salama, H; Ahmed, R; Michail, N; Edward, E; Jensen, SL
      E1B-deleted adenovirus (dl1520) gene therapy for patients with primary andsecondary liver tumors

      HUMAN GENE THERAPY
    3. Harrison, D; Sauthoff, H; Heitner, S; Jagirdar, J; Rom, WN; Hay, JG
      Wild-type adenovirus decreases tumor xenograft growth, but despite viral persistence complete tumor responses are rarely achieved - Deletion of the viral E1b-19-kD gene increases the viral oncolytic effect

      HUMAN GENE THERAPY
    4. Gao, C; Miyazaki, M; Kondo, T; Tsuji, T; Sakaguchi, M; Namba, M
      Overexpression of platelet-derived growth factor B and downregulation of PDGF-receptor alpha in human immortalized fibroblasts

      INTERNATIONAL JOURNAL OF ONCOLOGY
    5. Reid, T; Galanis, E; Abbruzzese, J; Sze, D; Andrews, J; Romel, L; Hatfield, M; Rubin, J; Kirn, D
      Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase Itrial

      GENE THERAPY
    6. Kirn, D
      Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned?

      GENE THERAPY
    7. Jiang, XH; Wong, BCY; Lin, MCM; Zhu, GH; Kung, HF; Jiang, SH; Yang, D; Lam, SK
      Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappa B activation in gastric cancer cells

      ONCOGENE
    8. Lee, YJ; Galoforo, SS; Battle, P; Lee, H; Corry, PM; Jessup, JM
      Replicating adenoviral vector-mediated transfer of a heat-inducible doublesuicide gene for gene therapy

      CANCER GENE THERAPY
    9. Kumamoto, H; Kimi, K; Ooya, K
      Detection of cell cycle-related factors in ameloblastomas

      JOURNAL OF ORAL PATHOLOGY & MEDICINE
    10. Frank, DK
      Gene therapy for head and neck cancers - The Lamont et al article reviewed

      ONCOLOGY-NEW YORK
    11. Villafranca, E; Okruzhnov, Y; Dominguez, MA; Garcia-Foncillas, J; Azinovic, I; Martinez, E; Ilarramendi, JJ; Arias, F; Monge, RM; Salgado, E; Angeletti, S; Brugarolas, A
      Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer

      JOURNAL OF CLINICAL ONCOLOGY
    12. Schwartz, JL; Jordan, R; Evans, HH
      Characteristics of chromosome instability in the human lymphoblast cell line WTK1

      CANCER GENETICS AND CYTOGENETICS
    13. Evans, HH; Horng, MF; Evans, TE; Jordan, R; Schwartz, JL
      Genotoxic effects of high-energy iron particles in human lymphoblasts differing in radiation sensitivity

      RADIATION RESEARCH
    14. Shen, YQ; Kitzes, G; Nye, JA; Fattaey, A; Hermiston, T
      Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein

      JOURNAL OF VIROLOGY
    15. Doronin, K; Kuppuswamy, M; Toth, K; Tollefson, AE; Krajcsi, P; Krougliak, V; Wold, WSM
      Tissue-specific, tumor-selective, replication-competent adenovirus vector for cancer gene therapy

      JOURNAL OF VIROLOGY
    16. Brunori, M; Malerba, M; Kashiwazaki, H; Iggo, R
      Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway

      JOURNAL OF VIROLOGY
    17. Deplanque, G; Ceraline, J; Mah-Becherel, MCM; Cazenave, JP; Bergerat, JP; Klein-Soyer, C
      Caffeine and the G2/M block override: A concept resulting from a misleading cell kinetic delay, independent of functional p53

      INTERNATIONAL JOURNAL OF CANCER
    18. Yoshikawa, R; Kusunoki, M; Yanagi, H; Noda, M; Furuyama, J; Yamamura, T; Hashimoto-Tamaoki, T
      Dual antitumor effects of 5-fluorouracil on the cell cycle in colorectal carcinoma cells: A novel target mechanism concept for pharmacokinetic modulating chemotherapy

      CANCER RESEARCH
    19. Andreu, T; Ebensperger, C; Westphal, EM; Klenner, T; Stewart, AF; Westhof, A; Muller, P; Knaus, R; von Melchner, H
      Self-deleting suicide vectors (SDSV): Selective killing of p53-deficient cancer cells

      CANCER RESEARCH
    20. Yang, XH; Sladek, TL; Liu, XS; Butler, BR; Froelich, CJ; Thor, AD
      Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis

      CANCER RESEARCH
    21. Natsume, T; Kobayashi, M; Fujimoto, S
      Association of p53 gene mutations with sensitivity to TZT-1027 in patientswith clinical lung and renal carcinoma

      CANCER
    22. Magnet, KJ; Orr, MS; Cleveland, JL; Rodriguez-Galindo, C; Yang, H; Yang, CY; Di, YM; Jain, PT; Gewirtz, DA
      Suppression of c-myc expression and c-Myc function in response to sustained DNA damage in MCF-7 breast tumor cells

      BIOCHEMICAL PHARMACOLOGY
    23. Ohashi, M; Kanai, F; Tateishi, K; Taniguchi, H; Marignani, PA; Yoshida, Y; Shiratori, Y; Hamada, H; Omata, M
      Target gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by E1B55k-attenuated adenovirus

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
    24. Howe, JA; Demers, GW; Johnson, DE; Neugebauer, SEA; Perry, ST; Vaillancourt, MT; Faha, B
      Evaluation of E1-mutant adenoviruses as conditionally replicating agents for cancer therapy

      MOLECULAR THERAPY
    25. Morris, JC; Wildner, O
      Therapy of head and neck squamous cell carcinoma with an oncolytic adenovirus expressing HSV-tk

      MOLECULAR THERAPY
    26. Wildner, O; Morris, JC
      Therapy of peritoneal carcinomatosis from colon cancer with oncolytic adenoviruses

      JOURNAL OF GENE MEDICINE
    27. Alemany, R; Balague, C; Curiel, DT
      Replicative adenoviruses for cancer therapy

      NATURE BIOTECHNOLOGY
    28. Ries, SJ; Brandts, CH; Chung, AS; Biederer, CH; Hann, BC; Lipner, EM; McCormick, F; Korn, WM
      Loss of p14(ARF) in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015)

      NATURE MEDICINE
    29. Curiel, DT
      The development of conditionally replicative adenoviruses for cancer therapy

      CLINICAL CANCER RESEARCH
    30. Perez-Soler, R; Kemp, B; Wu, QP; Mao, L; Gomez, J; Zeleniuch-Jacquotte, A; Yee, H; Lee, JS; Jagirdar, J; Ling, YH
      Response and determinants of sensitivity to paclitaxel in human non-small cell lung cancer tumors heterotransplanted in nude mice

      CLINICAL CANCER RESEARCH
    31. Sauthoff, H; Heitner, S; Rom, WN; Hay, JG
      Deletion of the adenoviral E1b-19kD gene enhances tumor cell killing of a replicating adenoviral vector

      HUMAN GENE THERAPY
    32. Steinwaerder, DS; Carlson, CA; Lieber, A
      DNA replication of first-generation adenovirus vectors in tumor cells

      HUMAN GENE THERAPY
    33. Rogulski, KR; Wing, MS; Paielli, DL; Gilbert, JD; Kim, JH; Freytag, SO
      Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radiosensitization

      HUMAN GENE THERAPY
    34. Szostak, MJ; Kyprianou, N
      Radiation-induced apoptosis: Predictive and therapeutic significance in radiotherapy of prostate cancer (Review)

      ONCOLOGY REPORTS
    35. Kirn, D
      Replication-selective oncolytic adenoviruses: virotherapy aimed at genetictargets in cancer

      ONCOGENE
    36. McCormick, F
      ONYX-015 selectivity and the p14ARF pathway

      ONCOGENE
    37. Petrasch, S; Reinacher-Schick, A; Busemann, B; Radtke, J; Philippou, S; Dorr, T; Kemmeries, G; Eufinger, H; Schmiegel, W
      Neoadjuvant, hyperfractionated irradiation induces apoptosis and decreasesproliferation in squamous cell cancer of the oral cavity

      INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
    38. Yoon, SS; Nakamura, H; Carroll, NM; Bode, BP; Chiocca, EA; Tanabe, KK
      An oncolytic herpes simplex virus type 1 selectively destroys diffuse liver metastases from colon carcinoma

      FASEB JOURNAL
    39. Kim, YT; Choi, EK; Cho, NH; Ko, JH; Yang, WI; Kim, JW; Lee, SH
      Expression of cyclin E and p27(KIP1) in cervical carcinoma

      CANCER LETTERS
    40. Sundaram, S; Chaudhry, M; Reardon, D; Gupta, M; Gewirtz, DA
      The vitamin D-3 analog EB 1089 enhances the antiproliferative and apoptotic effects of adriamycin in MCF-7 breast tumor cells

      BREAST CANCER RESEARCH AND TREATMENT
    41. Doronin, K; Toth, K; Kuppuswamy, M; Ward, P; Tollefson, AE; Wold, WSM
      Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein

      JOURNAL OF VIROLOGY
    42. Kurihara, T; Brough, DE; Kovesdi, I; Kufe, DW
      Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen

      JOURNAL OF CLINICAL INVESTIGATION
    43. Vietor, M; Winter, S; Groscurth, P; Naumann, U; Weller, M
      On the significance of telomerase activity in human malignant glioma cells

      EUROPEAN JOURNAL OF PHARMACOLOGY
    44. Qiu, HM; Sirivongs, P; Rothenberger, M; Rothenberger, DA; Garcia-Aguilar, J
      Molecular prognostic factors in rectal cancer treated by radiation and surgery

      DISEASES OF THE COLON & RECTUM
    45. Liang, Y; Yang, CT; Jablons, DM
      ONYX-015 works synergistically with chemotherapy in lung cancer cell linesand primary cultures freshly made from lung cancer patients

      CANCER RESEARCH
    46. Wildner, O; Morris, JC
      The role of the E1B 55 kDa gene product in oncolytic adenoviral vectors expressing herpes simplex virus-tk: Assessment of antitumor efficacy and toxicity

      CANCER RESEARCH
    47. Harima, Y; Nagata, K; Harima, K; Oka, A; Ostapenko, VV; Shikata, N; Ohnishi, T; Tanaka, Y
      Bax and Bcl-2 protein expression following radiation therapy versus radiation plus thermoradiotherapy in stage IIIB cervical carcinoma

      CANCER
    48. Mirjolet, JF; Barberi-Heyob, M; Didelot, C; Peyrat, JP; Abecassis, J; Millon, R; Merlin, JL
      Bcl-2/Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status

      BRITISH JOURNAL OF CANCER
    49. Hermiston, T; Heise, C; Kirn, DH
      The discovery and development of selectively replicating adenoviruses as anticancer agents

      TUMOR TARGETING
    50. Wu, X; Goldsmith, K; Okoh, V; Garver, RI
      Antineoplastic 'multimodality adenovirus' containing E1A and a therapeutictransgene

      TUMOR TARGETING
    51. Barnetson, AR; Banasiak, D; Fisher, RJ; Mameghan, H; Ribeiro, JCC; Brown, K; Brown, JL; O'Mara, SM; Russell, PJ
      Heterogeneity of in vitro radiosensitivity in human bladder cancer cells

      RADIATION ONCOLOGY INVESTIGATIONS
    52. Lee, JU; Hosotani, R; Wada, M; Doi, R; Kosiba, T; Fujimoto, K; Miyamoto, Y; Tsuji, S; Nakajima, S; Nishimura, Y; Imamura, M
      Role of Bcl-2 family proteins (Bax, Bcl-2 and Bcl-X) on cellular susceptibility to radiation in pancreatic cancer cells

      EUROPEAN JOURNAL OF CANCER
    53. Hayashi, S; Kano, E; Matsumoto, H; Hatashita, M; Ohtsubo, T; Nishida, T; Shioura, H; Kitai, R
      Thermosensitivity, incidence of apoptosis and accumulations of hsp72 and p53 proteins of murine L cells in wild type status of p53 gene

      JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
    54. Finucane, DM; Bossy-Wetzel, E; Waterhouse, NJ; Cotter, TG; Green, DR
      Bax-induced caspase activation and apoptosis via cytochrome c release frommitochondria is inhibitable by Bcl-xL

      JOURNAL OF BIOLOGICAL CHEMISTRY
    55. Alemany, R; Gomez-Manzano, C; Balague, C; Yung, WKA; Curiel, DT; Kyritsis, AP; Fueyo, J
      Gene therapy for gliomas: Molecular targets, adenoviral vectors, and oncolytic adenoviruses

      EXPERIMENTAL CELL RESEARCH
    56. Perez, JM; Camazon, M; Alvarez-Valdes, A; Quiroga, AG; Kelland, LR; Alonso, C; Navarro-Ranninger, MC
      Synthesis, characterization and DNA modification induced by a novel Pt(IV)-bis(monoglutarate) complex which induces apoptosis in glioma cells

      CHEMICO-BIOLOGICAL INTERACTIONS
    57. Advani, SJ; Chung, SM; Yan, SY; Gillespie, GY; Markert, JM; Whitley, RJ; Roizman, B; Weichselbaum, RR
      Replication-competent, nonneuroinvasive genetically engineered herpes virus is highly effective in the treatment of therapy-resistant experimental human tumors

      CANCER RESEARCH
    58. Yu, DC; Sakamoto, GT; Henderson, DR
      Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of Calydon virus 764, an attenuated replication competent adenovirus for prostate cancer therapy

      CANCER RESEARCH
    59. Shinoura, N; Yoshida, Y; Tsunoda, R; Ohashi, M; Zhang, WP; Asai, A; Kirino, T; Hamada, H
      Highly augmented cytopathic effect of a fiber-mutant E1B-defective adenovirus for gene therapy of gliomas

      CANCER RESEARCH
    60. Chuang, YYE; Chen, Q; Liber, HL
      Radiation-induced mutations at the autosomal thymidine kinase locus are not elevated in p53-null cells

      CANCER RESEARCH
    61. O'Neill, CF; Koberle, B; Masters, JRW; Kelland, LR
      Gene-specific repair of Pt/DNA lesions and induction of apoptosis by the oral platinum drug JM216 in three human ovarian carcinoma cell lines sensitive and resistant to cisplatin

      BRITISH JOURNAL OF CANCER
    62. MORRIS SM; CHEN JJ; DOMON OE; MCGARRITY LJ; BISHOP ME; MANJANATHA MG; CASCIANO DA
      P53, MUTATIONS, AND APOPTOSIS IN GENISTEIN-EXPOSED HUMAN LYMPHOBLASTOID-CELLS

      Mutation research. Fundamental and molecular mechanisms of mutagenesis
    63. DENOOIJVANDALEN AG; VANBUURENVANSEGGELEN VHA; LOHMAN PHM; GIPHARTGASSLER M
      CHROMOSOME LOSS WITH CONCOMITANT DUPLICATION AND RECOMBINATION BOTH CONTRIBUTE MOST TO LOSS OF HETEROZYGOSITY IN-VITRO

      Genes, chromosomes & cancer
    64. DZIADZIUSZKO R; JASSEM E; JASSEM J
      CLINICAL IMPLICATIONS OF MOLECULAR ABNORMALITIES IN LUNG-CANCER

      Cancer treatment reviews
    65. GRADZKA I; SKIERSKI J; SZUMIEL I
      DNA-REPAIR, CELL-CYCLE PROGRESSION AND CELL-DEATH FOLLOWING CAMPTOTHECIN TREATMENT IN 2 MURINE LYMPHOMA L5178Y SUBLINES

      Cell biochemistry and function
    66. TAUBERT H; MEYE A; BACHE M; HINZE R; HOLZHAUSEN HJ; SCHMIDT H; RATH FW; DUNST J; WURL P
      P53 STATUS IN RADIATION-INDUCED SOFT-TISSUE SARCOMAS

      Strahlentherapie und Onkologie
    67. HARIMA Y; HARIMA K; SHIKATA N; OKA A; OHNISHI T; TANAKA Y
      BAX AND BCL-2 EXPRESSIONS PREDICT RESPONSE TO RADIOTHERAPY IN HUMAN CERVICAL-CANCER

      Journal of cancer research and clinical oncology
    68. HUSAIN A; ROSALES N; SCHWARTZ GK; SPRIGGS DR
      LISOFYLLINE SENSITIZES P53 MUTANT HUMAN OVARIAN-CARCINOMA CELLS TO THE CYTOTOXIC EFFECTS OF CIS-DIAMMINEDICHLOROPLATINUM(II)

      Gynecologic oncology (Print)
    69. HE J; HORNG MF; DEAHL JT; OLEINICK NL; EVANS HH
      VARIATION IN PHOTODYNAMIC EFFICACY DURING THE CELLULAR UPTAKE OF 2 PHTHALOCYANINE PHOTOSENSITIZERS

      Photochemistry and photobiology
    70. ALDRIDGE DR; RADFORD IR
      EXPLAINING DIFFERENCES IN SENSITIVITY TO KILLING BY IONIZING-RADIATION BETWEEN HUMAN LYMPHOID-CELL LINES

      Cancer research
    71. BROWN JM
      EXPLOITING TUMOR HYPOXIA AND OVERCOMING MUTANT P53 WITH TIRAPAZAMINE

      British Journal of Cancer
    72. FUKUSHIMA S; OZEKI S; TANG JT; KOIZUMI M; MATSUMURA S; INOUE T; INOUE T; YAMAZAKI H; MURAYAMA S; HATANAKA K; EJIRI H; KASAI K
      INDUCTION OF P53 PROTEIN BY CARBON-ION AND PROTON-BEAM IRRADIATION IN2 CLOSE HUMAN LYMPHOBLASTOID CELL-LINES WITH DIFFERENT P53 STATUS

      Oncology Reports
    73. MAYER V; EBBESEN P
      PROGRAMMED CELL-DEATH - WILL IT BECOME A FACTOR IN CANCER PREVENTION

      European journal of cancer prevention
    74. HO YS; LEE HM; MOU TC; WANG YJ; LIN JK
      SUPPRESSION OF NITRIC OXIDE-INDUCED APOPTOSIS BY N-ACETYL-L-CYSTEINE THROUGH MODULATION OF GLUTATHIONE, BCL-2, AND BAX PROTEIN-LEVELS

      Molecular carcinogenesis
    75. EVANS HH; HORNG MF; RICANATI M; DEAHL JT; OLEINICK NL
      MUTAGENICITY OF PHOTODYNAMIC THERAPY AS COMPARED TO UVC AND IONIZING-RADIATION IN HUMAN AND MURINE LYMPHOBLAST CELL-LINES

      Photochemistry and photobiology
    76. KIM CY; TSAI MH; OSMANIAN C; GRAEBER TG; LEE JE; GIFFARD RG; DIPAOLO JA; PEEHL DM; GIACCIA AJ
      SELECTION OF HUMAN CERVICAL EPITHELIAL-CELLS THAT POSSESS REDUCED APOPTOTIC POTENTIAL TO LOW-OXYGEN CONDITIONS

      Cancer research
    77. CHMURA SJ; MAUCERI HJ; ADVANI S; HEIMANN R; BECKETT MA; NODZENSKI E; QUINTANS J; KUFE DW; WEICHSELBAUM RR
      DECREASING THE APOPTOTIC THRESHOLD OF TUMOR-CELLS THROUGH PROTEIN-KINASE-C INHIBITION AND SPHINGOMYELINASE ACTIVATION INCREASES TUMOR KILLING BY IONIZING-RADIATION

      Cancer research
    78. BERGH J
      TIME FOR INTEGRATION OF PREDICTIVE FACTORS FOR SELECTION OF BREAST-CANCER PATIENTS WHO NEED POSTOPERATIVE RADIATION-THERAPY

      Journal of the National Cancer Institute
    79. SKORSKI T; NIEBOROWSKASKORSKA M; WLODARSKI P; PERROTTI D; HOSER G; KAWIAK J; MAJEWSKI M; CHRISTENSEN L; IOZZO RV; CALABRETTA B
      TREATMENT OF PHILADELPHIA LEUKEMIA IN SEVERE COMBINED IMMUNODEFICIENTMICE BY COMBINATION OF CYCLOPHOSPHAMIDE AND BCR ABL ANTISENSE OLIGODEOXYNUCLEOTIDES/

      Journal of the National Cancer Institute
    80. CHERBONNELLASSERRE C; GAUNY S; KRONENBERG A
      SUPPRESSION OF APOPTOSIS BY BCL-2 OR BCL-X(L) PROMOTES SUSCEPTIBILITYTO MUTAGENESIS

      Oncogene
    81. OLIVE PL; BANATH JP; DURAND RE
      DEVELOPMENT OF APOPTOSIS AND POLYPLOIDY IN HUMAN LYMPHOBLAST CELLS ASA FUNCTION OF POSITION IN THE CELL-CYCLE AT THE TIME OF IRRADIATION

      Radiation research
    82. CHUANG YY; LIBER HL
      EFFECTS OF CELL-CYCLE POSITION ON IONIZING-RADIATION MUTAGENESIS .1. QUANTITATIVE ASSAYS OF 2 GENETIC-LOCI IN A HUMAN LYMPHOBLASTOID CELL-LINE

      Radiation research
    83. MORRIS SM; DOMON OE; MCGARRITY LJ; CHEN JJ; MANJANATHA MG; ANDREWS AM; AIDOO A; CASCIANO DA
      A ROLE FOR APOPTOSIS IN THE TOXICITY AND MUTAGENICITY OF BLEOMYCIN INAHH-1 TK(+ -) HUMAN LYMPHOBLASTOID-CELLS/

      Mutation research
    84. KROPVELD A; SLOOTWEG PJ; VANMANSFELD ADM; BLANKENSTEIN MA; HORDIJK GJ
      RADIORESISTANCE AND P53 STATUS OF T2 LARYNGEAL CARCINOMA - ANALYSIS BY IMMUNOHISTOCHEMISTRY AND DENATURING GRADIENT GEL-ELECTROPHORESIS

      Cancer


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Documento generato il 27/05/20 alle ore 12:37:39